T0942_30-290_1_261 - CASP12 - GREMLIN Contacts

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T0942_30-290_1_261 - T0942_30-290 1-261

ID:	124	Sequences: ADTLPDMGTSAGSTLSIGQEMQMGDYYVRQLRGSAPLINDPLLTQYINSLGMRLVSHANSVKTPFHFFLINNDEINAFAFFGGNVVLHSALFRYSDNESQLASVMAHEISHVTQRHLARAMEDQQRSAPLTWVGALGSILLAMASPQAGMAALTGTLAGTRQGMISFTQQNEQEADRIGIQVLQRSGFDPQAMPTFLEKLLDQARYSSRPPEILLTHPLPESRLADARNRANQMRPMVVQSSEDFYLAKARTLGMYNSGRN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	261 (248)
Sequences:	4154 (2742)
Seq/√Len:	174.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
51_G	67_F	4.741	1.00
96_D	199_K	4.040	1.00
48_N	52_M	3.263	1.00
54_L	109_I	2.909	1.00
100_Q	195_T	2.845	1.00
99_S	192_A	2.697	1.00
212_E	222_S	2.650	1.00
43_L	69_L	2.595	1.00
47_I	69_L	2.594	1.00
173_Q	226_D	2.446	1.00
20_E	115_R	2.444	1.00
103_S	193_M	2.438	1.00
173_Q	222_S	2.305	1.00
59_N	181_Q	2.211	1.00
174_E	177_R	2.188	1.00
170_Q	173_Q	2.074	1.00
194_P	227_A	1.997	1.00
57_H	186_S	1.966	1.00
43_L	248_A	1.906	1.00
198_E	228_R	1.898	1.00
19_Q	22_Q	1.853	1.00
67_F	109_I	1.846	1.00
152_A	155_G	1.841	1.00
95_S	245_F	1.835	1.00
21_M	25_D	1.823	1.00
27_Y	80_F	1.796	1.00
114_Q	178_I	1.786	1.00
110_S	182_V	1.760	1.00
30_Q	33_G	1.759	1.00
95_S	196_F	1.751	1.00
165_I	168_T	1.748	1.00
15_L	121_M	1.716	1.00
50_L	188_F	1.714	1.00
97_N	240_Q	1.696	1.00
180_I	227_A	1.688	1.00
18_G	22_Q	1.656	1.00
177_R	226_D	1.650	1.00
28_V	32_R	1.638	1.00
181_Q	185_R	1.634	1.00
166_S	170_Q	1.628	1.00
97_N	100_Q	1.623	1.00
37_L	68_F	1.609	1.00
11_A	119_R	1.580	1.00
28_V	86_V	1.574	1.00
103_S	192_A	1.570	1.00
50_L	102_A	1.564	1.00
100_Q	199_K	1.555	1.00
91_L	104_V	1.522	1.00
17_I	60_S	1.517	1.00
27_Y	30_Q	1.515	1.00
50_L	101_L	1.510	1.00
96_D	100_Q	1.506	1.00
28_V	68_F	1.504	1.00
137_G	141_L	1.504	1.00
92_F	101_L	1.481	1.00
49_S	244_D	1.456	1.00
95_S	101_L	1.449	1.00
68_F	86_V	1.434	1.00
100_Q	192_A	1.429	1.00
220_P	224_L	1.422	1.00
67_F	85_V	1.399	1.00
21_M	64_P	1.383	1.00
49_S	53_R	1.379	1.00
65_F	113_T	1.374	1.00
32_R	68_F	1.372	1.00
165_I	216_T	1.355	1.00
24_G	84_N	1.350	1.00
74_E	88_H	1.346	1.00
138_S	141_L	1.335	1.00
110_S	113_T	1.317	1.00
120_A	171_N	1.303	1.00
25_D	84_N	1.303	1.00
136_L	139_I	1.301	1.00
177_R	230_R	1.301	1.00
165_I	215_L	1.290	1.00
87_L	101_L	1.288	1.00
180_I	231_A	1.274	1.00
40_D	251_R	1.269	1.00
66_H	84_N	1.268	1.00
58_A	61_V	1.250	1.00
87_L	105_M	1.250	1.00
103_S	183_L	1.238	1.00
147_Q	150_M	1.229	1.00
123_D	171_N	1.224	1.00
245_F	249_K	1.223	1.00
41_P	45_Q	1.223	1.00
54_L	182_V	1.211	1.00
42_L	251_R	1.211	1.00
58_A	109_I	1.198	1.00
222_S	226_D	1.197	1.00
201_L	224_L	1.197	1.00
97_N	195_T	1.195	1.00
20_E	24_G	1.193	1.00
45_Q	49_S	1.191	1.00
46_Y	98_E	1.185	1.00
9_T	12_G	1.170	1.00
38_I	89_S	1.163	1.00
21_M	84_N	1.161	1.00
103_S	196_F	1.154	1.00
244_D	248_A	1.153	1.00
119_R	174_E	1.150	1.00
36_P	71_N	1.135	1.00
110_S	114_Q	1.127	1.00
184_Q	234_M	1.122	1.00
59_N	185_R	1.121	1.00
46_Y	50_L	1.119	1.00
162_Q	166_S	1.119	1.00
201_L	221_E	1.103	1.00
13_S	118_A	1.098	1.00
53_R	239_V	1.095	1.00
71_N	89_S	1.094	1.00
249_K	253_L	1.089	1.00
89_S	93_R	1.089	1.00
136_L	140_L	1.085	1.00
80_F	112_V	1.074	1.00
197_L	224_L	1.072	1.00
161_R	164_M	1.070	1.00
191_Q	232_N	1.063	1.00
137_G	140_L	1.062	1.00
153_L	157_L	1.051	1.00
22_Q	26_Y	1.050	1.00
52_M	56_S	1.049	1.00
28_V	84_N	1.045	0.99
135_A	139_I	1.043	0.99
241_S	244_D	1.042	0.99
226_D	230_R	1.029	0.99
97_N	192_A	1.027	0.99
23_M	27_Y	1.022	0.99
151_A	155_G	1.022	0.99
16_S	19_Q	1.018	0.99
167_F	171_N	1.015	0.99
184_Q	190_P	1.015	0.99
241_S	246_Y	1.007	0.99
121_M	125_Q	1.005	0.99
165_I	214_L	1.005	0.99
35_A	70_I	1.002	0.99
79_A	112_V	0.993	0.99
5_P	8_G	0.991	0.99
12_G	122_E	0.991	0.99
15_L	118_A	0.988	0.99
114_Q	174_E	0.981	0.99
47_I	87_L	0.973	0.99
194_P	231_A	0.972	0.99
119_R	171_N	0.967	0.99
124_Q	128_A	0.962	0.99
55_V	65_F	0.960	0.99
199_K	202_D	0.960	0.99
15_L	20_E	0.957	0.99
157_L	161_R	0.953	0.99
80_F	117_L	0.950	0.99
72_N	88_H	0.947	0.99
51_G	109_I	0.947	0.99
31_L	35_A	0.946	0.99
250_A	253_L	0.944	0.99
154_T	158_A	0.943	0.99
58_A	113_T	0.934	0.99
180_I	230_R	0.929	0.99
192_A	195_T	0.918	0.99
115_R	118_A	0.917	0.99
106_A	110_S	0.916	0.99
30_Q	34_S	0.915	0.99
75_I	94_Y	0.915	0.99
22_Q	25_D	0.914	0.99
92_F	245_F	0.911	0.99
50_L	105_M	0.907	0.99
227_A	231_A	0.902	0.99
168_T	173_Q	0.902	0.99
168_T	175_A	0.897	0.98
26_Y	30_Q	0.897	0.98
113_T	182_V	0.892	0.98
31_L	86_V	0.891	0.98
60_S	63_T	0.890	0.98
75_I	196_F	0.882	0.98
24_G	82_G	0.881	0.98
47_I	51_G	0.880	0.98
155_G	159_G	0.880	0.98
32_R	37_L	0.874	0.98
145_S	148_A	0.870	0.98
168_T	171_N	0.869	0.98
110_S	178_I	0.868	0.98
17_I	62_K	0.866	0.98
58_A	63_T	0.866	0.98
38_I	69_L	0.857	0.98
15_L	23_M	0.855	0.98
85_V	109_I	0.852	0.98
94_Y	199_K	0.846	0.98
14_T	122_E	0.841	0.98
153_L	156_T	0.834	0.98
127_S	130_L	0.830	0.97
123_D	126_R	0.824	0.97
47_I	101_L	0.820	0.97
36_P	88_H	0.819	0.97
55_V	58_A	0.819	0.97
226_D	229_N	0.817	0.97
177_R	181_Q	0.812	0.97
221_E	225_A	0.812	0.97
251_R	254_G	0.811	0.97
13_S	122_E	0.806	0.97
49_S	248_A	0.806	0.97
31_L	70_I	0.806	0.97
197_L	220_P	0.801	0.97
141_L	145_S	0.797	0.97
37_L	44_T	0.797	0.97
27_Y	31_L	0.797	0.97
20_E	60_S	0.793	0.97
228_R	232_N	0.788	0.97
32_R	86_V	0.786	0.96
88_H	91_L	0.784	0.96
117_L	121_M	0.783	0.96
211_P	214_L	0.777	0.96
44_T	48_N	0.777	0.96
35_A	88_H	0.775	0.96
127_S	164_M	0.771	0.96
246_Y	249_K	0.769	0.96
159_G	163_G	0.767	0.96
212_E	219_L	0.765	0.96
138_S	142_A	0.764	0.96
80_F	84_N	0.761	0.96
65_F	109_I	0.761	0.96
198_E	202_D	0.756	0.96
243_E	247_L	0.751	0.95
24_G	80_F	0.751	0.95
190_P	234_M	0.750	0.95
46_Y	101_L	0.746	0.95
104_V	196_F	0.740	0.95
53_R	186_S	0.739	0.95
225_A	228_R	0.739	0.95
130_L	134_G	0.735	0.95
196_F	199_K	0.732	0.95
60_S	65_F	0.731	0.95
42_L	45_Q	0.730	0.95
219_L	222_S	0.722	0.94
189_D	195_T	0.718	0.94
202_D	205_R	0.717	0.94
229_N	232_N	0.717	0.94
191_Q	231_A	0.716	0.94
249_K	252_T	0.715	0.94
178_I	182_V	0.715	0.94
6_D	11_A	0.714	0.94
29_R	36_P	0.709	0.94
150_M	159_G	0.709	0.94
242_S	246_Y	0.708	0.94
117_L	167_F	0.702	0.93
118_A	122_E	0.701	0.93
52_M	64_P	0.699	0.93
210_P	215_L	0.694	0.93
99_S	196_F	0.693	0.93
173_Q	177_R	0.691	0.93
53_R	57_H	0.691	0.93
99_S	241_S	0.689	0.93
59_N	182_V	0.688	0.93
17_I	63_T	0.686	0.93
109_I	113_T	0.685	0.93
23_M	81_F	0.685	0.93
201_L	219_L	0.683	0.93
96_D	249_K	0.680	0.92
51_G	101_L	0.679	0.92
23_M	121_M	0.678	0.92
201_L	205_R	0.677	0.92
29_R	33_G	0.675	0.92
120_A	168_T	0.672	0.92
51_G	98_E	0.672	0.92
42_L	248_A	0.667	0.92
146_P	149_G	0.666	0.92
225_A	229_N	0.666	0.92
194_P	224_L	0.665	0.92
148_A	152_A	0.662	0.91
156_T	159_G	0.661	0.91
251_R	255_M	0.661	0.91
224_L	228_R	0.658	0.91
145_S	149_G	0.654	0.91
131_T	156_T	0.651	0.91
19_Q	23_M	0.650	0.91
85_V	105_M	0.649	0.91
102_A	188_F	0.648	0.90
196_F	220_P	0.647	0.90
152_A	156_T	0.645	0.90
166_S	169_Q	0.643	0.90
135_A	141_L	0.638	0.90
209_R	221_E	0.633	0.89
195_T	198_E	0.631	0.89
193_M	197_L	0.631	0.89
84_N	112_V	0.630	0.89
243_E	246_Y	0.627	0.89
31_L	78_F	0.625	0.89
166_S	212_E	0.623	0.89
180_I	234_M	0.621	0.88
250_A	254_G	0.620	0.88
25_D	29_R	0.619	0.88
230_R	234_M	0.617	0.88
70_I	88_H	0.613	0.88
142_A	145_S	0.613	0.88
149_G	153_L	0.612	0.88
79_A	85_V	0.608	0.87
126_R	130_L	0.608	0.87
183_L	192_A	0.608	0.87
131_T	160_T	0.607	0.87
165_I	211_P	0.604	0.87
67_F	196_F	0.599	0.87
139_I	142_A	0.595	0.86
50_L	54_L	0.595	0.86
57_H	185_R	0.594	0.86
68_F	84_N	0.593	0.86
211_P	215_L	0.591	0.86
155_G	158_A	0.587	0.86
180_I	190_P	0.587	0.86
136_L	142_A	0.583	0.85
180_I	184_Q	0.580	0.85
81_F	112_V	0.579	0.85
59_N	113_T	0.579	0.85
229_N	233_Q	0.576	0.84
11_A	174_E	0.569	0.84
38_I	93_R	0.569	0.84
20_E	118_A	0.568	0.84
31_L	84_N	0.567	0.84
15_L	122_E	0.567	0.84
184_Q	231_A	0.566	0.83
228_R	231_A	0.565	0.83
246_Y	250_A	0.565	0.83
195_T	199_K	0.564	0.83
242_S	249_K	0.562	0.83
106_A	179_G	0.562	0.83
166_S	211_P	0.561	0.83
198_E	201_L	0.561	0.83
72_N	197_L	0.561	0.83
12_G	126_R	0.558	0.83
146_P	156_T	0.557	0.82
134_G	138_S	0.556	0.82
142_A	148_A	0.555	0.82
124_Q	164_M	0.552	0.82
7_M	11_A	0.552	0.82
119_R	122_E	0.551	0.82
52_M	55_V	0.550	0.82
65_F	112_V	0.550	0.82
241_S	245_F	0.550	0.82
120_A	123_D	0.547	0.81
25_D	66_H	0.544	0.81
31_L	80_F	0.543	0.81
25_D	64_P	0.539	0.80
191_Q	228_R	0.534	0.80
98_E	101_L	0.534	0.80
53_R	188_F	0.533	0.80
14_T	121_M	0.533	0.80
240_Q	243_E	0.532	0.80
88_H	183_L	0.532	0.80
119_R	123_D	0.530	0.79
53_R	56_S	0.528	0.79
114_Q	182_V	0.528	0.79
51_G	65_F	0.526	0.79
150_M	153_L	0.526	0.79
36_P	89_S	0.525	0.79
40_D	43_L	0.524	0.79
179_G	193_M	0.523	0.78
26_Y	29_R	0.522	0.78
78_F	197_L	0.521	0.78
201_L	220_P	0.521	0.78
44_T	47_I	0.518	0.78
235_R	238_V	0.517	0.78
85_V	112_V	0.514	0.77
75_I	203_Q	0.513	0.77
194_P	228_R	0.513	0.77
38_I	43_L	0.512	0.77
162_Q	165_I	0.508	0.76
61_V	65_F	0.507	0.76
184_Q	235_R	0.507	0.76
28_V	31_L	0.506	0.76
166_S	214_L	0.505	0.76
137_G	142_A	0.503	0.76
44_T	68_F	0.503	0.76
192_A	197_L	0.502	0.76
97_N	241_S	0.502	0.76
86_V	167_F	0.500	0.75

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3c37_A	1	0.8506	100	0.373	Contact Map
4aw6_A	1	0.8199	100	0.636	Contact Map
4il3_A	1	0.8046	100	0.641	Contact Map
3cqb_A	1	0.3831	99.5	0.798	Contact Map
4qhj_A	1	0.4023	96.9	0.904	Contact Map
4jix_A	1	0.4138	78.8	0.94	Contact Map
1c7k_A	1	0.4866	75.1	0.942	Contact Map
4jiu_A	1	0.387	73.6	0.943	Contact Map
4iuw_A	1	0.8736	53	0.95	Contact Map
3zuk_A	1	0.8736	48.7	0.951	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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