GREMLIN Database
T0942_30-487_c90_1_458 - T0942_30-487_c90 1-458
ID: 137 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 458 (450)
Sequences: 2355 (1708)
Seq/√Len: 80.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
295_K298_E5.3151.00
329_K332_E5.2181.00
96_D199_K4.7401.00
362_Q365_E4.6631.00
353_L357_Y4.3231.00
243_E247_L4.1981.00
165_I168_T4.1301.00
103_S192_A3.8631.00
405_A421_L3.5861.00
27_Y80_F3.0331.00
100_Q195_T3.0291.00
87_L105_M3.0061.00
406_E441_R2.9891.00
74_E88_H2.9121.00
51_G67_F2.8781.00
290_A298_E2.8771.00
283_Q302_T2.8151.00
43_L69_L2.7981.00
241_S245_F2.7931.00
162_Q166_S2.6881.00
100_Q199_K2.6861.00
396_N399_Q2.5901.00
384_W403_A2.5231.00
286_R290_A2.5201.00
194_P227_A2.5201.00
134_G156_T2.4751.00
300_R324_D2.4341.00
110_S182_V2.4221.00
334_I353_L2.4191.00
212_E222_S2.4021.00
99_S192_A2.3721.00
338_K365_E2.3501.00
47_I69_L2.2881.00
50_L188_F2.2631.00
21_M25_D2.2361.00
334_I356_A2.2081.00
243_E246_Y2.1661.00
418_I442_I2.1291.00
304_Q320_A2.0551.00
210_P215_L2.0391.00
325_L356_A2.0311.00
198_E228_R1.9921.00
247_L250_A1.9551.00
276_V279_Q1.9461.00
57_H186_S1.9131.00
65_F113_T1.8941.00
324_D336_R1.8891.00
92_F101_L1.8841.00
95_S101_L1.8691.00
413_R416_Q1.8651.00
239_V245_F1.8481.00
432_S436_A1.8481.00
341_R349_L1.8341.00
245_F250_A1.8241.00
245_F248_A1.8191.00
220_P224_L1.8091.00
161_R164_M1.8081.00
425_S439_D1.8011.00
290_A295_K1.7941.00
422_S446_R1.7931.00
249_K253_L1.7921.00
242_S245_F1.7881.00
106_A183_L1.7701.00
290_A302_T1.7411.00
324_D332_E1.7101.00
72_N88_H1.7071.00
157_L161_R1.7031.00
280_R316_Y1.7001.00
337_L352_N1.6891.00
401_L420_L1.6821.00
247_L252_T1.6811.00
358_L390_A1.6811.00
103_S193_M1.6711.00
367_A391_E1.6641.00
264_T268_L1.6481.00
246_Y250_A1.6331.00
259_G262_Q1.6201.00
320_A324_D1.6191.00
307_L320_A1.6181.00
9_T12_G1.6181.00
38_I89_S1.6111.00
173_Q222_S1.5991.00
137_G141_L1.5791.00
168_T171_N1.5641.00
138_S156_T1.5420.99
138_S153_L1.5360.99
167_F171_N1.5330.99
110_S113_T1.5280.99
268_L271_W1.5270.99
244_D247_L1.5200.99
55_V85_V1.5160.99
138_S152_A1.5130.99
68_F86_V1.4980.99
54_L109_I1.4980.99
357_Y365_E1.4900.99
300_R304_Q1.4890.99
280_R309_A1.4870.99
321_T337_L1.4850.99
80_F117_L1.4820.99
95_S196_F1.4730.99
300_R327_Q1.4630.99
120_A171_N1.4310.99
273_K277_R1.4260.99
273_K276_V1.4140.99
242_S247_L1.4130.99
401_L423_S1.4110.99
28_V84_N1.4100.99
54_L182_V1.4090.99
69_L92_F1.4000.99
374_T383_G1.3970.99
150_M154_T1.3900.99
363_P393_A1.3850.99
97_N100_Q1.3770.99
338_K353_L1.3740.99
357_Y369_I1.3720.99
304_Q308_A1.3710.99
102_A183_L1.3670.99
245_F249_K1.3620.99
95_S245_F1.3570.99
180_I227_A1.3520.99
47_I67_F1.3490.99
47_I87_L1.3480.99
340_A349_L1.3440.99
75_I94_Y1.3420.99
281_A285_G1.3420.99
364_Q394_L1.3370.98
248_A251_R1.3340.98
310_E316_Y1.3300.98
310_E313_N1.3300.98
367_A387_L1.3150.98
239_V243_E1.3080.98
243_E248_A1.3020.98
36_P71_N1.2920.98
67_F109_I1.2880.98
367_A390_A1.2880.98
151_A155_G1.2850.98
283_Q309_A1.2840.98
339_N342_D1.2790.98
51_G109_I1.2720.98
300_R323_I1.2690.98
267_L271_W1.2630.98
85_V109_I1.2620.98
119_R174_E1.2600.98
283_Q305_P1.2590.98
239_V247_L1.2550.98
27_Y31_L1.2410.98
170_Q173_Q1.2390.98
350_Q369_I1.2310.97
20_E115_R1.2280.97
353_L369_I1.2230.97
247_L254_G1.2220.97
243_E250_A1.2210.97
391_E396_N1.2190.97
130_L134_G1.2180.97
402_A406_E1.2070.97
363_P390_A1.2060.97
5_P8_G1.2050.97
147_Q150_M1.2030.97
439_D443_D1.1990.97
303_L319_L1.1960.97
43_L248_A1.1940.97
239_V242_S1.1930.97
114_Q178_I1.1900.97
104_V196_F1.1880.97
305_P308_A1.1730.97
324_D329_K1.1710.97
418_I445_L1.1690.96
409_A448_L1.1650.96
244_D248_A1.1640.96
330_A356_A1.1620.96
409_A445_L1.1620.96
273_K279_Q1.1530.96
25_D84_N1.1410.96
133_V140_L1.1320.96
275_N278_Q1.1290.96
391_E399_Q1.1270.96
291_M323_I1.1170.95
307_L317_L1.1160.95
173_Q226_D1.1150.95
268_L285_G1.1140.95
442_I445_L1.1120.95
389_Q393_A1.1090.95
240_Q243_E1.1050.95
102_A188_F1.1030.95
28_V32_R1.1000.95
291_M319_L1.0970.95
55_V109_I1.0960.95
259_G263_L1.0940.95
194_P231_A1.0940.95
146_P149_G1.0940.95
377_N380_D1.0940.95
137_G142_A1.0900.95
334_I360_G1.0890.95
177_R226_D1.0870.95
367_A394_L1.0870.95
300_R320_A1.0800.95
262_Q265_S1.0740.94
291_M296_Y1.0720.94
43_L246_Y1.0700.94
142_A148_A1.0670.94
152_A155_G1.0660.94
289_Q293_A1.0570.94
50_L101_L1.0540.94
241_S246_Y1.0520.94
10_S122_E1.0520.94
371_N391_E1.0510.94
354_A370_L1.0480.94
201_L224_L1.0470.94
247_L251_R1.0460.94
421_L438_Y1.0430.93
180_I184_Q1.0430.93
407_G411_A1.0330.93
181_Q185_R1.0310.93
68_F84_N1.0310.93
358_L363_P1.0290.93
96_D100_Q1.0260.93
374_T387_L1.0210.93
245_F256_Y1.0180.93
184_Q234_M1.0150.92
51_G196_F1.0140.92
51_G85_V1.0110.92
302_T305_P1.0100.92
145_S148_A1.0090.92
296_Y327_Q1.0090.92
51_G65_F1.0070.92
374_T384_W1.0060.92
258_S261_N1.0000.92
51_G68_F0.9940.92
95_S243_E0.9930.92
240_Q247_L0.9910.92
291_M326_G0.9880.91
358_L386_L0.9870.91
195_T199_K0.9830.91
322_D352_N0.9790.91
245_F254_G0.9780.91
191_Q232_N0.9770.91
91_L104_V0.9740.91
241_S244_D0.9710.91
320_A323_I0.9700.91
33_G192_A0.9690.91
187_G236_P0.9630.90
261_N265_S0.9620.90
437_R442_I0.9590.90
29_R33_G0.9530.90
330_A334_I0.9520.90
356_A360_G0.9490.90
55_V65_F0.9470.90
402_A437_R0.9460.90
332_E335_N0.9400.89
114_Q230_R0.9390.89
246_Y252_T0.9390.89
243_E254_G0.9350.89
187_G219_L0.9310.89
21_M64_P0.9270.89
317_L340_A0.9270.89
134_G138_S0.9260.89
446_R449_Q0.9220.88
434_Q437_R0.9220.88
121_M124_Q0.9200.88
156_T160_T0.9160.88
283_Q306_L0.9130.88
19_Q22_Q0.9090.88
4_L8_G0.9060.87
154_T157_L0.9040.87
123_D126_R0.9030.87
127_S130_L0.9010.87
371_N387_L0.8960.87
54_L192_A0.8950.87
265_S268_L0.8950.87
138_S149_G0.8930.87
296_Y323_I0.8920.87
355_N359_Q0.8910.87
241_S248_A0.8900.86
233_Q338_K0.8900.86
24_G84_N0.8880.86
21_M84_N0.8820.86
51_G105_M0.8810.86
440_A444_Q0.8810.86
31_L35_A0.8760.86
84_N117_L0.8710.85
58_A61_V0.8710.85
227_A231_A0.8670.85
250_A254_G0.8660.85
179_G186_S0.8620.85
325_L330_A0.8620.85
245_F251_R0.8610.85
418_I449_Q0.8610.85
369_I373_Y0.8550.84
392_A397_R0.8530.84
112_V117_L0.8510.84
265_S269_D0.8510.84
275_N279_Q0.8470.84
431_G436_A0.8460.84
219_L227_A0.8420.83
248_A315_W0.8390.83
193_M231_A0.8380.83
246_Y249_K0.8370.83
54_L105_M0.8350.83
209_R221_E0.8340.83
209_R215_L0.8320.83
248_A252_T0.8300.82
179_G193_M0.8300.82
89_S252_T0.8270.82
312_G339_N0.8270.82
284_Y288_L0.8260.82
79_A112_V0.8230.82
449_Q452_F0.8220.82
13_S16_S0.8220.82
196_F220_P0.8220.82
103_S227_A0.8210.82
70_I200_L0.8200.82
323_I327_Q0.8200.82
388_A404_R0.8190.82
131_T160_T0.8160.81
110_S178_I0.8130.81
78_F86_V0.8090.81
50_L54_L0.8060.81
320_A336_R0.8060.81
173_Q177_R0.8060.81
42_L322_D0.8010.80
168_T215_L0.7960.80
23_M26_Y0.7940.80
114_Q174_E0.7940.80
442_I446_R0.7930.79
259_G265_S0.7930.79
20_E24_G0.7920.79
287_A291_M0.7920.79
46_Y50_L0.7900.79
80_F84_N0.7900.79
59_N62_K0.7900.79
28_V31_L0.7870.79
129_P132_W0.7870.79
297_D301_K0.7850.79
241_S247_L0.7810.78
197_L227_A0.7800.78
258_S262_Q0.7790.78
357_Y362_Q0.7780.78
184_Q190_P0.7770.78
10_S134_G0.7740.78
211_P215_L0.7740.78
120_A168_T0.7730.78
324_D327_Q0.7700.77
42_L251_R0.7690.77
165_I216_T0.7670.77
192_A215_L0.7660.77
354_A369_I0.7660.77
241_S250_A0.7640.77
46_Y214_L0.7640.77
306_L316_Y0.7630.77
269_D273_K0.7620.77
48_N52_M0.7560.76
247_L256_Y0.7550.76
240_Q246_Y0.7530.76
260_R264_T0.7520.76
435_Q439_D0.7470.75
179_G187_G0.7450.75
228_R232_N0.7440.75
48_N377_N0.7430.75
303_L320_A0.7420.75
391_E403_A0.7400.75
392_A400_E0.7400.75
244_D250_A0.7400.75
151_A158_A0.7380.74
239_V244_D0.7370.74
436_A439_D0.7340.74
266_D270_E0.7340.74
30_Q33_G0.7330.74
97_N199_K0.7330.74
415_D449_Q0.7320.74
162_Q165_I0.7300.74
302_T306_L0.7280.73
75_I196_F0.7270.73
449_Q453_K0.7260.73
322_D325_L0.7250.73
398_D428_V0.7240.73
365_E368_N0.7230.73
288_L319_L0.7210.73
114_Q119_R0.7190.72
364_Q368_N0.7180.72
331_N362_Q0.7180.72
149_G153_L0.7150.72
120_A167_F0.7140.72
319_L323_I0.7140.72
404_R407_G0.7140.72
334_I357_Y0.7130.72
243_E252_T0.7120.72
430_L434_Q0.7120.72
288_L291_M0.7110.72
27_Y35_A0.7110.72
43_L250_A0.7110.72
242_S246_Y0.7100.71
266_D269_D0.7070.71
385_D407_G0.7040.71
254_G292_E0.7020.71
47_I101_L0.7000.70
201_L221_E0.7000.70
23_M80_F0.6990.70
355_N358_L0.6990.70
8_G119_R0.6960.70
61_V337_L0.6950.70
46_Y98_E0.6950.70
419_S423_S0.6950.70
304_Q332_E0.6950.70
192_A197_L0.6920.70
56_S112_V0.6910.69
259_G264_T0.6890.69
239_V250_A0.6880.69
12_G15_L0.6870.69
444_Q448_L0.6870.69
337_L404_R0.6870.69
65_F109_I0.6850.69
351_L383_G0.6840.69
409_A441_R0.6800.68
321_T336_R0.6790.68
318_D352_N0.6770.68
25_D56_S0.6760.68
174_E230_R0.6730.67
110_S227_A0.6720.67
86_V197_L0.6720.67
51_G112_V0.6690.67
216_T300_R0.6690.67
402_A438_Y0.6680.67
338_K362_Q0.6670.67
335_N342_D0.6670.67
70_I178_I0.6670.67
179_G230_R0.6660.67
340_A344_R0.6660.67
347_P380_D0.6650.66
355_N386_L0.6640.66
204_A215_L0.6630.66
4_L7_M0.6620.66
252_T267_L0.6610.66
297_D329_K0.6610.66
212_E215_L0.6590.66
81_F117_L0.6580.66
421_L425_S0.6570.66
213_I216_T0.6560.65
298_E302_T0.6510.65
168_T200_L0.6510.65
104_V230_R0.6510.65
142_A149_G0.6500.65
30_Q82_G0.6490.65
67_F85_V0.6490.65
46_Y101_L0.6450.64
316_Y405_A0.6450.64
338_K342_D0.6440.64
109_I112_V0.6440.64
99_S188_F0.6440.64
248_A253_L0.6430.64
213_I227_A0.6430.64
431_G434_Q0.6420.64
243_E251_R0.6390.63
28_V68_F0.6370.63
238_V241_S0.6370.63
390_A394_L0.6370.63
437_R440_A0.6340.63
123_D167_F0.6330.63
338_K357_Y0.6320.63
132_W431_G0.6320.63
191_Q194_P0.6320.63
408_Y416_Q0.6310.62
18_G22_Q0.6300.62
97_N195_T0.6290.62
263_L266_D0.6290.62
261_N264_T0.6290.62
286_R293_A0.6270.62
372_R387_L0.6270.62
110_S179_G0.6260.62
254_G257_N0.6240.62
66_H84_N0.6240.62
68_F80_F0.6240.62
157_L160_T0.6230.61
226_D229_N0.6230.61
404_R408_Y0.6220.61
180_I231_A0.6210.61
219_L224_L0.6200.61
23_M449_Q0.6190.61
156_T353_L0.6180.61
252_T262_Q0.6170.61
27_Y117_L0.6160.61
119_R186_S0.6160.61
67_F196_F0.6160.61
100_Q215_L0.6150.60
315_W318_D0.6140.60
79_A83_G0.6140.60
312_G362_Q0.6130.60
245_F258_S0.6130.60
358_L370_L0.6130.60
70_I88_H0.6130.60
20_E118_A0.6130.60
159_G163_G0.6120.60
88_H113_T0.6120.60
322_D326_G0.6110.60
95_S104_V0.6110.60
44_T48_N0.6110.60
258_S265_S0.6110.60
117_L121_M0.6100.60
279_Q282_A0.6090.60
237_M364_Q0.6060.59
405_A412_G0.6060.59
248_A265_S0.6050.59
17_I63_T0.6050.59
151_A354_A0.6040.59
245_F316_Y0.6040.59
57_H182_V0.6040.59
222_S407_G0.6030.59
385_D389_Q0.6020.59
334_I338_K0.6000.59
89_S250_A0.6000.59
196_F200_L0.6000.59
301_K305_P0.6000.59
420_L423_S0.5980.58
53_R98_E0.5980.58
15_L23_M0.5980.58
155_G159_G0.5980.58
321_T356_A0.5960.58
194_P226_D0.5960.58
146_P389_Q0.5960.58
133_V149_G0.5950.58
247_L255_M0.5940.58
60_S65_F0.5940.58
437_R441_R0.5940.58
260_R265_S0.5930.58
113_T182_V0.5930.58
423_S427_Q0.5910.57
247_L258_S0.5900.57
177_R181_Q0.5900.57
123_D163_G0.5890.57
330_A359_Q0.5880.57
162_Q168_T0.5880.57
384_W409_A0.5870.57
136_L139_I0.5860.57
441_R444_Q0.5860.57
82_G167_F0.5840.57
180_I213_I0.5830.56
94_Y203_Q0.5820.56
158_A173_Q0.5820.56
274_G279_Q0.5820.56
212_E219_L0.5810.56
31_L70_I0.5790.56
97_N447_Q0.5790.56
295_K301_K0.5790.56
195_T200_L0.5780.56
81_F112_V0.5770.56
215_L220_P0.5760.56
242_S248_A0.5750.55
299_A323_I0.5750.55
24_G32_R0.5740.55
273_K278_Q0.5740.55
59_N185_R0.5730.55
354_A390_A0.5710.55
348_V352_N0.5710.55
162_Q201_L0.5710.55
408_Y420_L0.5690.55
222_S419_S0.5690.55
350_Q373_Y0.5680.54
400_E404_R0.5670.54
27_Y112_V0.5670.54
322_D373_Y0.5660.54
190_P361_G0.5650.54
82_G152_A0.5650.54
308_A329_K0.5640.54
31_L144_A0.5620.54
132_W136_L0.5620.54
58_A316_Y0.5610.54
148_A152_A0.5610.54
253_L259_G0.5610.54
279_Q283_Q0.5610.54
252_T261_N0.5600.53
38_I307_L0.5600.53
45_Q57_H0.5590.53
182_V186_S0.5590.53
3_T325_L0.5590.53
174_E178_I0.5590.53
27_Y228_R0.5580.53
135_A153_L0.5560.53
94_Y136_L0.5550.53
85_V225_A0.5540.53
146_P154_T0.5530.53
143_M167_F0.5530.53
47_I127_S0.5510.52
331_N360_G0.5500.52
23_M286_R0.5500.52
142_A145_S0.5500.52
87_L255_M0.5500.52
234_M314_A0.5500.52
330_A333_A0.5490.52
31_L80_F0.5490.52
38_I195_T0.5470.52
287_A320_A0.5470.52
23_M167_F0.5450.51
189_D195_T0.5450.51
261_N266_D0.5450.51
163_G384_W0.5450.51
133_V392_A0.5430.51
123_D128_A0.5430.51
435_Q438_Y0.5430.51
325_L359_Q0.5420.51
72_N192_A0.5420.51
162_Q214_L0.5410.51
247_L265_S0.5410.51
432_S435_Q0.5400.51
16_S20_E0.5390.51
9_T15_L0.5390.51
287_A303_L0.5370.50
250_A253_L0.5360.50
50_L105_M0.5360.50
45_Q49_S0.5360.50
85_V163_G0.5360.50
247_L316_Y0.5350.50
47_I149_G0.5350.50
50_L102_A0.5330.50
398_D438_Y0.5330.50
86_V95_S0.5320.50
446_R450_E0.5320.50
313_N318_D0.5320.50
337_L353_L0.5320.50
44_T47_I0.5310.50
300_R338_K0.5310.50
441_R445_L0.5310.50
103_S318_D0.5310.50
347_P351_L0.5300.50
79_A86_V0.5300.50
110_S114_Q0.5290.49
35_A70_I0.5280.49
141_L444_Q0.5270.49
15_L109_I0.5270.49
433_L436_A0.5250.49
149_G211_P0.5250.49
162_Q213_I0.5250.49
45_Q346_N0.5240.49
57_H185_R0.5220.49
86_V420_L0.5220.49
50_L98_E0.5220.49
81_F168_T0.5210.48
89_S303_L0.5200.48
249_K252_T0.5200.48
75_I212_E0.5190.48
134_G392_A0.5190.48
256_Y260_R0.5190.48
127_S163_G0.5180.48
293_A331_N0.5170.48
226_D230_R0.5150.48
370_L374_T0.5140.47
348_V380_D0.5140.47
185_R453_K0.5130.47
18_G183_L0.5130.47
51_G384_W0.5130.47
385_D404_R0.5130.47
143_M149_G0.5120.47
68_F109_I0.5120.47
207_S210_P0.5110.47
314_A318_D0.5100.47
282_A305_P0.5090.47
297_D331_N0.5090.47
341_R353_L0.5090.47
242_S328_N0.5090.47
416_Q420_L0.5090.47
29_R406_E0.5080.47
201_L220_P0.5070.47
131_T200_L0.5070.47
102_A186_S0.5070.47
274_G278_Q0.5060.46
95_S167_F0.5060.46
245_F306_L0.5040.46
438_Y445_L0.5030.46
254_G262_Q0.5030.46
347_P377_N0.5020.46
18_G25_D0.5020.46
439_D445_L0.5020.46
274_G277_R0.5020.46
110_S171_N0.5010.46
252_T255_M0.5010.46
328_N356_A0.5000.46
269_D298_E0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c37_A 1 0.4847 100 0.66 Contact Map
4il3_A 1 0.4607 99.9 0.801 Contact Map
4aw6_A 1 0.4694 99.9 0.805 Contact Map
3ieg_A 1 0.4694 99.7 0.869 Contact Map
3as5_A 1 0.3603 99.7 0.87 Contact Map
2y4t_A 1 0.4694 99.6 0.873 Contact Map
2pl2_A 1 0.3624 99.6 0.874 Contact Map
3jb9_R 1 0.0262 99.6 0.874 Contact Map
3vtx_A 1 0.3559 99.6 0.874 Contact Map
2yhc_A 1 0.393 99.6 0.875 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0114 seconds.