GREMLIN Database
T0946_1_292 - T0946 1-292
ID: 123 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 292 (258)
Sequences: 104 (100)
Seq/√Len: 6.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_G109_F6.5821.00
111_R115_G4.6310.98
84_C126_F4.4170.97
12_C17_M4.4080.97
285_F289_K3.7740.92
231_F262_P3.1000.81
208_N226_D3.0770.81
46_Q174_M3.0240.80
60_I111_R2.8820.76
185_I208_N2.8480.75
160_N261_H2.7860.74
187_P249_G2.3980.61
68_L86_F2.3970.61
6_V18_S2.3850.61
161_S170_E2.3180.59
245_D253_R2.3100.58
204_L286_I2.2720.57
245_D256_R2.2030.55
190_P228_L2.0700.50
91_G231_F2.0660.50
239_Y253_R2.0440.49
253_R256_R1.9950.47
33_A45_S1.9660.46
262_P278_N1.9280.45
262_P274_G1.9220.44
187_P289_K1.9140.44
242_D254_S1.9070.44
235_Y239_Y1.9040.44
38_S173_T1.8880.43
172_H214_D1.8370.41
215_F278_N1.8330.41
7_V48_A1.8280.41
7_V39_D1.8120.41
42_V275_A1.8060.40
161_S168_V1.8040.40
124_A219_Y1.7970.40
241_G253_R1.7750.39
86_F109_F1.6990.37
94_S117_A1.6620.35
61_P111_R1.6190.34
230_N236_N1.5960.33
156_W208_N1.5550.32
186_C282_I1.5370.31
68_L84_C1.5160.31
172_H215_F1.5050.30
186_C289_K1.5000.30
95_T107_L1.4820.30
29_I213_A1.4810.30
175_V178_M1.4760.30
236_N239_Y1.4610.29
263_S274_G1.4420.29
159_R211_L1.4300.28
96_T106_Q1.4190.28
33_A79_G1.4070.28
212_K219_Y1.4050.28
187_P216_P1.4020.27
158_G255_L1.3970.27
175_V183_F1.3950.27
160_N242_D1.3640.26
283_A286_I1.3610.26
44_M115_G1.3530.26
256_R279_A1.3340.26
60_I109_F1.3310.25
229_Q249_G1.3290.25
9_H14_S1.3280.25
8_G158_G1.3200.25
36_G242_D1.3170.25
120_V185_I1.3090.25
189_F251_T1.3070.25
96_T198_T1.3020.25
91_G110_T1.3010.25
86_F91_G1.2840.24
62_A115_G1.2830.24
230_N279_A1.2770.24
185_I226_D1.2660.24
7_V33_A1.2630.24
5_T204_L1.2610.24
63_S66_V1.2580.23
181_Q243_V1.2570.23
216_P289_K1.2400.23
36_G160_N1.2330.23
42_V45_S1.2330.23
89_I212_K1.2250.23
24_L173_T1.2210.23
42_V249_G1.2100.22
183_F218_N1.1920.22
211_L219_Y1.1820.22
60_I91_G1.1820.22
175_V215_F1.1720.21
84_C192_D1.1540.21
111_R254_S1.1510.21
111_R118_V1.1480.21
71_T173_T1.1450.21
9_H159_R1.1430.21
53_Y126_F1.1400.21
44_M50_T1.1330.20
83_K256_R1.1310.20
9_H188_E1.1300.20
63_S209_N1.1280.20
195_T198_T1.1200.20
114_A273_I1.1190.20
235_Y255_L1.1170.20
159_R175_V1.1140.20
49_I235_Y1.1100.20
66_V109_F1.1050.20
174_M215_F1.1020.20
36_G261_H1.1000.20
158_G258_D1.0940.19
17_M33_A1.0830.19
182_R273_I1.0790.19
109_F115_G1.0790.19
13_T24_L1.0690.19
204_L208_N1.0640.19
43_A174_M1.0580.19
43_A48_A1.0500.19
36_G48_A1.0500.19
161_S226_D1.0500.19
43_A159_R1.0410.18
159_R188_E1.0400.18
6_V12_C1.0360.18
4_V14_S1.0320.18
42_V160_N1.0240.18
6_V33_A1.0140.18
121_S235_Y1.0060.18
53_Y68_L1.0010.17
155_V212_K0.9970.17
261_H274_G0.9940.17
36_G254_S0.9940.17
27_T152_I0.9870.17
219_Y279_A0.9850.17
106_Q219_Y0.9830.17
188_E208_N0.9720.17
18_S21_L0.9710.17
24_L115_G0.9650.17
156_W278_N0.9610.17
156_W233_S0.9580.17
24_L279_A0.9570.17
7_V88_G0.9510.16
118_V237_P0.9510.16
258_D261_H0.9480.16
108_V121_S0.9470.16
215_F249_G0.9440.16
69_T206_A0.9410.16
159_R194_E0.9400.16
37_A41_E0.9340.16
159_R171_L0.9340.16
184_V285_F0.9300.16
36_G279_A0.9290.16
154_I168_V0.9230.16
231_F255_L0.9210.16
160_N274_G0.9180.16
61_P64_G0.9150.16
84_C194_E0.9100.16
187_P226_D0.9080.16
238_A253_R0.9050.16
38_S154_I0.9050.16
263_S275_A0.9030.16
61_P66_V0.9030.16
10_S258_D0.9020.16
155_V184_V0.9020.16
9_H12_C0.9000.15
178_M208_N0.8950.15
19_T92_T0.8930.15
47_E186_C0.8880.15
91_G115_G0.8790.15
54_A64_G0.8750.15
27_T37_A0.8730.15
162_T186_C0.8720.15
104_E219_Y0.8650.15
9_H171_L0.8650.15
17_M119_S0.8640.15
39_D186_C0.8580.15
180_T186_C0.8550.15
156_W159_R0.8520.15
9_H36_G0.8480.15
161_S204_L0.8470.14
192_D273_I0.8470.14
32_F68_L0.8390.14
216_P285_F0.8290.14
241_G249_G0.8280.14
159_R225_V0.8280.14
155_V174_M0.8250.14
212_K248_N0.8220.14
225_V260_L0.8210.14
208_N258_D0.8180.14
35_G168_V0.8060.14
143_R147_L0.8060.14
209_N212_K0.8060.14
58_G120_V0.8050.14
235_Y243_V0.8030.14
11_F48_A0.7980.14
39_D274_G0.7950.14
263_S272_Y0.7940.14
40_V92_T0.7940.14
195_T214_D0.7930.14
31_N274_G0.7930.14
250_I279_A0.7920.14
153_Y179_H0.7790.13
25_L283_A0.7790.13
22_N195_T0.7770.13
201_A239_Y0.7740.13
69_T247_A0.7730.13
3_S20_E0.7640.13
262_P279_A0.7630.13
123_T174_M0.7620.13
62_A111_R0.7590.13
36_G41_E0.7560.13
190_P251_T0.7550.13
74_G257_E0.7540.13
44_M65_S0.7520.13
212_K262_P0.7470.13
47_E230_N0.7440.13
12_C107_L0.7420.13
42_V237_P0.7410.13
178_M219_Y0.7400.13
33_A219_Y0.7390.13
151_D228_L0.7370.13
15_D107_L0.7370.13
55_P89_I0.7360.13
24_L242_D0.7340.13
53_Y136_T0.7340.13
23_R154_I0.7310.13
39_D258_D0.7310.13
171_L188_E0.7310.13
66_V86_F0.7270.12
213_A273_I0.7250.12
54_A182_R0.7230.12
4_V87_G0.7210.12
42_V215_F0.7190.12
150_D231_F0.7180.12
158_G261_H0.7170.12
55_P58_G0.7170.12
47_E282_I0.7140.12
156_W185_I0.7130.12
136_T144_K0.7120.12
44_M60_I0.7100.12
225_V272_Y0.7070.12
228_L232_K0.7070.12
5_T96_T0.7030.12
185_I272_Y0.7010.12
36_G57_G0.6980.12
65_S96_T0.6960.12
118_V282_I0.6940.12
107_L124_A0.6940.12
78_N89_I0.6910.12
179_H183_F0.6880.12
26_G160_N0.6870.12
53_Y124_A0.6830.12
37_A86_F0.6830.12
188_E207_L0.6810.12
26_G242_D0.6770.12
155_V219_Y0.6750.12
21_L47_E0.6750.12
151_D171_L0.6730.12
38_S110_T0.6720.12
21_L33_A0.6710.12
238_A246_I0.6680.12
85_I185_I0.6660.12
52_Q263_S0.6660.12
25_L155_V0.6640.12
33_A153_Y0.6620.11
17_M155_V0.6620.11
157_G283_A0.6610.11
185_I258_D0.6600.11
46_Q215_F0.6580.11
239_Y242_D0.6580.11
276_K288_S0.6570.11
90_D277_V0.6560.11
43_A290_G0.6550.11
12_C188_E0.6520.11
242_D261_H0.6490.11
85_I136_T0.6490.11
191_Y263_S0.6480.11
42_V274_G0.6470.11
11_F177_N0.6450.11
171_L208_N0.6440.11
212_K285_F0.6440.11
14_S196_T0.6410.11
186_C262_P0.6390.11
47_E289_K0.6370.11
10_S47_E0.6350.11
227_L232_K0.6340.11
218_N289_K0.6330.11
24_L111_R0.6320.11
8_G258_D0.6310.11
5_T54_A0.6310.11
63_S225_V0.6270.11
94_S195_T0.6240.11
116_S238_A0.6230.11
91_G255_L0.6230.11
10_S21_L0.6220.11
251_T256_R0.6210.11
116_S163_D0.6210.11
33_A226_D0.6200.11
92_T280_D0.6190.11
30_Y277_V0.6150.11
6_V31_N0.6140.11
155_V215_F0.6110.11
11_F148_H0.6090.11
83_K225_V0.6060.11
58_G119_S0.6050.11
65_S110_T0.6050.11
30_Y282_I0.6050.11
36_G194_E0.6040.11
149_R283_A0.6030.11
110_T185_I0.6030.11
7_V118_V0.6020.11
63_S94_S0.6020.11
216_P262_P0.6010.11
159_R207_L0.5970.11
69_T213_A0.5950.11
284_Q289_K0.5920.10
157_G187_P0.5920.10
160_N258_D0.5900.10
228_L236_N0.5880.10
59_S149_R0.5870.10
150_D290_G0.5860.10
198_T255_L0.5860.10
79_G246_I0.5860.10
36_G136_T0.5850.10
168_V219_Y0.5840.10
7_V46_Q0.5820.10
43_A51_R0.5820.10
3_S93_F0.5810.10
57_G217_D0.5790.10
150_D247_A0.5720.10
33_A42_V0.5720.10
64_G218_N0.5710.10
244_T290_G0.5690.10
79_G100_A0.5690.10
35_G245_D0.5690.10
81_T241_G0.5690.10
66_V110_T0.5680.10
39_D173_T0.5670.10
10_S158_G0.5620.10
16_V233_S0.5610.10
34_R277_V0.5600.10
90_D144_K0.5590.10
9_H291_W0.5590.10
7_V290_G0.5570.10
18_S39_D0.5570.10
175_V218_N0.5560.10
58_G123_T0.5560.10
164_Y257_E0.5540.10
43_A173_T0.5530.10
159_R208_N0.5530.10
12_C93_F0.5510.10
89_I252_P0.5480.10
28_D92_T0.5480.10
136_T177_N0.5470.10
9_H257_E0.5460.10
86_F184_V0.5460.10
80_A96_T0.5460.10
91_G185_I0.5450.10
249_G260_L0.5450.10
56_V202_T0.5440.10
33_A47_E0.5440.10
150_D169_S0.5430.10
208_N228_L0.5410.10
172_H245_D0.5380.10
65_S199_T0.5370.10
155_V282_I0.5370.10
158_G279_A0.5350.10
230_N238_A0.5320.10
227_L278_N0.5310.10
60_I115_G0.5280.10
205_A214_D0.5280.10
226_D251_T0.5260.10
84_C209_N0.5260.10
87_G239_Y0.5260.10
43_A211_L0.5250.10
107_L189_F0.5240.10
123_T193_T0.5240.10
38_S164_Y0.5230.10
251_T255_L0.5210.10
157_G188_E0.5200.10
25_L29_I0.5200.10
117_A173_T0.5190.10
178_M228_L0.5130.09
44_M111_R0.5120.09
9_H211_L0.5090.09
47_E50_T0.5070.09
39_D164_Y0.5050.09
22_N136_T0.5050.09
226_D291_W0.5050.09
171_L175_V0.5040.09
85_I144_K0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q9a_A 1 0.5753 99.5 0.828 Contact Map
1k7c_A 1 0.5993 99.5 0.831 Contact Map
1yzf_A 1 0.5788 99.5 0.834 Contact Map
4jhl_A 1 0.5822 99.4 0.837 Contact Map
4rw0_A 1 0.5753 99.4 0.838 Contact Map
3rjt_A 1 0.5719 99.4 0.839 Contact Map
2hsj_A 1 0.5616 99.4 0.839 Contact Map
3skv_A 1 0.5719 99.4 0.84 Contact Map
1esc_A 1 0.6507 99.4 0.842 Contact Map
4lhs_A 1 0.5548 99.4 0.843 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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