GREMLIN Database
T0877_1_142 - T0877 1-142
ID: 15 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 142 (140)
Sequences: 77 (43)
Seq/√Len: 3.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
2_Y107_Q2.5770.45
98_N142_C2.3910.40
1_P22_A2.2200.35
7_C98_N2.1500.34
7_C142_C2.1500.34
8_M13_H2.1280.33
60_R136_S2.1130.33
26_I124_T2.1040.32
29_E32_D2.0270.31
52_C68_W2.0170.30
11_D34_T2.0160.30
10_N142_C1.9970.30
10_N98_N1.9970.30
48_N66_M1.9790.30
34_T130_N1.9660.29
68_W117_G1.9040.28
27_K32_D1.8700.27
12_T112_M1.8510.27
7_C10_N1.7820.25
4_P85_C1.7790.25
73_L80_T1.7500.25
50_S137_N1.7130.24
95_A133_I1.7010.24
76_D108_V1.6990.24
18_G68_W1.6830.23
11_D51_K1.6420.22
138_W142_C1.6040.22
98_N138_W1.6040.22
132_L137_N1.5770.21
85_C116_F1.5520.21
33_V136_S1.5520.21
100_T140_N1.5480.21
92_E116_F1.5290.20
4_P7_C1.5280.20
16_L38_V1.5120.20
19_P49_I1.4930.20
41_D74_E1.4890.20
48_N138_W1.4800.19
4_P142_C1.4460.19
4_P98_N1.4460.19
12_T49_I1.4370.19
35_T95_A1.4360.19
9_I120_K1.3900.18
7_C138_W1.3890.18
112_M137_N1.3700.18
30_I99_I1.3470.17
37_V84_I1.3240.17
76_D140_N1.3230.17
104_H107_Q1.3130.17
35_T88_V1.2900.16
63_G70_L1.2630.16
13_H29_E1.2630.16
42_N45_N1.2630.16
45_N53_F1.2610.16
34_T78_H1.2290.16
129_Q133_I1.2200.15
23_S59_E1.2120.15
25_A135_V1.1700.15
10_N138_W1.1610.15
8_M129_Q1.1600.15
61_L86_G1.1420.14
51_K67_E1.1130.14
66_M99_I1.1090.14
17_R83_I1.1090.14
4_P10_N1.1080.14
15_L25_A1.1010.14
3_V114_R1.0980.14
5_M9_I1.0920.14
4_P52_C1.0730.13
128_K141_Q1.0710.13
53_F111_K1.0680.13
19_P100_T1.0530.13
124_T133_I1.0480.13
31_T48_N1.0440.13
95_A131_V1.0220.13
88_V103_D1.0210.13
7_C85_C1.0120.13
94_N112_M1.0110.13
35_T68_W1.0050.13
11_D130_N0.9980.12
52_C112_M0.9950.12
19_P117_G0.9890.12
29_E113_R0.9850.12
17_R22_A0.9770.12
65_T115_I0.9640.12
40_T108_V0.9630.12
92_E137_N0.9450.12
66_M97_V0.9410.12
19_P24_W0.9380.12
12_T94_N0.9370.12
30_I136_S0.9340.12
100_T111_K0.9270.12
105_C119_F0.9220.12
81_P101_M0.9190.12
3_V112_M0.9170.12
32_D77_H0.9090.11
58_D81_P0.8970.11
20_F58_D0.8970.11
28_L90_K0.8920.11
10_N68_W0.8840.11
85_C142_C0.8800.11
85_C98_N0.8800.11
81_P121_N0.8750.11
17_R71_S0.8710.11
78_H140_N0.8660.11
26_I97_V0.8440.11
1_P24_W0.8430.11
8_M141_Q0.8390.11
8_M33_V0.8360.11
59_E113_R0.8260.11
66_M106_S0.8250.11
6_P31_T0.8250.11
35_T131_V0.8220.11
58_D121_N0.8160.10
3_V54_A0.8090.10
68_W98_N0.8080.10
68_W142_C0.8080.10
28_L92_E0.8040.10
31_T138_W0.7680.10
34_T51_K0.7610.10
32_D46_P0.7600.10
4_P138_W0.7600.10
86_G106_S0.7540.10
26_I133_I0.7500.10
14_F38_V0.7490.10
2_Y114_R0.7390.10
12_T48_N0.7360.10
17_R58_D0.7320.10
62_L121_N0.7260.10
26_I135_V0.7250.10
87_N115_I0.7190.09
47_T140_N0.7160.09
81_P122_P0.7160.09
40_T44_A0.7110.09
14_F134_S0.7060.09
18_G69_F0.7020.09
12_T98_N0.7010.09
12_T142_C0.7010.09
13_H138_W0.6970.09
16_L110_L0.6970.09
45_N54_A0.6870.09
62_L140_N0.6870.09
104_H130_N0.6850.09
13_H25_A0.6850.09
14_F74_E0.6790.09
65_T73_L0.6760.09
103_D132_L0.6740.09
135_V138_W0.6660.09
4_P100_T0.6480.09
70_L120_K0.6440.09
93_V137_N0.6420.09
27_K53_F0.6420.09
17_R68_W0.6400.09
110_L122_P0.6390.09
58_D115_I0.6370.09
66_M140_N0.6360.09
44_A123_C0.6340.09
35_T84_I0.6280.09
19_P114_R0.6270.09
16_L105_C0.6240.09
12_T19_P0.6230.09
64_F114_R0.6220.09
35_T99_I0.6180.09
7_C68_W0.6170.09
118_V129_Q0.6160.09
100_T117_G0.6070.08
96_Q142_C0.5910.08
50_S99_I0.5840.08
68_W112_M0.5770.08
10_N37_V0.5770.08
62_L103_D0.5740.08
26_I66_M0.5730.08
76_D115_I0.5620.08
18_G112_M0.5620.08
37_V43_V0.5620.08
46_P75_H0.5600.08
65_T83_I0.5600.08
1_P65_T0.5590.08
37_V96_Q0.5550.08
116_F119_F0.5530.08
5_M63_G0.5530.08
50_S56_N0.5490.08
81_P107_Q0.5490.08
45_N65_T0.5470.08
51_K61_L0.5470.08
32_D92_E0.5460.08
52_C117_G0.5440.08
132_L139_T0.5440.08
24_W52_C0.5430.08
16_L79_F0.5420.08
52_C81_P0.5410.08
28_L69_F0.5320.08
26_I86_G0.5240.08
62_L92_E0.5230.08
109_F132_L0.5230.08
99_I132_L0.5200.08
73_L116_F0.5200.08
48_N100_T0.5180.08
26_I77_H0.5140.08
13_H31_T0.5110.08
7_C12_T0.5090.08
18_G117_G0.5090.08
65_T96_Q0.5090.08
13_H103_D0.5070.08
49_I100_T0.5060.08
7_C96_Q0.5060.08
54_A70_L0.5040.08
80_T83_I0.5030.08
14_F30_I0.5010.08
81_P111_K0.5000.08
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5en2_C 1 0.9296 100 0.18 Contact Map
4zjf_A 1 0.9014 100 0.195 Contact Map
2wfo_A 1 0.9296 100 0.208 Contact Map
1v90_A 1 0.2606 2.4 0.965 Contact Map
1ms9_A 1 0.4225 1.8 0.967 Contact Map
5f3x_B 1 0.4718 1.6 0.968 Contact Map
4hfl_A 1 0.2676 1.4 0.969 Contact Map
2zdj_A 1 0.1831 1.3 0.969 Contact Map
2aqx_A 1 0.507 1.2 0.97 Contact Map
3h75_A 1 0.3592 1.2 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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