GREMLIN Database
T0933_c90_1_346 - T0933_c90 1-346
ID: 133 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 346 (325)
Sequences: 607 (453)
Seq/√Len: 25.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
172_N183_S5.4911.00
48_K178_D5.1871.00
42_S174_E5.0261.00
92_R108_I4.6021.00
291_L322_Y4.5241.00
23_L212_L4.3531.00
189_V200_V4.1521.00
42_S171_A3.9081.00
175_I189_V3.5581.00
222_K309_D3.3511.00
237_K300_T3.2761.00
296_T300_T3.2731.00
145_L148_L3.2731.00
184_I191_D3.2101.00
226_K230_E2.9591.00
225_V303_I2.9481.00
304_D307_K2.9441.00
322_Y329_L2.8571.00
36_Y178_D2.8391.00
184_I189_V2.8100.99
174_E181_K2.6170.99
85_N90_G2.6110.99
23_L210_I2.4770.99
296_T302_E2.4600.99
175_I182_R2.4530.99
68_N78_A2.4120.98
303_I308_L2.4010.98
204_T209_P2.2290.97
95_I119_L2.1700.97
173_G200_V2.1630.97
22_I204_T2.1540.97
23_L38_I2.1320.97
175_I200_V2.1240.96
46_S124_T2.1000.96
204_T210_I2.0920.96
86_N90_G2.0630.96
111_D116_R2.0170.95
236_T240_N1.9710.95
229_V308_L1.9640.94
35_T213_T1.9100.94
189_V192_V1.8970.93
15_Y25_A1.8810.93
257_G260_L1.8700.93
39_Q176_T1.8340.92
205_E208_K1.8240.92
223_D227_K1.8230.92
145_L150_F1.8090.92
239_I242_Q1.7730.91
338_K342_D1.7700.91
126_D172_N1.7580.90
132_V136_D1.7570.90
295_T301_L1.7200.89
66_T78_A1.7060.89
145_L149_A1.6970.89
144_S151_D1.6860.88
90_G94_A1.6780.88
226_K303_I1.6520.87
41_N174_E1.6360.87
81_V86_N1.6280.86
238_F242_Q1.6090.86
39_Q209_P1.6010.86
308_L312_I1.5630.84
243_T265_V1.5230.82
83_S86_N1.4590.80
149_A153_A1.4480.79
225_V323_F1.4480.79
38_I177_V1.4470.79
177_V182_R1.4320.78
148_L153_A1.4280.78
144_S149_A1.4180.78
104_V186_S1.3930.76
268_L340_Y1.3880.76
38_I175_I1.3870.76
41_N175_I1.3830.76
337_M341_T1.3780.76
182_R268_L1.3690.75
93_D108_I1.3640.75
38_I188_S1.3630.75
188_S199_D1.3570.74
47_S245_V1.3570.74
38_I173_G1.3500.74
136_D140_G1.3470.74
310_K314_A1.3420.74
76_L79_I1.3380.73
87_T90_G1.3330.73
192_V214_V1.3120.72
222_K226_K1.3050.71
114_G120_S1.2850.70
107_T133_E1.2620.69
23_L198_F1.2540.68
312_I319_V1.2520.68
143_T148_L1.2350.67
323_F330_A1.2260.67
34_G200_V1.2070.65
110_T191_D1.1940.64
35_T211_T1.1890.64
199_D244_V1.1820.64
226_K305_E1.1720.63
150_F153_A1.1710.63
46_S232_Y1.1690.63
49_I130_I1.1650.62
86_N94_A1.1570.62
48_K170_A1.1540.62
38_I212_L1.1450.61
296_T319_V1.1420.61
178_D204_T1.1410.61
144_S147_Q1.1230.60
16_F42_S1.1200.59
36_Y193_I1.1170.59
17_Q23_L1.1170.59
175_I198_F1.1140.59
174_E183_S1.1110.59
144_S148_L1.1090.59
306_K310_K1.1020.58
263_A337_M1.1010.58
126_D183_S1.0970.58
51_L99_G1.0970.58
29_Q196_V1.0960.58
173_G186_S1.0940.58
147_Q151_D1.0900.57
291_L295_T1.0890.57
56_D306_K1.0820.57
235_L239_I1.0810.57
151_D154_T1.0790.56
246_T254_P1.0750.56
21_D235_L1.0690.56
108_I115_S1.0650.55
19_N22_I1.0620.55
27_A223_D1.0600.55
315_D318_G1.0590.55
90_G284_S1.0590.55
39_Q204_T1.0550.55
62_F65_G1.0460.54
14_L323_F1.0430.54
229_V293_I1.0410.54
146_S149_A1.0370.53
259_L268_L1.0370.53
111_D121_S1.0360.53
229_V311_A1.0360.53
21_D35_T1.0330.53
20_E213_T1.0330.53
45_T171_A1.0310.53
176_T181_K1.0300.53
65_G71_V1.0230.52
77_P83_S1.0110.52
257_G317_E1.0090.51
111_D329_L0.9950.50
124_T202_A0.9900.50
67_L71_V0.9780.49
227_K230_E0.9710.49
79_I83_S0.9620.48
61_K65_G0.9610.48
47_S166_Y0.9560.48
170_A235_L0.9550.48
41_N181_K0.9530.47
226_K309_D0.9510.47
65_G261_G0.9480.47
141_G145_L0.9460.47
92_R194_D0.9460.47
24_K82_D0.9460.47
50_A180_L0.9370.46
20_E23_L0.9350.46
90_G228_F0.9330.46
82_D85_N0.9320.46
136_D139_S0.9280.46
267_A346_I0.9260.45
72_G131_K0.9240.45
166_Y169_K0.9240.45
291_L301_L0.9190.45
182_R192_V0.9190.45
47_S168_T0.9060.44
15_Y214_V0.9020.44
237_K240_N0.9020.44
286_R290_A0.8990.43
146_S153_A0.8990.43
47_S197_S0.8990.43
287_N290_A0.8960.43
76_L259_L0.8930.43
130_I201_K0.8910.43
21_D135_S0.8790.42
81_V84_S0.8770.42
22_I210_I0.8760.42
92_R106_A0.8760.42
94_A131_K0.8730.42
270_N274_S0.8730.42
81_V317_E0.8680.41
151_D225_V0.8680.41
119_L228_F0.8660.41
20_E24_K0.8630.41
80_T330_A0.8630.41
95_I106_A0.8600.41
43_L92_R0.8580.41
200_V203_V0.8570.40
172_N185_A0.8570.40
22_I202_A0.8540.40
117_L288_L0.8480.40
175_I293_I0.8470.40
245_V260_L0.8440.40
186_S200_V0.8400.39
304_D337_M0.8370.39
24_K244_V0.8320.39
340_Y345_G0.8320.39
17_Q20_E0.8310.39
222_K243_T0.8300.39
145_L151_D0.8300.39
21_D237_K0.8300.39
282_N313_S0.8280.38
209_P242_Q0.8210.38
47_S129_D0.8190.38
81_V85_N0.8130.37
240_N346_I0.8100.37
34_G109_I0.8090.37
48_K193_I0.8080.37
266_R273_R0.8070.37
223_D337_M0.7960.36
72_G133_E0.7950.36
88_L108_I0.7940.36
30_S268_L0.7930.36
141_G144_S0.7920.36
16_F324_T0.7920.36
38_I53_A0.7910.36
22_I25_A0.7890.36
231_A267_A0.7870.36
81_V94_A0.7860.36
215_S302_E0.7830.35
193_I196_V0.7800.35
223_D283_G0.7790.35
175_I181_K0.7790.35
322_Y338_K0.7790.35
147_Q150_F0.7780.35
215_S346_I0.7740.35
45_T52_Q0.7710.35
69_I80_T0.7710.35
258_A329_L0.7700.35
110_T114_G0.7690.35
311_A319_V0.7680.34
124_T240_N0.7660.34
70_S131_K0.7640.34
136_D142_N0.7640.34
177_V193_I0.7620.34
49_I166_Y0.7620.34
180_L332_R0.7600.34
290_A316_F0.7590.34
171_A174_E0.7580.34
24_K277_I0.7580.34
198_F285_V0.7570.34
260_L265_V0.7550.34
170_A230_E0.7480.33
312_I337_M0.7480.33
53_A184_I0.7460.33
285_V291_L0.7460.33
253_N256_T0.7440.33
229_V303_I0.7410.33
67_L72_G0.7390.33
33_A91_M0.7380.33
51_L182_R0.7370.32
18_G142_N0.7350.32
35_T123_K0.7280.32
84_S90_G0.7280.32
219_A244_V0.7260.32
276_L337_M0.7260.32
112_N183_S0.7260.32
225_V312_I0.7250.32
222_K230_E0.7200.31
113_S165_G0.7190.31
144_S153_A0.7190.31
196_V333_L0.7160.31
285_V343_A0.7150.31
18_G204_T0.7070.31
30_S272_M0.7060.31
98_A212_L0.7050.30
53_A118_V0.7040.30
24_K199_D0.7040.30
271_T336_K0.7020.30
80_T83_S0.7020.30
114_G195_G0.7010.30
40_V125_G0.6990.30
25_A281_E0.6990.30
231_A282_N0.6990.30
312_I315_D0.6980.30
107_T130_I0.6980.30
245_V254_P0.6970.30
118_V273_R0.6960.30
149_A152_P0.6950.30
230_E234_T0.6910.30
134_V169_K0.6900.30
38_I270_N0.6890.29
16_F218_D0.6880.29
24_K212_L0.6850.29
65_G86_N0.6850.29
54_I65_G0.6850.29
125_G301_L0.6850.29
229_V259_L0.6820.29
341_T346_I0.6810.29
110_T115_S0.6800.29
212_L334_G0.6750.29
302_E305_E0.6750.29
30_S239_I0.6730.29
104_V214_V0.6720.28
48_K132_V0.6720.28
81_V91_M0.6710.28
69_I317_E0.6700.28
202_A264_S0.6700.28
198_F343_A0.6690.28
68_N344_Q0.6690.28
47_S167_V0.6690.28
134_V137_D0.6680.28
214_V336_K0.6650.28
186_S191_D0.6650.28
53_A315_D0.6640.28
21_D130_I0.6610.28
189_V198_F0.6600.28
77_P104_V0.6510.27
39_Q66_T0.6510.27
82_D151_D0.6510.27
120_S266_R0.6480.27
219_A235_L0.6470.27
189_V303_I0.6460.27
309_D326_D0.6450.27
176_T193_I0.6440.27
43_L164_A0.6440.27
192_V199_D0.6440.27
224_N227_K0.6420.27
234_T237_K0.6410.27
26_S70_S0.6410.27
123_K132_V0.6410.27
48_K316_F0.6380.26
57_P327_T0.6370.26
249_G252_K0.6350.26
143_T335_D0.6320.26
16_F273_R0.6310.26
291_L329_L0.6310.26
307_K318_G0.6300.26
14_L278_A0.6290.26
184_I190_S0.6280.26
99_G102_A0.6280.26
225_V247_K0.6270.26
208_K306_K0.6270.26
154_T214_V0.6250.26
182_R301_L0.6250.26
104_V141_G0.6250.26
102_A193_I0.6200.25
305_E309_D0.6200.25
99_G103_G0.6180.25
184_I204_T0.6170.25
293_I319_V0.6170.25
184_I256_T0.6160.25
82_D90_G0.6150.25
120_S211_T0.6150.25
90_G289_A0.6150.25
250_E255_V0.6130.25
25_A212_L0.6100.25
77_P186_S0.6100.25
242_Q263_A0.6090.25
60_A65_G0.6080.25
242_Q265_V0.6070.25
198_F232_Y0.6060.25
19_N264_S0.6030.25
16_F199_D0.6020.24
16_F278_A0.6020.24
276_L329_L0.6000.24
94_A133_E0.5980.24
210_I221_V0.5940.24
171_A198_F0.5930.24
187_N299_G0.5920.24
104_V212_L0.5900.24
49_I212_L0.5900.24
46_S55_A0.5900.24
24_K282_N0.5890.24
120_S169_K0.5860.24
91_M282_N0.5840.24
173_G187_N0.5840.24
158_L306_K0.5830.23
242_Q279_S0.5810.23
82_D86_N0.5810.23
55_A80_T0.5810.23
30_S186_S0.5790.23
35_T56_D0.5780.23
16_F119_L0.5760.23
60_A64_S0.5760.23
177_V218_D0.5730.23
218_D309_D0.5710.23
302_E306_K0.5700.23
22_I272_M0.5700.23
66_T79_I0.5690.23
240_N334_G0.5690.23
177_V215_S0.5680.23
178_D234_T0.5670.23
103_G229_V0.5660.23
69_I195_G0.5600.22
149_A154_T0.5600.22
81_V289_A0.5570.22
201_K330_A0.5560.22
153_A156_P0.5540.22
228_F332_R0.5540.22
150_F182_R0.5510.22
99_G178_D0.5500.22
24_K95_I0.5500.22
257_G265_V0.5500.22
93_D242_Q0.5480.22
68_N276_L0.5470.22
64_S289_A0.5470.22
198_F212_L0.5460.22
62_F303_I0.5460.22
23_L316_F0.5450.22
79_I200_V0.5450.22
42_S114_G0.5440.22
95_I104_V0.5440.22
214_V273_R0.5440.22
50_A246_T0.5420.21
265_V316_F0.5400.21
97_Q100_K0.5400.21
262_D293_I0.5400.21
25_A54_I0.5400.21
203_V209_P0.5390.21
50_A189_V0.5380.21
172_N318_G0.5380.21
248_V255_V0.5380.21
80_T234_T0.5370.21
95_I283_G0.5370.21
132_V184_I0.5370.21
186_S203_V0.5360.21
97_Q177_V0.5360.21
125_G233_N0.5340.21
137_D140_G0.5340.21
50_A184_I0.5330.21
220_G223_D0.5330.21
177_V203_V0.5320.21
49_I164_A0.5320.21
271_T339_P0.5320.21
27_A213_T0.5310.21
103_G122_T0.5300.21
71_V191_D0.5290.21
213_T234_T0.5290.21
19_N304_D0.5290.21
162_A323_F0.5280.21
111_D180_L0.5280.21
53_A196_V0.5270.21
110_T316_F0.5260.21
217_D220_G0.5250.21
152_P156_P0.5250.21
243_T311_A0.5230.21
67_L134_V0.5230.21
221_V320_A0.5230.21
23_L81_V0.5230.21
90_G229_V0.5220.20
190_S317_E0.5220.20
49_I150_F0.5220.20
293_I298_D0.5210.20
197_S265_V0.5200.20
284_S335_D0.5200.20
34_G192_V0.5200.20
132_V190_S0.5190.20
134_V138_G0.5190.20
146_S257_G0.5190.20
71_V131_K0.5190.20
274_S277_I0.5180.20
62_F119_L0.5170.20
105_S122_T0.5160.20
79_I306_K0.5160.20
143_T149_A0.5160.20
105_S211_T0.5160.20
225_V302_E0.5150.20
113_S210_I0.5140.20
271_T337_M0.5140.20
230_E286_R0.5140.20
62_F197_S0.5130.20
39_Q173_G0.5120.20
28_T198_F0.5120.20
76_L119_L0.5120.20
82_D115_S0.5110.20
25_A36_Y0.5110.20
28_T174_E0.5110.20
30_S313_S0.5100.20
306_K311_A0.5100.20
16_F215_S0.5090.20
273_R289_A0.5080.20
119_L314_A0.5080.20
156_P192_V0.5070.20
309_D313_S0.5060.20
62_F94_A0.5060.20
97_Q319_V0.5050.20
71_V323_F0.5050.20
264_S267_A0.5030.20
21_D314_A0.5030.20
214_V227_K0.5010.19
196_V230_E0.5010.19
166_Y303_I0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wpw_A 1 0.2312 11.7 0.969 Contact Map
3cwv_A 1 0.2803 10.3 0.97 Contact Map
1kij_A 1 0.2948 10.1 0.97 Contact Map
1jql_B 1 0.1358 10.1 0.97 Contact Map
3s4w_B 1 0.1734 9.6 0.971 Contact Map
2es7_A 1 0.1387 5.1 0.974 Contact Map
2e0q_A 1 0.1358 4.9 0.974 Contact Map
1y3j_A 1 0.2168 4.7 0.974 Contact Map
2dj0_A 1 0.159 4.4 0.975 Contact Map
1pc2_A 1 0.3382 4.4 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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