GREMLIN Database
T0947_1_220 - T0947 1-220
ID: 129 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 220 (182)
Sequences: 166 (127)
Seq/√Len: 9.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
127_D140_H4.8971.00
126_I139_L3.9520.98
160_G166_H3.4390.96
99_Y200_E3.1600.93
129_K207_E2.9200.90
78_I126_I2.8710.90
82_K143_Y2.6910.86
116_D143_Y2.5500.83
137_K199_E2.4830.81
56_K59_D2.4600.80
111_K116_D2.3600.77
186_W192_A2.2030.72
82_K116_D2.1540.70
179_S194_T2.1210.69
130_N133_S2.0150.65
111_K143_Y1.9980.64
111_K122_G1.9510.62
145_N148_D1.9020.60
200_E204_L1.8810.59
144_P190_C1.8680.59
160_G165_I1.8430.58
75_I88_Y1.8380.58
182_H194_T1.8000.56
82_K111_K1.7840.55
103_F185_D1.7700.55
124_Y148_D1.7690.55
79_V137_K1.7280.53
33_Q37_G1.7020.52
119_T129_K1.6740.50
152_A156_G1.6730.50
103_F192_A1.6570.50
116_D120_P1.6060.47
130_N138_S1.6030.47
85_R89_L1.5910.47
116_D187_T1.5630.45
111_K187_T1.5240.44
194_T197_E1.5230.44
208_R211_V1.4980.43
64_S79_V1.4580.41
136_T139_L1.4270.40
121_E187_T1.4070.39
49_D59_D1.4070.39
111_K120_P1.3850.38
116_D122_G1.3790.38
209_T213_V1.3640.37
86_Q185_D1.3530.36
73_L198_I1.3130.35
92_G195_N1.3060.35
78_I139_L1.3030.34
193_V201_I1.2880.34
185_D192_A1.2850.34
85_R185_D1.2690.33
193_V197_E1.2650.33
120_P143_Y1.2640.33
106_N153_K1.2520.32
34_S126_I1.2060.31
116_D121_E1.2050.31
136_T206_K1.2030.31
143_Y187_T1.2010.30
124_Y160_G1.1990.30
159_P197_E1.1720.29
55_D62_R1.1600.29
122_G143_Y1.1570.29
80_V211_V1.1270.28
39_K53_Q1.1130.27
29_L32_L1.1110.27
139_L193_V1.1090.27
166_H190_C1.0980.27
78_I198_I1.0880.26
129_K191_I1.0850.26
105_W117_G1.0780.26
40_A198_I1.0660.26
144_P189_G1.0400.25
129_K134_Q1.0390.25
121_E148_D1.0340.25
191_I211_V1.0300.24
124_Y167_G1.0280.24
34_S146_K1.0270.24
128_Y202_Y1.0210.24
69_Q94_T1.0180.24
87_L146_K1.0160.24
103_F135_F1.0120.24
179_S182_H1.0100.24
117_G188_L1.0080.24
80_V104_G1.0060.24
74_N88_Y1.0060.24
63_E98_T1.0050.24
169_P207_E0.9990.23
128_Y205_V0.9950.23
47_Y50_D0.9890.23
122_G189_G0.9890.23
121_E192_A0.9860.23
78_I94_T0.9840.23
82_K186_W0.9830.23
187_T192_A0.9830.23
75_I205_V0.9790.23
118_K169_P0.9790.23
137_K164_M0.9690.22
119_T148_D0.9680.22
60_R94_T0.9680.22
82_K120_P0.9640.22
93_D98_T0.9620.22
47_Y54_I0.9460.22
109_G198_I0.9450.22
66_E69_Q0.9440.22
126_I136_T0.9430.22
121_E143_Y0.9330.21
82_K187_T0.9320.21
111_K115_G0.9300.21
122_G126_I0.9290.21
102_A192_A0.9270.21
48_C61_S0.9250.21
97_R200_E0.9250.21
207_E210_L0.9140.21
146_K149_I0.9010.20
120_P189_G0.9000.20
121_E141_V0.8990.20
123_I210_L0.8940.20
46_K137_K0.8890.20
102_A197_E0.8790.20
111_K145_N0.8760.20
156_G212_E0.8750.20
116_D148_D0.8740.20
83_D162_D0.8650.19
53_Q84_K0.8640.19
55_D153_K0.8620.19
89_L119_T0.8620.19
97_R204_L0.8550.19
164_M169_P0.8550.19
138_S162_D0.8460.19
156_G159_P0.8430.19
133_S201_I0.8380.19
45_Y128_Y0.8380.19
119_T122_G0.8380.19
124_Y145_N0.8360.19
138_S161_G0.8340.19
120_P126_I0.8340.19
42_D45_Y0.8290.18
76_E93_D0.8230.18
143_Y186_W0.8110.18
46_K68_I0.8080.18
103_F186_W0.8050.18
117_G130_N0.8000.18
42_D49_D0.7930.17
109_G200_E0.7900.17
137_K170_S0.7870.17
167_G189_G0.7870.17
89_L112_Q0.7850.17
65_V181_I0.7810.17
88_Y205_V0.7800.17
116_D192_A0.7790.17
111_K121_E0.7790.17
148_D192_A0.7770.17
208_R213_V0.7740.17
65_V98_T0.7720.17
67_R84_K0.7700.17
65_V69_Q0.7680.17
184_Y205_V0.7670.17
54_I146_K0.7660.17
113_F158_S0.7640.17
129_K202_Y0.7610.17
80_V186_W0.7590.17
99_Y193_V0.7530.16
40_A43_R0.7490.16
74_N205_V0.7480.16
59_D114_E0.7480.16
82_K122_G0.7470.16
80_V203_A0.7470.16
103_F121_E0.7470.16
67_R205_V0.7450.16
89_L107_F0.7450.16
83_D212_E0.7410.16
111_K148_D0.7410.16
82_K192_A0.7380.16
46_K98_T0.7360.16
88_Y211_V0.7340.16
174_K180_K0.7310.16
97_R210_L0.7300.16
33_Q36_A0.7290.16
138_S164_M0.7260.16
125_S183_P0.7250.16
161_G166_H0.7250.16
137_K182_H0.7220.16
68_I83_D0.7170.16
162_D179_S0.7080.15
161_G167_G0.7020.15
122_G187_T0.7000.15
173_Q181_I0.6980.15
144_P166_H0.6970.15
85_R103_F0.6930.15
121_E195_N0.6900.15
31_S90_V0.6820.15
116_D119_T0.6780.15
99_Y201_I0.6760.15
85_R152_A0.6760.15
129_K185_D0.6710.15
72_G181_I0.6640.14
46_K54_I0.6620.14
160_G164_M0.6620.14
91_S210_L0.6600.14
49_D153_K0.6540.14
87_L191_I0.6540.14
43_R159_P0.6490.14
102_A164_M0.6400.14
142_D148_D0.6390.14
75_I80_V0.6390.14
78_I90_V0.6310.14
106_N149_I0.6260.14
54_I65_V0.6250.14
179_S206_K0.6220.14
78_I184_Y0.6190.13
98_T170_S0.6170.13
115_G189_G0.6170.13
104_G119_T0.6100.13
157_R193_V0.6010.13
47_Y149_I0.6000.13
47_Y60_R0.5970.13
163_I187_T0.5910.13
145_N151_Y0.5900.13
99_Y133_S0.5880.13
50_D57_L0.5870.13
188_L202_Y0.5830.13
163_I166_H0.5810.13
93_D96_L0.5790.13
122_G190_C0.5750.13
42_D92_G0.5740.13
36_A202_Y0.5740.13
72_G93_D0.5730.13
120_P187_T0.5640.12
102_A152_A0.5630.12
89_L130_N0.5630.12
90_V213_V0.5620.12
96_L191_I0.5620.12
86_Q94_T0.5620.12
180_K202_Y0.5610.12
43_R92_G0.5590.12
98_T131_P0.5570.12
119_T159_P0.5570.12
167_G191_I0.5570.12
135_F188_L0.5560.12
43_R62_R0.5560.12
136_T162_D0.5510.12
66_E71_E0.5470.12
116_D145_N0.5430.12
46_K58_L0.5430.12
53_Q95_L0.5420.12
56_K106_N0.5420.12
88_Y202_Y0.5410.12
131_P202_Y0.5400.12
109_G148_D0.5380.12
81_S201_I0.5370.12
144_P148_D0.5370.12
143_Y192_A0.5350.12
62_R97_R0.5330.12
92_G168_L0.5280.12
160_G167_G0.5280.12
31_S34_S0.5250.12
152_A160_G0.5240.12
133_S138_S0.5220.12
104_G129_K0.5180.12
54_I71_E0.5160.11
121_E156_G0.5120.11
84_K108_I0.5120.11
39_K55_D0.5110.11
205_V211_V0.5090.11
114_E201_I0.5090.11
46_K135_F0.5070.11
45_Y56_K0.5050.11
102_A199_E0.5040.11
85_R104_G0.5040.11
115_G144_P0.5030.11
54_I64_S0.5000.11
145_N160_G0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xzz_A 1 0.8409 100 0.677 Contact Map
4jmn_A 1 0.8591 99.9 0.708 Contact Map
4z7a_A 1 0.8773 99.9 0.711 Contact Map
4xvo_A 1 0.8636 99.9 0.716 Contact Map
4lzh_A 1 0.8318 99.9 0.724 Contact Map
4k73_A 1 0.8182 99.9 0.725 Contact Map
3vyp_A 1 0.9136 99.9 0.726 Contact Map
1zat_A 1 0.8818 99.9 0.73 Contact Map
4qrb_A 1 0.8682 99.9 0.731 Contact Map
4lpq_A 1 0.8591 99.9 0.735 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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