T0946_1_292 - CASP12 - GREMLIN Contacts

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T0946_1_292 - T0946 1-292

ID:	123	Sequences: SRSVTVVGHSFCTSDVMSTELNRLLGTDIYNFARGGASDVEVAMSQEAITRQYAPVGGSIPASGSVALTPTEVGIFWNGATGKCIFGGIDGTFSTTLVNAGTGETQLVFTRDSAGSAVSVSTTATFAMRPYTRFNTNTIPAGRKHSLHRDDIYIVWGGRNSTDYTRYVSELHTMVANMHTQRFVICPEFPYDTETTGTTGATNLAALNNNLKADFPDNYCQISGVDLLQNFKSKYNPAYAGDVTDIANGITPRSLREDNLHPSETLQPNGLYIGAKVNADFIAQFIKSKGWG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	292 (258)
Sequences:	104 (100)
Seq/√Len:	6.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
91_G	109_F	6.582	1.00
111_R	115_G	4.631	0.98
84_C	126_F	4.417	0.97
12_C	17_M	4.408	0.97
285_F	289_K	3.774	0.92
231_F	262_P	3.100	0.81
208_N	226_D	3.077	0.81
46_Q	174_M	3.024	0.80
60_I	111_R	2.882	0.76
185_I	208_N	2.848	0.75
160_N	261_H	2.786	0.74
187_P	249_G	2.398	0.61
68_L	86_F	2.397	0.61
6_V	18_S	2.385	0.61
161_S	170_E	2.318	0.59
245_D	253_R	2.310	0.58
204_L	286_I	2.272	0.57
245_D	256_R	2.203	0.55
190_P	228_L	2.070	0.50
91_G	231_F	2.066	0.50
239_Y	253_R	2.044	0.49
253_R	256_R	1.995	0.47
33_A	45_S	1.966	0.46
262_P	278_N	1.928	0.45
262_P	274_G	1.922	0.44
187_P	289_K	1.914	0.44
242_D	254_S	1.907	0.44
235_Y	239_Y	1.904	0.44
38_S	173_T	1.888	0.43
172_H	214_D	1.837	0.41
215_F	278_N	1.833	0.41
7_V	48_A	1.828	0.41
7_V	39_D	1.812	0.41
42_V	275_A	1.806	0.40
161_S	168_V	1.804	0.40
124_A	219_Y	1.797	0.40
241_G	253_R	1.775	0.39
86_F	109_F	1.699	0.37
94_S	117_A	1.662	0.35
61_P	111_R	1.619	0.34
230_N	236_N	1.596	0.33
156_W	208_N	1.555	0.32
186_C	282_I	1.537	0.31
68_L	84_C	1.516	0.31
172_H	215_F	1.505	0.30
186_C	289_K	1.500	0.30
95_T	107_L	1.482	0.30
29_I	213_A	1.481	0.30
175_V	178_M	1.476	0.30
236_N	239_Y	1.461	0.29
263_S	274_G	1.442	0.29
159_R	211_L	1.430	0.28
96_T	106_Q	1.419	0.28
33_A	79_G	1.407	0.28
212_K	219_Y	1.405	0.28
187_P	216_P	1.402	0.27
158_G	255_L	1.397	0.27
175_V	183_F	1.395	0.27
160_N	242_D	1.364	0.26
283_A	286_I	1.361	0.26
44_M	115_G	1.353	0.26
256_R	279_A	1.334	0.26
60_I	109_F	1.331	0.25
229_Q	249_G	1.329	0.25
9_H	14_S	1.328	0.25
8_G	158_G	1.320	0.25
36_G	242_D	1.317	0.25
120_V	185_I	1.309	0.25
189_F	251_T	1.307	0.25
96_T	198_T	1.302	0.25
91_G	110_T	1.301	0.25
86_F	91_G	1.284	0.24
62_A	115_G	1.283	0.24
230_N	279_A	1.277	0.24
185_I	226_D	1.266	0.24
7_V	33_A	1.263	0.24
5_T	204_L	1.261	0.24
63_S	66_V	1.258	0.23
181_Q	243_V	1.257	0.23
216_P	289_K	1.240	0.23
36_G	160_N	1.233	0.23
42_V	45_S	1.233	0.23
89_I	212_K	1.225	0.23
24_L	173_T	1.221	0.23
42_V	249_G	1.210	0.22
183_F	218_N	1.192	0.22
211_L	219_Y	1.182	0.22
60_I	91_G	1.182	0.22
175_V	215_F	1.172	0.21
84_C	192_D	1.154	0.21
111_R	254_S	1.151	0.21
111_R	118_V	1.148	0.21
71_T	173_T	1.145	0.21
9_H	159_R	1.143	0.21
53_Y	126_F	1.140	0.21
44_M	50_T	1.133	0.20
83_K	256_R	1.131	0.20
9_H	188_E	1.130	0.20
63_S	209_N	1.128	0.20
195_T	198_T	1.120	0.20
114_A	273_I	1.119	0.20
235_Y	255_L	1.117	0.20
159_R	175_V	1.114	0.20
49_I	235_Y	1.110	0.20
66_V	109_F	1.105	0.20
174_M	215_F	1.102	0.20
36_G	261_H	1.100	0.20
158_G	258_D	1.094	0.19
17_M	33_A	1.083	0.19
182_R	273_I	1.079	0.19
109_F	115_G	1.079	0.19
13_T	24_L	1.069	0.19
204_L	208_N	1.064	0.19
43_A	174_M	1.058	0.19
43_A	48_A	1.050	0.19
36_G	48_A	1.050	0.19
161_S	226_D	1.050	0.19
43_A	159_R	1.041	0.18
159_R	188_E	1.040	0.18
6_V	12_C	1.036	0.18
4_V	14_S	1.032	0.18
42_V	160_N	1.024	0.18
6_V	33_A	1.014	0.18
121_S	235_Y	1.006	0.18
53_Y	68_L	1.001	0.17
155_V	212_K	0.997	0.17
261_H	274_G	0.994	0.17
36_G	254_S	0.994	0.17
27_T	152_I	0.987	0.17
219_Y	279_A	0.985	0.17
106_Q	219_Y	0.983	0.17
188_E	208_N	0.972	0.17
18_S	21_L	0.971	0.17
24_L	115_G	0.965	0.17
156_W	278_N	0.961	0.17
156_W	233_S	0.958	0.17
24_L	279_A	0.957	0.17
7_V	88_G	0.951	0.16
118_V	237_P	0.951	0.16
258_D	261_H	0.948	0.16
108_V	121_S	0.947	0.16
215_F	249_G	0.944	0.16
69_T	206_A	0.941	0.16
159_R	194_E	0.940	0.16
37_A	41_E	0.934	0.16
159_R	171_L	0.934	0.16
184_V	285_F	0.930	0.16
36_G	279_A	0.929	0.16
154_I	168_V	0.923	0.16
231_F	255_L	0.921	0.16
160_N	274_G	0.918	0.16
61_P	64_G	0.915	0.16
84_C	194_E	0.910	0.16
187_P	226_D	0.908	0.16
238_A	253_R	0.905	0.16
38_S	154_I	0.905	0.16
263_S	275_A	0.903	0.16
61_P	66_V	0.903	0.16
10_S	258_D	0.902	0.16
155_V	184_V	0.902	0.16
9_H	12_C	0.900	0.15
178_M	208_N	0.895	0.15
19_T	92_T	0.893	0.15
47_E	186_C	0.888	0.15
91_G	115_G	0.879	0.15
54_A	64_G	0.875	0.15
27_T	37_A	0.873	0.15
162_T	186_C	0.872	0.15
104_E	219_Y	0.865	0.15
9_H	171_L	0.865	0.15
17_M	119_S	0.864	0.15
39_D	186_C	0.858	0.15
180_T	186_C	0.855	0.15
156_W	159_R	0.852	0.15
9_H	36_G	0.848	0.15
161_S	204_L	0.847	0.14
192_D	273_I	0.847	0.14
32_F	68_L	0.839	0.14
216_P	285_F	0.829	0.14
241_G	249_G	0.828	0.14
159_R	225_V	0.828	0.14
155_V	174_M	0.825	0.14
212_K	248_N	0.822	0.14
225_V	260_L	0.821	0.14
208_N	258_D	0.818	0.14
35_G	168_V	0.806	0.14
143_R	147_L	0.806	0.14
209_N	212_K	0.806	0.14
58_G	120_V	0.805	0.14
235_Y	243_V	0.803	0.14
11_F	48_A	0.798	0.14
39_D	274_G	0.795	0.14
263_S	272_Y	0.794	0.14
40_V	92_T	0.794	0.14
195_T	214_D	0.793	0.14
31_N	274_G	0.793	0.14
250_I	279_A	0.792	0.14
153_Y	179_H	0.779	0.13
25_L	283_A	0.779	0.13
22_N	195_T	0.777	0.13
201_A	239_Y	0.774	0.13
69_T	247_A	0.773	0.13
3_S	20_E	0.764	0.13
262_P	279_A	0.763	0.13
123_T	174_M	0.762	0.13
62_A	111_R	0.759	0.13
36_G	41_E	0.756	0.13
190_P	251_T	0.755	0.13
74_G	257_E	0.754	0.13
44_M	65_S	0.752	0.13
212_K	262_P	0.747	0.13
47_E	230_N	0.744	0.13
12_C	107_L	0.742	0.13
42_V	237_P	0.741	0.13
178_M	219_Y	0.740	0.13
33_A	219_Y	0.739	0.13
151_D	228_L	0.737	0.13
15_D	107_L	0.737	0.13
55_P	89_I	0.736	0.13
24_L	242_D	0.734	0.13
53_Y	136_T	0.734	0.13
23_R	154_I	0.731	0.13
39_D	258_D	0.731	0.13
171_L	188_E	0.731	0.13
66_V	86_F	0.727	0.12
213_A	273_I	0.725	0.12
54_A	182_R	0.723	0.12
4_V	87_G	0.721	0.12
42_V	215_F	0.719	0.12
150_D	231_F	0.718	0.12
158_G	261_H	0.717	0.12
55_P	58_G	0.717	0.12
47_E	282_I	0.714	0.12
156_W	185_I	0.713	0.12
136_T	144_K	0.712	0.12
44_M	60_I	0.710	0.12
225_V	272_Y	0.707	0.12
228_L	232_K	0.707	0.12
5_T	96_T	0.703	0.12
185_I	272_Y	0.701	0.12
36_G	57_G	0.698	0.12
65_S	96_T	0.696	0.12
118_V	282_I	0.694	0.12
107_L	124_A	0.694	0.12
78_N	89_I	0.691	0.12
179_H	183_F	0.688	0.12
26_G	160_N	0.687	0.12
53_Y	124_A	0.683	0.12
37_A	86_F	0.683	0.12
188_E	207_L	0.681	0.12
26_G	242_D	0.677	0.12
155_V	219_Y	0.675	0.12
21_L	47_E	0.675	0.12
151_D	171_L	0.673	0.12
38_S	110_T	0.672	0.12
21_L	33_A	0.671	0.12
238_A	246_I	0.668	0.12
85_I	185_I	0.666	0.12
52_Q	263_S	0.666	0.12
25_L	155_V	0.664	0.12
33_A	153_Y	0.662	0.11
17_M	155_V	0.662	0.11
157_G	283_A	0.661	0.11
185_I	258_D	0.660	0.11
46_Q	215_F	0.658	0.11
239_Y	242_D	0.658	0.11
276_K	288_S	0.657	0.11
90_D	277_V	0.656	0.11
43_A	290_G	0.655	0.11
12_C	188_E	0.652	0.11
242_D	261_H	0.649	0.11
85_I	136_T	0.649	0.11
191_Y	263_S	0.648	0.11
42_V	274_G	0.647	0.11
11_F	177_N	0.645	0.11
171_L	208_N	0.644	0.11
212_K	285_F	0.644	0.11
14_S	196_T	0.641	0.11
186_C	262_P	0.639	0.11
47_E	289_K	0.637	0.11
10_S	47_E	0.635	0.11
227_L	232_K	0.634	0.11
218_N	289_K	0.633	0.11
24_L	111_R	0.632	0.11
8_G	258_D	0.631	0.11
5_T	54_A	0.631	0.11
63_S	225_V	0.627	0.11
94_S	195_T	0.624	0.11
116_S	238_A	0.623	0.11
91_G	255_L	0.623	0.11
10_S	21_L	0.622	0.11
251_T	256_R	0.621	0.11
116_S	163_D	0.621	0.11
33_A	226_D	0.620	0.11
92_T	280_D	0.619	0.11
30_Y	277_V	0.615	0.11
6_V	31_N	0.614	0.11
155_V	215_F	0.611	0.11
11_F	148_H	0.609	0.11
83_K	225_V	0.606	0.11
58_G	119_S	0.605	0.11
65_S	110_T	0.605	0.11
30_Y	282_I	0.605	0.11
36_G	194_E	0.604	0.11
149_R	283_A	0.603	0.11
110_T	185_I	0.603	0.11
7_V	118_V	0.602	0.11
63_S	94_S	0.602	0.11
216_P	262_P	0.601	0.11
159_R	207_L	0.597	0.11
69_T	213_A	0.595	0.11
284_Q	289_K	0.592	0.10
157_G	187_P	0.592	0.10
160_N	258_D	0.590	0.10
228_L	236_N	0.588	0.10
59_S	149_R	0.587	0.10
150_D	290_G	0.586	0.10
198_T	255_L	0.586	0.10
79_G	246_I	0.586	0.10
36_G	136_T	0.585	0.10
168_V	219_Y	0.584	0.10
7_V	46_Q	0.582	0.10
43_A	51_R	0.582	0.10
3_S	93_F	0.581	0.10
57_G	217_D	0.579	0.10
150_D	247_A	0.572	0.10
33_A	42_V	0.572	0.10
64_G	218_N	0.571	0.10
244_T	290_G	0.569	0.10
79_G	100_A	0.569	0.10
35_G	245_D	0.569	0.10
81_T	241_G	0.569	0.10
66_V	110_T	0.568	0.10
39_D	173_T	0.567	0.10
10_S	158_G	0.562	0.10
16_V	233_S	0.561	0.10
34_R	277_V	0.560	0.10
90_D	144_K	0.559	0.10
9_H	291_W	0.559	0.10
7_V	290_G	0.557	0.10
18_S	39_D	0.557	0.10
175_V	218_N	0.556	0.10
58_G	123_T	0.556	0.10
164_Y	257_E	0.554	0.10
43_A	173_T	0.553	0.10
159_R	208_N	0.553	0.10
12_C	93_F	0.551	0.10
89_I	252_P	0.548	0.10
28_D	92_T	0.548	0.10
136_T	177_N	0.547	0.10
9_H	257_E	0.546	0.10
86_F	184_V	0.546	0.10
80_A	96_T	0.546	0.10
91_G	185_I	0.545	0.10
249_G	260_L	0.545	0.10
56_V	202_T	0.544	0.10
33_A	47_E	0.544	0.10
150_D	169_S	0.543	0.10
208_N	228_L	0.541	0.10
172_H	245_D	0.538	0.10
65_S	199_T	0.537	0.10
155_V	282_I	0.537	0.10
158_G	279_A	0.535	0.10
230_N	238_A	0.532	0.10
227_L	278_N	0.531	0.10
60_I	115_G	0.528	0.10
205_A	214_D	0.528	0.10
226_D	251_T	0.526	0.10
84_C	209_N	0.526	0.10
87_G	239_Y	0.526	0.10
43_A	211_L	0.525	0.10
107_L	189_F	0.524	0.10
123_T	193_T	0.524	0.10
38_S	164_Y	0.523	0.10
251_T	255_L	0.521	0.10
157_G	188_E	0.520	0.10
25_L	29_I	0.520	0.10
117_A	173_T	0.519	0.10
178_M	228_L	0.513	0.09
44_M	111_R	0.512	0.09
9_H	211_L	0.509	0.09
47_E	50_T	0.507	0.09
39_D	164_Y	0.505	0.09
22_N	136_T	0.505	0.09
226_D	291_W	0.505	0.09
171_L	175_V	0.504	0.09
85_I	144_K	0.500	0.09

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4q9a_A	1	0.5753	99.5	0.828	Contact Map
1k7c_A	1	0.5993	99.5	0.831	Contact Map
1yzf_A	1	0.5788	99.5	0.834	Contact Map
4jhl_A	1	0.5822	99.4	0.837	Contact Map
4rw0_A	1	0.5753	99.4	0.838	Contact Map
3rjt_A	1	0.5719	99.4	0.839	Contact Map
2hsj_A	1	0.5616	99.4	0.839	Contact Map
3skv_A	1	0.5719	99.4	0.84	Contact Map
1esc_A	1	0.6507	99.4	0.842	Contact Map
4lhs_A	1	0.5548	99.4	0.843	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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