T0938_c90_1_259 - CASP12 - GREMLIN Contacts

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T0938_c90_1_259 - T0938_c90 1-259

ID:	131	Sequences: MTSIPVDPAADLLRERAAHYAAEAALFLRDQALSTASHDLRSPLNAMHSWAYVLERQLASADPSLQRALAGIRTGIDQQVALIDDVLDAPRAETRTLAITAQPFALRPLLDDTLALVRFALADARQVSIDATLPDGEPSLSADRERVAQALWTMLTTAVEASAAGNRVTFACTRDGAQCVAHVTCGVSAAALADPALPHAFDAFARREMLRSRDAKRVAWVLALCQRVALAHGGTFTHAAFADGAVVTLSLAVPCKAAG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	259 (241)
Sequences:	5035 (4015)
Seq/√Len:	258.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
51_A	72_I	3.811	1.00
241_F	245_A	3.357	1.00
237_T	250_S	3.306	1.00
104_F	142_A	3.181	1.00
197_L	238_H	3.169	1.00
225_C	236_F	3.131	1.00
226_Q	230_L	2.727	1.00
102_Q	144_R	2.587	1.00
19_H	23_E	2.503	1.00
162_S	188_S	2.397	1.00
150_A	229_A	2.338	1.00
19_H	22_A	2.266	1.00
182_H	252_A	2.266	1.00
193_A	196_A	2.242	1.00
103_P	141_S	2.232	1.00
186_G	248_T	2.205	1.00
48_H	76_I	2.187	1.00
230_L	235_T	2.148	1.00
182_H	250_S	2.084	1.00
151_L	183_V	2.045	1.00
57_Q	65_L	1.978	1.00
27_F	31_Q	1.962	1.00
55_E	73_R	1.912	1.00
150_A	228_V	1.902	1.00
55_E	70_A	1.891	1.00
229_A	251_L	1.885	1.00
193_A	243_D	1.866	1.00
155_L	170_F	1.844	1.00
196_A	199_H	1.843	1.00
183_V	251_L	1.838	1.00
142_A	232_H	1.827	1.00
171_A	186_G	1.816	1.00
118_R	123_D	1.812	1.00
18_A	22_A	1.803	1.00
211_R	216_K	1.795	1.00
105_A	108_P	1.767	1.00
105_A	138_P	1.736	1.00
184_T	248_T	1.731	1.00
132_T	171_A	1.666	1.00
238_H	249_L	1.626	1.00
192_L	196_A	1.615	1.00
190_A	215_A	1.563	1.00
117_V	159_V	1.555	1.00
117_V	155_L	1.537	1.00
171_A	184_T	1.526	1.00
120_A	124_A	1.515	1.00
239_A	248_T	1.493	1.00
54_L	65_L	1.465	1.00
112_D	148_A	1.459	1.00
54_L	69_L	1.458	1.00
130_D	169_T	1.452	1.00
180_V	254_P	1.452	1.00
21_A	24_A	1.434	1.00
50_W	68_A	1.432	1.00
169_T	186_G	1.428	1.00
154_M	251_L	1.409	1.00
15_E	19_H	1.397	1.00
18_A	21_A	1.384	1.00
36_A	86_V	1.382	1.00
150_A	251_L	1.375	1.00
117_V	152_W	1.371	1.00
101_A	256_K	1.370	1.00
199_H	205_A	1.362	1.00
161_A	206_R	1.361	1.00
207_R	211_R	1.339	1.00
208_E	213_R	1.337	1.00
91_R	218_V	1.332	1.00
110_L	172_C	1.314	1.00
99_I	232_H	1.305	1.00
229_A	234_G	1.294	1.00
146_R	149_Q	1.292	1.00
101_A	142_A	1.284	1.00
173_T	184_T	1.273	1.00
80_V	84_D	1.262	1.00
175_D	182_H	1.245	1.00
173_T	182_H	1.244	1.00
73_R	77_D	1.239	1.00
122_A	159_V	1.232	1.00
51_A	76_I	1.229	1.00
192_L	238_H	1.226	1.00
196_A	207_R	1.220	1.00
194_D	241_F	1.215	1.00
53_V	68_A	1.208	1.00
184_T	250_S	1.196	1.00
26_L	29_R	1.190	1.00
24_A	28_L	1.189	1.00
51_A	55_E	1.187	1.00
206_R	215_A	1.184	1.00
74_T	112_D	1.181	1.00
26_L	30_D	1.180	1.00
132_T	169_T	1.178	1.00
97_L	146_R	1.176	1.00
211_R	215_A	1.172	1.00
220_W	224_L	1.168	1.00
122_A	168_V	1.160	1.00
17_A	21_A	1.160	1.00
47_M	72_I	1.160	1.00
57_Q	60_S	1.157	1.00
55_E	66_Q	1.156	1.00
31_Q	209_M	1.137	1.00
52_Y	73_R	1.120	1.00
202_D	205_A	1.117	1.00
66_Q	70_A	1.098	1.00
240_A	244_G	1.093	1.00
30_D	93_E	1.090	1.00
150_A	225_C	1.089	1.00
166_N	169_T	1.086	1.00
225_C	229_A	1.082	1.00
16_R	19_H	1.078	1.00
46_A	75_G	1.077	1.00
67_R	71_G	1.077	1.00
101_A	141_S	1.077	1.00
142_A	255_C	1.071	1.00
50_W	71_G	1.060	1.00
50_W	72_I	1.057	1.00
197_L	240_A	1.057	1.00
206_R	216_K	1.041	1.00
125_R	159_V	1.035	1.00
110_L	131_A	1.034	1.00
127_V	168_V	1.032	1.00
104_F	109_L	1.030	1.00
142_A	147_V	1.028	1.00
57_Q	68_A	1.022	1.00
16_R	20_Y	1.021	1.00
147_V	255_C	1.019	1.00
125_R	163_A	1.018	1.00
107_R	138_P	1.018	1.00
240_A	245_A	1.018	1.00
47_M	76_I	1.016	1.00
167_R	188_S	1.014	1.00
107_R	111_D	1.013	1.00
114_L	129_I	1.003	1.00
44_L	83_I	1.003	1.00
137_E	140_L	1.003	1.00
114_L	131_A	0.998	1.00
235_T	252_A	0.995	1.00
146_R	228_V	0.992	1.00
208_E	212_S	0.987	1.00
192_L	197_L	0.987	1.00
236_F	251_L	0.984	1.00
169_T	188_S	0.983	1.00
39_D	206_R	0.978	1.00
237_T	251_L	0.977	1.00
127_V	188_S	0.976	1.00
166_N	188_S	0.976	1.00
162_S	166_N	0.972	1.00
182_H	237_T	0.970	1.00
129_I	170_F	0.969	1.00
140_L	255_C	0.969	1.00
24_A	27_F	0.964	1.00
71_G	75_G	0.958	1.00
20_Y	24_A	0.955	1.00
74_T	115_A	0.949	1.00
163_A	214_D	0.940	1.00
54_L	72_I	0.939	1.00
127_V	159_V	0.937	1.00
59_A	65_L	0.934	1.00
161_A	215_A	0.934	1.00
45_N	75_G	0.930	1.00
23_E	26_L	0.927	1.00
46_A	50_W	0.924	1.00
201_F	236_F	0.922	1.00
143_D	146_R	0.920	1.00
18_A	23_E	0.919	1.00
175_D	252_A	0.917	1.00
78_Q	82_L	0.913	1.00
240_A	247_V	0.908	1.00
22_A	28_L	0.905	1.00
201_F	249_L	0.905	1.00
203_A	227_R	0.899	1.00
78_Q	148_A	0.898	1.00
51_A	73_R	0.891	1.00
44_L	84_D	0.887	1.00
239_A	250_S	0.884	1.00
51_A	69_L	0.884	1.00
193_A	207_R	0.869	1.00
206_R	213_R	0.867	1.00
15_E	18_A	0.866	1.00
99_I	231_A	0.864	1.00
210_L	213_R	0.864	1.00
180_V	252_A	0.859	1.00
190_A	207_R	0.856	1.00
154_M	185_C	0.852	0.99
213_R	216_K	0.842	0.99
238_H	247_V	0.841	0.99
227_R	231_A	0.833	0.99
134_P	173_T	0.826	0.99
104_F	141_S	0.826	0.99
229_A	236_F	0.815	0.99
194_D	197_L	0.814	0.99
192_L	222_L	0.812	0.99
192_L	198_P	0.802	0.99
88_D	91_R	0.797	0.99
60_S	65_L	0.796	0.99
147_V	183_V	0.793	0.99
229_A	235_T	0.789	0.99
110_L	151_L	0.787	0.99
76_I	79_Q	0.782	0.99
192_L	200_A	0.782	0.99
85_D	149_Q	0.780	0.99
237_T	252_A	0.779	0.99
82_L	89_A	0.777	0.99
20_Y	23_E	0.774	0.99
99_I	146_R	0.773	0.99
54_L	68_A	0.770	0.99
151_L	155_L	0.770	0.99
47_M	51_A	0.769	0.99
113_T	117_V	0.769	0.99
199_H	202_D	0.764	0.99
170_F	183_V	0.762	0.99
162_S	165_G	0.760	0.99
81_A	85_D	0.757	0.99
126_Q	164_A	0.751	0.99
31_Q	203_A	0.750	0.99
234_G	254_P	0.750	0.99
187_V	191_A	0.750	0.99
113_T	155_L	0.744	0.99
192_L	240_A	0.737	0.99
117_V	129_I	0.729	0.98
25_A	29_R	0.729	0.98
200_A	223_A	0.728	0.98
172_C	183_V	0.726	0.98
40_L	44_L	0.721	0.98
166_N	186_G	0.721	0.98
109_L	113_T	0.720	0.98
178_Q	254_P	0.710	0.98
226_Q	235_T	0.709	0.98
61_A	65_L	0.698	0.98
241_F	244_G	0.698	0.98
154_M	236_F	0.697	0.98
26_L	92_A	0.695	0.98
225_C	251_L	0.693	0.98
78_Q	145_E	0.687	0.98
112_D	144_R	0.687	0.98
208_E	215_A	0.687	0.98
251_L	254_P	0.685	0.98
48_H	52_Y	0.683	0.98
151_L	185_C	0.679	0.97
22_A	26_L	0.679	0.97
104_F	255_C	0.675	0.97
42_S	45_N	0.673	0.97
137_E	174_R	0.672	0.97
152_W	156_T	0.665	0.97
88_D	146_R	0.664	0.97
89_A	92_A	0.662	0.97
130_D	167_R	0.662	0.97
130_D	166_N	0.662	0.97
103_P	139_S	0.662	0.97
23_E	27_F	0.661	0.97
50_W	54_L	0.658	0.97
81_A	145_E	0.657	0.97
129_I	155_L	0.656	0.97
46_A	71_G	0.654	0.97
201_F	247_V	0.654	0.97
127_V	161_A	0.651	0.97
110_L	170_F	0.650	0.97
52_Y	124_A	0.648	0.97
67_R	70_A	0.647	0.97
146_R	222_L	0.647	0.97
144_R	148_A	0.646	0.97
49_S	79_Q	0.644	0.97
48_H	80_V	0.641	0.96
132_T	173_T	0.639	0.96
111_D	118_R	0.636	0.96
179_C	254_P	0.631	0.96
107_R	133_L	0.626	0.96
128_S	167_R	0.626	0.96
207_R	216_K	0.621	0.96
125_R	162_S	0.620	0.96
114_L	155_L	0.620	0.96
197_L	200_A	0.616	0.96
60_S	64_S	0.611	0.95
122_A	127_V	0.611	0.95
85_D	146_R	0.607	0.95
55_E	69_L	0.607	0.95
227_R	230_L	0.606	0.95
153_T	224_L	0.605	0.95
64_S	68_A	0.604	0.95
78_Q	152_W	0.599	0.95
141_S	256_K	0.599	0.95
110_L	183_V	0.597	0.95
233_G	251_L	0.590	0.94
108_P	112_D	0.590	0.94
68_A	72_I	0.589	0.94
44_L	80_V	0.589	0.94
178_Q	256_K	0.589	0.94
150_A	232_H	0.586	0.94
32_A	36_A	0.586	0.94
35_T	203_A	0.585	0.94
114_L	118_R	0.585	0.94
123_D	128_S	0.583	0.94
22_A	49_S	0.582	0.94
44_L	76_I	0.581	0.94
45_N	49_S	0.580	0.94
72_I	78_Q	0.580	0.94
116_L	152_W	0.580	0.94
50_W	75_G	0.580	0.94
109_L	151_L	0.579	0.94
46_A	116_L	0.579	0.94
89_A	227_R	0.577	0.94
109_L	144_R	0.577	0.94
113_T	129_I	0.574	0.94
125_R	164_A	0.571	0.93
28_L	49_S	0.571	0.93
76_I	80_V	0.571	0.93
183_V	253_V	0.570	0.93
208_E	211_R	0.566	0.93
49_S	76_I	0.565	0.93
200_A	236_F	0.564	0.93
91_R	98_A	0.559	0.93
110_L	133_L	0.559	0.93
92_A	224_L	0.558	0.93
22_A	25_A	0.558	0.93
225_C	230_L	0.557	0.93
154_M	222_L	0.557	0.93
228_V	232_H	0.553	0.92
229_A	254_P	0.552	0.92
31_Q	83_I	0.551	0.92
42_S	49_S	0.551	0.92
183_V	255_C	0.550	0.92
106_L	172_C	0.550	0.92
35_T	213_R	0.548	0.92
193_A	197_L	0.548	0.92
117_V	156_T	0.547	0.92
146_R	201_F	0.546	0.92
72_I	76_I	0.545	0.92
34_S	90_P	0.542	0.91
40_L	82_L	0.541	0.91
39_D	149_Q	0.541	0.91
147_V	253_V	0.539	0.91
127_V	164_A	0.536	0.91
52_Y	77_D	0.535	0.91
25_A	30_D	0.532	0.91
91_R	206_R	0.530	0.91
127_V	163_A	0.530	0.91
201_F	238_H	0.529	0.90
160_E	191_A	0.529	0.90
25_A	28_L	0.527	0.90
115_A	118_R	0.526	0.90
162_S	206_R	0.526	0.90
52_Y	55_E	0.526	0.90
48_H	51_A	0.524	0.90
113_T	148_A	0.524	0.90
25_A	33_L	0.523	0.90
113_T	152_W	0.522	0.90
49_S	69_L	0.515	0.89
194_D	243_D	0.515	0.89
46_A	82_L	0.510	0.89
88_D	149_Q	0.508	0.89
113_T	159_V	0.508	0.89
203_A	223_A	0.507	0.89
53_V	72_I	0.506	0.88
123_D	126_Q	0.506	0.88
46_A	78_Q	0.506	0.88
110_L	113_T	0.505	0.88
87_L	218_V	0.505	0.88
35_T	50_W	0.505	0.88
191_A	217_R	0.503	0.88
200_A	238_H	0.501	0.88
33_L	204_F	0.501	0.88
202_D	223_A	0.500	0.88
54_L	71_G	0.500	0.88

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4u7o_A	1	0.8842	100	0.389	Contact Map
4i5s_A	1	0.8726	100	0.394	Contact Map
3a0r_A	1	0.9151	100	0.404	Contact Map
4q20_A	1	0.8919	100	0.41	Contact Map
2e0a_A	1	0.9614	100	0.412	Contact Map
4mpc_A	1	0.9266	100	0.416	Contact Map
4gcz_A	1	0.9459	100	0.418	Contact Map
4e01_A	1	0.9421	100	0.419	Contact Map
3jz3_A	1	0.583	100	0.424	Contact Map
2c2a_A	1	0.9073	100	0.426	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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