GREMLIN Database
T0947_69_214 - T0947 69-214
ID: 130 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 146 (135)
Sequences: 2263 (1444)
Seq/√Len: 124.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_R132_E3.9541.00
31_Y132_E3.8511.00
22_V27_L2.9451.00
55_I144_E2.8981.00
14_K53_E2.7841.00
45_F89_R2.7771.00
18_Q30_T2.6741.00
17_R117_D2.6101.00
20_Y27_L2.5911.00
55_I142_L2.5191.00
125_V133_I2.4701.00
9_R144_E2.4451.00
132_E136_L2.3421.00
37_W49_G2.2611.00
61_K134_Y2.2341.00
42_H53_E2.1271.00
61_K139_E1.9911.00
84_A131_E1.9061.00
11_V146_C1.9061.00
17_R35_F1.8881.00
20_Y30_T1.8101.00
13_S146_C1.7831.00
126_T129_E1.7811.00
13_S16_K1.7571.00
12_V143_V1.6511.00
69_K131_E1.6361.00
70_S96_M1.6361.00
58_I71_L1.6061.00
45_F83_Y1.5641.00
12_V33_V1.5291.00
68_T131_E1.4781.00
10_I21_L1.4461.00
19_L33_V1.4411.00
49_G120_L1.4391.00
78_K82_A1.4371.00
45_F87_Q1.4091.00
83_Y87_Q1.3691.00
58_I87_Q1.3611.00
33_V125_V1.3291.00
97_I130_I1.2841.00
57_S142_L1.2821.00
105_Q114_H1.2801.00
44_Q83_Y1.2631.00
59_D72_H1.2521.00
38_N50_K1.2260.99
32_T129_E1.2170.99
77_N80_D1.2130.99
13_S20_Y1.2090.99
78_K81_I1.2030.99
18_Q32_T1.1880.99
44_Q87_Q1.1810.99
83_Y86_S1.1760.99
86_S96_M1.1490.99
62_N65_S1.1440.99
11_V20_Y1.1340.99
137_V141_T1.1130.99
62_N70_S1.1070.99
114_H126_T1.0890.99
61_K138_K1.0870.99
119_T124_A1.0590.98
31_Y129_E1.0410.98
58_I143_V1.0330.98
23_S28_L1.0290.98
10_I137_V1.0110.98
35_F117_D0.9990.98
12_V123_I0.9630.97
51_T123_I0.9500.97
46_E93_G0.9380.97
97_I143_V0.9350.96
41_G50_K0.9160.96
16_K20_Y0.9130.96
7_I142_L0.9110.96
21_L136_L0.9110.96
14_K117_D0.9010.96
51_T56_Y0.8910.95
11_V22_V0.8830.95
100_L103_N0.8770.95
36_G51_T0.8720.95
104_P114_H0.8640.95
8_E23_S0.8590.94
97_I125_V0.8550.94
14_K35_F0.8510.94
60_Y72_H0.8480.94
34_A114_H0.8450.94
46_E49_G0.8420.94
119_T125_V0.8340.93
83_Y89_R0.8310.93
9_R55_I0.8300.93
81_I85_K0.8170.93
7_I23_S0.8130.93
46_E90_S0.8120.92
72_H96_M0.7950.92
71_L97_I0.7930.92
42_H50_K0.7920.92
24_G27_L0.7810.91
63_P134_Y0.7730.91
9_R142_L0.7720.90
62_N125_V0.7630.90
84_A91_P0.7620.90
43_K46_E0.7530.89
9_R22_V0.7520.89
37_W120_L0.7450.89
8_E21_L0.7450.89
88_G96_M0.7440.89
62_N96_M0.7410.89
74_D77_N0.7350.88
27_L30_T0.7350.88
60_Y139_E0.7310.88
34_A115_P0.7300.88
19_L97_I0.7280.88
34_A100_L0.7260.88
79_A83_Y0.7200.87
125_V129_E0.7120.87
32_T116_Y0.7020.86
34_A116_Y0.7010.86
40_I46_E0.6960.85
125_V130_I0.6950.85
31_Y125_V0.6940.85
34_A118_W0.6930.85
101_P114_H0.6920.85
87_Q90_S0.6880.85
39_F53_E0.6860.84
19_L133_I0.6810.84
62_N134_Y0.6790.84
51_T95_I0.6770.84
68_T130_I0.6760.84
95_I123_I0.6750.84
10_I58_I0.6690.83
102_S105_Q0.6660.83
82_A86_S0.6650.83
102_S127_N0.6640.83
73_V76_P0.6590.82
61_K137_V0.6440.81
105_Q118_W0.6440.81
52_P96_M0.6430.80
29_R136_L0.6410.80
9_R24_G0.6390.80
19_L129_E0.6370.80
53_E92_G0.6350.80
44_Q85_K0.6270.79
22_V43_K0.6230.78
73_V77_N0.6200.78
60_Y94_D0.6160.78
47_G92_G0.6140.77
14_K43_K0.6020.76
100_L114_H0.5950.75
67_F115_P0.5930.75
60_Y96_M0.5930.75
100_L115_P0.5920.75
56_Y59_D0.5910.75
104_P115_P0.5870.74
14_K40_I0.5860.74
56_Y77_N0.5860.74
52_P56_Y0.5840.74
59_D141_T0.5840.74
62_N72_H0.5760.73
75_Y92_G0.5760.73
80_D83_Y0.5690.72
44_Q115_P0.5670.72
40_I45_F0.5660.71
75_Y95_I0.5660.71
5_L10_I0.5640.71
46_E92_G0.5570.70
48_D92_G0.5550.70
56_Y92_G0.5530.70
102_S114_H0.5510.69
100_L127_N0.5510.69
7_I11_V0.5510.69
42_H83_Y0.5480.69
40_I44_Q0.5470.69
79_A82_A0.5470.69
43_K47_G0.5450.69
56_Y62_N0.5440.69
52_P88_G0.5440.69
10_I20_Y0.5430.68
40_I53_E0.5410.68
44_Q79_A0.5370.68
34_A101_P0.5340.67
100_L120_L0.5320.67
71_L76_P0.5290.66
17_R36_G0.5260.66
22_V25_D0.5260.66
14_K50_K0.5230.66
62_N94_D0.5210.65
33_V123_I0.5210.65
51_T145_V0.5190.65
89_R143_V0.5170.65
48_D62_N0.5160.64
101_P105_Q0.5160.64
85_K88_G0.5130.64
116_Y126_T0.5130.64
32_T85_K0.5120.64
14_K69_K0.5110.64
123_I145_V0.5090.63
115_P126_T0.5080.63
8_E25_D0.5080.63
43_K77_N0.5070.63
127_N137_V0.5060.63
35_F39_F0.5060.63
14_K39_F0.5010.62
21_L125_V0.5010.62
31_Y136_L0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xzz_A 1 0.911 100 0.335 Contact Map
4lzh_A 1 0.8288 100 0.362 Contact Map
4jmn_A 1 0.8836 99.9 0.38 Contact Map
4xvo_A 1 0.8836 99.9 0.381 Contact Map
4z7a_A 1 0.8356 99.9 0.385 Contact Map
4qrb_A 1 0.8219 99.9 0.389 Contact Map
4k73_A 1 0.8356 99.9 0.39 Contact Map
3vyp_A 1 0.8767 99.9 0.394 Contact Map
1zat_A 1 0.8493 99.9 0.397 Contact Map
4lpq_A 1 0.863 99.9 0.41 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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