GREMLIN Database
T0937_60-210_1_151 - T0937_60-210 1-151
ID: 126 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 151 (142)
Sequences: 596 (411)
Seq/√Len: 34.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_A87_S8.7001.00
21_K25_D4.1961.00
47_R87_S3.6451.00
93_S101_W3.5971.00
43_R131_E3.3181.00
34_A130_I2.9641.00
43_R89_E2.7161.00
29_N116_T2.6181.00
94_A106_P2.4351.00
115_Q126_A2.3590.99
43_R91_V2.3330.99
44_V92_L2.3270.99
92_L104_M2.2500.99
44_V111_L2.2250.99
45_T129_K2.2120.99
113_V130_I2.0090.98
40_C132_R2.0080.98
94_A104_M1.9800.98
50_T123_E1.8380.97
46_G88_V1.8310.97
47_R127_Q1.8080.96
81_E100_N1.6940.95
81_E99_G1.6750.95
91_V101_W1.5910.93
41_E134_D1.5870.93
84_P87_S1.5590.92
43_R133_I1.5460.92
41_E132_R1.5400.92
12_F44_V1.5310.91
118_L123_E1.4750.90
20_A116_T1.4660.90
24_A116_T1.4470.89
55_S74_F1.4280.88
32_Q115_Q1.3960.87
12_F113_V1.3920.87
56_F113_V1.2450.80
58_T72_T1.2450.80
36_V92_L1.2130.78
47_R83_A1.2110.78
60_K70_L1.2040.78
145_L149_G1.2040.78
8_A37_D1.1910.77
70_L107_D1.1860.77
38_G108_T1.1770.76
23_G49_G1.1240.73
89_E131_E1.1070.72
58_T104_M1.0930.71
51_V115_Q1.0830.70
17_H21_K1.0820.70
93_S103_R1.0660.69
33_Y110_A1.0400.67
22_I59_Q1.0400.67
17_H116_T1.0330.66
37_D40_C1.0320.66
41_E93_S1.0240.65
45_T131_E1.0160.65
8_A124_T1.0110.64
45_T89_E1.0090.64
88_V130_I0.9970.63
40_C134_D0.9830.62
102_V111_L0.9810.62
32_Q128_L0.9800.62
92_L102_V0.9760.62
96_P101_W0.9670.61
143_D146_A0.9540.60
82_I100_N0.9450.59
146_A149_G0.9420.59
125_P139_P0.9410.59
91_V133_I0.9370.59
75_L100_N0.9320.58
24_A57_G0.9230.57
9_W138_R0.9170.57
47_R85_D0.9110.56
143_D149_G0.9070.56
60_K71_Q0.8980.55
145_L148_Q0.8940.55
57_G71_Q0.8920.55
30_L117_F0.8900.55
89_E102_V0.8800.54
18_E85_D0.8790.54
34_A117_F0.8770.53
14_S125_P0.8760.53
33_Y112_L0.8730.53
91_V99_G0.8600.52
119_D122_T0.8590.52
51_V54_L0.8580.52
48_R101_W0.8340.50
80_L90_I0.8280.49
8_A40_C0.8280.49
81_E129_K0.8240.49
12_F130_I0.8160.48
143_D148_Q0.8140.48
83_A88_V0.8110.48
42_Y114_R0.8080.48
75_L102_V0.8060.47
24_A53_Y0.8010.47
24_A29_N0.7960.47
22_I120_R0.7900.46
143_D147_L0.7880.46
41_E95_T0.7800.45
44_V91_V0.7770.45
83_A100_N0.7740.45
90_I129_K0.7710.44
58_T92_L0.7640.44
46_G86_G0.7630.44
80_L117_F0.7620.44
38_G106_P0.7610.44
55_S77_A0.7500.43
122_T129_K0.7490.43
37_D112_L0.7460.42
93_S106_P0.7430.42
10_P42_Y0.7400.42
89_E100_N0.7380.42
30_L125_P0.7370.42
23_G50_T0.7350.41
9_W137_A0.7340.41
38_G107_D0.7300.41
12_F112_L0.7240.41
20_A29_N0.7220.40
121_R124_T0.7120.40
82_I139_P0.7090.39
21_K53_Y0.7030.39
35_R112_L0.7020.39
56_F80_L0.6880.38
27_P110_A0.6870.38
83_A134_D0.6840.37
57_G74_F0.6820.37
54_L115_Q0.6800.37
80_L136_Q0.6790.37
129_K133_I0.6770.37
53_Y116_T0.6750.37
135_A139_P0.6750.37
58_T108_T0.6720.36
23_G29_N0.6680.36
32_Q126_A0.6660.36
21_K71_Q0.6650.36
27_P67_G0.6560.35
90_I141_P0.6520.35
37_D109_N0.6480.35
39_R90_I0.6470.34
93_S97_R0.6400.34
25_D55_S0.6340.33
44_V56_F0.6340.33
3_E120_R0.6310.33
95_T142_L0.6300.33
94_A103_R0.6280.33
38_G147_L0.6270.33
89_E98_A0.6220.33
47_R136_Q0.6180.32
49_G54_L0.6170.32
73_G103_R0.6150.32
29_N76_D0.6130.32
18_E108_T0.6110.32
81_E98_A0.6040.31
144_P148_Q0.6040.31
88_V121_R0.6030.31
75_L90_I0.6000.31
44_V119_D0.5940.30
4_F12_F0.5940.30
20_A24_A0.5940.30
38_G104_M0.5890.30
73_G79_Q0.5890.30
47_R56_F0.5890.30
15_P33_Y0.5880.30
45_T100_N0.5880.30
71_Q74_F0.5830.30
93_S100_N0.5820.30
54_L126_A0.5810.30
81_E134_D0.5800.29
16_S22_I0.5780.29
21_K26_N0.5770.29
24_A31_Y0.5730.29
127_Q133_I0.5720.29
36_V130_I0.5710.29
51_V56_F0.5700.29
85_D100_N0.5690.29
51_V57_G0.5680.29
52_A118_L0.5660.29
26_N55_S0.5650.28
55_S113_V0.5640.28
79_Q137_A0.5630.28
47_R121_R0.5620.28
29_N53_Y0.5590.28
144_P149_G0.5460.27
40_C80_L0.5430.27
16_S20_A0.5420.27
97_R136_Q0.5410.27
66_D70_L0.5400.27
80_L99_G0.5350.26
73_G87_S0.5300.26
101_W115_Q0.5270.26
121_R138_R0.5270.26
48_R54_L0.5250.26
117_F123_E0.5240.26
81_E122_T0.5240.26
50_T59_Q0.5240.26
23_G115_Q0.5190.25
25_D65_T0.5190.25
8_A103_R0.5180.25
41_E133_I0.5160.25
55_S118_L0.5160.25
82_I105_E0.5140.25
27_P55_S0.5140.25
51_V123_E0.5130.25
85_D97_R0.5130.25
84_P99_G0.5110.25
53_Y120_R0.5110.25
30_L95_T0.5100.25
33_Y113_V0.5090.25
10_P114_R0.5080.25
56_F61_G0.5060.25
41_E131_E0.5030.24
44_V125_P0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3u07_A 1 0.8675 98.8 0.745 Contact Map
2p3y_A 1 0.894 97.9 0.801 Contact Map
1zvn_A 1 0.6424 19.9 0.932 Contact Map
3lnd_A 1 0.5828 18.5 0.933 Contact Map
2omz_B 1 0.6556 17.9 0.933 Contact Map
1wuz_A 1 0.5894 16.6 0.934 Contact Map
1zxk_A 1 0.6225 13 0.937 Contact Map
1ncg_A 1 0.6291 12.2 0.938 Contact Map
4apx_B 1 0.8344 11.3 0.939 Contact Map
3ppe_A 1 0.6225 11 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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