GREMLIN Database
LOLC_1_399 - LOLC 1-399
ID: 122 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 399 (380)
Sequences: 6937 (4990)
Seq/√Len: 256.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
148_E191_A4.1631.00
161_Q183_L3.8631.00
161_Q185_N3.8121.00
89_G227_D3.3921.00
156_V186_V3.3641.00
133_K187_I3.3251.00
148_E152_S3.2071.00
297_V314_F3.1821.00
143_N187_I3.0551.00
144_V201_M2.9921.00
203_V208_A2.9821.00
144_V184_F2.7831.00
158_R189_T2.7251.00
145_I188_G2.6901.00
226_L235_L2.6851.00
93_V222_W2.6561.00
143_N185_N2.6031.00
231_K234_S2.6011.00
326_A369_A2.5741.00
146_L201_M2.4361.00
151_A189_T2.4021.00
163_R183_L2.3521.00
146_L186_V2.3491.00
133_K143_N2.3191.00
391_Q394_E2.3111.00
96_I221_G2.2901.00
144_V162_I2.2881.00
325_G329_G2.2801.00
293_K317_Q2.2561.00
91_N227_D2.2401.00
301_Q307_P2.2351.00
91_N225_W2.2321.00
308_R312_M2.1871.00
157_N160_D2.1831.00
129_L188_G2.1771.00
146_L189_T2.1361.00
35_T328_L2.1351.00
53_R359_A2.1201.00
116_G208_A2.1121.00
82_E85_V2.1081.00
184_F207_D2.0891.00
335_L339_Q2.0201.00
140_G206_E2.0181.00
34_I325_G2.0181.00
228_E231_K2.0151.00
101_V114_M2.0141.00
297_V310_I2.0091.00
366_I370_L2.0051.00
144_V203_V1.9521.00
31_T35_T1.9481.00
370_L374_A1.9331.00
66_A226_L1.9261.00
331_A335_L1.8821.00
298_A395_A1.8741.00
77_P80_L1.8261.00
205_I209_S1.8251.00
142_Y207_D1.7641.00
385_W389_A1.7471.00
158_R187_I1.6791.00
146_L150_L1.6611.00
89_G235_L1.6601.00
322_G376_A1.6441.00
128_Y191_A1.6421.00
134_Q145_I1.6311.00
206_E209_S1.6281.00
362_P366_I1.6211.00
9_I313_V1.6201.00
293_K296_E1.6101.00
147_G190_F1.5881.00
92_R225_W1.5871.00
35_T332_L1.5831.00
145_I190_F1.5831.00
204_N207_D1.5651.00
66_A235_L1.5631.00
156_V162_I1.5601.00
160_D186_V1.5541.00
15_R18_A1.5531.00
38_V329_G1.5221.00
131_N157_N1.5091.00
326_A372_A1.5031.00
233_D237_Q1.4911.00
31_T324_I1.4901.00
78_Q82_E1.4881.00
81_P93_V1.4861.00
327_I331_A1.4841.00
20_D292_E1.4801.00
227_D231_K1.4741.00
28_W32_I1.4731.00
149_Q152_S1.4711.00
10_G316_V1.4651.00
66_A224_L1.4621.00
31_T325_G1.4531.00
381_L385_W1.4501.00
311_M385_W1.4491.00
91_N226_L1.4431.00
326_A373_M1.4361.00
298_A302_T1.4341.00
328_L331_A1.4231.00
132_V188_G1.4131.00
306_T309_Q1.4121.00
31_T328_L1.4061.00
39_M332_L1.4041.00
294_Q395_A1.3941.00
79_Q82_E1.3941.00
43_T336_L1.3901.00
13_Y296_E1.3871.00
319_A377_L1.3811.00
164_V184_F1.3811.00
296_E317_Q1.3741.00
81_P85_V1.3641.00
85_V93_V1.3601.00
146_L162_I1.3581.00
30_S284_T1.3541.00
384_S388_A1.3461.00
8_F12_R1.3461.00
81_P222_W1.3401.00
163_R181_Q1.3311.00
132_V189_T1.3251.00
146_L151_A1.3021.00
383_P387_A1.2951.00
147_G150_L1.2731.00
90_V93_V1.2651.00
205_I219_I1.2631.00
133_K136_D1.2511.00
184_F203_V1.2401.00
39_M336_L1.2381.00
334_A360_I1.2371.00
298_A396_L1.2341.00
53_R57_N1.2301.00
290_V387_A1.2291.00
87_L240_L1.2231.00
235_L240_L1.2231.00
360_I365_V1.2201.00
39_M43_T1.2171.00
68_L224_L1.2141.00
156_V160_D1.2141.00
114_M203_V1.2131.00
145_I187_I1.2091.00
42_V333_G1.2081.00
39_M333_G1.2071.00
146_L156_V1.2071.00
386_R389_A1.1991.00
236_S241_P1.1821.00
361_E364_Q1.1721.00
305_L309_Q1.1681.00
14_M27_S1.1601.00
35_T325_G1.1591.00
130_V191_A1.1561.00
318_G380_T1.1551.00
334_A338_S1.1511.00
238_Q242_E1.1501.00
129_L134_Q1.1451.00
309_Q312_M1.1431.00
132_V135_T1.1431.00
144_V186_V1.1381.00
322_G326_A1.1321.00
87_L235_L1.1281.00
116_G205_I1.1261.00
84_A224_L1.1211.00
82_E86_K1.1091.00
237_Q242_E1.1081.00
393_A397_R1.1081.00
147_G197_D1.1051.00
385_W388_A1.1011.00
97_T209_S1.0961.00
79_Q83_T1.0961.00
115_L200_E1.0911.00
11_L15_R1.0891.00
13_Y317_Q1.0881.00
135_T143_N1.0831.00
80_L83_T1.0821.00
335_L338_S1.0811.00
118_D121_Q1.0801.00
97_T208_A1.0771.00
392_P395_A1.0741.00
131_N158_R1.0721.00
96_I115_L1.0701.00
142_Y185_N1.0681.00
110_A153_Q1.0681.00
83_T243_G1.0681.00
6_A312_M1.0651.00
298_A392_P1.0611.00
54_E58_N1.0531.00
294_Q390_T1.0521.00
80_L222_W1.0501.00
118_D205_I1.0501.00
135_T145_I1.0421.00
129_L133_K1.0411.00
7_L320_S1.0391.00
6_A309_Q1.0341.00
103_L112_G1.0301.00
234_S238_Q1.0301.00
68_L246_W1.0281.00
236_S248_D1.0241.00
226_L232_V1.0231.00
49_N364_Q1.0231.00
382_Y385_W1.0201.00
37_G274_I1.0151.00
241_P246_W1.0131.00
142_Y182_R1.0071.00
90_V224_L1.0051.00
7_L316_V1.0041.00
84_A240_L1.0041.00
12_R15_R1.0021.00
311_M384_S1.0011.00
93_V224_L0.9991.00
27_S321_A0.9991.00
237_Q241_P0.9981.00
99_G212_M0.9941.00
83_T86_K0.9811.00
97_T116_G0.9781.00
384_S387_A0.9781.00
330_A365_V0.9761.00
145_I202_L0.9621.00
87_L238_Q0.9611.00
38_V372_A0.9601.00
165_M181_Q0.9591.00
139_P143_N0.9591.00
4_P7_L0.9581.00
120_A123_D0.9561.00
84_A222_W0.9541.00
328_L332_L0.9491.00
129_L145_I0.9411.00
330_A369_A0.9401.00
35_T38_V0.9321.00
46_S337_A0.9291.00
367_V370_L0.9231.00
233_D236_S0.9201.00
290_V390_T0.9161.00
363_L367_V0.9071.00
209_S216_A0.9051.00
135_T187_I0.8951.00
207_D210_R0.8921.00
90_V235_L0.8911.00
298_A314_F0.8881.00
158_R188_G0.8841.00
43_T333_G0.8801.00
5_V9_I0.8781.00
302_T396_L0.8771.00
136_D187_I0.8771.00
130_V148_E0.8741.00
232_V236_S0.8711.00
130_V189_T0.8701.00
331_A334_A0.8701.00
327_I369_A0.8691.00
112_G201_M0.8621.00
363_L366_I0.8621.00
376_A380_T0.8601.00
315_M377_L0.8570.99
66_A246_W0.8500.99
27_S298_A0.8480.99
268_G272_S0.8480.99
166_V169_A0.8480.99
68_L84_A0.8460.99
87_L90_V0.8460.99
34_I322_G0.8420.99
339_Q342_N0.8400.99
42_V368_I0.8400.99
379_S393_A0.8400.99
164_V201_M0.8390.99
89_G238_Q0.8360.99
5_V309_Q0.8310.99
30_S289_M0.8300.99
295_G399_E0.8290.99
149_Q198_G0.8280.99
278_A282_I0.8260.99
279_A375_I0.8250.99
205_I208_A0.8230.99
386_R390_T0.8220.99
143_N204_N0.8210.99
114_M201_M0.8210.99
394_E397_R0.8200.99
96_I223_R0.8200.99
286_L318_G0.8190.99
284_T289_M0.8150.99
48_M264_K0.8130.99
131_N189_T0.8120.99
49_N53_R0.8100.99
35_T39_M0.8100.99
20_D284_T0.8080.99
322_G372_A0.8020.99
103_L164_V0.8010.99
301_Q392_P0.7970.99
66_A236_S0.7970.99
5_V8_F0.7960.99
34_I38_V0.7920.99
307_P311_M0.7880.99
346_I351_L0.7880.99
254_G258_Q0.7870.99
373_M377_L0.7830.99
339_Q343_L0.7780.99
149_Q192_A0.7720.99
84_A89_G0.7700.99
9_I13_Y0.7700.99
203_V207_D0.7680.99
34_I321_A0.7680.99
130_V190_F0.7670.99
11_L320_S0.7650.99
89_G231_K0.7650.99
159_G162_I0.7620.99
6_A10_G0.7600.99
285_S289_M0.7570.99
284_T288_L0.7500.99
101_V112_G0.7460.99
367_V371_V0.7450.99
235_L238_Q0.7440.99
300_L313_V0.7440.99
292_E325_G0.7400.99
120_A124_P0.7380.98
133_K188_G0.7370.98
337_A341_N0.7370.98
96_I122_K0.7360.98
86_K238_Q0.7290.98
94_A122_K0.7270.98
43_T294_Q0.7260.98
234_S237_Q0.7260.98
78_Q81_P0.7250.98
148_E151_A0.7240.98
379_S383_P0.7210.98
46_S358_V0.7190.98
53_R256_L0.7180.98
47_V51_F0.7130.98
291_M294_Q0.7110.98
376_A383_P0.7110.98
269_L273_L0.7100.98
380_T395_A0.7090.98
49_N52_E0.7090.98
294_Q298_A0.7090.98
46_S50_G0.7070.98
37_G281_N0.7040.98
169_A177_R0.7020.98
329_G393_A0.7010.98
365_V368_I0.7000.98
92_R124_P0.6970.98
97_T205_I0.6960.98
122_K126_T0.6950.98
222_W225_W0.6950.98
295_G299_I0.6920.98
307_P388_A0.6830.97
37_G280_F0.6820.97
333_G337_A0.6800.97
324_I327_I0.6790.97
6_A316_V0.6790.97
186_V189_T0.6770.97
65_Q225_W0.6720.97
226_L229_P0.6720.97
114_M208_A0.6700.97
151_A186_V0.6680.97
65_Q226_L0.6670.97
392_P396_L0.6660.97
81_P95_P0.6650.97
81_P84_A0.6640.97
50_G337_A0.6630.97
390_T395_A0.6620.97
90_V227_D0.6600.97
290_V314_F0.6580.97
55_L59_I0.6570.97
112_G149_Q0.6570.97
149_Q153_Q0.6560.97
262_M266_M0.6540.97
37_G40_A0.6530.97
39_M329_G0.6530.97
284_T387_A0.6520.97
150_L199_Y0.6510.97
338_S360_I0.6490.97
139_P142_Y0.6480.97
8_F331_A0.6470.97
29_L279_A0.6470.97
334_A365_V0.6460.96
207_D211_L0.6450.96
27_S31_T0.6440.96
233_D250_R0.6440.96
82_E227_D0.6430.96
17_R20_D0.6420.96
30_S321_A0.6420.96
87_L243_G0.6410.96
372_A376_A0.6410.96
195_E200_E0.6410.96
329_G333_G0.6410.96
215_P219_I0.6390.96
208_A212_M0.6350.96
271_L274_I0.6340.96
191_A197_D0.6340.96
383_P388_A0.6330.96
190_F202_L0.6330.96
94_A118_D0.6330.96
84_A93_V0.6330.96
84_A87_L0.6320.96
299_I396_L0.6310.96
279_A379_S0.6310.96
133_K185_N0.6300.96
305_L310_I0.6300.96
87_L227_D0.6290.96
33_G281_N0.6290.96
115_L202_L0.6290.96
98_T221_G0.6270.96
307_P389_A0.6270.96
133_K145_I0.6250.96
52_E264_K0.6200.96
60_L65_Q0.6190.96
38_V368_I0.6190.96
281_N284_T0.6180.95
30_S33_G0.6180.95
44_V267_M0.6150.95
16_G296_E0.6150.95
319_A373_M0.6150.95
290_V384_S0.6140.95
50_G334_A0.6140.95
98_T115_L0.6130.95
12_R329_G0.6090.95
41_L368_I0.6080.95
13_Y299_I0.6060.95
297_V387_A0.6050.95
326_A374_A0.6020.95
166_V170_S0.6020.95
271_L275_V0.6020.95
104_Q181_Q0.6010.95
151_A154_L0.6010.95
314_F318_G0.6000.95
326_A330_A0.6000.95
203_V212_M0.6000.95
49_N264_K0.5980.95
13_Y301_Q0.5980.95
278_A285_S0.5970.95
150_L154_L0.5960.95
44_V270_L0.5910.94
95_P222_W0.5870.94
372_A379_S0.5860.94
259_A263_E0.5850.94
140_G204_N0.5830.94
123_D134_Q0.5810.94
163_R182_R0.5800.94
147_G199_Y0.5800.94
150_L201_M0.5800.94
190_F195_E0.5780.94
147_G200_E0.5780.94
43_T47_V0.5760.93
310_I392_P0.5760.93
336_L340_L0.5760.93
314_F384_S0.5750.93
373_M376_A0.5740.93
42_V364_Q0.5740.93
38_V344_M0.5710.93
359_A362_P0.5710.93
293_K396_L0.5710.93
327_I330_A0.5700.93
33_G280_F0.5700.93
33_G274_I0.5700.93
46_S360_I0.5700.93
154_L162_I0.5690.93
286_L289_M0.5690.93
296_E302_T0.5670.93
52_E56_Q0.5660.93
310_I395_A0.5660.93
8_F317_Q0.5650.93
10_G13_Y0.5650.93
38_V46_S0.5640.93
182_R207_D0.5620.93
76_N218_N0.5610.93
42_V365_V0.5610.93
323_I382_Y0.5610.93
298_A391_Q0.5600.93
149_Q199_Y0.5580.92
17_R27_S0.5560.92
240_L246_W0.5550.92
115_L254_G0.5550.92
33_G37_G0.5540.92
263_E266_M0.5530.92
131_N148_E0.5530.92
151_A157_N0.5530.92
121_Q124_P0.5530.92
48_M267_M0.5520.92
65_Q249_W0.5510.92
19_A28_W0.5510.92
85_V89_G0.5500.92
208_A211_L0.5500.92
103_L144_V0.5500.92
380_T384_S0.5500.92
286_L314_F0.5490.92
333_G392_P0.5480.92
158_R161_Q0.5470.92
121_Q186_V0.5470.92
208_A213_R0.5460.92
5_V305_L0.5460.92
333_G368_I0.5460.92
44_V263_E0.5450.91
48_M52_E0.5440.91
255_E258_Q0.5420.91
69_S247_Q0.5390.91
281_N379_S0.5370.91
297_V388_A0.5370.91
224_L235_L0.5360.91
265_N269_L0.5360.91
49_N361_E0.5360.91
286_L294_Q0.5350.91
238_Q243_G0.5340.91
20_D289_M0.5330.91
38_V380_T0.5330.91
102_V111_V0.5320.91
67_I221_G0.5320.91
13_Y38_V0.5320.91
334_A362_P0.5320.91
291_M298_A0.5310.90
132_V158_R0.5310.90
43_T340_L0.5310.90
17_R55_L0.5300.90
34_I284_T0.5300.90
290_V376_A0.5290.90
18_A31_T0.5290.90
114_M164_V0.5290.90
346_I349_V0.5290.90
366_I369_A0.5280.90
102_V109_V0.5270.90
20_D30_S0.5270.90
215_P218_N0.5250.90
224_L240_L0.5250.90
98_T113_V0.5240.90
326_A376_A0.5240.90
99_G114_M0.5240.90
318_G393_A0.5240.90
312_M381_L0.5240.90
53_R56_Q0.5230.90
100_D113_V0.5230.90
209_S219_I0.5230.90
145_I158_R0.5230.90
82_E363_L0.5210.90
40_A376_A0.5210.90
95_P219_I0.5210.90
132_V136_D0.5200.90
64_P254_G0.5190.89
64_P196_V0.5190.89
92_R125_L0.5190.89
310_I314_F0.5180.89
44_V387_A0.5170.89
56_Q59_I0.5170.89
146_L155_G0.5160.89
294_Q398_Y0.5160.89
277_V318_G0.5150.89
69_S98_T0.5150.89
298_A390_T0.5150.89
63_M128_Y0.5150.89
33_G284_T0.5140.89
32_I332_L0.5140.89
148_E189_T0.5140.89
37_G372_A0.5140.89
289_M292_E0.5130.89
279_A283_I0.5110.89
14_M320_S0.5110.89
33_G263_E0.5100.89
277_V379_S0.5100.89
71_E381_L0.5100.89
283_I379_S0.5090.89
248_D251_D0.5090.89
338_S342_N0.5080.88
112_G150_L0.5080.88
275_V371_V0.5080.88
111_V197_D0.5070.88
89_G234_S0.5070.88
274_I282_I0.5070.88
360_I364_Q0.5060.88
7_L298_A0.5060.88
38_V325_G0.5050.88
84_A95_P0.5050.88
31_T321_A0.5040.88
148_E192_A0.5030.88
259_A267_M0.5020.88
161_Q381_L0.5020.88
210_R366_I0.5020.88
149_Q352_D0.5000.88
44_V285_S0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5f9q_A 1 0.4511 99.2 0.796 Contact Map
3ftj_A 1 0.4887 99.1 0.808 Contact Map
3is6_A 1 0.5414 98.3 0.852 Contact Map
3o27_A 1 0.1454 35.1 0.948 Contact Map
2l66_A 1 0.1328 26.5 0.952 Contact Map
1yfb_A 1 0.1303 24.2 0.952 Contact Map
1mvf_D 1 0.1103 21.5 0.954 Contact Map
1rz2_A 1 0.4286 20.7 0.954 Contact Map
4av3_A 1 0.2707 16.9 0.956 Contact Map
2mrn_A 1 0.1679 14.3 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0101 seconds.