GREMLIN Database
T0945_16_302 - T0945 16-302
ID: 120 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 287 (252)
Sequences: 3351 (2068)
Seq/√Len: 130.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
214_M251_V4.0861.00
93_C118_A3.2551.00
53_L92_C2.9631.00
49_G95_I2.8681.00
11_T223_G2.5621.00
192_I215_I2.5511.00
52_F217_F2.4951.00
181_A221_T2.4421.00
184_S188_S2.4091.00
112_L115_P2.4001.00
213_F247_T2.3561.00
97_L114_L2.2971.00
185_L218_F2.2811.00
195_N255_G2.1831.00
15_I47_I2.1701.00
99_F103_V2.1651.00
3_V216_P2.1571.00
217_F244_A2.1551.00
51_V55_I2.1541.00
181_A185_L2.0911.00
111_K115_P2.0891.00
217_F247_T2.0061.00
6_L59_F2.0021.00
122_L250_G1.9631.00
11_T51_V1.9581.00
90_A250_G1.9521.00
189_A218_F1.9511.00
192_I214_M1.9241.00
103_V107_R1.9111.00
94_M119_S1.8681.00
18_F47_I1.8561.00
162_L166_C1.8411.00
171_N238_D1.8331.00
87_A210_S1.8171.00
184_S244_A1.8031.00
133_T150_D1.7761.00
10_A51_V1.7641.00
172_I272_F1.7511.00
48_S220_T1.7241.00
183_Q268_Q1.7131.00
91_I243_F1.7131.00
119_S160_G1.6881.00
12_V226_Y1.6831.00
158_Y162_L1.6761.00
116_T160_G1.6741.00
187_I248_F1.6691.00
225_L229_W1.6581.00
31_D34_K1.6491.00
52_F91_I1.6481.00
89_L93_C1.6401.00
187_I264_F1.6351.00
273_L277_P1.6281.00
169_A272_F1.6241.00
112_L116_T1.6231.00
6_L55_I1.6161.00
275_S279_L1.6051.00
170_I180_E1.5881.00
190_S264_F1.5681.00
16_P20_G1.5591.00
187_I268_Q1.5581.00
4_S215_I1.5491.00
48_S236_V1.5061.00
168_N171_N1.4931.00
154_L157_V1.4731.00
188_S247_T1.4711.00
93_C114_L1.4621.00
27_L106_L1.4541.00
276_L279_L1.4531.00
90_A122_L1.4491.00
265_F268_Q1.4471.00
120_L124_M1.4211.00
116_T164_V1.4131.00
184_S248_F1.4111.00
15_I234_V1.4031.00
183_Q267_P1.4011.00
104_L108_W1.3881.00
187_I265_F1.3651.00
159_M163_A1.3591.00
91_I213_F1.3001.00
100_A104_L1.2861.00
277_P280_L1.2841.00
155_Y159_M1.2761.00
95_I243_F1.2691.00
12_V223_G1.2611.00
115_P167_T1.2481.00
188_S217_F1.2451.00
30_Q33_N1.2321.00
52_F220_T1.2311.00
185_L221_T1.2301.00
55_I216_P1.2301.00
20_G24_A1.2201.00
190_S194_F1.2151.00
192_I218_F1.2090.99
159_M253_I1.1960.99
112_L164_V1.1940.99
216_P219_F1.1870.99
166_C252_G1.1750.99
165_F276_L1.1650.99
28_C39_Q1.1640.99
116_T120_L1.1590.99
170_I184_S1.1380.99
173_L183_Q1.1320.99
188_S214_M1.1280.99
96_F100_A1.1200.99
91_I247_T1.1080.99
3_V55_I1.0960.99
21_H24_A1.0960.99
6_L58_C1.0810.99
165_F272_F1.0730.99
259_K262_L1.0650.99
8_F226_Y1.0640.99
170_I187_I1.0580.99
223_G227_H1.0570.99
192_I211_L1.0490.99
29_G34_K1.0480.99
115_P168_N1.0460.99
153_I157_V1.0290.98
115_P242_Y1.0180.98
89_L121_P1.0130.98
140_P146_G1.0120.98
166_C261_M1.0100.98
90_A118_A1.0050.98
166_C269_V1.0020.98
265_F269_V1.0020.98
214_M247_T1.0000.98
163_A249_A0.9950.98
53_L88_L0.9920.98
195_N211_L0.9910.98
188_S248_F0.9860.98
29_G32_L0.9860.98
47_I51_V0.9810.98
94_M246_M0.9770.98
120_L160_G0.9740.98
276_L280_L0.9720.98
182_G186_V0.9720.98
236_V241_C0.9700.98
51_V220_T0.9700.98
109_R112_L0.9680.98
81_F209_F0.9670.98
87_A250_G0.9640.97
275_S278_Q0.9640.97
22_F47_I0.9590.97
191_I255_G0.9460.97
272_F275_S0.9460.97
249_A253_I0.9450.97
195_N210_S0.9420.97
174_A180_E0.9410.97
48_S221_T0.9390.97
48_S52_F0.9380.97
224_L236_V0.9380.97
172_I276_L0.9370.97
14_L51_V0.9360.97
119_S164_V0.9320.97
211_L215_I0.9260.97
8_F223_G0.9230.97
32_L35_T0.9210.97
267_P271_N0.9150.97
123_L159_M0.9120.96
194_F264_F0.9110.96
7_G219_F0.9090.96
171_N245_G0.9050.96
2_I6_L0.8990.96
87_A213_F0.8970.96
123_L160_G0.8970.96
21_H25_A0.8960.96
10_A14_L0.8910.96
14_L17_A0.8890.96
94_M167_T0.8860.96
170_I265_F0.8780.96
261_M269_V0.8730.95
49_G91_I0.8720.95
271_N275_S0.8690.95
60_I84_L0.8670.95
172_I279_L0.8660.95
261_M272_F0.8580.95
174_A236_V0.8570.95
177_N236_V0.8570.95
184_S221_T0.8550.95
6_L10_A0.8550.95
17_A20_G0.8530.95
15_I223_G0.8520.95
8_F12_V0.8490.95
191_I264_F0.8470.95
56_L84_L0.8440.95
274_Y278_Q0.8400.94
101_D171_N0.8380.94
270_F273_L0.8380.94
237_G245_G0.8370.94
221_T244_A0.8350.94
15_I19_R0.8340.94
18_F22_F0.8320.94
196_L211_L0.8270.94
25_A106_L0.8190.94
200_E203_C0.8160.93
123_L156_Y0.8160.93
252_G256_H0.8100.93
213_F251_V0.8100.93
5_L9_V0.8090.93
16_P47_I0.8090.93
272_F276_L0.8040.93
30_Q39_Q0.8040.93
16_P19_R0.7980.93
157_V160_G0.7970.93
22_F27_L0.7960.93
112_L160_G0.7890.92
176_I225_L0.7890.92
221_T240_F0.7890.92
23_I233_R0.7870.92
242_Y246_M0.7800.92
119_S163_A0.7800.92
201_G204_R0.7790.92
150_D154_L0.7780.92
269_V272_F0.7740.92
212_Y215_I0.7740.92
51_V216_P0.7700.91
180_E244_A0.7690.91
40_I235_F0.7680.91
185_L222_L0.7670.91
161_L262_L0.7630.91
56_L88_L0.7580.91
95_I239_T0.7580.91
172_I275_S0.7580.91
266_M270_F0.7570.91
176_I243_F0.7530.90
181_A225_L0.7490.90
195_N214_M0.7480.90
17_A23_I0.7450.90
222_L226_Y0.7360.89
3_V215_I0.7330.89
165_F262_L0.7320.89
111_K170_I0.7270.89
188_S218_F0.7180.88
56_L60_I0.7130.88
19_R233_R0.7120.88
14_L46_V0.7070.87
238_D245_G0.7060.87
257_F260_T0.7040.87
235_F238_D0.7040.87
236_V240_F0.6980.87
174_A240_F0.6960.87
150_D157_V0.6950.87
192_I196_L0.6940.87
271_N278_Q0.6930.86
101_D238_D0.6910.86
189_A222_L0.6870.86
130_F205_D0.6820.86
115_P164_V0.6810.85
191_I265_F0.6800.85
219_F223_G0.6770.85
49_G243_F0.6740.85
1_L5_L0.6730.85
270_F277_P0.6730.85
11_T47_I0.6720.85
10_A13_T0.6690.84
192_I195_N0.6690.84
111_K167_T0.6650.84
171_N241_C0.6610.84
174_A241_C0.6610.84
57_F61_P0.6590.84
243_F263_L0.6560.83
4_S219_F0.6530.83
16_P211_L0.6500.83
7_G216_P0.6490.83
20_G226_Y0.6430.82
226_Y229_W0.6400.82
168_N238_D0.6390.82
109_R113_L0.6390.82
8_F222_L0.6370.81
34_K38_Q0.6360.81
115_P119_S0.6350.81
224_L240_F0.6350.81
20_G23_I0.6320.81
14_L56_L0.6310.81
262_L269_V0.6310.81
44_Q48_S0.6290.81
194_F257_F0.6290.81
13_T17_A0.6290.81
28_C106_L0.6260.80
154_L158_Y0.6250.80
201_G270_F0.6250.80
29_G42_E0.6210.80
175_G179_L0.6200.80
29_G33_N0.6190.80
170_I268_Q0.6180.79
90_A246_M0.6140.79
146_G149_L0.6140.79
229_W233_R0.6130.79
30_Q40_I0.6120.79
162_L252_G0.6110.79
266_M269_V0.6080.78
155_Y256_H0.6040.78
130_F204_R0.6010.78
9_V56_L0.5980.77
54_I113_L0.5970.77
111_K168_N0.5940.77
224_L232_S0.5930.77
37_R41_P0.5930.77
174_A177_N0.5920.77
162_L276_L0.5910.76
263_L266_M0.5900.76
163_A250_G0.5900.76
171_N235_F0.5890.76
58_C197_V0.5870.76
183_Q187_I0.5870.76
155_Y258_S0.5860.76
268_Q271_N0.5850.76
91_I250_G0.5830.75
94_M114_L0.5820.75
42_E111_K0.5820.75
185_L189_A0.5790.75
230_Y239_T0.5790.75
263_L269_V0.5780.75
90_A94_M0.5770.75
16_P49_G0.5750.74
43_S103_V0.5740.74
20_G53_L0.5730.74
93_C97_L0.5720.74
60_I88_L0.5720.74
11_T15_I0.5710.74
136_V140_P0.5700.74
22_F239_T0.5690.74
166_C276_L0.5670.73
57_F88_L0.5660.73
157_V169_A0.5610.73
182_G255_G0.5580.72
96_F103_V0.5570.72
180_E268_Q0.5570.72
98_G102_D0.5560.72
4_S14_L0.5560.72
151_L158_Y0.5560.72
127_F156_Y0.5550.72
18_F46_V0.5500.71
170_I189_A0.5490.71
51_V54_I0.5490.71
10_A55_I0.5490.71
11_T220_T0.5480.71
133_T156_Y0.5470.71
84_L213_F0.5460.71
103_V106_L0.5430.70
139_K146_G0.5420.70
133_T152_G0.5390.70
173_L267_P0.5390.70
240_F244_A0.5380.70
22_F39_Q0.5370.69
83_A209_F0.5370.69
180_E224_L0.5360.69
210_S215_I0.5350.69
199_L203_C0.5350.69
166_C265_F0.5340.69
107_R249_A0.5320.69
121_P266_M0.5320.69
10_A54_I0.5320.69
172_I269_V0.5320.69
119_S123_L0.5310.69
94_M115_P0.5310.69
97_L115_P0.5300.68
162_L262_L0.5280.68
87_A254_L0.5270.68
123_L165_F0.5230.67
163_A167_T0.5210.67
19_R227_H0.5190.67
94_M118_A0.5170.67
267_P275_S0.5170.67
16_P227_H0.5140.66
4_S154_L0.5140.66
140_P151_L0.5130.66
2_I24_A0.5120.66
241_C245_G0.5120.66
166_C262_L0.5120.66
166_C249_A0.5100.65
5_L13_T0.5100.65
199_L204_R0.5090.65
232_S235_F0.5080.65
167_T172_I0.5020.64
267_P270_F0.5020.64
100_A239_T0.5010.64
42_E243_F0.5000.64
55_I59_F0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5ckr_A 1 0.899 100 0.254 Contact Map
2ls4_A 1 0.0836 12.3 0.959 Contact Map
3dh4_A 1 0.0139 2.6 0.97 Contact Map
2m3e_A 1 0.1359 2 0.972 Contact Map
3ije_A 1 0.2056 1.9 0.972 Contact Map
4wk0_A 1 0.2021 1.9 0.973 Contact Map
4um9_A 1 0.2056 1.8 0.973 Contact Map
2wsc_I 1 0.1045 1.8 0.973 Contact Map
4um8_A 1 0.2056 1.5 0.974 Contact Map
3vi3_A 1 0.2021 1.5 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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