GREMLIN Database
T0933_c85_1_346 - T0933_c85 1-346
ID: 134 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 346 (314)
Sequences: 2127 (1646)
Seq/√Len: 92.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
172_N183_S4.3151.00
42_S174_E4.2341.00
42_S171_A4.2171.00
226_K230_E3.6411.00
222_K309_D3.6251.00
48_K178_D3.5831.00
189_V200_V3.4131.00
175_I189_V3.1361.00
237_K300_T3.1111.00
303_I308_L3.0471.00
296_T300_T2.9801.00
174_E181_K2.9411.00
291_L322_Y2.8631.00
315_D318_G2.8441.00
92_R108_I2.7671.00
95_I119_L2.7131.00
226_K305_E2.6651.00
184_I191_D2.6311.00
296_T302_E2.5491.00
66_T78_A2.4591.00
86_N94_A2.4311.00
23_L38_I2.4291.00
304_D307_K2.4251.00
223_D227_K2.4201.00
172_N185_A2.3831.00
23_L212_L2.3601.00
39_Q176_T2.3381.00
175_I182_R2.2611.00
176_T181_K2.2461.00
41_N174_E2.2301.00
111_D116_R2.2181.00
86_N90_G2.1851.00
226_K303_I2.0811.00
222_K305_E2.0541.00
322_Y329_L2.0371.00
204_T210_I2.0221.00
45_T171_A2.0041.00
23_L210_I1.9471.00
22_I204_T1.9451.00
47_S130_I1.9391.00
174_E183_S1.9301.00
310_K314_A1.9301.00
188_S199_D1.9221.00
85_N90_G1.9061.00
46_S124_T1.8641.00
70_S131_K1.8351.00
238_F242_Q1.8281.00
204_T209_P1.8211.00
108_I115_S1.7791.00
35_T213_T1.7701.00
193_I196_V1.7541.00
49_I130_I1.7481.00
43_L200_V1.7461.00
68_N78_A1.7431.00
230_E234_T1.7431.00
295_T301_L1.7341.00
166_Y169_K1.7321.00
41_N176_T1.7121.00
225_V303_I1.7021.00
90_G94_A1.6841.00
82_D85_N1.6511.00
105_S122_T1.6411.00
189_V192_V1.6401.00
19_N22_I1.6101.00
257_G260_L1.5941.00
77_P102_A1.5931.00
82_D86_N1.5711.00
87_T90_G1.5641.00
338_K342_D1.5591.00
36_Y178_D1.5501.00
246_T254_P1.5081.00
19_N202_A1.5001.00
237_K241_E1.5001.00
222_K226_K1.4851.00
223_D226_K1.4821.00
287_N290_A1.4741.00
41_N181_K1.4641.00
308_L312_I1.4611.00
189_V198_F1.4461.00
66_T80_T1.4421.00
245_V254_P1.4350.99
81_V91_M1.4340.99
175_I200_V1.4310.99
243_T265_V1.4240.99
39_Q209_P1.4020.99
286_R290_A1.3990.99
38_I177_V1.3910.99
225_V323_F1.3800.99
225_V308_L1.3790.99
227_K230_E1.3750.99
37_Q209_P1.3650.99
38_I212_L1.3650.99
184_I189_V1.3460.99
119_L132_V1.3380.99
294_T304_D1.3060.99
82_D90_G1.3030.99
126_D172_N1.3010.99
235_L239_I1.2890.99
246_T253_N1.2830.99
205_E208_K1.2790.99
81_V86_N1.2710.99
224_N227_K1.2620.99
110_T115_S1.2580.99
236_T240_N1.2550.99
25_A198_F1.2440.99
229_V303_I1.2400.98
70_S76_L1.2220.98
236_T300_T1.2170.98
221_V224_N1.2160.98
219_A223_D1.1680.98
177_V192_V1.1630.98
239_I265_V1.1520.98
128_K185_A1.1520.98
146_S150_F1.1500.98
41_N175_I1.1470.97
88_L108_I1.1420.97
39_Q204_T1.1370.97
312_I319_V1.1270.97
236_T269_V1.1220.97
35_T211_T1.1180.97
25_A212_L1.1170.97
203_V209_P1.1150.97
177_V182_R1.1040.97
93_D97_Q1.0860.96
47_S166_Y1.0840.96
103_G122_T1.0800.96
45_T203_V1.0770.96
22_I202_A1.0600.96
311_A319_V1.0510.96
291_L319_V1.0470.96
229_V308_L1.0430.96
309_D313_S1.0390.95
49_I166_Y1.0300.95
67_L134_V1.0280.95
18_G210_I1.0220.95
59_N62_F1.0200.95
220_G223_D1.0100.95
43_L203_V1.0100.95
245_V260_L1.0010.94
25_A196_V0.9990.94
146_S151_D0.9960.94
204_T208_K0.9940.94
223_D230_E0.9940.94
134_V138_G0.9920.94
182_R192_V0.9870.94
47_S129_D0.9790.94
171_A174_E0.9750.94
93_D108_I0.9740.94
144_S149_A0.9710.93
221_V316_F0.9670.93
23_L198_F0.9660.93
64_S86_N0.9650.93
275_E332_R0.9640.93
50_A116_R0.9640.93
189_V199_D0.9640.93
70_S133_E0.9640.93
51_L54_I0.9640.93
334_G338_K0.9620.93
239_I242_Q0.9580.93
335_D338_K0.9560.93
64_S82_D0.9530.93
68_N135_S0.9380.92
144_S151_D0.9350.92
24_K201_K0.9330.92
293_I301_L0.9280.92
42_S203_V0.9240.92
222_K303_I0.9230.92
81_V94_A0.9210.92
112_N115_S0.9200.92
37_Q211_T0.9100.91
336_K340_Y0.9060.91
218_D313_S0.9060.91
325_G331_K0.9040.91
99_G102_A0.9000.91
235_L272_M0.8980.91
175_I198_F0.8930.90
68_N76_L0.8900.90
305_E309_D0.8880.90
268_L340_Y0.8870.90
85_N94_A0.8850.90
337_M341_T0.8810.90
229_V293_I0.8800.90
127_G185_A0.8700.89
92_R117_L0.8690.89
239_I269_V0.8690.89
69_I102_A0.8600.89
45_T168_T0.8590.88
112_N183_S0.8580.88
49_I164_A0.8560.88
95_I106_A0.8480.88
41_N203_V0.8480.88
275_E336_K0.8440.88
323_F328_G0.8420.87
70_S73_D0.8420.87
245_V253_N0.8340.87
17_Q20_E0.8300.87
89_A108_I0.8300.87
173_G186_S0.8300.87
203_V206_A0.8280.87
127_G172_N0.8280.87
141_G146_S0.8270.87
150_F153_A0.8250.86
60_A63_N0.8230.86
232_Y236_T0.8220.86
21_D202_A0.8180.86
73_D76_L0.8180.86
24_K199_D0.8180.86
83_S86_N0.8170.86
69_I79_I0.8150.86
123_K128_K0.8140.86
92_R194_D0.8060.85
38_I191_D0.8050.85
80_T83_S0.8030.85
64_S85_N0.7970.84
126_D185_A0.7930.84
342_D345_G0.7910.84
274_S277_I0.7890.84
245_V256_T0.7890.84
123_K186_S0.7860.84
47_S170_A0.7850.84
225_V312_I0.7780.83
234_T238_F0.7770.83
313_S316_F0.7730.83
128_K170_A0.7700.82
24_K212_L0.7700.82
225_V291_L0.7680.82
126_D183_S0.7680.82
225_V293_I0.7630.82
111_D114_G0.7630.82
142_N145_L0.7630.82
271_T336_K0.7600.82
146_S149_A0.7590.81
175_I181_K0.7570.81
173_G200_V0.7560.81
124_T128_K0.7550.81
296_T301_L0.7540.81
22_I210_I0.7540.81
114_G184_I0.7520.81
294_T302_E0.7500.81
335_D339_P0.7500.81
50_A167_V0.7500.81
306_K309_D0.7490.81
288_L293_I0.7480.80
235_L268_L0.7470.80
184_I190_S0.7460.80
130_I166_Y0.7450.80
62_F65_G0.7410.80
289_A294_T0.7410.80
89_A93_D0.7410.80
17_Q22_I0.7360.79
145_L148_L0.7320.79
228_F288_L0.7280.79
285_V311_A0.7250.78
91_M149_A0.7240.78
50_A118_V0.7240.78
219_A309_D0.7220.78
39_Q206_A0.7190.78
145_L150_F0.7190.78
246_T260_L0.7180.78
184_I192_V0.7150.77
317_E321_S0.7110.77
225_V261_G0.7050.76
145_L149_A0.7050.76
225_V329_L0.7030.76
291_L303_I0.7000.76
59_N63_N0.6990.76
246_T256_T0.6980.76
136_D142_N0.6970.76
38_I175_I0.6960.76
220_G224_N0.6940.75
73_D126_D0.6890.75
109_I180_L0.6880.75
291_L295_T0.6870.75
253_N256_T0.6860.74
107_T111_D0.6830.74
246_T255_V0.6830.74
91_M148_L0.6820.74
339_P342_D0.6810.74
150_F164_A0.6800.74
48_K120_S0.6800.74
269_V273_R0.6790.74
235_L265_V0.6770.74
36_Y214_V0.6760.73
144_S148_L0.6740.73
334_G337_M0.6740.73
83_S90_G0.6730.73
221_V312_I0.6700.73
131_K152_P0.6690.73
231_A234_T0.6680.73
310_K313_S0.6670.72
238_F241_E0.6660.72
307_K310_K0.6660.72
64_S90_G0.6650.72
242_Q265_V0.6640.72
27_A196_V0.6640.72
272_M333_L0.6620.72
39_Q205_E0.6620.72
136_D141_G0.6600.72
241_E244_V0.6580.71
18_G23_L0.6570.71
183_S186_S0.6550.71
67_L91_M0.6490.70
242_Q258_A0.6460.70
285_V291_L0.6460.70
291_L323_F0.6460.70
318_G321_S0.6450.70
205_E209_P0.6440.70
111_D180_L0.6430.70
79_I102_A0.6410.69
240_N269_V0.6410.69
128_K172_N0.6400.69
283_G318_G0.6390.69
69_I95_I0.6390.69
327_T332_R0.6370.69
196_V214_V0.6360.69
232_Y301_L0.6340.69
91_M95_I0.6290.68
242_Q268_L0.6260.68
47_S169_K0.6260.68
284_S315_D0.6260.68
25_A28_T0.6250.67
69_I78_A0.6240.67
23_L40_V0.6240.67
53_A113_S0.6230.67
329_L332_R0.6220.67
173_G187_N0.6210.67
328_G332_R0.6200.67
90_G93_D0.6200.67
226_K309_D0.6180.67
225_V328_G0.6160.66
263_A337_M0.6150.66
232_Y262_D0.6150.66
69_I338_K0.6150.66
147_Q150_F0.6130.66
248_V255_V0.6120.66
96_N106_A0.6120.66
71_V104_V0.6110.66
265_V269_V0.6110.66
234_T237_K0.6090.65
298_D302_E0.6090.65
144_S147_Q0.6060.65
329_L340_Y0.6040.65
248_V253_N0.6040.65
149_A152_P0.6040.65
117_L121_S0.6040.65
219_A222_K0.5990.64
87_T91_M0.5990.64
218_D309_D0.5980.64
289_A295_T0.5980.64
235_L276_L0.5960.64
254_P306_K0.5960.64
262_D266_R0.5960.64
69_I77_P0.5950.64
331_K335_D0.5940.64
180_L199_D0.5930.63
39_Q169_K0.5920.63
64_S83_S0.5900.63
245_V264_S0.5900.63
91_M132_V0.5860.63
110_T191_D0.5820.62
276_L301_L0.5810.62
144_S150_F0.5810.62
50_A180_L0.5800.62
278_A332_R0.5800.62
33_A215_S0.5780.61
53_A116_R0.5760.61
266_R269_V0.5740.61
42_S45_T0.5720.61
186_S189_V0.5710.61
235_L242_Q0.5690.60
81_V85_N0.5680.60
271_T340_Y0.5670.60
50_A184_I0.5660.60
91_M318_G0.5640.60
106_A119_L0.5630.59
271_T301_L0.5630.59
32_V296_T0.5630.59
115_S178_D0.5620.59
303_I323_F0.5610.59
280_N329_L0.5610.59
317_E320_A0.5600.59
102_A132_V0.5590.59
203_V208_K0.5590.59
45_T126_D0.5570.59
134_V139_S0.5570.59
31_A196_V0.5570.59
325_G329_L0.5560.59
69_I88_L0.5560.59
223_D278_A0.5550.58
73_D78_A0.5530.58
327_T335_D0.5530.58
245_V268_L0.5530.58
71_V77_P0.5530.58
92_R106_A0.5520.58
243_T260_L0.5510.58
135_S138_G0.5510.58
139_S144_S0.5510.58
172_N175_I0.5480.57
201_K285_V0.5480.57
38_I173_G0.5480.57
148_L153_A0.5470.57
232_Y299_G0.5470.57
240_N300_T0.5460.57
198_F201_K0.5460.57
231_A236_T0.5450.57
285_V290_A0.5440.57
273_R296_T0.5440.57
337_M340_Y0.5440.57
312_I334_G0.5430.57
31_A214_V0.5420.57
319_V322_Y0.5410.56
22_I38_I0.5410.56
311_A322_Y0.5390.56
46_S168_T0.5380.56
229_V233_N0.5380.56
21_D288_L0.5380.56
33_A216_R0.5370.56
52_Q215_S0.5360.56
168_T193_I0.5360.56
26_S234_T0.5350.56
20_E24_K0.5350.56
92_R180_L0.5340.56
48_K118_V0.5320.55
89_A115_S0.5320.55
266_R270_N0.5310.55
274_S335_D0.5310.55
256_T261_G0.5310.55
20_E23_L0.5290.55
235_L341_T0.5290.55
47_S121_S0.5280.55
118_V243_T0.5260.54
177_V257_G0.5250.54
225_V268_L0.5250.54
136_D139_S0.5240.54
320_A324_T0.5230.54
124_T185_A0.5230.54
48_K107_T0.5210.54
186_S200_V0.5210.54
293_I303_I0.5210.54
26_S343_A0.5210.54
48_K51_L0.5200.54
245_V261_G0.5190.53
61_K65_G0.5190.53
34_G192_V0.5180.53
24_K27_A0.5180.53
138_G219_A0.5170.53
243_T257_G0.5160.53
33_A282_N0.5150.53
60_A64_S0.5150.53
65_G86_N0.5150.53
39_Q203_V0.5150.53
108_I131_K0.5140.53
45_T170_A0.5130.53
146_S153_A0.5130.53
112_N182_R0.5120.52
260_L333_L0.5120.52
311_A329_L0.5110.52
115_S118_V0.5100.52
210_I260_L0.5090.52
284_S318_G0.5070.52
109_I118_V0.5070.52
89_A322_Y0.5070.52
108_I117_L0.5060.52
136_D149_A0.5060.52
112_N289_A0.5060.52
273_R295_T0.5060.52
222_K313_S0.5030.51
55_A59_N0.5020.51
220_G230_E0.5010.51
303_I312_I0.5000.51
102_A130_I0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wpw_A 1 0.2312 15.4 0.961 Contact Map
3s4w_B 1 0.1792 9.6 0.965 Contact Map
1pc2_A 1 0.3382 9.1 0.965 Contact Map
1jql_B 1 0.1358 7.2 0.967 Contact Map
1yj7_A 1 0.211 4.4 0.97 Contact Map
3cwv_A 1 0.2803 3.8 0.971 Contact Map
4w4m_A 1 0.1329 3.7 0.971 Contact Map
3dxi_A 1 0.2514 3.1 0.972 Contact Map
3gfz_A 1 0.2399 2.8 0.973 Contact Map
1cpz_A 1 0.1965 2.7 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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