GREMLIN Database
T0872_1_91 - T0872 1-91
ID: 12 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 91 (81)
Sequences: 1516 (1162)
Seq/√Len: 129.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_Q52_L4.4871.00
16_H24_V3.1911.00
28_S36_V2.8521.00
36_V48_R2.8351.00
26_L50_V2.2441.00
47_E50_V2.0771.00
33_S68_T2.0661.00
25_Y51_T1.9731.00
11_A29_L1.9671.00
40_H50_V1.9611.00
41_P54_M1.8321.00
68_T72_I1.6801.00
39_Q63_T1.5991.00
5_D72_I1.5701.00
21_P24_V1.5571.00
59_K79_T1.5131.00
54_M62_V1.4661.00
76_N79_T1.4591.00
22_N82_I1.4231.00
41_P52_L1.3841.00
26_L62_V1.3611.00
13_S29_L1.3361.00
68_T73_V1.2941.00
40_H52_L1.2871.00
33_S36_V1.2601.00
23_I53_Q1.2481.00
26_L40_H1.2211.00
38_W58_G1.2120.99
65_G75_G1.2100.99
11_A76_N1.1770.99
14_I76_N1.1550.99
36_V64_F1.1420.99
33_S66_V1.0800.99
35_Q47_E1.0760.99
61_E77_P1.0750.99
44_R52_L1.0670.99
16_H22_N1.0520.99
15_T25_Y1.0470.98
27_K49_E1.0230.98
57_E60_Y1.0050.98
19_E72_I1.0020.98
54_M64_F0.9740.98
73_V78_A0.9720.98
40_H45_S0.9640.97
7_V70_G0.9630.97
8_E71_G0.9490.97
30_M34_Y0.9300.97
59_K81_T0.9300.97
21_P34_Y0.9280.97
28_S48_R0.9220.97
10_I66_V0.9180.96
6_L72_I0.9100.96
61_E79_T0.9090.96
28_S49_E0.9070.96
38_W64_F0.8950.96
44_R55_P0.8920.96
11_A61_E0.8800.96
63_T77_P0.8690.95
67_Q83_D0.8610.95
37_C56_F0.8470.95
12_F28_S0.8280.94
8_E12_F0.8250.94
57_E84_S0.8220.94
21_P71_G0.8200.94
23_I56_F0.8190.93
14_I17_D0.8110.93
40_H54_M0.7820.92
14_I21_P0.7760.92
70_G74_Y0.7550.90
33_S69_R0.7490.90
12_F78_A0.7330.89
63_T74_Y0.7210.88
77_P81_T0.7160.88
12_F30_M0.7120.88
12_F64_F0.7100.87
10_I74_Y0.7030.87
40_H43_G0.6970.86
26_L48_R0.6930.86
51_T61_E0.6920.86
9_G57_E0.6880.86
8_E68_T0.6740.85
27_K47_E0.6670.84
38_W54_M0.6620.84
20_N56_F0.6600.83
28_S64_F0.6510.83
27_K31_P0.6490.82
9_G63_T0.6490.82
26_L49_E0.6220.80
46_Q62_V0.6180.79
68_T71_G0.6130.79
15_T19_E0.6100.78
23_I51_T0.6080.78
28_S50_V0.6050.78
17_D81_T0.5990.77
25_Y48_R0.5950.77
61_E76_N0.5920.76
15_T70_G0.5860.75
74_Y77_P0.5820.75
19_E70_G0.5700.73
34_Y59_K0.5700.73
41_P45_S0.5590.72
12_F62_V0.5540.71
10_I30_M0.5530.71
38_W50_V0.5520.71
5_D70_G0.5450.70
65_G76_N0.5450.70
9_G73_V0.5430.70
39_Q65_G0.5410.70
5_D63_T0.5370.69
15_T27_K0.5350.69
6_L32_S0.5330.68
5_D69_R0.5320.68
13_S78_A0.5300.68
25_Y29_L0.5250.67
41_P44_R0.5230.67
67_Q72_I0.5170.66
56_F60_Y0.5170.66
37_C46_Q0.5150.66
35_Q67_Q0.5120.65
51_T57_E0.5080.65
26_L52_L0.5060.65
53_Q83_D0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kzw_A 1 0.978 99.4 0.253 Contact Map
2c4x_A 1 0.978 99.3 0.285 Contact Map
4jgu_A 1 0.9231 99.3 0.285 Contact Map
2y3u_A 1 0.022 99.3 0.286 Contact Map
4l9d_A 1 0.8462 99.3 0.305 Contact Map
1b4r_A 1 0.8132 99.2 0.318 Contact Map
4xed_A 1 0.9011 99.2 0.331 Contact Map
4u6t_A 1 0.8791 99.1 0.354 Contact Map
4aqo_A 1 0.8791 99.1 0.358 Contact Map
1l0q_A 1 0.044 98.6 0.467 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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