GREMLIN Database
T0938_c90_1_259 - T0938_c90 1-259
ID: 131 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 259 (241)
Sequences: 5035 (4015)
Seq/√Len: 258.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_A72_I3.8111.00
241_F245_A3.3571.00
237_T250_S3.3061.00
104_F142_A3.1811.00
197_L238_H3.1691.00
225_C236_F3.1311.00
226_Q230_L2.7271.00
102_Q144_R2.5871.00
19_H23_E2.5031.00
162_S188_S2.3971.00
150_A229_A2.3381.00
19_H22_A2.2661.00
182_H252_A2.2661.00
193_A196_A2.2421.00
103_P141_S2.2321.00
186_G248_T2.2051.00
48_H76_I2.1871.00
230_L235_T2.1481.00
182_H250_S2.0841.00
151_L183_V2.0451.00
57_Q65_L1.9781.00
27_F31_Q1.9621.00
55_E73_R1.9121.00
150_A228_V1.9021.00
55_E70_A1.8911.00
229_A251_L1.8851.00
193_A243_D1.8661.00
155_L170_F1.8441.00
196_A199_H1.8431.00
183_V251_L1.8381.00
142_A232_H1.8271.00
171_A186_G1.8161.00
118_R123_D1.8121.00
18_A22_A1.8031.00
211_R216_K1.7951.00
105_A108_P1.7671.00
105_A138_P1.7361.00
184_T248_T1.7311.00
132_T171_A1.6661.00
238_H249_L1.6261.00
192_L196_A1.6151.00
190_A215_A1.5631.00
117_V159_V1.5551.00
117_V155_L1.5371.00
171_A184_T1.5261.00
120_A124_A1.5151.00
239_A248_T1.4931.00
54_L65_L1.4651.00
112_D148_A1.4591.00
54_L69_L1.4581.00
130_D169_T1.4521.00
180_V254_P1.4521.00
21_A24_A1.4341.00
50_W68_A1.4321.00
169_T186_G1.4281.00
154_M251_L1.4091.00
15_E19_H1.3971.00
18_A21_A1.3841.00
36_A86_V1.3821.00
150_A251_L1.3751.00
117_V152_W1.3711.00
101_A256_K1.3701.00
199_H205_A1.3621.00
161_A206_R1.3611.00
207_R211_R1.3391.00
208_E213_R1.3371.00
91_R218_V1.3321.00
110_L172_C1.3141.00
99_I232_H1.3051.00
229_A234_G1.2941.00
146_R149_Q1.2921.00
101_A142_A1.2841.00
173_T184_T1.2731.00
80_V84_D1.2621.00
175_D182_H1.2451.00
173_T182_H1.2441.00
73_R77_D1.2391.00
122_A159_V1.2321.00
51_A76_I1.2291.00
192_L238_H1.2261.00
196_A207_R1.2201.00
194_D241_F1.2151.00
53_V68_A1.2081.00
184_T250_S1.1961.00
26_L29_R1.1901.00
24_A28_L1.1891.00
51_A55_E1.1871.00
206_R215_A1.1841.00
74_T112_D1.1811.00
26_L30_D1.1801.00
132_T169_T1.1781.00
97_L146_R1.1761.00
211_R215_A1.1721.00
220_W224_L1.1681.00
122_A168_V1.1601.00
17_A21_A1.1601.00
47_M72_I1.1601.00
57_Q60_S1.1571.00
55_E66_Q1.1561.00
31_Q209_M1.1371.00
52_Y73_R1.1201.00
202_D205_A1.1171.00
66_Q70_A1.0981.00
240_A244_G1.0931.00
30_D93_E1.0901.00
150_A225_C1.0891.00
166_N169_T1.0861.00
225_C229_A1.0821.00
16_R19_H1.0781.00
46_A75_G1.0771.00
67_R71_G1.0771.00
101_A141_S1.0771.00
142_A255_C1.0711.00
50_W71_G1.0601.00
50_W72_I1.0571.00
197_L240_A1.0571.00
206_R216_K1.0411.00
125_R159_V1.0351.00
110_L131_A1.0341.00
127_V168_V1.0321.00
104_F109_L1.0301.00
142_A147_V1.0281.00
57_Q68_A1.0221.00
16_R20_Y1.0211.00
147_V255_C1.0191.00
125_R163_A1.0181.00
107_R138_P1.0181.00
240_A245_A1.0181.00
47_M76_I1.0161.00
167_R188_S1.0141.00
107_R111_D1.0131.00
114_L129_I1.0031.00
44_L83_I1.0031.00
137_E140_L1.0031.00
114_L131_A0.9981.00
235_T252_A0.9951.00
146_R228_V0.9921.00
208_E212_S0.9871.00
192_L197_L0.9871.00
236_F251_L0.9841.00
169_T188_S0.9831.00
39_D206_R0.9781.00
237_T251_L0.9771.00
127_V188_S0.9761.00
166_N188_S0.9761.00
162_S166_N0.9721.00
182_H237_T0.9701.00
129_I170_F0.9691.00
140_L255_C0.9691.00
24_A27_F0.9641.00
71_G75_G0.9581.00
20_Y24_A0.9551.00
74_T115_A0.9491.00
163_A214_D0.9401.00
54_L72_I0.9391.00
127_V159_V0.9371.00
59_A65_L0.9341.00
161_A215_A0.9341.00
45_N75_G0.9301.00
23_E26_L0.9271.00
46_A50_W0.9241.00
201_F236_F0.9221.00
143_D146_R0.9201.00
18_A23_E0.9191.00
175_D252_A0.9171.00
78_Q82_L0.9131.00
240_A247_V0.9081.00
22_A28_L0.9051.00
201_F249_L0.9051.00
203_A227_R0.8991.00
78_Q148_A0.8981.00
51_A73_R0.8911.00
44_L84_D0.8871.00
239_A250_S0.8841.00
51_A69_L0.8841.00
193_A207_R0.8691.00
206_R213_R0.8671.00
15_E18_A0.8661.00
99_I231_A0.8641.00
210_L213_R0.8641.00
180_V252_A0.8591.00
190_A207_R0.8561.00
154_M185_C0.8520.99
213_R216_K0.8420.99
238_H247_V0.8410.99
227_R231_A0.8330.99
134_P173_T0.8260.99
104_F141_S0.8260.99
229_A236_F0.8150.99
194_D197_L0.8140.99
192_L222_L0.8120.99
192_L198_P0.8020.99
88_D91_R0.7970.99
60_S65_L0.7960.99
147_V183_V0.7930.99
229_A235_T0.7890.99
110_L151_L0.7870.99
76_I79_Q0.7820.99
192_L200_A0.7820.99
85_D149_Q0.7800.99
237_T252_A0.7790.99
82_L89_A0.7770.99
20_Y23_E0.7740.99
99_I146_R0.7730.99
54_L68_A0.7700.99
151_L155_L0.7700.99
47_M51_A0.7690.99
113_T117_V0.7690.99
199_H202_D0.7640.99
170_F183_V0.7620.99
162_S165_G0.7600.99
81_A85_D0.7570.99
126_Q164_A0.7510.99
31_Q203_A0.7500.99
234_G254_P0.7500.99
187_V191_A0.7500.99
113_T155_L0.7440.99
192_L240_A0.7370.99
117_V129_I0.7290.98
25_A29_R0.7290.98
200_A223_A0.7280.98
172_C183_V0.7260.98
40_L44_L0.7210.98
166_N186_G0.7210.98
109_L113_T0.7200.98
178_Q254_P0.7100.98
226_Q235_T0.7090.98
61_A65_L0.6980.98
241_F244_G0.6980.98
154_M236_F0.6970.98
26_L92_A0.6950.98
225_C251_L0.6930.98
78_Q145_E0.6870.98
112_D144_R0.6870.98
208_E215_A0.6870.98
251_L254_P0.6850.98
48_H52_Y0.6830.98
151_L185_C0.6790.97
22_A26_L0.6790.97
104_F255_C0.6750.97
42_S45_N0.6730.97
137_E174_R0.6720.97
152_W156_T0.6650.97
88_D146_R0.6640.97
89_A92_A0.6620.97
130_D167_R0.6620.97
130_D166_N0.6620.97
103_P139_S0.6620.97
23_E27_F0.6610.97
50_W54_L0.6580.97
81_A145_E0.6570.97
129_I155_L0.6560.97
46_A71_G0.6540.97
201_F247_V0.6540.97
127_V161_A0.6510.97
110_L170_F0.6500.97
52_Y124_A0.6480.97
67_R70_A0.6470.97
146_R222_L0.6470.97
144_R148_A0.6460.97
49_S79_Q0.6440.97
48_H80_V0.6410.96
132_T173_T0.6390.96
111_D118_R0.6360.96
179_C254_P0.6310.96
107_R133_L0.6260.96
128_S167_R0.6260.96
207_R216_K0.6210.96
125_R162_S0.6200.96
114_L155_L0.6200.96
197_L200_A0.6160.96
60_S64_S0.6110.95
122_A127_V0.6110.95
85_D146_R0.6070.95
55_E69_L0.6070.95
227_R230_L0.6060.95
153_T224_L0.6050.95
64_S68_A0.6040.95
78_Q152_W0.5990.95
141_S256_K0.5990.95
110_L183_V0.5970.95
233_G251_L0.5900.94
108_P112_D0.5900.94
68_A72_I0.5890.94
44_L80_V0.5890.94
178_Q256_K0.5890.94
150_A232_H0.5860.94
32_A36_A0.5860.94
35_T203_A0.5850.94
114_L118_R0.5850.94
123_D128_S0.5830.94
22_A49_S0.5820.94
44_L76_I0.5810.94
45_N49_S0.5800.94
72_I78_Q0.5800.94
116_L152_W0.5800.94
50_W75_G0.5800.94
109_L151_L0.5790.94
46_A116_L0.5790.94
89_A227_R0.5770.94
109_L144_R0.5770.94
113_T129_I0.5740.94
125_R164_A0.5710.93
28_L49_S0.5710.93
76_I80_V0.5710.93
183_V253_V0.5700.93
208_E211_R0.5660.93
49_S76_I0.5650.93
200_A236_F0.5640.93
91_R98_A0.5590.93
110_L133_L0.5590.93
92_A224_L0.5580.93
22_A25_A0.5580.93
225_C230_L0.5570.93
154_M222_L0.5570.93
228_V232_H0.5530.92
229_A254_P0.5520.92
31_Q83_I0.5510.92
42_S49_S0.5510.92
183_V255_C0.5500.92
106_L172_C0.5500.92
35_T213_R0.5480.92
193_A197_L0.5480.92
117_V156_T0.5470.92
146_R201_F0.5460.92
72_I76_I0.5450.92
34_S90_P0.5420.91
40_L82_L0.5410.91
39_D149_Q0.5410.91
147_V253_V0.5390.91
127_V164_A0.5360.91
52_Y77_D0.5350.91
25_A30_D0.5320.91
91_R206_R0.5300.91
127_V163_A0.5300.91
201_F238_H0.5290.90
160_E191_A0.5290.90
25_A28_L0.5270.90
115_A118_R0.5260.90
162_S206_R0.5260.90
52_Y55_E0.5260.90
48_H51_A0.5240.90
113_T148_A0.5240.90
25_A33_L0.5230.90
113_T152_W0.5220.90
49_S69_L0.5150.89
194_D243_D0.5150.89
46_A82_L0.5100.89
88_D149_Q0.5080.89
113_T159_V0.5080.89
203_A223_A0.5070.89
53_V72_I0.5060.88
123_D126_Q0.5060.88
46_A78_Q0.5060.88
110_L113_T0.5050.88
87_L218_V0.5050.88
35_T50_W0.5050.88
191_A217_R0.5030.88
200_A238_H0.5010.88
33_L204_F0.5010.88
202_D223_A0.5000.88
54_L71_G0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4u7o_A 1 0.8842 100 0.389 Contact Map
4i5s_A 1 0.8726 100 0.394 Contact Map
3a0r_A 1 0.9151 100 0.404 Contact Map
4q20_A 1 0.8919 100 0.41 Contact Map
2e0a_A 1 0.9614 100 0.412 Contact Map
4mpc_A 1 0.9266 100 0.416 Contact Map
4gcz_A 1 0.9459 100 0.418 Contact Map
4e01_A 1 0.9421 100 0.419 Contact Map
3jz3_A 1 0.583 100 0.424 Contact Map
2c2a_A 1 0.9073 100 0.426 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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