GREMLIN Database
T0945_303_409 - T0945 303-409
ID: 121 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 107 (104)
Sequences: 338 (261)
Seq/√Len: 25.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_N14_E4.1061.00
66_L85_L2.5920.99
91_A95_S2.4970.99
15_M68_K2.4600.99
90_S98_Y2.4240.99
70_L81_L2.3680.98
36_A41_L2.1870.97
19_K56_E2.1860.97
37_E46_Q2.1360.97
45_H56_E2.1120.97
6_L11_G2.0600.96
94_F98_Y2.0570.96
42_V60_M2.0200.95
73_I81_L1.9890.95
63_I82_L1.8600.93
12_K72_P1.8160.92
90_S94_F1.6450.88
90_S93_T1.6400.87
40_Q69_V1.6390.87
83_L104_F1.5880.86
26_S30_T1.5840.86
3_I87_I1.5690.85
70_L73_I1.5370.84
82_L101_V1.4870.82
11_G74_H1.4800.81
15_M67_L1.4790.81
1_H4_P1.4340.79
34_K46_Q1.4150.78
33_L44_V1.3660.76
60_M63_I1.3210.73
10_T14_E1.3080.72
99_Q102_R1.2910.71
29_G32_I1.2700.70
57_C70_L1.2620.70
8_I14_E1.2590.69
33_L42_V1.2460.69
63_I79_T1.2080.66
13_L100_L1.2040.66
75_E86_Q1.1840.65
95_S99_Q1.1780.64
5_R58_N1.1670.63
60_M89_G1.1310.61
9_K12_K1.0850.58
59_N75_E1.0730.57
13_L89_G1.0700.57
18_S26_S1.0610.56
54_F60_M1.0560.56
62_L96_I1.0240.53
61_T75_E0.9850.50
67_L92_I0.9830.50
56_E63_I0.9810.50
43_T58_N0.9770.50
98_Y105_Y0.9720.49
47_S51_D0.9670.49
18_S79_T0.9600.49
89_G94_F0.9580.48
27_F55_T0.9430.47
65_L69_V0.9280.46
87_I90_S0.9270.46
88_L92_I0.9220.46
59_N64_N0.9180.46
61_T64_N0.9120.45
36_A40_Q0.9120.45
27_F30_T0.9100.45
71_G75_E0.9010.44
17_Y20_F0.8860.43
75_E78_L0.8780.43
93_T99_Q0.8700.42
69_V73_I0.8650.42
92_I95_S0.8540.41
96_I105_Y0.8470.40
15_M58_N0.8460.40
60_M94_F0.8400.40
62_L83_L0.8170.38
7_N10_T0.8140.38
31_F34_K0.8060.38
89_G98_Y0.8000.37
97_R101_V0.8000.37
94_F102_R0.7920.37
7_N35_V0.7900.36
35_V53_E0.7830.36
15_M42_V0.7820.36
26_S29_G0.7800.36
20_F25_L0.7790.36
59_N86_Q0.7760.36
17_Y56_E0.7690.35
61_T86_Q0.7680.35
44_V88_L0.7660.35
59_N67_L0.7630.35
90_S97_R0.7570.34
61_T67_L0.7550.34
15_M57_C0.7520.34
64_N75_E0.7490.34
5_R34_K0.7440.33
11_G46_Q0.7260.32
18_S33_L0.7090.31
68_K74_H0.7030.31
28_L32_I0.7030.31
24_S30_T0.6990.31
50_E103_L0.6990.31
26_S32_I0.6860.30
27_F37_E0.6850.30
37_E44_V0.6840.30
47_S52_G0.6790.29
40_Q47_S0.6780.29
52_G58_N0.6770.29
42_V91_A0.6740.29
25_L29_G0.6700.29
74_H98_Y0.6660.29
66_L81_L0.6640.28
3_I20_F0.6600.28
24_S27_F0.6500.28
62_L89_G0.6420.27
62_L70_L0.6420.27
11_G63_I0.6420.27
32_I36_A0.6400.27
23_K39_L0.6380.27
20_F96_I0.6380.27
50_E100_L0.6370.27
61_T78_L0.6240.26
38_S50_E0.6220.26
71_G86_Q0.6190.26
84_L88_L0.6150.26
59_N78_L0.6130.25
93_T97_R0.6130.25
36_A92_I0.5990.25
39_L42_V0.5980.25
78_L86_Q0.5930.24
25_L30_T0.5890.24
73_I80_L0.5890.24
43_T68_K0.5880.24
34_K47_S0.5830.24
13_L87_I0.5800.24
67_L75_E0.5760.23
32_I40_Q0.5740.23
86_Q97_R0.5720.23
28_L31_F0.5680.23
59_N71_G0.5650.23
26_S73_I0.5640.23
34_K50_E0.5560.22
47_S53_E0.5550.22
36_A62_L0.5530.22
93_T103_L0.5490.22
34_K37_E0.5450.22
12_K65_L0.5360.21
32_I45_H0.5340.21
81_L85_L0.5250.21
11_G30_T0.5220.21
13_L60_M0.5190.21
68_K76_R0.5160.20
3_I84_L0.5150.20
33_L37_E0.5110.20
61_T71_G0.5100.20
5_R11_G0.5020.20
42_V46_Q0.5010.20
21_K28_L0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2k44_A 1 0.2617 6 0.938 Contact Map
1wdc_A 1 0.2523 5.5 0.939 Contact Map
4h0e_A 1 0.4112 2.9 0.947 Contact Map
1x4w_A 1 0.215 2.7 0.948 Contact Map
2qc7_A 1 0.6542 2.2 0.95 Contact Map
4lzx_B 1 0.3458 2.1 0.951 Contact Map
3c5n_A 1 0.7757 2 0.951 Contact Map
3waj_A 1 0.2243 2 0.951 Contact Map
1ow3_A 1 0.8505 1.9 0.952 Contact Map
4buj_A 1 0.0654 1.8 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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