GREMLIN Database
T0942_30-290_1_261 - T0942_30-290 1-261
ID: 124 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 261 (248)
Sequences: 4154 (2742)
Seq/√Len: 174.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_G67_F4.7411.00
96_D199_K4.0401.00
48_N52_M3.2631.00
54_L109_I2.9091.00
100_Q195_T2.8451.00
99_S192_A2.6971.00
212_E222_S2.6501.00
43_L69_L2.5951.00
47_I69_L2.5941.00
173_Q226_D2.4461.00
20_E115_R2.4441.00
103_S193_M2.4381.00
173_Q222_S2.3051.00
59_N181_Q2.2111.00
174_E177_R2.1881.00
170_Q173_Q2.0741.00
194_P227_A1.9971.00
57_H186_S1.9661.00
43_L248_A1.9061.00
198_E228_R1.8981.00
19_Q22_Q1.8531.00
67_F109_I1.8461.00
152_A155_G1.8411.00
95_S245_F1.8351.00
21_M25_D1.8231.00
27_Y80_F1.7961.00
114_Q178_I1.7861.00
110_S182_V1.7601.00
30_Q33_G1.7591.00
95_S196_F1.7511.00
165_I168_T1.7481.00
15_L121_M1.7161.00
50_L188_F1.7141.00
97_N240_Q1.6961.00
180_I227_A1.6881.00
18_G22_Q1.6561.00
177_R226_D1.6501.00
28_V32_R1.6381.00
181_Q185_R1.6341.00
166_S170_Q1.6281.00
97_N100_Q1.6231.00
37_L68_F1.6091.00
11_A119_R1.5801.00
28_V86_V1.5741.00
103_S192_A1.5701.00
50_L102_A1.5641.00
100_Q199_K1.5551.00
91_L104_V1.5221.00
17_I60_S1.5171.00
27_Y30_Q1.5151.00
50_L101_L1.5101.00
96_D100_Q1.5061.00
28_V68_F1.5041.00
137_G141_L1.5041.00
92_F101_L1.4811.00
49_S244_D1.4561.00
95_S101_L1.4491.00
68_F86_V1.4341.00
100_Q192_A1.4291.00
220_P224_L1.4221.00
67_F85_V1.3991.00
21_M64_P1.3831.00
49_S53_R1.3791.00
65_F113_T1.3741.00
32_R68_F1.3721.00
165_I216_T1.3551.00
24_G84_N1.3501.00
74_E88_H1.3461.00
138_S141_L1.3351.00
110_S113_T1.3171.00
120_A171_N1.3031.00
25_D84_N1.3031.00
136_L139_I1.3011.00
177_R230_R1.3011.00
165_I215_L1.2901.00
87_L101_L1.2881.00
180_I231_A1.2741.00
40_D251_R1.2691.00
66_H84_N1.2681.00
58_A61_V1.2501.00
87_L105_M1.2501.00
103_S183_L1.2381.00
147_Q150_M1.2291.00
123_D171_N1.2241.00
245_F249_K1.2231.00
41_P45_Q1.2231.00
54_L182_V1.2111.00
42_L251_R1.2111.00
58_A109_I1.1981.00
222_S226_D1.1971.00
201_L224_L1.1971.00
97_N195_T1.1951.00
20_E24_G1.1931.00
45_Q49_S1.1911.00
46_Y98_E1.1851.00
9_T12_G1.1701.00
38_I89_S1.1631.00
21_M84_N1.1611.00
103_S196_F1.1541.00
244_D248_A1.1531.00
119_R174_E1.1501.00
36_P71_N1.1351.00
110_S114_Q1.1271.00
184_Q234_M1.1221.00
59_N185_R1.1211.00
46_Y50_L1.1191.00
162_Q166_S1.1191.00
201_L221_E1.1031.00
13_S118_A1.0981.00
53_R239_V1.0951.00
71_N89_S1.0941.00
249_K253_L1.0891.00
89_S93_R1.0891.00
136_L140_L1.0851.00
80_F112_V1.0741.00
197_L224_L1.0721.00
161_R164_M1.0701.00
191_Q232_N1.0631.00
137_G140_L1.0621.00
153_L157_L1.0511.00
22_Q26_Y1.0501.00
52_M56_S1.0491.00
28_V84_N1.0450.99
135_A139_I1.0430.99
241_S244_D1.0420.99
226_D230_R1.0290.99
97_N192_A1.0270.99
23_M27_Y1.0220.99
151_A155_G1.0220.99
16_S19_Q1.0180.99
167_F171_N1.0150.99
184_Q190_P1.0150.99
241_S246_Y1.0070.99
121_M125_Q1.0050.99
165_I214_L1.0050.99
35_A70_I1.0020.99
79_A112_V0.9930.99
5_P8_G0.9910.99
12_G122_E0.9910.99
15_L118_A0.9880.99
114_Q174_E0.9810.99
47_I87_L0.9730.99
194_P231_A0.9720.99
119_R171_N0.9670.99
124_Q128_A0.9620.99
55_V65_F0.9600.99
199_K202_D0.9600.99
15_L20_E0.9570.99
157_L161_R0.9530.99
80_F117_L0.9500.99
72_N88_H0.9470.99
51_G109_I0.9470.99
31_L35_A0.9460.99
250_A253_L0.9440.99
154_T158_A0.9430.99
58_A113_T0.9340.99
180_I230_R0.9290.99
192_A195_T0.9180.99
115_R118_A0.9170.99
106_A110_S0.9160.99
30_Q34_S0.9150.99
75_I94_Y0.9150.99
22_Q25_D0.9140.99
92_F245_F0.9110.99
50_L105_M0.9070.99
227_A231_A0.9020.99
168_T173_Q0.9020.99
168_T175_A0.8970.98
26_Y30_Q0.8970.98
113_T182_V0.8920.98
31_L86_V0.8910.98
60_S63_T0.8900.98
75_I196_F0.8820.98
24_G82_G0.8810.98
47_I51_G0.8800.98
155_G159_G0.8800.98
32_R37_L0.8740.98
145_S148_A0.8700.98
168_T171_N0.8690.98
110_S178_I0.8680.98
17_I62_K0.8660.98
58_A63_T0.8660.98
38_I69_L0.8570.98
15_L23_M0.8550.98
85_V109_I0.8520.98
94_Y199_K0.8460.98
14_T122_E0.8410.98
153_L156_T0.8340.98
127_S130_L0.8300.97
123_D126_R0.8240.97
47_I101_L0.8200.97
36_P88_H0.8190.97
55_V58_A0.8190.97
226_D229_N0.8170.97
177_R181_Q0.8120.97
221_E225_A0.8120.97
251_R254_G0.8110.97
13_S122_E0.8060.97
49_S248_A0.8060.97
31_L70_I0.8060.97
197_L220_P0.8010.97
141_L145_S0.7970.97
37_L44_T0.7970.97
27_Y31_L0.7970.97
20_E60_S0.7930.97
228_R232_N0.7880.97
32_R86_V0.7860.96
88_H91_L0.7840.96
117_L121_M0.7830.96
211_P214_L0.7770.96
44_T48_N0.7770.96
35_A88_H0.7750.96
127_S164_M0.7710.96
246_Y249_K0.7690.96
159_G163_G0.7670.96
212_E219_L0.7650.96
138_S142_A0.7640.96
80_F84_N0.7610.96
65_F109_I0.7610.96
198_E202_D0.7560.96
243_E247_L0.7510.95
24_G80_F0.7510.95
190_P234_M0.7500.95
46_Y101_L0.7460.95
104_V196_F0.7400.95
53_R186_S0.7390.95
225_A228_R0.7390.95
130_L134_G0.7350.95
196_F199_K0.7320.95
60_S65_F0.7310.95
42_L45_Q0.7300.95
219_L222_S0.7220.94
189_D195_T0.7180.94
202_D205_R0.7170.94
229_N232_N0.7170.94
191_Q231_A0.7160.94
249_K252_T0.7150.94
178_I182_V0.7150.94
6_D11_A0.7140.94
29_R36_P0.7090.94
150_M159_G0.7090.94
242_S246_Y0.7080.94
117_L167_F0.7020.93
118_A122_E0.7010.93
52_M64_P0.6990.93
210_P215_L0.6940.93
99_S196_F0.6930.93
173_Q177_R0.6910.93
53_R57_H0.6910.93
99_S241_S0.6890.93
59_N182_V0.6880.93
17_I63_T0.6860.93
109_I113_T0.6850.93
23_M81_F0.6850.93
201_L219_L0.6830.93
96_D249_K0.6800.92
51_G101_L0.6790.92
23_M121_M0.6780.92
201_L205_R0.6770.92
29_R33_G0.6750.92
120_A168_T0.6720.92
51_G98_E0.6720.92
42_L248_A0.6670.92
146_P149_G0.6660.92
225_A229_N0.6660.92
194_P224_L0.6650.92
148_A152_A0.6620.91
156_T159_G0.6610.91
251_R255_M0.6610.91
224_L228_R0.6580.91
145_S149_G0.6540.91
131_T156_T0.6510.91
19_Q23_M0.6500.91
85_V105_M0.6490.91
102_A188_F0.6480.90
196_F220_P0.6470.90
152_A156_T0.6450.90
166_S169_Q0.6430.90
135_A141_L0.6380.90
209_R221_E0.6330.89
195_T198_E0.6310.89
193_M197_L0.6310.89
84_N112_V0.6300.89
243_E246_Y0.6270.89
31_L78_F0.6250.89
166_S212_E0.6230.89
180_I234_M0.6210.88
250_A254_G0.6200.88
25_D29_R0.6190.88
230_R234_M0.6170.88
70_I88_H0.6130.88
142_A145_S0.6130.88
149_G153_L0.6120.88
79_A85_V0.6080.87
126_R130_L0.6080.87
183_L192_A0.6080.87
131_T160_T0.6070.87
165_I211_P0.6040.87
67_F196_F0.5990.87
139_I142_A0.5950.86
50_L54_L0.5950.86
57_H185_R0.5940.86
68_F84_N0.5930.86
211_P215_L0.5910.86
155_G158_A0.5870.86
180_I190_P0.5870.86
136_L142_A0.5830.85
180_I184_Q0.5800.85
81_F112_V0.5790.85
59_N113_T0.5790.85
229_N233_Q0.5760.84
11_A174_E0.5690.84
38_I93_R0.5690.84
20_E118_A0.5680.84
31_L84_N0.5670.84
15_L122_E0.5670.84
184_Q231_A0.5660.83
228_R231_A0.5650.83
246_Y250_A0.5650.83
195_T199_K0.5640.83
242_S249_K0.5620.83
106_A179_G0.5620.83
166_S211_P0.5610.83
198_E201_L0.5610.83
72_N197_L0.5610.83
12_G126_R0.5580.83
146_P156_T0.5570.82
134_G138_S0.5560.82
142_A148_A0.5550.82
124_Q164_M0.5520.82
7_M11_A0.5520.82
119_R122_E0.5510.82
52_M55_V0.5500.82
65_F112_V0.5500.82
241_S245_F0.5500.82
120_A123_D0.5470.81
25_D66_H0.5440.81
31_L80_F0.5430.81
25_D64_P0.5390.80
191_Q228_R0.5340.80
98_E101_L0.5340.80
53_R188_F0.5330.80
14_T121_M0.5330.80
240_Q243_E0.5320.80
88_H183_L0.5320.80
119_R123_D0.5300.79
53_R56_S0.5280.79
114_Q182_V0.5280.79
51_G65_F0.5260.79
150_M153_L0.5260.79
36_P89_S0.5250.79
40_D43_L0.5240.79
179_G193_M0.5230.78
26_Y29_R0.5220.78
78_F197_L0.5210.78
201_L220_P0.5210.78
44_T47_I0.5180.78
235_R238_V0.5170.78
85_V112_V0.5140.77
75_I203_Q0.5130.77
194_P228_R0.5130.77
38_I43_L0.5120.77
162_Q165_I0.5080.76
61_V65_F0.5070.76
184_Q235_R0.5070.76
28_V31_L0.5060.76
166_S214_L0.5050.76
137_G142_A0.5030.76
44_T68_F0.5030.76
192_A197_L0.5020.76
97_N241_S0.5020.76
86_V167_F0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c37_A 1 0.8506 100 0.373 Contact Map
4aw6_A 1 0.8199 100 0.636 Contact Map
4il3_A 1 0.8046 100 0.641 Contact Map
3cqb_A 1 0.3831 99.5 0.798 Contact Map
4qhj_A 1 0.4023 96.9 0.904 Contact Map
4jix_A 1 0.4138 78.8 0.94 Contact Map
1c7k_A 1 0.4866 75.1 0.942 Contact Map
4jiu_A 1 0.387 73.6 0.943 Contact Map
4iuw_A 1 0.8736 53 0.95 Contact Map
3zuk_A 1 0.8736 48.7 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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