GREMLIN Database
T0945_c90_1_409 - T0945_c90 1-409
ID: 132 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 409 (400)
Sequences: 250 (156)
Seq/√Len: 7.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
240_L244_W6.3051.00
309_N316_E4.5880.99
232_F259_A4.5490.99
207_I226_L3.9780.97
181_C280_F3.8480.96
197_G385_L3.5070.94
207_I233_F3.3610.92
59_Q62_I3.1660.90
258_F270_G3.1500.89
289_Y360_N2.8920.85
393_A397_S2.8780.84
338_A343_L2.8610.84
200_L233_F2.7300.81
368_L387_L2.6900.80
236_T255_F2.6870.80
131_T179_V2.6710.79
47_L305_I2.6230.78
194_L384_L2.5890.77
152_V176_L2.5550.76
196_A236_T2.4990.74
134_S150_I2.4900.74
181_C267_G2.4490.73
206_I322_F2.4490.73
335_L346_V2.4100.72
228_F240_L2.3520.70
244_W382_L2.3330.69
63_S298_I2.3230.69
48_N315_L2.2740.67
281_M288_L2.2230.65
392_S400_Y2.1690.63
344_V362_M2.1560.63
308_L313_G2.1190.61
128_L179_V2.0700.59
48_N308_L2.0550.59
315_L364_L2.0420.58
347_H358_E2.0300.58
317_M370_K2.0080.57
47_L230_I1.9410.54
245_Y364_L1.8850.52
23_F241_Y1.8570.51
160_L201_V1.8440.50
43_C54_Q1.8440.50
127_L182_T1.8330.50
311_K314_K1.8280.50
182_T400_Y1.8270.50
48_N313_G1.8150.49
22_G70_I1.7940.48
157_R161_G1.7730.47
176_L297_I1.7710.47
339_E348_Q1.7650.47
119_L135_L1.7380.46
392_S396_F1.7000.44
297_I320_S1.6780.44
146_G259_A1.6710.43
314_K374_P1.6700.43
228_F244_W1.6430.42
23_F62_I1.6410.42
338_A342_Q1.6320.42
62_I150_I1.6250.41
396_F400_Y1.6210.41
67_F209_F1.6160.41
127_L183_N1.6000.40
160_L164_L1.5970.40
239_L251_V1.5820.40
209_F213_E1.5730.39
98_A129_L1.5680.39
312_T316_E1.5670.39
239_L255_F1.5520.39
39_A56_P1.5510.39
375_I383_L1.5490.38
62_I255_F1.5430.38
111_F139_M1.5330.38
320_S335_L1.5330.38
206_I267_G1.5250.38
67_F213_E1.5020.37
95_E220_D1.5010.37
129_L178_A1.4980.37
38_I310_I1.4820.36
106_I119_L1.4810.36
313_G346_V1.4730.36
176_L396_F1.4400.34
109_M129_L1.4370.34
67_F229_M1.4240.34
182_T205_S1.4150.34
205_S396_F1.4100.33
315_L360_N1.4050.33
42_L139_M1.3840.32
289_Y367_L1.3790.32
131_T184_A1.3760.32
276_M323_K1.3700.32
47_L398_I1.3600.32
63_S308_L1.3530.31
127_L131_T1.3510.31
372_L375_I1.3490.31
109_M115_A1.3340.31
206_I229_M1.3340.31
176_L182_T1.3330.31
74_F227_Y1.3320.31
146_G315_L1.3310.31
22_G312_T1.3250.30
367_L371_V1.3120.30
134_S175_G1.3100.30
194_L364_L1.3030.30
121_L210_N1.2940.29
62_I230_I1.2890.29
238_G269_L1.2780.29
210_N225_S1.2680.28
61_V115_A1.2680.28
179_V232_F1.2670.28
227_Y230_I1.2660.28
240_L382_L1.2650.28
221_D255_F1.2630.28
205_S392_S1.2620.28
62_I101_G1.2600.28
166_L233_F1.2600.28
263_F289_Y1.2590.28
191_I230_I1.2530.28
17_I132_A1.2530.28
127_L179_V1.2520.28
119_L210_N1.2490.28
134_S151_V1.2410.28
359_C372_L1.2350.27
74_F322_F1.2260.27
45_Q55_I1.2250.27
33_F40_A1.2250.27
372_L383_L1.2250.27
210_N213_E1.2210.27
228_F266_V1.2170.27
47_L364_L1.2100.27
19_S69_I1.2090.27
205_S279_F1.2080.26
135_L210_N1.2040.26
100_I135_L1.2000.26
191_I328_S1.1950.26
264_A268_I1.1910.26
164_L240_L1.1870.26
146_G242_H1.1850.26
47_L357_T1.1840.26
201_V385_L1.1840.26
45_Q386_L1.1830.26
21_L362_M1.1780.26
12_L207_I1.1770.26
125_H308_L1.1720.25
68_L224_F1.1630.25
120_N236_T1.1580.25
384_L403_V1.1540.25
114_F205_S1.1530.25
360_N393_A1.1510.25
139_M296_H1.1500.25
208_V393_A1.1490.25
127_L400_Y1.1460.25
236_T364_L1.1370.24
29_L375_I1.1370.24
267_G342_Q1.1360.24
12_L281_M1.1330.24
66_V364_L1.1290.24
247_S381_T1.1270.24
182_T392_S1.1100.24
191_I402_L1.1070.23
335_L344_V1.1060.23
142_F307_R1.1000.23
228_F374_P1.0990.23
111_F259_A1.0970.23
176_L179_V1.0960.23
163_H395_T1.0890.23
78_P227_Y1.0860.23
75_I140_V1.0850.23
103_L150_I1.0840.23
127_L262_T1.0820.23
22_G36_H1.0770.23
107_C118_V1.0760.23
83_F279_F1.0750.23
67_F235_T1.0720.22
237_L285_F1.0690.22
151_V163_H1.0660.22
100_I370_K1.0590.22
132_A364_L1.0500.22
241_Y289_Y1.0420.22
315_L402_L1.0410.22
13_L16_L1.0400.22
71_L258_F1.0390.22
64_G77_F1.0390.22
74_F78_P1.0390.22
18_V281_M1.0350.21
365_I381_T1.0280.21
69_I398_I1.0260.21
25_A259_A1.0260.21
204_A390_L1.0210.21
19_S234_F1.0210.21
346_V355_E1.0200.21
342_Q371_V1.0200.21
108_C179_V1.0130.21
182_T396_F1.0110.21
200_L338_A1.0100.21
199_S236_T1.0090.21
15_N64_G1.0000.20
160_L402_L0.9980.20
205_S400_Y0.9930.20
155_P160_L0.9920.20
365_I384_L0.9890.20
45_Q390_L0.9760.20
152_V297_I0.9690.20
42_L281_M0.9650.20
79_F82_C0.9640.20
288_L297_I0.9640.20
52_R288_L0.9630.20
340_S357_T0.9600.19
175_G212_V0.9570.19
285_F343_L0.9570.19
107_C115_A0.9560.19
143_T211_L0.9520.19
401_Q404_R0.9460.19
45_Q164_L0.9430.19
19_S238_G0.9400.19
321_K358_E0.9400.19
307_R360_N0.9360.19
115_A129_L0.9310.19
228_F356_F0.9310.19
73_C230_I0.9310.19
96_F122_R0.9270.19
52_R362_M0.9250.19
48_N150_I0.9250.19
386_L390_L0.9240.19
61_V175_G0.9240.19
106_I263_F0.9220.18
91_F272_F0.9210.18
132_A202_I0.9210.18
137_L268_I0.9200.18
109_M179_V0.9200.18
16_L94_H0.9190.18
20_L368_L0.9170.18
281_M397_S0.9140.18
98_A115_A0.9140.18
74_F206_I0.9130.18
73_C387_L0.9130.18
202_I281_M0.9120.18
184_A209_F0.9100.18
62_I236_T0.9100.18
69_I102_A0.9100.18
251_V262_T0.9070.18
103_L165_D0.9050.18
178_A330_L0.9020.18
263_F266_V0.8990.18
25_A35_G0.8980.18
35_G206_I0.8960.18
119_L262_T0.8960.18
135_L385_L0.8950.18
38_I279_F0.8910.18
105_A226_L0.8880.18
118_V135_L0.8880.18
128_L131_T0.8840.18
102_A269_L0.8840.18
71_L228_F0.8820.18
309_N393_A0.8820.18
73_C203_S0.8800.17
125_H374_P0.8780.17
120_N223_V0.8780.17
183_N187_I0.8770.17
40_A119_L0.8750.17
175_G178_A0.8750.17
298_I320_S0.8740.17
119_L298_I0.8740.17
47_L359_C0.8740.17
179_V184_A0.8710.17
150_I228_F0.8700.17
114_F177_L0.8700.17
102_A224_F0.8700.17
115_A142_F0.8700.17
400_Y407_Y0.8690.17
105_A385_L0.8690.17
227_Y322_F0.8670.17
47_L335_L0.8670.17
177_L291_L0.8660.17
121_L175_G0.8630.17
224_F266_V0.8620.17
120_N143_T0.8610.17
71_L129_L0.8610.17
97_V214_L0.8600.17
166_L207_I0.8600.17
96_F206_I0.8590.17
128_L143_T0.8570.17
145_F289_Y0.8560.17
22_G353_D0.8540.17
35_G211_L0.8510.17
169_L307_R0.8510.17
31_P142_F0.8510.17
345_T360_N0.8470.17
16_L285_F0.8420.17
111_F152_V0.8420.17
169_L315_L0.8410.17
152_V196_A0.8390.17
175_G184_A0.8380.17
56_P341_L0.8370.16
72_F224_F0.8340.16
30_I38_I0.8340.16
19_S296_H0.8320.16
188_L289_Y0.8310.16
269_L335_L0.8280.16
62_I70_I0.8270.16
313_G337_V0.8260.16
159_I387_L0.8240.16
107_C208_V0.8240.16
109_M262_T0.8220.16
27_V241_Y0.8200.16
61_V146_G0.8180.16
135_L175_G0.8160.16
182_T262_T0.8120.16
335_L339_E0.8090.16
121_L276_M0.8070.16
67_F210_N0.8070.16
259_A368_L0.8060.16
22_G62_I0.8060.16
39_A45_Q0.8050.16
142_F404_R0.8050.16
37_F374_P0.8040.16
79_F115_A0.8020.16
212_V375_I0.7990.16
115_A121_L0.7970.16
189_A365_I0.7960.16
291_L294_L0.7930.16
106_I213_E0.7900.15
298_I357_T0.7880.15
125_H235_T0.7840.15
40_A206_I0.7830.15
110_I364_L0.7800.15
134_S288_L0.7790.15
47_L201_V0.7790.15
68_L102_A0.7780.15
22_G156_F0.7760.15
35_G333_F0.7760.15
108_C127_L0.7750.15
156_F202_I0.7710.15
152_V157_R0.7700.15
47_L69_I0.7680.15
15_N359_C0.7680.15
181_C264_A0.7680.15
179_V199_S0.7670.15
59_Q404_R0.7650.15
50_T159_I0.7640.15
48_N145_F0.7610.15
176_L205_S0.7600.15
239_L269_L0.7600.15
84_V240_L0.7600.15
204_A233_F0.7600.15
203_S386_L0.7600.15
68_L362_M0.7600.15
122_R189_A0.7590.15
37_F68_L0.7570.15
144_N182_T0.7570.15
22_G323_K0.7550.15
103_L108_C0.7520.15
21_L405_L0.7520.15
107_C179_V0.7500.15
288_L328_S0.7500.15
64_G110_I0.7470.15
154_K194_L0.7460.15
100_I317_M0.7460.15
107_C131_T0.7460.15
315_L391_G0.7450.15
108_C232_F0.7440.15
12_L245_Y0.7440.15
354_G375_I0.7410.14
364_L385_L0.7390.14
19_S310_I0.7380.14
71_L277_L0.7360.14
96_F120_N0.7360.14
114_F182_T0.7350.14
206_I233_F0.7350.14
142_F155_P0.7350.14
206_I276_M0.7350.14
320_S328_S0.7340.14
36_H42_L0.7320.14
93_H96_F0.7310.14
179_V209_F0.7310.14
58_S259_A0.7300.14
97_V262_T0.7300.14
23_F142_F0.7280.14
127_L176_L0.7270.14
158_P312_T0.7270.14
209_F234_F0.7260.14
170_Y280_F0.7230.14
101_G107_C0.7230.14
65_A358_E0.7210.14
54_Q107_C0.7200.14
82_C98_A0.7180.14
26_T238_G0.7180.14
91_F263_F0.7170.14
39_A120_N0.7160.14
93_H166_L0.7130.14
307_R405_L0.7120.14
184_A210_N0.7080.14
121_L223_V0.7060.14
132_A313_G0.7050.14
196_A387_L0.7050.14
65_A139_M0.7020.14
296_H359_C0.7020.14
91_F266_V0.6990.14
166_L276_M0.6990.14
394_I397_S0.6970.14
10_M61_V0.6960.14
78_P111_F0.6960.14
230_I357_T0.6960.14
114_F118_V0.6910.13
38_I50_T0.6880.13
128_L314_K0.6870.13
241_Y402_L0.6870.13
65_A396_F0.6850.13
248_R297_I0.6850.13
151_V228_F0.6850.13
228_F259_A0.6840.13
73_C87_Q0.6830.13
360_N367_L0.6810.13
176_L392_S0.6810.13
139_M323_K0.6780.13
127_L187_I0.6770.13
183_N277_L0.6760.13
81_N84_V0.6760.13
33_F169_L0.6760.13
349_S354_G0.6750.13
244_W381_T0.6740.13
47_L279_F0.6720.13
134_S168_I0.6710.13
121_L184_A0.6710.13
118_V400_Y0.6700.13
200_L248_R0.6700.13
92_P263_F0.6690.13
62_I338_A0.6690.13
313_G376_H0.6680.13
118_V313_G0.6640.13
115_A119_L0.6640.13
240_L335_L0.6640.13
102_A249_V0.6620.13
79_F98_A0.6620.13
42_L134_S0.6620.13
164_L245_Y0.6590.13
58_S147_N0.6580.13
120_N256_C0.6570.13
55_I172_V0.6550.13
178_A364_L0.6540.13
55_I140_V0.6530.13
107_C135_L0.6510.13
65_A111_F0.6510.13
106_I210_N0.6500.13
35_G393_A0.6470.13
55_I164_L0.6460.13
362_M391_G0.6450.13
297_I402_L0.6440.13
28_T398_I0.6440.13
191_I324_T0.6420.13
330_L357_T0.6410.13
109_M205_S0.6410.13
338_A394_I0.6410.13
177_L375_I0.6370.13
362_M403_V0.6350.12
217_D276_M0.6350.12
155_P381_T0.6330.12
127_L392_S0.6330.12
151_V398_I0.6320.12
233_F324_T0.6280.12
147_N234_F0.6270.12
259_A320_S0.6260.12
259_A401_Q0.6250.12
87_Q194_L0.6250.12
165_D406_F0.6220.12
224_F357_T0.6220.12
266_V272_F0.6210.12
31_P133_A0.6200.12
165_D168_I0.6200.12
79_F84_V0.6190.12
131_T182_T0.6160.12
53_Q357_T0.6160.12
229_M266_V0.6140.12
267_G280_F0.6130.12
277_L280_F0.6120.12
196_A271_H0.6070.12
184_A213_E0.6070.12
310_I316_E0.6070.12
196_A237_L0.6060.12
262_T384_L0.6050.12
196_A365_I0.6040.12
100_I110_I0.6030.12
19_S355_E0.6030.12
121_L209_F0.6020.12
344_V393_A0.6010.12
97_V151_V0.6010.12
80_L191_I0.6000.12
24_V368_L0.5970.12
166_L396_F0.5970.12
144_N176_L0.5960.12
58_S104_L0.5940.12
128_L291_L0.5930.12
125_H238_G0.5930.12
55_I383_L0.5930.12
398_I406_F0.5900.12
152_V387_L0.5900.12
54_Q108_C0.5890.12
59_Q147_N0.5890.12
100_I119_L0.5870.12
62_I347_H0.5870.12
144_N400_Y0.5850.12
211_L230_I0.5850.12
134_S178_A0.5840.12
155_P244_W0.5810.12
203_S229_M0.5810.12
297_I313_G0.5790.12
121_L262_T0.5790.12
288_L307_R0.5790.12
258_F269_L0.5790.12
114_F400_Y0.5780.11
240_L279_F0.5770.11
247_S406_F0.5750.11
48_N179_V0.5750.11
160_L237_L0.5740.11
191_I281_M0.5730.11
20_L310_I0.5720.11
139_M281_M0.5720.11
120_N233_F0.5710.11
12_L354_G0.5700.11
66_V142_F0.5700.11
50_T337_V0.5690.11
36_H163_H0.5680.11
70_I244_W0.5680.11
24_V288_L0.5670.11
54_Q150_I0.5670.11
21_L316_E0.5660.11
226_L230_I0.5660.11
50_T53_Q0.5650.11
118_V121_L0.5640.11
361_N377_E0.5640.11
108_C118_V0.5640.11
202_I312_T0.5610.11
15_N78_P0.5590.11
285_F354_G0.5590.11
96_F308_L0.5580.11
157_R160_L0.5570.11
38_I169_L0.5570.11
288_L334_I0.5560.11
105_A109_M0.5550.11
26_T161_G0.5540.11
105_A127_L0.5530.11
364_L390_L0.5530.11
114_F279_F0.5530.11
17_I64_G0.5480.11
90_A152_V0.5470.11
137_L194_L0.5460.11
212_V291_L0.5430.11
229_M276_M0.5430.11
229_M262_T0.5420.11
362_M396_F0.5420.11
207_I353_D0.5400.11
19_S156_F0.5400.11
34_R56_P0.5390.11
9_P405_L0.5350.11
155_P161_G0.5350.11
75_I93_H0.5340.11
18_V118_V0.5330.11
23_F223_V0.5330.11
284_V298_I0.5320.11
146_G326_S0.5310.11
179_V400_Y0.5310.11
14_I47_L0.5310.11
313_G348_Q0.5300.11
204_A334_I0.5300.11
166_L403_V0.5290.11
110_I369_L0.5290.11
107_C121_L0.5290.11
76_P124_R0.5280.11
58_S61_V0.5270.11
55_I288_L0.5260.11
322_F365_I0.5260.11
69_I360_N0.5250.11
78_P202_I0.5240.11
8_L259_A0.5240.11
197_G240_L0.5240.11
79_F407_Y0.5230.11
99_L321_K0.5210.11
110_I317_M0.5200.11
128_L384_L0.5180.11
197_G228_F0.5180.11
94_H259_A0.5180.11
62_I264_A0.5180.11
157_R394_I0.5160.11
28_T368_L0.5140.10
64_G96_F0.5130.10
328_S335_L0.5120.10
34_R403_V0.5120.10
78_P245_Y0.5110.10
228_F354_G0.5110.10
387_L405_L0.5090.10
144_N251_V0.5060.10
224_F299_P0.5050.10
122_R188_L0.5050.10
152_V338_A0.5040.10
342_Q389_I0.5030.10
201_V382_L0.5020.10
143_T289_Y0.5020.10
375_I382_L0.5020.10
134_S259_A0.5020.10
205_S278_L0.5000.10
54_Q149_T0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5ckr_A 1 0.7506 100 0.831 Contact Map
1wdc_A 1 0.066 5.5 0.988 Contact Map
2k44_A 1 0.0685 4.5 0.989 Contact Map
3dh4_A 1 0.0171 2.9 0.99 Contact Map
4px7_A 1 0.1394 2.6 0.99 Contact Map
4f4s_A 1 0.1638 2.5 0.99 Contact Map
2rky_B 1 0.0513 2.3 0.99 Contact Map
2vy4_A 1 0.0831 2.3 0.99 Contact Map
3mqp_B 1 0.0611 2.3 0.991 Contact Map
3mce_A 1 0.1222 1.9 0.991 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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