GREMLIN Database
T0873_1_501 - T0873 1-501
ID: 13 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 501 (431)
Sequences: 4539 (2659)
Seq/√Len: 128.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_E38_E4.6051.00
135_Q262_K4.1161.00
137_N317_D4.0571.00
38_E67_N3.9971.00
40_D67_N3.9111.00
279_H311_D3.7591.00
375_T415_D3.6151.00
211_W218_M3.4841.00
127_V257_E3.3641.00
46_H153_L3.2181.00
49_A78_I3.2001.00
190_D193_R3.1631.00
145_N191_G2.9051.00
257_E271_S2.8951.00
44_D70_T2.8831.00
421_D424_E2.8421.00
173_T210_L2.8381.00
42_P70_T2.8181.00
287_V304_M2.8081.00
227_E252_F2.8061.00
153_L161_P2.7891.00
395_S467_V2.7891.00
145_N148_R2.7391.00
212_D285_T2.7391.00
53_A80_A2.6051.00
35_D94_A2.5851.00
132_A259_V2.3461.00
175_D210_L2.2491.00
179_T267_L2.1701.00
137_N315_Y2.1331.00
279_H309_V2.1331.00
22_D271_S2.1261.00
220_F308_Y2.1031.00
217_P282_P2.0961.00
433_V468_L2.0931.00
276_I310_V2.0901.00
76_C274_I2.0521.00
287_V302_T2.0421.00
433_V439_R2.0291.00
418_D421_D1.9821.00
42_P68_D1.9811.00
27_L79_L1.9661.00
217_P279_H1.9271.00
186_V222_I1.9241.00
136_D317_D1.9141.00
217_P281_M1.9111.00
171_V207_I1.9081.00
439_R466_A1.9011.00
139_L315_Y1.8941.00
219_P264_V1.8881.00
28_A31_E1.8821.00
193_R286_A1.8811.00
193_R309_V1.8401.00
357_A373_C1.8301.00
411_F429_I1.8241.00
31_E67_N1.8231.00
192_K309_V1.8201.00
181_W245_V1.8171.00
79_L88_I1.8091.00
179_T243_E1.8021.00
261_A268_V1.7881.00
260_R265_D1.7761.00
284_R309_V1.7761.00
260_R267_L1.7681.00
35_D95_R1.7541.00
223_V226_T1.7541.00
436_A464_P1.7461.00
128_V267_L1.7451.00
194_M308_Y1.7441.00
195_T286_A1.7371.00
170_I245_V1.7191.00
125_A246_G1.7091.00
189_I195_T1.7081.00
189_I286_A1.6901.00
434_S452_C1.6751.00
221_A261_A1.6701.00
205_G209_K1.6631.00
28_A32_A1.6401.00
358_T420_S1.6321.00
154_L323_I1.6291.00
56_T64_L1.6261.00
134_C314_T1.6191.00
147_D191_G1.6091.00
135_Q314_T1.6071.00
396_Q442_R1.5721.00
372_V398_L1.5711.00
151_A188_K1.5691.00
146_L310_V1.5691.00
29_V33_H1.5331.00
114_S118_A1.5311.00
261_A264_V1.5291.00
263_T312_A1.5221.00
357_A375_T1.5131.00
36_V65_M1.5121.00
29_V98_L1.5091.00
219_P279_H1.5051.00
159_G187_M1.4861.00
395_S410_V1.4771.00
26_Y99_S1.4761.00
76_C319_P1.4731.00
139_L313_I1.4641.00
46_H161_P1.4551.00
222_I308_Y1.4331.00
209_K213_N1.4321.00
264_V267_L1.4231.00
370_L407_M1.4201.00
418_D424_E1.4111.00
180_N244_E1.4041.00
21_K254_E1.3901.00
110_E113_D1.3841.00
45_P71_G1.3831.00
147_D188_K1.3811.00
163_L224_Q1.3801.00
435_P464_P1.3721.00
170_I223_V1.3681.00
441_V464_P1.3601.00
139_L148_R1.3531.00
212_D283_G1.3411.00
138_V262_K1.3131.00
135_Q138_V1.3021.00
45_P161_P1.2951.00
436_A443_H1.2941.00
221_A264_V1.2881.00
373_C419_P1.2811.00
22_D25_E1.2771.00
409_R433_V1.2691.00
210_L213_N1.2681.00
29_V32_A1.2671.00
346_L350_R1.2641.00
175_D214_L1.2621.00
203_H244_E1.2561.00
224_Q322_P1.2501.00
357_A415_D1.2431.00
65_M320_I1.2401.00
33_H98_L1.2401.00
223_V272_A1.2391.00
146_L194_M1.2361.00
65_M79_L1.2351.00
33_H94_A1.2230.99
20_L29_V1.2180.99
36_V63_A1.2180.99
392_L440_L1.2150.99
238_L247_F1.2050.99
371_I425_L1.2000.99
173_T176_G1.1910.99
43_V52_A1.1810.99
230_I256_L1.1790.99
128_V258_L1.1790.99
182_A204_L1.1720.99
139_L143_D1.1720.99
171_V204_L1.1700.99
152_P323_I1.1670.99
144_A192_K1.1660.99
409_R435_P1.1660.99
274_I315_Y1.1600.99
245_V258_L1.1580.99
24_R273_E1.1560.99
67_N77_R1.1470.99
408_T450_A1.1420.99
169_I196_G1.1400.99
144_A191_G1.1380.99
139_L144_A1.1360.99
168_T181_W1.1320.99
369_W430_A1.1260.99
310_V313_I1.1240.99
24_R318_D1.1200.99
194_M310_V1.1160.99
281_M284_R1.1150.99
172_S265_D1.1140.99
411_F470_G1.1140.99
114_S117_A1.1130.99
157_G298_Q1.1070.99
429_I468_L1.1050.99
69_L78_I1.1040.99
261_A267_L1.1030.99
193_R284_R1.0990.99
433_V438_G1.0970.99
43_V49_A1.0970.99
358_T373_C1.0910.99
360_W420_S1.0860.99
30_L63_A1.0860.99
264_V311_D1.0850.99
63_A95_R1.0810.99
223_V275_V1.0800.99
194_M222_I1.0780.99
196_G280_V1.0730.99
395_S440_L1.0690.99
224_Q276_I1.0600.99
134_C272_A1.0590.99
399_A467_V1.0560.99
75_F148_R1.0530.98
243_E246_G1.0510.98
27_L320_I1.0490.98
295_A449_L1.0470.98
219_P265_D1.0420.98
371_I419_P1.0420.98
149_F274_I1.0390.98
196_G308_Y1.0360.98
186_V194_M1.0360.98
435_P466_A1.0350.98
281_M309_V1.0310.98
263_T311_D1.0270.98
358_T419_P1.0220.98
268_V275_V1.0170.98
254_E257_E1.0170.98
286_A307_E1.0170.98
212_D281_M1.0140.98
215_G283_G1.0130.98
276_I313_I1.0100.98
91_S95_R1.0080.98
252_F256_L1.0030.98
221_A268_V1.0000.98
262_K312_A0.9960.98
427_W431_T0.9920.98
49_A69_L0.9920.98
221_A275_V0.9920.98
76_C315_Y0.9920.98
413_L425_L0.9900.98
371_I413_L0.9880.98
90_G95_R0.9810.98
131_S135_Q0.9800.98
152_P321_W0.9790.98
409_R466_A0.9790.98
116_A350_R0.9730.97
45_P69_L0.9690.97
128_V260_R0.9600.97
24_R316_R0.9590.97
284_R307_E0.9560.97
380_E385_L0.9560.97
144_A310_V0.9530.97
24_R320_I0.9520.97
369_W409_R0.9500.97
230_I248_L0.9470.97
172_S267_L0.9460.97
276_I308_Y0.9450.97
124_V249_G0.9420.97
72_T75_F0.9400.97
379_R474_P0.9400.97
174_P210_L0.9340.97
348_L351_A0.9340.97
209_K212_D0.9330.97
163_L321_W0.9310.97
371_I411_F0.9270.97
375_T380_E0.9220.96
134_C259_V0.9190.96
226_T322_P0.9170.96
135_Q259_V0.9160.96
45_P72_T0.9130.96
40_D68_D0.9130.96
168_T226_T0.9120.96
190_D286_A0.9110.96
129_V132_A0.9090.96
94_A104_V0.9070.96
274_I321_W0.9060.96
21_K25_E0.9030.96
426_A429_I0.9000.96
207_I240_D0.8980.96
435_P439_R0.8900.96
265_D314_T0.8880.96
189_I193_R0.8870.96
199_I299_P0.8860.96
434_S463_G0.8850.96
21_K257_E0.8840.96
166_W322_P0.8830.96
273_E316_R0.8830.96
216_Q279_H0.8820.95
35_D98_L0.8790.95
75_F318_D0.8750.95
221_A266_L0.8750.95
422_Q426_A0.8730.95
395_S399_A0.8730.95
167_G222_I0.8730.95
52_A66_L0.8720.95
291_M326_A0.8670.95
78_I152_P0.8650.95
27_L88_I0.8650.95
100_L229_G0.8620.95
427_W432_R0.8620.95
53_A57_Y0.8600.95
262_K314_T0.8600.95
222_I276_I0.8590.95
24_R27_L0.8560.95
124_V250_A0.8530.95
369_W426_A0.8530.95
108_A112_V0.8520.95
261_A265_D0.8500.94
261_A314_T0.8490.94
356_V372_V0.8490.94
360_W363_F0.8470.94
113_D117_A0.8440.94
188_K194_M0.8430.94
374_L379_R0.8430.94
233_V248_L0.8400.94
43_V66_L0.8400.94
364_E423_T0.8400.94
172_S179_T0.8380.94
263_T314_T0.8350.94
50_G154_L0.8350.94
170_I181_W0.8340.94
259_V262_K0.8310.94
408_T452_C0.8270.94
227_E230_I0.8250.94
169_I186_V0.8220.93
133_P136_D0.8210.93
203_H206_Q0.8210.93
384_G393_R0.8190.93
77_R320_I0.8150.93
126_P249_G0.8130.93
211_W219_P0.8130.93
155_H292_G0.8110.93
319_P322_P0.8090.93
151_A163_L0.8080.93
226_T272_A0.8070.93
446_I463_G0.8060.93
360_W422_Q0.8040.93
49_A152_P0.8000.93
207_I218_M0.7990.92
138_V314_T0.7990.92
163_L167_G0.7970.92
183_I234_A0.7960.92
382_M385_L0.7940.92
362_P371_I0.7880.92
203_H240_D0.7870.92
79_L320_I0.7860.92
143_D191_G0.7850.92
144_A276_I0.7830.92
349_L394_I0.7830.92
217_P311_D0.7820.92
51_A55_W0.7790.91
44_D48_E0.7780.91
132_A136_D0.7730.91
37_R62_P0.7710.91
356_V359_A0.7710.91
169_I220_F0.7700.91
161_P188_K0.7670.91
379_R391_C0.7670.91
20_L227_E0.7650.91
64_L80_A0.7630.91
248_L256_L0.7590.90
63_A79_L0.7590.90
417_V428_A0.7530.90
305_Q448_P0.7530.90
194_M276_I0.7520.90
174_P214_L0.7520.90
162_Y187_M0.7520.90
108_A111_I0.7500.90
328_E424_E0.7470.90
193_R307_E0.7450.90
163_L188_K0.7450.90
168_T234_A0.7440.90
186_V196_G0.7430.89
50_G325_V0.7410.89
149_F313_I0.7390.89
212_D282_P0.7390.89
239_P242_I0.7350.89
345_A349_L0.7330.89
372_V412_V0.7330.89
362_P426_A0.7320.89
285_T304_M0.7320.89
369_W411_F0.7310.89
80_A323_I0.7290.89
440_L443_H0.7290.89
129_V270_A0.7280.89
198_F280_V0.7280.89
260_R264_V0.7280.89
384_G396_Q0.7280.89
39_I64_L0.7270.88
379_R383_P0.7250.88
448_P461_G0.7230.88
188_K313_I0.7210.88
180_N203_H0.7210.88
142_D192_K0.7190.88
49_A323_I0.7190.88
77_R318_D0.7180.88
413_L470_G0.7180.88
278_G308_Y0.7130.87
441_V466_A0.7110.87
69_L72_T0.7110.87
120_T347_A0.7110.87
411_F468_L0.7110.87
392_L396_Q0.7110.87
347_A351_A0.7110.87
443_H464_P0.7060.87
434_S437_H0.7060.87
52_A64_L0.7050.87
172_S219_P0.7050.87
161_P189_I0.7050.87
280_V308_Y0.7000.86
170_I266_L0.6960.86
158_D291_M0.6960.86
424_E427_W0.6950.86
440_L467_V0.6940.86
168_T223_V0.6910.86
361_M370_L0.6910.86
259_V314_T0.6900.86
23_L27_L0.6890.86
433_V441_V0.6870.85
65_M77_R0.6860.85
69_L77_R0.6850.85
169_I222_I0.6830.85
372_V410_V0.6820.85
184_A204_L0.6820.85
227_E271_S0.6810.85
22_D27_L0.6800.85
31_E40_D0.6800.85
355_P380_E0.6800.85
184_A198_F0.6790.85
213_N216_Q0.6790.85
345_A398_L0.6780.85
261_A277_E0.6770.85
223_V269_P0.6770.85
379_R414_D0.6760.85
221_A267_L0.6760.85
172_S264_V0.6750.84
176_G210_L0.6750.84
146_L151_A0.6740.84
113_D116_A0.6730.84
134_C137_N0.6730.84
103_D110_E0.6730.84
384_G462_Y0.6720.84
30_L36_V0.6690.84
56_T61_G0.6690.84
183_I235_S0.6670.84
124_V255_P0.6650.84
215_G282_P0.6620.83
37_R41_E0.6620.83
115_L118_A0.6620.83
135_Q263_T0.6600.83
31_E36_V0.6590.83
133_P271_S0.6590.83
219_P263_T0.6580.83
258_L267_L0.6580.83
74_R77_R0.6550.83
96_V340_V0.6550.83
168_T230_I0.6540.83
207_I211_W0.6530.82
184_A202_Q0.6520.82
224_Q321_W0.6510.82
192_K276_I0.6500.82
206_Q210_L0.6490.82
29_V101_G0.6480.82
43_V50_G0.6480.82
232_F341_T0.6480.82
282_P285_T0.6470.82
208_R212_D0.6460.82
173_T241_G0.6460.82
102_L110_E0.6450.82
20_L252_F0.6440.82
168_T231_P0.6440.82
167_G183_I0.6420.81
268_V314_T0.6410.81
31_E34_Q0.6410.81
78_I323_I0.6400.81
45_P152_P0.6380.81
178_F241_G0.6380.81
166_W324_S0.6380.81
397_V400_A0.6380.81
155_H326_A0.6360.81
37_R64_L0.6360.81
41_E68_D0.6340.81
172_S266_L0.6340.81
326_A333_T0.6340.81
170_I258_L0.6310.80
126_P258_L0.6300.80
261_A312_A0.6300.80
117_A120_T0.6290.80
160_G291_M0.6290.80
151_A321_W0.6290.80
162_Y194_M0.6290.80
373_C415_D0.6280.80
433_V470_G0.6270.80
391_C394_I0.6270.80
364_E426_A0.6240.80
87_T90_G0.6230.79
52_A55_W0.6220.79
162_Y195_T0.6210.79
19_R101_G0.6210.79
217_P283_G0.6200.79
136_D316_R0.6200.79
23_L320_I0.6200.79
198_F208_R0.6170.79
129_V257_E0.6160.79
148_R313_I0.6110.78
238_L242_I0.6110.78
26_Y79_L0.6100.78
170_I261_A0.6090.78
147_D161_P0.6080.78
186_V308_Y0.6060.78
138_V312_A0.6060.78
132_A138_V0.6040.77
68_D74_R0.6030.77
371_I422_Q0.6030.77
428_A431_T0.6020.77
439_R468_L0.5990.77
27_L36_V0.5990.77
359_A398_L0.5990.77
338_G360_W0.5970.77
125_A249_G0.5970.77
369_W373_C0.5960.76
409_R468_L0.5960.76
91_S94_A0.5950.76
156_E298_Q0.5950.76
216_Q317_D0.5950.76
346_L359_A0.5940.76
145_N192_K0.5940.76
149_F319_P0.5940.76
417_V432_R0.5930.76
48_E66_L0.5930.76
355_P375_T0.5920.76
47_L153_L0.5920.76
426_A430_A0.5920.76
49_A66_L0.5900.76
432_R472_L0.5900.76
163_L276_I0.5900.76
49_A80_A0.5880.75
155_H327_G0.5870.75
394_I398_L0.5870.75
277_E314_T0.5830.75
374_L412_V0.5830.75
315_Y319_P0.5820.75
144_A147_D0.5810.75
80_A325_V0.5800.74
434_S464_P0.5800.74
197_T305_Q0.5790.74
144_A148_R0.5780.74
330_V334_H0.5770.74
20_L25_E0.5770.74
371_I426_A0.5750.74
208_R306_P0.5730.74
334_H363_F0.5720.73
136_D315_Y0.5720.73
171_V184_A0.5710.73
25_E28_A0.5700.73
132_A135_Q0.5700.73
198_F204_L0.5700.73
106_A111_I0.5690.73
266_L269_P0.5690.73
259_V269_P0.5690.73
134_C270_A0.5680.73
231_P322_P0.5680.73
50_G152_P0.5660.73
354_L397_V0.5660.73
237_P368_H0.5660.73
126_P246_G0.5640.72
236_M341_T0.5610.72
409_R429_I0.5590.72
417_V427_W0.5580.72
395_S412_V0.5580.72
135_Q312_A0.5570.71
374_L385_L0.5570.71
362_P365_A0.5570.71
264_V312_A0.5560.71
438_G476_A0.5560.71
208_R218_M0.5560.71
379_R471_L0.5550.71
324_S333_T0.5550.71
413_L419_P0.5530.71
57_Y87_T0.5520.71
416_D432_R0.5520.71
126_P129_V0.5520.71
212_D218_M0.5520.71
442_R467_V0.5500.71
342_A360_W0.5500.71
50_G323_I0.5500.71
360_W419_P0.5490.70
197_T448_P0.5490.70
38_E65_M0.5480.70
158_D195_T0.5480.70
133_P316_R0.5480.70
186_V276_I0.5470.70
151_A194_M0.5470.70
132_A270_A0.5460.70
72_T76_C0.5460.70
113_D346_L0.5460.70
56_T90_G0.5450.70
197_T299_P0.5450.70
333_T337_W0.5430.70
97_A101_G0.5420.69
124_V246_G0.5410.69
411_F425_L0.5400.69
23_L79_L0.5390.69
372_V394_I0.5380.69
192_K311_D0.5370.69
438_G473_P0.5370.69
132_A258_L0.5360.69
174_P216_Q0.5350.68
187_M290_P0.5350.68
396_Q400_A0.5350.68
197_T449_L0.5350.68
208_R281_M0.5340.68
54_R58_E0.5330.68
102_L114_S0.5320.68
134_C315_Y0.5320.68
44_D71_G0.5310.68
163_L222_I0.5310.68
171_V182_A0.5290.68
393_R396_Q0.5250.67
181_W244_E0.5250.67
179_T258_L0.5240.67
274_I319_P0.5240.67
64_L87_T0.5230.67
122_E130_D0.5220.67
207_I241_G0.5220.67
53_A56_T0.5210.66
95_R98_L0.5200.66
35_D91_S0.5200.66
257_E270_A0.5190.66
76_C318_D0.5190.66
286_A304_M0.5190.66
398_L410_V0.5190.66
160_G187_M0.5180.66
199_I202_Q0.5170.66
226_T230_I0.5150.66
134_C271_S0.5150.66
173_T177_S0.5150.66
187_M298_Q0.5130.65
80_A154_L0.5130.65
130_D143_D0.5130.65
365_A368_H0.5130.65
384_G400_A0.5120.65
139_L142_D0.5110.65
392_L442_R0.5110.65
391_C395_S0.5110.65
397_V401_T0.5110.65
188_K310_V0.5100.65
213_N375_T0.5100.65
113_D350_R0.5080.64
89_P336_A0.5080.64
96_V335_T0.5080.64
166_W326_A0.5070.64
202_Q237_P0.5070.64
133_P270_A0.5070.64
62_P95_R0.5070.64
42_P69_L0.5060.64
43_V69_L0.5060.64
110_E114_S0.5060.64
293_E343_A0.5060.64
34_Q62_P0.5040.64
219_P261_A0.5040.64
264_V268_V0.5020.64
331_D334_H0.5020.64
143_D192_K0.5020.64
424_E428_A0.5010.63
369_W435_P0.5000.63
362_P422_Q0.5000.63
41_E52_A0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ip2_A 1 0.9541 100 0.129 Contact Map
4zad_A 1 0.9381 100 0.139 Contact Map
4za9_A 1 0.9421 100 0.14 Contact Map
2idb_A 1 0.9082 100 0.142 Contact Map
4zac_A 1 0.9481 100 0.144 Contact Map
3a5i_A 1 0.3154 15.9 0.982 Contact Map
2x49_A 1 0.3134 15.8 0.982 Contact Map
4a5p_A 1 0.012 15.7 0.982 Contact Map
2e1c_A 1 0.2555 14.6 0.982 Contact Map
3mix_A 1 0.3094 14.4 0.982 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.011 seconds.