GREMLIN Database
T0875_1_122 - T0875 1-122
ID: 14 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 122 (108)
Sequences: 1767 (1206)
Seq/√Len: 116.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_L16_Y5.5301.00
18_I88_A3.8871.00
85_E100_Q3.1651.00
60_L68_V3.0511.00
65_E92_F2.8011.00
23_Q45_K2.6591.00
68_V90_D2.6021.00
10_R13_Y2.5711.00
72_V75_K2.5051.00
45_K70_S2.0901.00
62_Y66_K1.9961.00
46_E51_N1.7691.00
86_T98_I1.7571.00
2_D66_K1.7481.00
20_I70_S1.7411.00
59_P92_F1.7311.00
87_I91_I1.6441.00
18_I65_E1.5501.00
20_I25_Y1.5421.00
97_G102_K1.5051.00
78_F84_C1.4941.00
16_Y85_E1.4921.00
64_T67_Y1.4841.00
9_N13_Y1.4551.00
72_V90_D1.4531.00
89_R93_P1.4351.00
8_K17_G1.4041.00
83_N100_Q1.3951.00
43_F51_N1.3281.00
7_Y14_K1.3251.00
60_L64_T1.2770.99
47_Q50_G1.2350.99
27_L75_K1.2290.99
84_C100_Q1.2180.99
69_N74_S1.1970.99
2_D63_F1.1950.99
23_Q47_Q1.1880.99
15_H84_C1.1740.99
66_K69_N1.1660.99
71_M90_D1.1620.99
48_D51_N1.1360.99
69_N91_I1.1210.99
27_L77_I1.0920.98
20_I45_K1.0810.98
69_N73_G1.0680.98
82_T96_S1.0400.98
101_S104_L1.0320.98
78_F83_N1.0260.97
15_H83_N1.0230.97
3_I19_R1.0190.97
17_G51_N0.9940.97
41_S45_K0.9880.97
4_E65_E0.9750.97
52_W56_M0.9690.96
1_P4_E0.9650.96
75_K82_T0.9610.96
38_T41_S0.9600.96
44_I48_D0.9520.96
9_N14_K0.9480.96
47_Q51_N0.9240.95
43_F48_D0.9150.95
16_Y89_R0.9080.95
6_V24_I0.9070.95
4_E92_F0.8990.95
43_F46_E0.8800.94
53_T56_M0.8790.94
42_E47_Q0.8670.94
104_L108_G0.8580.93
19_R22_D0.8560.93
25_Y69_N0.8450.93
4_E62_Y0.8440.93
41_S44_I0.8260.92
72_V96_S0.8250.92
59_P65_E0.8190.91
60_L66_K0.8120.91
68_V73_G0.8060.91
20_I66_K0.8050.91
83_N86_T0.7970.90
40_K46_E0.7970.90
61_D65_E0.7860.90
65_E68_V0.7860.90
74_S78_F0.7770.89
38_T46_E0.7590.88
83_N98_I0.7590.88
49_D55_A0.7550.88
17_G43_F0.7540.88
35_T41_S0.7510.87
62_Y107_V0.7480.87
7_Y16_Y0.7420.87
95_Q99_S0.7400.87
58_A62_Y0.7380.87
41_S46_E0.7280.86
27_L82_T0.7260.86
7_Y55_A0.7220.85
88_A93_P0.7200.85
78_F82_T0.7140.85
99_S102_K0.7120.85
67_Y71_M0.7060.84
52_W55_A0.6960.83
25_Y45_K0.6780.82
98_I101_S0.6760.81
85_E98_I0.6740.81
66_K70_S0.6710.81
26_H46_E0.6580.80
79_S91_I0.6580.80
79_S92_F0.6570.80
25_Y70_S0.6550.79
11_G107_V0.6550.79
5_L91_I0.6540.79
2_D19_R0.6520.79
24_I27_L0.6500.79
19_R23_Q0.6460.78
62_Y65_E0.6400.78
69_N87_I0.6390.78
53_T58_A0.6300.77
104_L107_V0.6280.76
65_E69_N0.6270.76
56_M59_P0.6260.76
42_E46_E0.6250.76
18_I92_F0.6230.76
68_V72_V0.6220.76
22_D79_S0.6180.75
7_Y17_G0.6090.74
31_D41_S0.6070.74
12_F106_I0.6070.74
49_D67_Y0.6060.74
42_E50_G0.6050.74
6_V59_P0.6000.73
59_P93_P0.5870.72
96_S102_K0.5790.70
75_K96_S0.5770.70
34_T39_G0.5680.69
6_V19_R0.5650.69
88_A92_F0.5640.69
40_K48_D0.5630.68
28_N103_A0.5560.67
35_T40_K0.5540.67
77_I104_L0.5480.66
78_F87_I0.5450.66
5_L14_K0.5440.66
14_K29_S0.5430.66
89_R99_S0.5400.65
18_I62_Y0.5380.65
4_E88_A0.5370.65
105_G108_G0.5360.65
30_Q76_H0.5250.63
16_Y20_I0.5210.62
6_V48_D0.5200.62
67_Y103_A0.5180.62
89_R92_F0.5160.62
17_G24_I0.5120.61
1_P6_V0.5120.61
7_Y93_P0.5100.61
45_K48_D0.5090.61
82_T90_D0.5080.61
90_D96_S0.5050.60
19_R48_D0.5040.60
51_N56_M0.5030.60
17_G46_E0.5030.60
59_P63_F0.5020.60
67_Y70_S0.5020.60
5_L19_R0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q95_A 1 0.8689 99.9 0.305 Contact Map
4dot_A 1 0.7049 99.9 0.336 Contact Map
4dpz_X 1 0.7295 99.9 0.343 Contact Map
2lkt_A 1 0.7869 99.9 0.356 Contact Map
4q4g_X 1 0.4426 96.2 0.805 Contact Map
2im9_A 1 0.5738 96 0.808 Contact Map
4q68_A 1 0.4836 95.7 0.812 Contact Map
2if6_A 1 0.8361 94.9 0.822 Contact Map
2p1g_A 1 0.4672 94.5 0.825 Contact Map
3kw0_A 1 0.8525 94.5 0.826 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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