T0933_c85_1_346 - CASP12 - GREMLIN Contacts

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T0933_c85_1_346 - T0933_c85 1-346

ID:	134	Sequences: MGHHHHHHGGSENLYFQGNEDILKASATQSAVAGTYQIQVNSLATSSKIALQAIADPANAKFNSGTLNISVGDTKLPAITVDSSNNTLAGMRDAINQAGKEAGVSATIITDNSGSRLVLSSTKTGDGKDIKVEVSDDGSGGNTSLSQLAFDPATAPKLSDGAAAGYVTKAANGEITVDGLKRSIASNSVSDVIDGVSFDVKAVTEAGKPITLTVSRDDAGVKDNVKKFVEAYNTLTKFINEQTVVTKVGEDKNPVTGALLGDASVRALVNTMRSELIASNENGSVRNLAALGITTTKDGTLEIDEKKLDKAISADFEGVASYFTGDTGLAKRLGDKMKPYTDAQGI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	346 (314)
Sequences:	2127 (1646)
Seq/√Len:	92.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
172_N	183_S	4.315	1.00
42_S	174_E	4.234	1.00
42_S	171_A	4.217	1.00
226_K	230_E	3.641	1.00
222_K	309_D	3.625	1.00
48_K	178_D	3.583	1.00
189_V	200_V	3.413	1.00
175_I	189_V	3.136	1.00
237_K	300_T	3.111	1.00
303_I	308_L	3.047	1.00
296_T	300_T	2.980	1.00
174_E	181_K	2.941	1.00
291_L	322_Y	2.863	1.00
315_D	318_G	2.844	1.00
92_R	108_I	2.767	1.00
95_I	119_L	2.713	1.00
226_K	305_E	2.665	1.00
184_I	191_D	2.631	1.00
296_T	302_E	2.549	1.00
66_T	78_A	2.459	1.00
86_N	94_A	2.431	1.00
23_L	38_I	2.429	1.00
304_D	307_K	2.425	1.00
223_D	227_K	2.420	1.00
172_N	185_A	2.383	1.00
23_L	212_L	2.360	1.00
39_Q	176_T	2.338	1.00
175_I	182_R	2.261	1.00
176_T	181_K	2.246	1.00
41_N	174_E	2.230	1.00
111_D	116_R	2.218	1.00
86_N	90_G	2.185	1.00
226_K	303_I	2.081	1.00
222_K	305_E	2.054	1.00
322_Y	329_L	2.037	1.00
204_T	210_I	2.022	1.00
45_T	171_A	2.004	1.00
23_L	210_I	1.947	1.00
22_I	204_T	1.945	1.00
47_S	130_I	1.939	1.00
174_E	183_S	1.930	1.00
310_K	314_A	1.930	1.00
188_S	199_D	1.922	1.00
85_N	90_G	1.906	1.00
46_S	124_T	1.864	1.00
70_S	131_K	1.835	1.00
238_F	242_Q	1.828	1.00
204_T	209_P	1.821	1.00
108_I	115_S	1.779	1.00
35_T	213_T	1.770	1.00
193_I	196_V	1.754	1.00
49_I	130_I	1.748	1.00
43_L	200_V	1.746	1.00
68_N	78_A	1.743	1.00
230_E	234_T	1.743	1.00
295_T	301_L	1.734	1.00
166_Y	169_K	1.732	1.00
41_N	176_T	1.712	1.00
225_V	303_I	1.702	1.00
90_G	94_A	1.684	1.00
82_D	85_N	1.651	1.00
105_S	122_T	1.641	1.00
189_V	192_V	1.640	1.00
19_N	22_I	1.610	1.00
257_G	260_L	1.594	1.00
77_P	102_A	1.593	1.00
82_D	86_N	1.571	1.00
87_T	90_G	1.564	1.00
338_K	342_D	1.559	1.00
36_Y	178_D	1.550	1.00
246_T	254_P	1.508	1.00
19_N	202_A	1.500	1.00
237_K	241_E	1.500	1.00
222_K	226_K	1.485	1.00
223_D	226_K	1.482	1.00
287_N	290_A	1.474	1.00
41_N	181_K	1.464	1.00
308_L	312_I	1.461	1.00
189_V	198_F	1.446	1.00
66_T	80_T	1.442	1.00
245_V	254_P	1.435	0.99
81_V	91_M	1.434	0.99
175_I	200_V	1.431	0.99
243_T	265_V	1.424	0.99
39_Q	209_P	1.402	0.99
286_R	290_A	1.399	0.99
38_I	177_V	1.391	0.99
225_V	323_F	1.380	0.99
225_V	308_L	1.379	0.99
227_K	230_E	1.375	0.99
37_Q	209_P	1.365	0.99
38_I	212_L	1.365	0.99
184_I	189_V	1.346	0.99
119_L	132_V	1.338	0.99
294_T	304_D	1.306	0.99
82_D	90_G	1.303	0.99
126_D	172_N	1.301	0.99
235_L	239_I	1.289	0.99
246_T	253_N	1.283	0.99
205_E	208_K	1.279	0.99
81_V	86_N	1.271	0.99
224_N	227_K	1.262	0.99
110_T	115_S	1.258	0.99
236_T	240_N	1.255	0.99
25_A	198_F	1.244	0.99
229_V	303_I	1.240	0.98
70_S	76_L	1.222	0.98
236_T	300_T	1.217	0.98
221_V	224_N	1.216	0.98
219_A	223_D	1.168	0.98
177_V	192_V	1.163	0.98
239_I	265_V	1.152	0.98
128_K	185_A	1.152	0.98
146_S	150_F	1.150	0.98
41_N	175_I	1.147	0.97
88_L	108_I	1.142	0.97
39_Q	204_T	1.137	0.97
312_I	319_V	1.127	0.97
236_T	269_V	1.122	0.97
35_T	211_T	1.118	0.97
25_A	212_L	1.117	0.97
203_V	209_P	1.115	0.97
177_V	182_R	1.104	0.97
93_D	97_Q	1.086	0.96
47_S	166_Y	1.084	0.96
103_G	122_T	1.080	0.96
45_T	203_V	1.077	0.96
22_I	202_A	1.060	0.96
311_A	319_V	1.051	0.96
291_L	319_V	1.047	0.96
229_V	308_L	1.043	0.96
309_D	313_S	1.039	0.95
49_I	166_Y	1.030	0.95
67_L	134_V	1.028	0.95
18_G	210_I	1.022	0.95
59_N	62_F	1.020	0.95
220_G	223_D	1.010	0.95
43_L	203_V	1.010	0.95
245_V	260_L	1.001	0.94
25_A	196_V	0.999	0.94
146_S	151_D	0.996	0.94
204_T	208_K	0.994	0.94
223_D	230_E	0.994	0.94
134_V	138_G	0.992	0.94
182_R	192_V	0.987	0.94
47_S	129_D	0.979	0.94
171_A	174_E	0.975	0.94
93_D	108_I	0.974	0.94
144_S	149_A	0.971	0.93
221_V	316_F	0.967	0.93
23_L	198_F	0.966	0.93
64_S	86_N	0.965	0.93
275_E	332_R	0.964	0.93
50_A	116_R	0.964	0.93
189_V	199_D	0.964	0.93
70_S	133_E	0.964	0.93
51_L	54_I	0.964	0.93
334_G	338_K	0.962	0.93
239_I	242_Q	0.958	0.93
335_D	338_K	0.956	0.93
64_S	82_D	0.953	0.93
68_N	135_S	0.938	0.92
144_S	151_D	0.935	0.92
24_K	201_K	0.933	0.92
293_I	301_L	0.928	0.92
42_S	203_V	0.924	0.92
222_K	303_I	0.923	0.92
81_V	94_A	0.921	0.92
112_N	115_S	0.920	0.92
37_Q	211_T	0.910	0.91
336_K	340_Y	0.906	0.91
218_D	313_S	0.906	0.91
325_G	331_K	0.904	0.91
99_G	102_A	0.900	0.91
235_L	272_M	0.898	0.91
175_I	198_F	0.893	0.90
68_N	76_L	0.890	0.90
305_E	309_D	0.888	0.90
268_L	340_Y	0.887	0.90
85_N	94_A	0.885	0.90
337_M	341_T	0.881	0.90
229_V	293_I	0.880	0.90
127_G	185_A	0.870	0.89
92_R	117_L	0.869	0.89
239_I	269_V	0.869	0.89
69_I	102_A	0.860	0.89
45_T	168_T	0.859	0.88
112_N	183_S	0.858	0.88
49_I	164_A	0.856	0.88
95_I	106_A	0.848	0.88
41_N	203_V	0.848	0.88
275_E	336_K	0.844	0.88
323_F	328_G	0.842	0.87
70_S	73_D	0.842	0.87
245_V	253_N	0.834	0.87
17_Q	20_E	0.830	0.87
89_A	108_I	0.830	0.87
173_G	186_S	0.830	0.87
203_V	206_A	0.828	0.87
127_G	172_N	0.828	0.87
141_G	146_S	0.827	0.87
150_F	153_A	0.825	0.86
60_A	63_N	0.823	0.86
232_Y	236_T	0.822	0.86
21_D	202_A	0.818	0.86
73_D	76_L	0.818	0.86
24_K	199_D	0.818	0.86
83_S	86_N	0.817	0.86
69_I	79_I	0.815	0.86
123_K	128_K	0.814	0.86
92_R	194_D	0.806	0.85
38_I	191_D	0.805	0.85
80_T	83_S	0.803	0.85
64_S	85_N	0.797	0.84
126_D	185_A	0.793	0.84
342_D	345_G	0.791	0.84
274_S	277_I	0.789	0.84
245_V	256_T	0.789	0.84
123_K	186_S	0.786	0.84
47_S	170_A	0.785	0.84
225_V	312_I	0.778	0.83
234_T	238_F	0.777	0.83
313_S	316_F	0.773	0.83
128_K	170_A	0.770	0.82
24_K	212_L	0.770	0.82
225_V	291_L	0.768	0.82
126_D	183_S	0.768	0.82
225_V	293_I	0.763	0.82
111_D	114_G	0.763	0.82
142_N	145_L	0.763	0.82
271_T	336_K	0.760	0.82
146_S	149_A	0.759	0.81
175_I	181_K	0.757	0.81
173_G	200_V	0.756	0.81
124_T	128_K	0.755	0.81
296_T	301_L	0.754	0.81
22_I	210_I	0.754	0.81
114_G	184_I	0.752	0.81
294_T	302_E	0.750	0.81
335_D	339_P	0.750	0.81
50_A	167_V	0.750	0.81
306_K	309_D	0.749	0.81
288_L	293_I	0.748	0.80
235_L	268_L	0.747	0.80
184_I	190_S	0.746	0.80
130_I	166_Y	0.745	0.80
62_F	65_G	0.741	0.80
289_A	294_T	0.741	0.80
89_A	93_D	0.741	0.80
17_Q	22_I	0.736	0.79
145_L	148_L	0.732	0.79
228_F	288_L	0.728	0.79
285_V	311_A	0.725	0.78
91_M	149_A	0.724	0.78
50_A	118_V	0.724	0.78
219_A	309_D	0.722	0.78
39_Q	206_A	0.719	0.78
145_L	150_F	0.719	0.78
246_T	260_L	0.718	0.78
184_I	192_V	0.715	0.77
317_E	321_S	0.711	0.77
225_V	261_G	0.705	0.76
145_L	149_A	0.705	0.76
225_V	329_L	0.703	0.76
291_L	303_I	0.700	0.76
59_N	63_N	0.699	0.76
246_T	256_T	0.698	0.76
136_D	142_N	0.697	0.76
38_I	175_I	0.696	0.76
220_G	224_N	0.694	0.75
73_D	126_D	0.689	0.75
109_I	180_L	0.688	0.75
291_L	295_T	0.687	0.75
253_N	256_T	0.686	0.74
107_T	111_D	0.683	0.74
246_T	255_V	0.683	0.74
91_M	148_L	0.682	0.74
339_P	342_D	0.681	0.74
150_F	164_A	0.680	0.74
48_K	120_S	0.680	0.74
269_V	273_R	0.679	0.74
235_L	265_V	0.677	0.74
36_Y	214_V	0.676	0.73
144_S	148_L	0.674	0.73
334_G	337_M	0.674	0.73
83_S	90_G	0.673	0.73
221_V	312_I	0.670	0.73
131_K	152_P	0.669	0.73
231_A	234_T	0.668	0.73
310_K	313_S	0.667	0.72
238_F	241_E	0.666	0.72
307_K	310_K	0.666	0.72
64_S	90_G	0.665	0.72
242_Q	265_V	0.664	0.72
27_A	196_V	0.664	0.72
272_M	333_L	0.662	0.72
39_Q	205_E	0.662	0.72
136_D	141_G	0.660	0.72
241_E	244_V	0.658	0.71
18_G	23_L	0.657	0.71
183_S	186_S	0.655	0.71
67_L	91_M	0.649	0.70
242_Q	258_A	0.646	0.70
285_V	291_L	0.646	0.70
291_L	323_F	0.646	0.70
318_G	321_S	0.645	0.70
205_E	209_P	0.644	0.70
111_D	180_L	0.643	0.70
79_I	102_A	0.641	0.69
240_N	269_V	0.641	0.69
128_K	172_N	0.640	0.69
283_G	318_G	0.639	0.69
69_I	95_I	0.639	0.69
327_T	332_R	0.637	0.69
196_V	214_V	0.636	0.69
232_Y	301_L	0.634	0.69
91_M	95_I	0.629	0.68
242_Q	268_L	0.626	0.68
47_S	169_K	0.626	0.68
284_S	315_D	0.626	0.68
25_A	28_T	0.625	0.67
69_I	78_A	0.624	0.67
23_L	40_V	0.624	0.67
53_A	113_S	0.623	0.67
329_L	332_R	0.622	0.67
173_G	187_N	0.621	0.67
328_G	332_R	0.620	0.67
90_G	93_D	0.620	0.67
226_K	309_D	0.618	0.67
225_V	328_G	0.616	0.66
263_A	337_M	0.615	0.66
232_Y	262_D	0.615	0.66
69_I	338_K	0.615	0.66
147_Q	150_F	0.613	0.66
248_V	255_V	0.612	0.66
96_N	106_A	0.612	0.66
71_V	104_V	0.611	0.66
265_V	269_V	0.611	0.66
234_T	237_K	0.609	0.65
298_D	302_E	0.609	0.65
144_S	147_Q	0.606	0.65
329_L	340_Y	0.604	0.65
248_V	253_N	0.604	0.65
149_A	152_P	0.604	0.65
117_L	121_S	0.604	0.65
219_A	222_K	0.599	0.64
87_T	91_M	0.599	0.64
218_D	309_D	0.598	0.64
289_A	295_T	0.598	0.64
235_L	276_L	0.596	0.64
254_P	306_K	0.596	0.64
262_D	266_R	0.596	0.64
69_I	77_P	0.595	0.64
331_K	335_D	0.594	0.64
180_L	199_D	0.593	0.63
39_Q	169_K	0.592	0.63
64_S	83_S	0.590	0.63
245_V	264_S	0.590	0.63
91_M	132_V	0.586	0.63
110_T	191_D	0.582	0.62
276_L	301_L	0.581	0.62
144_S	150_F	0.581	0.62
50_A	180_L	0.580	0.62
278_A	332_R	0.580	0.62
33_A	215_S	0.578	0.61
53_A	116_R	0.576	0.61
266_R	269_V	0.574	0.61
42_S	45_T	0.572	0.61
186_S	189_V	0.571	0.61
235_L	242_Q	0.569	0.60
81_V	85_N	0.568	0.60
271_T	340_Y	0.567	0.60
50_A	184_I	0.566	0.60
91_M	318_G	0.564	0.60
106_A	119_L	0.563	0.59
271_T	301_L	0.563	0.59
32_V	296_T	0.563	0.59
115_S	178_D	0.562	0.59
303_I	323_F	0.561	0.59
280_N	329_L	0.561	0.59
317_E	320_A	0.560	0.59
102_A	132_V	0.559	0.59
203_V	208_K	0.559	0.59
45_T	126_D	0.557	0.59
134_V	139_S	0.557	0.59
31_A	196_V	0.557	0.59
325_G	329_L	0.556	0.59
69_I	88_L	0.556	0.59
223_D	278_A	0.555	0.58
73_D	78_A	0.553	0.58
327_T	335_D	0.553	0.58
245_V	268_L	0.553	0.58
71_V	77_P	0.553	0.58
92_R	106_A	0.552	0.58
243_T	260_L	0.551	0.58
135_S	138_G	0.551	0.58
139_S	144_S	0.551	0.58
172_N	175_I	0.548	0.57
201_K	285_V	0.548	0.57
38_I	173_G	0.548	0.57
148_L	153_A	0.547	0.57
232_Y	299_G	0.547	0.57
240_N	300_T	0.546	0.57
198_F	201_K	0.546	0.57
231_A	236_T	0.545	0.57
285_V	290_A	0.544	0.57
273_R	296_T	0.544	0.57
337_M	340_Y	0.544	0.57
312_I	334_G	0.543	0.57
31_A	214_V	0.542	0.57
319_V	322_Y	0.541	0.56
22_I	38_I	0.541	0.56
311_A	322_Y	0.539	0.56
46_S	168_T	0.538	0.56
229_V	233_N	0.538	0.56
21_D	288_L	0.538	0.56
33_A	216_R	0.537	0.56
52_Q	215_S	0.536	0.56
168_T	193_I	0.536	0.56
26_S	234_T	0.535	0.56
20_E	24_K	0.535	0.56
92_R	180_L	0.534	0.56
48_K	118_V	0.532	0.55
89_A	115_S	0.532	0.55
266_R	270_N	0.531	0.55
274_S	335_D	0.531	0.55
256_T	261_G	0.531	0.55
20_E	23_L	0.529	0.55
235_L	341_T	0.529	0.55
47_S	121_S	0.528	0.55
118_V	243_T	0.526	0.54
177_V	257_G	0.525	0.54
225_V	268_L	0.525	0.54
136_D	139_S	0.524	0.54
320_A	324_T	0.523	0.54
124_T	185_A	0.523	0.54
48_K	107_T	0.521	0.54
186_S	200_V	0.521	0.54
293_I	303_I	0.521	0.54
26_S	343_A	0.521	0.54
48_K	51_L	0.520	0.54
245_V	261_G	0.519	0.53
61_K	65_G	0.519	0.53
34_G	192_V	0.518	0.53
24_K	27_A	0.518	0.53
138_G	219_A	0.517	0.53
243_T	257_G	0.516	0.53
33_A	282_N	0.515	0.53
60_A	64_S	0.515	0.53
65_G	86_N	0.515	0.53
39_Q	203_V	0.515	0.53
108_I	131_K	0.514	0.53
45_T	170_A	0.513	0.53
146_S	153_A	0.513	0.53
112_N	182_R	0.512	0.52
260_L	333_L	0.512	0.52
311_A	329_L	0.511	0.52
115_S	118_V	0.510	0.52
210_I	260_L	0.509	0.52
284_S	318_G	0.507	0.52
109_I	118_V	0.507	0.52
89_A	322_Y	0.507	0.52
108_I	117_L	0.506	0.52
136_D	149_A	0.506	0.52
112_N	289_A	0.506	0.52
273_R	295_T	0.506	0.52
222_K	313_S	0.503	0.51
55_A	59_N	0.502	0.51
220_G	230_E	0.501	0.51
303_I	312_I	0.500	0.51
102_A	130_I	0.500	0.51

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3wpw_A	1	0.2312	15.4	0.961	Contact Map
3s4w_B	1	0.1792	9.6	0.965	Contact Map
1pc2_A	1	0.3382	9.1	0.965	Contact Map
1jql_B	1	0.1358	7.2	0.967	Contact Map
1yj7_A	1	0.211	4.4	0.97	Contact Map
3cwv_A	1	0.2803	3.8	0.971	Contact Map
4w4m_A	1	0.1329	3.7	0.971	Contact Map
3dxi_A	1	0.2514	3.1	0.972	Contact Map
3gfz_A	1	0.2399	2.8	0.973	Contact Map
1cpz_A	1	0.1965	2.7	0.973	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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