GREMLIN Database
T0942_c75_1_487 - T0942_c75 1-487
ID: 138 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 487 (417)
Sequences: 3839 (2751)
Seq/√Len: 134.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
358_K361_E5.7531.00
324_K327_E5.2301.00
391_Q394_E4.2211.00
129_Q224_T4.1211.00
125_D228_K3.8861.00
425_N428_Q3.8401.00
382_L386_Y3.1941.00
333_Q349_A3.1171.00
367_K394_E2.8911.00
435_E470_R2.7721.00
312_Q331_T2.7651.00
227_E257_R2.7511.00
132_S221_A2.7361.00
194_I197_T2.7331.00
413_W432_A2.6181.00
442_R445_Q2.5581.00
363_I382_L2.5551.00
163_G185_T2.5471.00
116_L134_M2.4571.00
103_E117_H2.4441.00
129_Q228_K2.4331.00
329_R353_D2.3741.00
83_L138_I2.3191.00
434_A450_L2.3171.00
363_I385_A2.3131.00
309_R345_Y2.2691.00
124_S130_L2.2691.00
319_A327_E2.2371.00
312_Q338_A2.2181.00
396_A419_A2.2141.00
393_Q423_L2.2101.00
366_L381_N2.1641.00
368_N371_D2.1501.00
339_E342_N2.1481.00
80_G96_F2.1451.00
76_I98_L2.1241.00
367_K382_L2.0961.00
210_Q214_R2.0571.00
354_L385_A2.0491.00
223_P256_A2.0441.00
121_F130_L2.0271.00
241_E251_S2.0221.00
128_S221_A2.0131.00
396_A420_E1.9901.00
272_E276_L1.9891.00
312_Q334_P1.9821.00
396_A423_L1.9641.00
80_G134_M1.9541.00
379_Q398_I1.9191.00
239_P244_L1.8951.00
191_Q195_S1.8681.00
132_S222_M1.8531.00
420_E425_N1.8381.00
101_N117_H1.8381.00
142_T211_V1.8361.00
403_T412_G1.8161.00
139_S211_V1.8131.00
336_L349_A1.7651.00
396_A416_L1.7551.00
319_A324_K1.7431.00
125_D129_Q1.7331.00
353_D361_E1.7121.00
336_L346_L1.7041.00
83_L211_V1.6631.00
451_S475_R1.6561.00
79_L217_F1.6541.00
353_D365_R1.6461.00
315_R319_A1.6451.00
295_D299_E1.6401.00
370_R378_L1.6371.00
319_A331_T1.6361.00
72_L98_L1.6331.00
202_Q251_S1.6261.00
351_D355_G1.6081.00
208_G222_M1.6001.00
65_P100_N1.5961.00
329_R349_A1.5911.00
386_Y398_I1.5821.00
181_A184_G1.5801.00
278_K282_L1.5711.00
199_Q202_Q1.5671.00
87_A90_V1.5561.00
135_A212_L1.5521.00
418_Q422_A1.5471.00
329_R356_Q1.5461.00
386_Y394_E1.5451.00
86_H215_S1.5411.00
349_A365_R1.5411.00
430_L449_L1.5271.00
84_V138_I1.5181.00
387_L419_A1.5101.00
454_S468_D1.5061.00
120_L133_V1.4871.00
271_S275_Y1.4801.00
295_D314_G1.4561.00
349_A353_D1.4541.00
447_I471_I1.4361.00
257_R261_N1.4321.00
216_G265_P1.4241.00
209_I256_A1.4101.00
353_D358_K1.3971.00
420_E428_Q1.3871.00
350_T366_L1.3841.00
320_M352_I1.3841.00
97_F115_V1.3691.00
124_S274_F1.3671.00
363_I389_G1.3661.00
291_Q295_D1.3641.00
400_N416_L1.3471.00
430_L452_S1.3431.00
292_L318_Q1.3411.00
72_L275_Y1.3371.00
167_S182_L1.3291.00
186_L190_R1.3261.00
436_G440_A1.3251.00
329_R333_Q1.3231.00
329_R352_I1.3201.00
131_A217_F1.3161.00
190_R193_M1.3111.00
143_Q207_I1.2941.00
149_A200_N1.2931.00
124_S225_F1.2881.00
392_P422_A1.2851.00
70_P375_N1.2841.00
310_A314_G1.2821.00
333_Q337_A1.2721.00
361_E364_N1.2721.00
84_V114_V1.2631.00
334_P337_A1.2581.00
309_R338_A1.2531.00
167_S178_G1.2511.00
400_N420_E1.2461.00
272_E275_Y1.2451.00
275_Y278_K1.2431.00
226_L256_A1.2361.00
305_V308_Q1.2361.00
331_T334_P1.2261.00
275_Y279_A1.2211.00
206_R255_D1.2091.00
383_A399_L1.2031.00
296_L327_E1.2021.00
75_Y79_L1.1981.00
75_Y277_A1.1820.99
269_Q272_E1.1680.99
468_D472_D1.1670.99
438_A477_L1.1660.99
359_A385_A1.1610.99
220_Q261_N1.1600.99
94_F142_T1.1580.99
461_S465_A1.1550.99
316_A332_L1.1520.99
109_F146_L1.1500.99
270_S274_F1.1480.99
292_L315_R1.1470.99
126_N129_Q1.1460.99
180_A184_G1.1450.99
382_L398_I1.1410.99
171_A178_G1.1400.99
359_A362_A1.1330.99
175_P178_G1.1300.99
72_L277_A1.1250.99
96_F138_I1.1160.99
224_T228_K1.1110.99
197_T200_N1.1100.99
166_G170_L1.1060.99
176_Q179_M1.1030.99
133_V225_F1.1020.99
346_L365_R1.1000.99
339_E345_Y1.0970.99
299_E305_V1.0960.99
78_S273_D1.0940.99
196_F200_N1.0870.99
332_L348_L1.0800.99
268_V273_D1.0790.99
363_I367_K1.0780.99
213_Q219_P1.0770.99
471_I474_L1.0770.99
367_K371_D1.0760.99
77_N81_M1.0740.99
124_S272_E1.0710.99
385_A389_G1.0700.99
222_M226_L1.0670.99
320_M355_G1.0670.99
139_S142_T1.0660.99
76_I96_F1.0650.99
160_T189_T1.0630.99
403_T413_W1.0600.99
292_L319_A1.0590.99
95_H113_N1.0590.99
159_L163_G1.0560.99
67_I118_S1.0550.99
451_S455_S1.0550.99
268_V272_E1.0480.99
167_S185_T1.0470.99
167_S181_A1.0460.99
108_A141_V1.0350.99
360_N389_G1.0320.99
291_Q321_E1.0280.99
417_A433_R1.0270.98
274_F277_A1.0250.98
274_F345_Y1.0230.98
353_D356_Q1.0100.98
208_G215_S1.0090.98
387_L392_P1.0090.98
399_L403_T1.0050.98
220_Q224_T1.0030.98
352_I356_Q1.0020.98
448_S452_S0.9970.98
470_R473_Q0.9970.98
126_N224_T0.9930.98
290_N293_T0.9920.98
458_K465_A0.9870.98
270_S273_D0.9860.98
330_K334_P0.9840.98
233_A249_P0.9780.98
249_P253_L0.9770.98
421_A433_R0.9730.98
274_F279_A0.9710.98
369_A378_L0.9710.98
114_V138_I0.9690.98
80_G138_I0.9690.98
104_I123_Y0.9670.98
346_L369_A0.9630.98
244_L249_P0.9610.98
98_L121_F0.9580.98
202_Q255_D0.9570.98
79_L130_L0.9540.98
248_L253_L0.9520.98
225_F249_P0.9520.98
276_L280_R0.9510.98
177_A181_A0.9480.97
320_M348_L0.9450.97
296_L299_E0.9410.97
223_P260_A0.9400.97
447_I451_S0.9380.97
427_D456_Q0.9320.97
277_A295_D0.9310.97
280_R283_G0.9290.97
463_Q466_R0.9280.97
128_S217_F0.9260.97
152_D155_R0.9240.97
304_N307_Q0.9240.97
464_Q468_D0.9230.97
325_Y356_Q0.9140.97
359_A388_Q0.9130.97
179_M183_T0.9120.97
380_L412_G0.9120.97
447_I474_L0.9100.97
139_S207_I0.9100.97
80_G114_V0.9050.97
122_R282_L0.9040.97
360_N391_Q0.9020.97
88_N91_K0.9010.97
76_I116_L0.8990.97
268_V271_S0.8990.97
354_L359_A0.8980.96
222_M260_A0.8980.96
379_Q401_R0.8970.96
384_N388_Q0.8950.96
281_T284_M0.8910.96
230_L250_E0.8910.96
276_L279_A0.8900.96
420_E432_A0.8900.96
143_Q203_E0.8880.96
327_E330_K0.8860.96
312_Q335_L0.8850.96
81_M85_S0.8850.96
97_F113_N0.8830.96
271_S276_L0.8830.96
158_P161_W0.8780.96
156_S189_T0.8780.96
273_D276_L0.8750.96
187_A190_R0.8710.96
108_A112_G0.8700.96
327_E331_T0.8690.96
401_R404_F0.8680.96
256_A260_A0.8670.96
230_L253_L0.8660.96
79_L131_A0.8660.96
392_P419_A0.8650.96
438_A474_L0.8650.96
431_A471_I0.8640.96
258_N261_N0.8620.96
364_N368_N0.8620.96
471_I475_R0.8600.96
148_R203_E0.8560.95
332_L349_A0.8540.95
427_D457_V0.8530.95
241_E244_L0.8530.95
416_L420_E0.8500.95
433_R437_Y0.8500.95
351_D381_N0.8480.95
184_G188_G0.8470.95
64_A99_I0.8450.95
233_A244_L0.8450.95
478_Q481_F0.8430.95
84_V94_F0.8430.95
272_E281_T0.8410.95
187_A191_Q0.8400.95
433_R436_G0.8380.95
346_L368_N0.8350.95
393_Q397_N0.8340.95
390_G422_A0.8330.95
188_G192_G0.8310.95
273_D277_A0.8280.94
183_T186_L0.8270.94
107_F115_V0.8250.94
308_Q311_A0.8250.94
421_A426_R0.8250.94
406_N409_D0.8220.94
414_D436_G0.8180.94
359_A363_I0.8160.94
450_L467_Y0.8140.94
258_N262_Q0.8130.94
224_T227_E0.8120.94
326_D330_K0.8120.94
415_L418_Q0.8070.94
435_E439_L0.8060.94
475_R478_Q0.8030.94
387_L415_L0.8030.94
444_D478_Q0.8000.93
141_V146_L0.7990.93
316_A320_M0.7980.93
207_I211_V0.7940.93
457_V467_Y0.7850.93
186_L189_T0.7830.93
213_Q263_M0.7820.93
320_M325_Y0.7810.93
226_L253_L0.7810.93
238_R250_E0.7810.93
431_A435_E0.7810.93
400_N403_T0.7810.93
335_L345_Y0.7770.92
466_R469_A0.7750.92
325_Y352_I0.7750.92
100_N285_Y0.7750.92
187_A243_L0.7740.92
334_P338_A0.7700.92
225_F229_L0.7690.92
80_G94_F0.7650.92
67_I98_L0.7640.92
113_N146_L0.7640.92
118_S279_A0.7590.91
450_L454_S0.7550.91
317_L320_M0.7520.91
461_S464_Q0.7520.91
376_P379_Q0.7510.91
108_A115_V0.7510.91
203_E207_I0.7510.91
478_Q482_K0.7500.91
394_E397_N0.7470.91
359_A389_G0.7470.91
309_R339_E0.7460.91
219_P263_M0.7450.91
294_S298_D0.7450.91
384_N387_L0.7400.90
219_P260_A0.7400.90
220_Q223_P0.7400.90
363_I386_Y0.7390.90
465_A468_D0.7380.90
277_A280_R0.7350.90
401_R405_N0.7350.90
213_Q259_R0.7330.90
469_A473_Q0.7320.90
269_Q275_Y0.7310.90
284_M351_D0.7310.90
208_G216_G0.7300.90
465_A472_D0.7300.90
149_A196_F0.7300.90
104_I241_E0.7280.90
396_A400_N0.7280.90
341_G368_N0.7250.90
275_Y344_W0.7250.90
276_L342_N0.7210.89
255_D259_R0.7210.89
120_L130_L0.7200.89
101_N119_A0.7170.89
467_Y470_R0.7150.89
344_W347_D0.7150.89
209_I260_A0.7120.89
185_T189_T0.7070.88
453_A457_V0.7050.88
286_N290_N0.7030.88
304_N308_Q0.7030.88
467_Y471_I0.7010.88
272_E278_K0.7010.88
447_I478_Q0.7000.88
289_R293_T0.7000.88
280_R284_M0.6980.88
296_L315_R0.6970.88
118_S281_T0.6920.87
431_A467_Y0.6890.87
152_D192_G0.6890.87
367_K386_Y0.6870.87
470_R474_L0.6850.87
123_Y228_K0.6840.87
466_R471_I0.6840.87
303_G308_Q0.6800.86
203_E206_R0.6790.86
132_S226_L0.6790.86
380_L402_Y0.6790.86
222_M256_A0.6780.86
274_F278_K0.6780.86
146_L150_M0.6770.86
248_L256_A0.6750.86
336_L345_Y0.6750.86
215_S219_P0.6750.86
366_L385_A0.6740.86
419_A423_L0.6720.86
279_A310_A0.6720.86
349_A352_I0.6690.85
167_S171_A0.6690.85
254_A257_R0.6660.85
131_A212_L0.6630.85
180_A187_A0.6630.85
209_I219_P0.6620.85
394_E398_I0.6610.85
99_I117_H0.6610.85
477_L480_R0.6610.85
206_R210_Q0.6590.85
127_E271_S0.6580.84
143_Q148_R0.6580.84
149_A197_T0.6570.84
437_Y440_A0.6570.84
313_Y317_L0.6560.84
326_D356_Q0.6560.84
437_Y442_R0.6540.84
464_Q467_Y0.6540.84
87_A91_K0.6530.84
437_Y449_L0.6520.84
364_N367_K0.6490.84
94_F138_I0.6490.84
230_L249_P0.6470.84
269_Q273_D0.6470.84
202_Q206_R0.6460.83
279_A283_G0.6460.83
194_I245_T0.6450.83
68_N73_T0.6430.83
451_S454_S0.6430.83
420_E423_L0.6420.83
299_E307_Q0.6410.83
284_M321_E0.6410.83
149_A152_D0.6370.83
398_I402_Y0.6340.82
393_Q396_A0.6320.82
452_S456_Q0.6290.82
452_S455_S0.6290.82
231_D234_R0.6280.82
370_R382_L0.6270.82
84_V90_V0.6250.81
402_Y412_G0.6230.81
332_L352_I0.6220.81
210_Q259_R0.6210.81
72_L75_Y0.6210.81
409_D412_G0.6190.81
172_M178_G0.6190.81
292_L296_L0.6190.81
451_S479_E0.6190.81
216_G248_L0.6180.81
426_R456_Q0.6180.81
70_P74_Q0.6170.81
255_D258_N0.6170.81
75_Y127_E0.6170.81
128_S274_F0.6160.80
267_V270_S0.6160.80
308_Q312_Q0.6150.80
413_W435_E0.6150.80
341_G397_N0.6140.80
127_E274_F0.6110.80
292_L299_E0.6100.80
270_S275_Y0.6100.80
114_V134_M0.6100.80
410_S440_A0.6100.80
276_L281_T0.6090.80
272_E283_G0.6080.80
272_E279_A0.6080.80
276_L283_G0.6070.79
79_L134_M0.6070.79
221_A226_L0.6060.79
110_F146_L0.6060.79
396_A425_N0.6050.79
150_M154_Q0.6050.79
476_Q479_E0.6020.79
384_N415_L0.6000.79
146_L196_F0.5980.78
79_L274_F0.5980.78
171_A177_A0.5980.78
220_Q260_A0.5980.78
200_N203_E0.5980.78
149_A242_I0.5980.78
135_A139_S0.5960.78
229_L233_A0.5960.78
74_Q78_S0.5940.78
315_R331_T0.5940.78
401_R416_L0.5920.78
139_S143_Q0.5900.78
282_L288_G0.5890.77
466_R472_D0.5880.77
354_L388_Q0.5860.77
284_M348_L0.5840.77
299_E311_A0.5820.77
104_I229_L0.5820.77
283_G321_E0.5810.76
229_L249_P0.5810.76
384_N418_Q0.5790.76
161_W165_L0.5780.76
71_L351_D0.5770.76
414_D418_Q0.5770.76
333_Q336_L0.5760.76
376_P402_Y0.5750.76
242_I256_A0.5740.76
410_S436_G0.5740.76
272_E339_E0.5720.75
323_N356_Q0.5720.75
73_T76_I0.5710.75
66_L97_F0.5710.75
208_G213_Q0.5710.75
331_T335_L0.5710.75
104_I225_F0.5700.75
462_L465_A0.5700.75
160_T164_A0.5700.75
299_E308_Q0.5670.75
227_E230_L0.5670.75
429_E433_R0.5640.74
70_P82_R0.5640.74
75_Y80_G0.5630.74
80_G116_L0.5630.74
151_E154_Q0.5630.74
445_Q449_L0.5620.74
293_T297_L0.5620.74
72_L156_S0.5620.74
169_L172_M0.5600.74
365_R427_D0.5580.74
426_R430_L0.5570.73
221_A244_L0.5560.73
195_S199_Q0.5560.73
171_A175_P0.5550.73
171_A182_L0.5540.73
333_Q361_E0.5530.73
328_A352_I0.5530.73
362_A385_A0.5520.73
246_H252_R0.5510.73
432_A435_E0.5510.73
421_A429_E0.5510.73
326_D358_K0.5500.72
123_Y232_Q0.5500.72
79_L83_L0.5500.72
292_L322_A0.5500.72
475_R479_E0.5490.72
320_M356_Q0.5490.72
241_E248_L0.5480.72
377_V381_N0.5480.72
268_V276_L0.5480.72
318_Q322_A0.5480.72
225_F228_K0.5480.72
110_F113_N0.5460.72
86_H214_R0.5460.72
468_D474_L0.5460.72
387_L399_L0.5460.72
437_Y445_Q0.5450.72
109_F113_N0.5440.72
272_E277_A0.5430.72
242_I245_T0.5430.72
244_L348_L0.5410.71
322_A360_N0.5410.71
163_G169_L0.5400.71
191_Q243_L0.5390.71
83_L221_A0.5370.71
132_S256_A0.5370.71
473_Q477_L0.5360.71
476_Q480_R0.5350.70
195_S244_L0.5350.70
363_I370_R0.5350.70
116_L130_L0.5340.70
260_A441_G0.5340.70
435_E438_A0.5330.70
281_T285_Y0.5320.70
149_A193_M0.5310.70
237_S244_L0.5310.70
387_L395_A0.5310.70
379_Q402_Y0.5310.70
158_P166_G0.5300.70
317_L348_L0.5300.70
104_I120_L0.5290.70
206_R259_R0.5280.69
96_F114_V0.5250.69
274_F281_T0.5250.69
73_T419_A0.5250.69
320_M347_D0.5240.69
238_R244_L0.5230.69
354_L362_A0.5220.69
95_H408_D0.5220.69
83_L134_M0.5210.68
428_Q463_Q0.5210.68
336_L339_E0.5210.68
277_A281_T0.5200.68
108_A114_V0.5180.68
120_L225_F0.5160.68
164_A167_S0.5150.68
223_P255_D0.5150.68
380_L406_N0.5150.68
289_R326_D0.5140.67
194_I243_L0.5140.67
386_Y391_Q0.5130.67
240_P244_L0.5130.67
126_N228_K0.5130.67
78_S81_M0.5120.67
177_A438_A0.5110.67
466_R470_R0.5110.67
293_T308_Q0.5100.67
111_G196_F0.5100.67
354_L384_N0.5090.67
235_Y239_P0.5090.67
354_L381_N0.5090.67
130_L229_L0.5080.67
472_D476_Q0.5080.67
459_L464_Q0.5060.66
199_Q203_E0.5060.66
438_A470_R0.5040.66
472_D475_R0.5040.66
345_Y434_A0.5010.65
233_A236_S0.5010.65
105_N247_P0.5000.65
445_Q448_S0.5000.65
73_T77_N0.5000.65
294_S297_L0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c37_A 1 0.4559 100 0.63 Contact Map
4aw6_A 1 0.4887 100 0.779 Contact Map
4il3_A 1 0.4764 99.9 0.781 Contact Map
3as5_A 1 0.3737 99.7 0.856 Contact Map
4gyw_A 1 0.3717 99.6 0.862 Contact Map
2y4t_A 1 0.4415 99.6 0.862 Contact Map
3ieg_A 1 0.4394 99.6 0.863 Contact Map
1w3b_A 1 0.5708 99.6 0.864 Contact Map
2ho1_A 1 0.4148 99.6 0.865 Contact Map
3vtx_A 1 0.3347 99.6 0.866 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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