T0945_16_302 - CASP12 - GREMLIN Contacts

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T0945_16_302 - T0945 16-302

ID:	120	Sequences: LIVSLLGFVATVTLIPAFRGHFIAARLCGQDLNKTSRQQIPESQGVISGAVFLIILFCFIPFPFLNCFVKEQCKAFPHHEFVALIGALLAICCMIFLGFADDVLNLRWRHKLLLPTAASLPLLMVYFTNFGNTTIVVPKPFRPILGLHLDLGILYYVYMGLLAVFCTNAINILAGINGLEAGQSLVISASIIVFNLVELEGDCRDDHVFSLYFMIPFFFTTLGLLYHNWYPSRVFVGDTFCYFAGMTFAGVGILGHFSKTMLLFFMPQVFNFLYSLPQLLHIIPCPR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	287 (252)
Sequences:	3351 (2068)
Seq/√Len:	130.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
214_M	251_V	4.086	1.00
93_C	118_A	3.255	1.00
53_L	92_C	2.963	1.00
49_G	95_I	2.868	1.00
11_T	223_G	2.562	1.00
192_I	215_I	2.551	1.00
52_F	217_F	2.495	1.00
181_A	221_T	2.442	1.00
184_S	188_S	2.409	1.00
112_L	115_P	2.400	1.00
213_F	247_T	2.356	1.00
97_L	114_L	2.297	1.00
185_L	218_F	2.281	1.00
195_N	255_G	2.183	1.00
15_I	47_I	2.170	1.00
99_F	103_V	2.165	1.00
3_V	216_P	2.157	1.00
217_F	244_A	2.155	1.00
51_V	55_I	2.154	1.00
181_A	185_L	2.091	1.00
111_K	115_P	2.089	1.00
217_F	247_T	2.006	1.00
6_L	59_F	2.002	1.00
122_L	250_G	1.963	1.00
11_T	51_V	1.958	1.00
90_A	250_G	1.952	1.00
189_A	218_F	1.951	1.00
192_I	214_M	1.924	1.00
103_V	107_R	1.911	1.00
94_M	119_S	1.868	1.00
18_F	47_I	1.856	1.00
162_L	166_C	1.841	1.00
171_N	238_D	1.833	1.00
87_A	210_S	1.817	1.00
184_S	244_A	1.803	1.00
133_T	150_D	1.776	1.00
10_A	51_V	1.764	1.00
172_I	272_F	1.751	1.00
48_S	220_T	1.724	1.00
183_Q	268_Q	1.713	1.00
91_I	243_F	1.713	1.00
119_S	160_G	1.688	1.00
12_V	226_Y	1.683	1.00
158_Y	162_L	1.676	1.00
116_T	160_G	1.674	1.00
187_I	248_F	1.669	1.00
225_L	229_W	1.658	1.00
31_D	34_K	1.649	1.00
52_F	91_I	1.648	1.00
89_L	93_C	1.640	1.00
187_I	264_F	1.635	1.00
273_L	277_P	1.628	1.00
169_A	272_F	1.624	1.00
112_L	116_T	1.623	1.00
6_L	55_I	1.616	1.00
275_S	279_L	1.605	1.00
170_I	180_E	1.588	1.00
190_S	264_F	1.568	1.00
16_P	20_G	1.559	1.00
187_I	268_Q	1.558	1.00
4_S	215_I	1.549	1.00
48_S	236_V	1.506	1.00
168_N	171_N	1.493	1.00
154_L	157_V	1.473	1.00
188_S	247_T	1.471	1.00
93_C	114_L	1.462	1.00
27_L	106_L	1.454	1.00
276_L	279_L	1.453	1.00
90_A	122_L	1.449	1.00
265_F	268_Q	1.447	1.00
120_L	124_M	1.421	1.00
116_T	164_V	1.413	1.00
184_S	248_F	1.411	1.00
15_I	234_V	1.403	1.00
183_Q	267_P	1.401	1.00
104_L	108_W	1.388	1.00
187_I	265_F	1.365	1.00
159_M	163_A	1.359	1.00
91_I	213_F	1.300	1.00
100_A	104_L	1.286	1.00
277_P	280_L	1.284	1.00
155_Y	159_M	1.276	1.00
95_I	243_F	1.269	1.00
12_V	223_G	1.261	1.00
115_P	167_T	1.248	1.00
188_S	217_F	1.245	1.00
30_Q	33_N	1.232	1.00
52_F	220_T	1.231	1.00
185_L	221_T	1.230	1.00
55_I	216_P	1.230	1.00
20_G	24_A	1.220	1.00
190_S	194_F	1.215	1.00
192_I	218_F	1.209	0.99
159_M	253_I	1.196	0.99
112_L	164_V	1.194	0.99
216_P	219_F	1.187	0.99
166_C	252_G	1.175	0.99
165_F	276_L	1.165	0.99
28_C	39_Q	1.164	0.99
116_T	120_L	1.159	0.99
170_I	184_S	1.138	0.99
173_L	183_Q	1.132	0.99
188_S	214_M	1.128	0.99
96_F	100_A	1.120	0.99
91_I	247_T	1.108	0.99
3_V	55_I	1.096	0.99
21_H	24_A	1.096	0.99
6_L	58_C	1.081	0.99
165_F	272_F	1.073	0.99
259_K	262_L	1.065	0.99
8_F	226_Y	1.064	0.99
170_I	187_I	1.058	0.99
223_G	227_H	1.057	0.99
192_I	211_L	1.049	0.99
29_G	34_K	1.048	0.99
115_P	168_N	1.046	0.99
153_I	157_V	1.029	0.98
115_P	242_Y	1.018	0.98
89_L	121_P	1.013	0.98
140_P	146_G	1.012	0.98
166_C	261_M	1.010	0.98
90_A	118_A	1.005	0.98
166_C	269_V	1.002	0.98
265_F	269_V	1.002	0.98
214_M	247_T	1.000	0.98
163_A	249_A	0.995	0.98
53_L	88_L	0.992	0.98
195_N	211_L	0.991	0.98
188_S	248_F	0.986	0.98
29_G	32_L	0.986	0.98
47_I	51_V	0.981	0.98
94_M	246_M	0.977	0.98
120_L	160_G	0.974	0.98
276_L	280_L	0.972	0.98
182_G	186_V	0.972	0.98
236_V	241_C	0.970	0.98
51_V	220_T	0.970	0.98
109_R	112_L	0.968	0.98
81_F	209_F	0.967	0.98
87_A	250_G	0.964	0.97
275_S	278_Q	0.964	0.97
22_F	47_I	0.959	0.97
191_I	255_G	0.946	0.97
272_F	275_S	0.946	0.97
249_A	253_I	0.945	0.97
195_N	210_S	0.942	0.97
174_A	180_E	0.941	0.97
48_S	221_T	0.939	0.97
48_S	52_F	0.938	0.97
224_L	236_V	0.938	0.97
172_I	276_L	0.937	0.97
14_L	51_V	0.936	0.97
119_S	164_V	0.932	0.97
211_L	215_I	0.926	0.97
8_F	223_G	0.923	0.97
32_L	35_T	0.921	0.97
267_P	271_N	0.915	0.97
123_L	159_M	0.912	0.96
194_F	264_F	0.911	0.96
7_G	219_F	0.909	0.96
171_N	245_G	0.905	0.96
2_I	6_L	0.899	0.96
87_A	213_F	0.897	0.96
123_L	160_G	0.897	0.96
21_H	25_A	0.896	0.96
10_A	14_L	0.891	0.96
14_L	17_A	0.889	0.96
94_M	167_T	0.886	0.96
170_I	265_F	0.878	0.96
261_M	269_V	0.873	0.95
49_G	91_I	0.872	0.95
271_N	275_S	0.869	0.95
60_I	84_L	0.867	0.95
172_I	279_L	0.866	0.95
261_M	272_F	0.858	0.95
174_A	236_V	0.857	0.95
177_N	236_V	0.857	0.95
184_S	221_T	0.855	0.95
6_L	10_A	0.855	0.95
17_A	20_G	0.853	0.95
15_I	223_G	0.852	0.95
8_F	12_V	0.849	0.95
191_I	264_F	0.847	0.95
56_L	84_L	0.844	0.95
274_Y	278_Q	0.840	0.94
101_D	171_N	0.838	0.94
270_F	273_L	0.838	0.94
237_G	245_G	0.837	0.94
221_T	244_A	0.835	0.94
15_I	19_R	0.834	0.94
18_F	22_F	0.832	0.94
196_L	211_L	0.827	0.94
25_A	106_L	0.819	0.94
200_E	203_C	0.816	0.93
123_L	156_Y	0.816	0.93
252_G	256_H	0.810	0.93
213_F	251_V	0.810	0.93
5_L	9_V	0.809	0.93
16_P	47_I	0.809	0.93
272_F	276_L	0.804	0.93
30_Q	39_Q	0.804	0.93
16_P	19_R	0.798	0.93
157_V	160_G	0.797	0.93
22_F	27_L	0.796	0.93
112_L	160_G	0.789	0.92
176_I	225_L	0.789	0.92
221_T	240_F	0.789	0.92
23_I	233_R	0.787	0.92
242_Y	246_M	0.780	0.92
119_S	163_A	0.780	0.92
201_G	204_R	0.779	0.92
150_D	154_L	0.778	0.92
269_V	272_F	0.774	0.92
212_Y	215_I	0.774	0.92
51_V	216_P	0.770	0.91
180_E	244_A	0.769	0.91
40_I	235_F	0.768	0.91
185_L	222_L	0.767	0.91
161_L	262_L	0.763	0.91
56_L	88_L	0.758	0.91
95_I	239_T	0.758	0.91
172_I	275_S	0.758	0.91
266_M	270_F	0.757	0.91
176_I	243_F	0.753	0.90
181_A	225_L	0.749	0.90
195_N	214_M	0.748	0.90
17_A	23_I	0.745	0.90
222_L	226_Y	0.736	0.89
3_V	215_I	0.733	0.89
165_F	262_L	0.732	0.89
111_K	170_I	0.727	0.89
188_S	218_F	0.718	0.88
56_L	60_I	0.713	0.88
19_R	233_R	0.712	0.88
14_L	46_V	0.707	0.87
238_D	245_G	0.706	0.87
257_F	260_T	0.704	0.87
235_F	238_D	0.704	0.87
236_V	240_F	0.698	0.87
174_A	240_F	0.696	0.87
150_D	157_V	0.695	0.87
192_I	196_L	0.694	0.87
271_N	278_Q	0.693	0.86
101_D	238_D	0.691	0.86
189_A	222_L	0.687	0.86
130_F	205_D	0.682	0.86
115_P	164_V	0.681	0.85
191_I	265_F	0.680	0.85
219_F	223_G	0.677	0.85
49_G	243_F	0.674	0.85
1_L	5_L	0.673	0.85
270_F	277_P	0.673	0.85
11_T	47_I	0.672	0.85
10_A	13_T	0.669	0.84
192_I	195_N	0.669	0.84
111_K	167_T	0.665	0.84
171_N	241_C	0.661	0.84
174_A	241_C	0.661	0.84
57_F	61_P	0.659	0.84
243_F	263_L	0.656	0.83
4_S	219_F	0.653	0.83
16_P	211_L	0.650	0.83
7_G	216_P	0.649	0.83
20_G	226_Y	0.643	0.82
226_Y	229_W	0.640	0.82
168_N	238_D	0.639	0.82
109_R	113_L	0.639	0.82
8_F	222_L	0.637	0.81
34_K	38_Q	0.636	0.81
115_P	119_S	0.635	0.81
224_L	240_F	0.635	0.81
20_G	23_I	0.632	0.81
14_L	56_L	0.631	0.81
262_L	269_V	0.631	0.81
44_Q	48_S	0.629	0.81
194_F	257_F	0.629	0.81
13_T	17_A	0.629	0.81
28_C	106_L	0.626	0.80
154_L	158_Y	0.625	0.80
201_G	270_F	0.625	0.80
29_G	42_E	0.621	0.80
175_G	179_L	0.620	0.80
29_G	33_N	0.619	0.80
170_I	268_Q	0.618	0.79
90_A	246_M	0.614	0.79
146_G	149_L	0.614	0.79
229_W	233_R	0.613	0.79
30_Q	40_I	0.612	0.79
162_L	252_G	0.611	0.79
266_M	269_V	0.608	0.78
155_Y	256_H	0.604	0.78
130_F	204_R	0.601	0.78
9_V	56_L	0.598	0.77
54_I	113_L	0.597	0.77
111_K	168_N	0.594	0.77
224_L	232_S	0.593	0.77
37_R	41_P	0.593	0.77
174_A	177_N	0.592	0.77
162_L	276_L	0.591	0.76
263_L	266_M	0.590	0.76
163_A	250_G	0.590	0.76
171_N	235_F	0.589	0.76
58_C	197_V	0.587	0.76
183_Q	187_I	0.587	0.76
155_Y	258_S	0.586	0.76
268_Q	271_N	0.585	0.76
91_I	250_G	0.583	0.75
94_M	114_L	0.582	0.75
42_E	111_K	0.582	0.75
185_L	189_A	0.579	0.75
230_Y	239_T	0.579	0.75
263_L	269_V	0.578	0.75
90_A	94_M	0.577	0.75
16_P	49_G	0.575	0.74
43_S	103_V	0.574	0.74
20_G	53_L	0.573	0.74
93_C	97_L	0.572	0.74
60_I	88_L	0.572	0.74
11_T	15_I	0.571	0.74
136_V	140_P	0.570	0.74
22_F	239_T	0.569	0.74
166_C	276_L	0.567	0.73
57_F	88_L	0.566	0.73
157_V	169_A	0.561	0.73
182_G	255_G	0.558	0.72
96_F	103_V	0.557	0.72
180_E	268_Q	0.557	0.72
98_G	102_D	0.556	0.72
4_S	14_L	0.556	0.72
151_L	158_Y	0.556	0.72
127_F	156_Y	0.555	0.72
18_F	46_V	0.550	0.71
170_I	189_A	0.549	0.71
51_V	54_I	0.549	0.71
10_A	55_I	0.549	0.71
11_T	220_T	0.548	0.71
133_T	156_Y	0.547	0.71
84_L	213_F	0.546	0.71
103_V	106_L	0.543	0.70
139_K	146_G	0.542	0.70
133_T	152_G	0.539	0.70
173_L	267_P	0.539	0.70
240_F	244_A	0.538	0.70
22_F	39_Q	0.537	0.69
83_A	209_F	0.537	0.69
180_E	224_L	0.536	0.69
210_S	215_I	0.535	0.69
199_L	203_C	0.535	0.69
166_C	265_F	0.534	0.69
107_R	249_A	0.532	0.69
121_P	266_M	0.532	0.69
10_A	54_I	0.532	0.69
172_I	269_V	0.532	0.69
119_S	123_L	0.531	0.69
94_M	115_P	0.531	0.69
97_L	115_P	0.530	0.68
162_L	262_L	0.528	0.68
87_A	254_L	0.527	0.68
123_L	165_F	0.523	0.67
163_A	167_T	0.521	0.67
19_R	227_H	0.519	0.67
94_M	118_A	0.517	0.67
267_P	275_S	0.517	0.67
16_P	227_H	0.514	0.66
4_S	154_L	0.514	0.66
140_P	151_L	0.513	0.66
2_I	24_A	0.512	0.66
241_C	245_G	0.512	0.66
166_C	262_L	0.512	0.66
166_C	249_A	0.510	0.65
5_L	13_T	0.510	0.65
199_L	204_R	0.509	0.65
232_S	235_F	0.508	0.65
167_T	172_I	0.502	0.64
267_P	270_F	0.502	0.64
100_A	239_T	0.501	0.64
42_E	243_F	0.500	0.64
55_I	59_F	0.500	0.64

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
5ckr_A	1	0.899	100	0.254	Contact Map
2ls4_A	1	0.0836	12.3	0.959	Contact Map
3dh4_A	1	0.0139	2.6	0.97	Contact Map
2m3e_A	1	0.1359	2	0.972	Contact Map
3ije_A	1	0.2056	1.9	0.972	Contact Map
4wk0_A	1	0.2021	1.9	0.973	Contact Map
4um9_A	1	0.2056	1.8	0.973	Contact Map
2wsc_I	1	0.1045	1.8	0.973	Contact Map
4um8_A	1	0.2056	1.5	0.974	Contact Map
3vi3_A	1	0.2021	1.5	0.974	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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