GREMLIN Database
T0942_260-487_1_228 - T0942_260-487 1-228
ID: 125 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 228 (221)
Sequences: 2065 (1485)
Seq/√Len: 99.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_K68_E5.0271.00
99_K102_E4.6381.00
132_Q135_E4.6331.00
176_E211_R3.8061.00
175_A191_L3.6181.00
13_E17_L3.3331.00
123_L127_Y3.0521.00
94_D106_R2.7141.00
56_R60_A2.4741.00
60_A68_E2.4131.00
188_I212_I2.3611.00
53_Q72_T2.2821.00
95_L126_A2.2381.00
70_R94_D2.2131.00
188_I215_L2.2021.00
195_S209_D2.1881.00
34_T38_L2.1711.00
35_S38_L2.1481.00
60_A72_T2.0571.00
16_Y20_A2.0471.00
38_L41_W2.0141.00
60_A65_K2.0041.00
107_L122_N1.9971.00
202_S206_A1.9541.00
179_A215_L1.9341.00
192_S216_R1.9251.00
80_E86_Y1.8941.00
13_E16_Y1.8931.00
70_R97_Q1.8921.00
171_L193_S1.8921.00
179_A218_L1.8221.00
37_L41_W1.7781.00
73_L89_L1.7691.00
17_L20_A1.7041.00
166_N169_Q1.6561.00
108_K135_E1.6551.00
91_T107_L1.6181.00
172_A207_R1.6171.00
185_D219_Q1.6141.00
35_S39_D1.5591.00
137_A161_E1.5571.00
70_R74_Q1.5521.00
90_A94_D1.5501.00
6_P9_V1.5471.00
61_M66_Y1.5311.00
154_W173_A1.5081.00
11_S15_F1.4991.00
128_L160_A1.4991.00
50_R79_A1.4571.00
161_E166_N1.4211.00
104_I126_A1.4151.00
104_I130_G1.4111.00
61_M93_I1.4101.00
94_D102_E1.3650.99
46_V49_Q1.3630.99
18_A21_R1.3610.99
183_R186_Q1.3200.99
201_G204_Q1.3180.99
59_Q63_A1.3060.99
133_P160_A1.3010.99
162_A170_E1.2840.99
127_Y135_E1.2840.99
133_P163_A1.2830.99
72_T75_P1.2690.99
31_N35_S1.2430.99
104_I123_L1.2360.99
147_N150_D1.2360.99
50_R86_Y1.2280.99
194_A208_Y1.2150.99
51_A55_G1.2150.99
90_A93_I1.1970.98
137_A157_L1.1820.98
92_D122_N1.1730.98
28_S31_N1.1710.98
144_T157_L1.1700.98
18_A35_S1.1640.98
108_K123_L1.1570.98
219_Q223_K1.1510.98
75_P78_A1.1490.98
5_R9_V1.1410.98
58_L89_L1.1340.98
77_L87_L1.1310.98
124_A140_L1.1260.98
188_I219_Q1.1260.98
38_L42_A1.1160.98
125_N129_Q1.1010.97
155_D177_G1.0960.97
125_N156_L1.0950.97
15_F20_A1.0930.97
8_V11_S1.0900.97
195_S208_Y1.0880.97
17_L21_R1.0840.97
32_Q35_S1.0740.97
19_K31_N1.0710.97
141_N161_E1.0620.97
13_E20_A1.0600.97
155_D159_Q1.0540.97
87_L110_A1.0490.97
171_L190_L1.0360.96
12_S15_F1.0330.96
128_L133_P1.0330.96
31_N34_T1.0280.96
30_R34_T1.0270.96
17_L24_G1.0160.96
171_L194_A1.0110.96
28_S32_Q1.0090.96
36_D39_D1.0070.96
12_S17_L1.0020.95
123_L139_I0.9980.95
191_L208_Y0.9970.95
179_A184_L0.9920.95
219_Q222_F0.9870.95
54_Y58_L0.9790.95
57_A61_M0.9720.95
80_E83_N0.9630.94
77_L90_A0.9610.94
25_M28_S0.9580.94
22_T58_L0.9530.94
120_Q143_Y0.9480.94
144_T153_G0.9470.94
212_I215_L0.9460.94
126_A130_G0.9440.94
137_A160_A0.9420.94
159_Q163_A0.9290.93
211_R215_L0.9200.93
13_E18_A0.9190.93
18_A85_W0.9170.93
70_R93_I0.9070.92
17_L22_T0.9060.92
144_T154_W0.8990.92
74_Q90_A0.8980.92
68_E71_K0.8980.92
189_S193_S0.8960.92
38_L55_G0.8880.92
70_R90_A0.8860.92
74_Q78_A0.8840.91
71_K75_P0.8760.91
172_A176_E0.8750.91
127_Y139_I0.8620.90
117_P150_D0.8610.90
61_M89_L0.8610.90
94_D99_K0.8580.90
117_P147_N0.8530.90
191_L195_S0.8520.90
151_S181_A0.8510.90
85_W88_D0.8480.90
177_G181_A0.8440.89
15_F18_A0.8400.89
16_Y85_W0.8400.89
105_N108_K0.8300.89
67_D97_Q0.8270.88
119_L153_G0.8240.88
76_L86_Y0.8230.88
30_R35_S0.8230.88
117_P143_Y0.8210.88
200_L208_Y0.8160.88
27_N31_N0.8140.88
14_D18_A0.8100.87
101_N132_Q0.8070.87
24_G27_N0.8020.87
86_Y204_Q0.8000.87
78_A192_S0.7970.87
217_Q221_R0.7960.86
65_K71_K0.7890.86
53_Q75_P0.7860.86
34_T39_D0.7860.86
202_S205_Q0.7850.86
5_R8_V0.7820.86
172_A208_Y0.7780.85
119_L123_L0.7780.85
14_D17_L0.7770.85
179_A188_I0.7770.85
66_Y93_I0.7760.85
205_Q209_D0.7690.85
104_I127_Y0.7670.84
36_D40_E0.7660.84
56_R63_A0.7650.84
120_Q139_I0.7650.84
10_Q13_E0.7620.84
4_M9_V0.7590.84
9_V12_S0.7580.84
66_Y97_Q0.7580.84
90_A106_R0.7540.83
30_R33_L0.7480.83
53_Q79_A0.7460.83
57_A89_L0.7450.83
204_Q207_R0.7440.83
22_T25_M0.7440.83
184_L219_Q0.7440.83
13_E22_T0.7370.82
50_R80_E0.7370.82
150_D176_E0.7360.82
192_S212_I0.7300.81
6_P10_Q0.7270.81
21_R24_G0.7270.81
83_N86_Y0.7240.81
19_K23_L0.7230.81
118_V158_A0.7220.81
116_N120_Q0.7210.81
161_E173_A0.7200.80
61_M96_G0.7170.80
13_E24_G0.7130.80
88_D122_N0.7080.79
48_Q52_A0.7070.79
39_D43_K0.7070.79
158_A174_R0.7050.79
128_L156_L0.7040.79
7_M10_Q0.7030.79
154_W157_L0.6980.78
44_G49_Q0.6970.78
175_A182_G0.6960.78
88_D119_L0.6950.78
168_D208_Y0.6930.78
178_Y186_Q0.6920.78
49_Q52_A0.6920.78
128_L136_A0.6910.78
141_N157_L0.6860.77
16_Y22_T0.6850.77
40_E43_K0.6820.77
91_T106_R0.6820.77
161_E164_L0.6780.76
117_P121_L0.6770.76
102_E105_N0.6760.76
157_L173_A0.6740.76
34_T41_W0.6700.76
93_I97_Q0.6690.75
170_E174_R0.6660.75
174_R178_Y0.6610.75
125_N128_L0.6580.74
49_Q53_Q0.6580.74
124_A157_L0.6560.74
143_Y153_G0.6550.74
210_A214_Q0.6530.74
101_N105_N0.6530.74
137_A164_L0.6470.73
34_T37_L0.6470.73
107_L123_L0.6460.73
20_A24_G0.6450.73
33_L37_L0.6440.73
67_D71_K0.6430.72
155_D160_A0.6390.72
27_N32_Q0.6370.72
179_A211_R0.6360.72
134_Q138_N0.6330.71
76_L81_P0.6310.71
27_N30_R0.6290.71
4_M7_M0.6280.71
15_F24_G0.6190.70
184_L215_L0.6180.70
169_Q172_A0.6180.70
97_Q127_Y0.6160.69
216_R219_Q0.6150.69
19_K22_T0.6150.69
26_Y29_G0.6130.69
28_S35_S0.6130.69
44_G47_R0.6130.69
9_V17_L0.6100.69
17_L86_Y0.6090.68
190_L206_A0.6060.68
5_R10_Q0.6050.68
15_F25_M0.6050.68
155_D181_A0.6050.68
172_A186_Q0.6040.68
39_D68_E0.6040.68
67_D98_N0.6000.67
89_L93_I0.5980.67
139_I143_Y0.5930.66
15_F51_A0.5860.65
12_S16_Y0.5860.65
141_N145_F0.5860.65
182_G191_L0.5840.65
22_T29_G0.5830.65
174_R177_G0.5830.65
155_D174_R0.5820.65
121_L153_G0.5820.65
19_K161_E0.5810.65
45_N64_N0.5790.65
53_Q76_L0.5790.65
134_Q164_L0.5770.64
73_L90_A0.5770.64
10_Q16_Y0.5760.64
52_A182_G0.5750.64
192_S196_S0.5740.64
123_L199_K0.5700.63
120_Q144_T0.5610.62
5_R11_S0.5600.62
6_P11_S0.5580.62
142_R146_N0.5530.61
124_A139_I0.5490.60
207_R212_I0.5470.60
140_L144_T0.5450.60
176_E179_A0.5440.60
190_L193_S0.5420.59
94_D97_Q0.5410.59
85_W180_L0.5400.59
159_Q178_Y0.5400.59
35_S206_A0.5370.59
71_K139_I0.5360.59
95_L103_A0.5340.58
221_R224_P0.5330.58
68_E72_T0.5330.58
154_W170_E0.5310.58
113_L197_Q0.5290.58
187_A212_I0.5290.58
11_S16_Y0.5270.57
171_L178_Y0.5260.57
178_Y183_R0.5260.57
150_D154_W0.5250.57
29_G34_T0.5250.57
55_G59_Q0.5240.57
5_R12_S0.5230.57
63_A220_E0.5220.57
191_L215_L0.5220.57
66_Y96_G0.5200.56
32_Q63_A0.5190.56
20_A23_L0.5180.56
56_R72_T0.5170.56
33_L36_D0.5160.56
32_Q39_D0.5160.56
21_R54_Y0.5140.56
95_L100_A0.5130.55
84_A113_L0.5120.55
137_A141_N0.5110.55
150_D153_G0.5100.55
135_E205_Q0.5050.54
69_A93_I0.5030.54
120_Q147_N0.5030.54
170_E200_L0.5030.54
9_V15_F0.5010.54
193_S196_S0.5010.54
22_T26_Y0.5000.54
49_Q72_T0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3as5_A 1 0.7237 99.6 0.663 Contact Map
2pl2_A 1 0.7149 99.6 0.678 Contact Map
1xnf_A 1 0.886 99.5 0.683 Contact Map
3vtx_A 1 0.7149 99.5 0.684 Contact Map
1w3b_A 1 0.9386 99.5 0.685 Contact Map
3ieg_A 1 0.9386 99.5 0.686 Contact Map
4kvm_A 1 0.9561 99.5 0.691 Contact Map
2y4t_A 1 0.943 99.5 0.692 Contact Map
2yhc_A 1 0.7895 99.5 0.693 Contact Map
3uq3_A 1 0.8947 99.5 0.696 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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