GREMLIN Database
T0945_1_409 - T0945 1-409
ID: 119 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 409 (333)
Sequences: 1678 (1319)
Seq/√Len: 72.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
240_L244_W5.5841.00
207_I230_I4.6861.00
200_L233_F3.5841.00
23_F238_G3.1631.00
197_G385_L3.0661.00
189_A195_E3.0581.00
229_M266_V2.8711.00
196_A236_T2.8511.00
204_A233_F2.8071.00
26_T66_V2.7391.00
44_G57_E2.7281.00
239_L251_V2.7021.00
26_T238_G2.6891.00
207_I229_M2.6861.00
27_V241_Y2.6261.00
196_A240_L2.6161.00
376_H379_N2.6121.00
45_Q54_Q2.5851.00
207_I226_L2.5791.00
181_C264_A2.5781.00
185_I199_S2.4061.00
27_V238_G2.4031.00
64_G110_I2.2451.00
106_I258_F2.1581.00
110_I254_T2.0351.00
58_S114_F2.0331.00
200_L236_T1.9881.00
64_G107_C1.9671.00
267_G276_M1.9521.00
67_F258_F1.9291.00
189_A256_C1.8851.00
126_K253_D1.8471.00
206_I229_M1.8341.00
232_F262_T1.8281.00
67_F232_F1.8251.00
33_F37_F1.8201.00
205_S392_S1.8181.00
375_I383_L1.7881.00
46_D49_K1.7831.00
30_I249_V1.7701.00
201_V385_L1.7691.00
244_W382_L1.7421.00
369_L373_G1.7281.00
31_P35_G1.7131.00
31_P242_H1.7101.00
23_F241_Y1.6861.00
34_R38_I1.6781.00
122_R125_H1.6761.00
199_S236_T1.6421.00
66_V70_I1.6330.99
34_R248_R1.6290.99
16_L20_L1.6190.99
25_A66_V1.5930.99
22_G70_I1.5840.99
22_G235_T1.5750.99
203_S232_F1.5300.99
197_G201_V1.5270.99
126_K257_Y1.5130.99
134_S138_L1.5070.99
207_I233_F1.4950.99
203_S229_M1.4680.99
115_A119_L1.4590.99
196_A239_L1.4580.99
381_T385_L1.4530.99
231_P234_F1.4390.99
36_H39_A1.4290.99
240_L382_L1.4250.99
33_F62_I1.4190.99
102_A262_T1.4190.99
199_S259_A1.3800.98
236_T259_A1.3790.98
105_A261_M1.3760.98
130_P179_V1.3490.98
183_N186_N1.3460.98
178_A264_A1.3360.98
199_S203_S1.3340.98
236_T255_F1.3320.98
59_Q62_I1.3300.98
45_Q52_R1.3290.98
59_Q63_S1.3280.98
382_L386_L1.3040.97
112_L129_L1.2900.97
367_L371_V1.2580.97
30_I238_G1.2540.97
102_A269_L1.2240.96
232_F259_A1.2070.96
205_S396_F1.1930.96
255_F259_A1.1760.95
137_L178_A1.1740.95
190_G194_L1.1670.95
240_L385_L1.1590.95
189_A251_V1.1550.95
63_S251_V1.1470.95
195_E251_V1.1390.94
251_V259_A1.1340.94
194_L384_L1.1330.94
19_S234_F1.1320.94
258_F261_M1.1290.94
123_W127_L1.1100.94
127_L130_P1.0910.93
279_F395_T1.0800.93
191_I381_T1.0740.92
19_S23_F1.0690.92
126_K187_I1.0640.92
196_A251_V1.0600.92
204_A208_V1.0590.92
150_I155_P1.0510.92
108_C133_A1.0460.91
203_S233_F1.0450.91
43_C54_Q1.0430.91
180_F287_F1.0370.91
150_I153_P1.0340.91
233_F240_L1.0200.90
221_D226_L1.0200.90
375_I379_N1.0100.90
126_K183_N1.0080.90
237_L241_Y1.0050.90
170_Y174_M1.0050.90
194_L381_T0.9940.89
62_I66_V0.9920.89
195_E256_C0.9910.89
135_L139_M0.9830.89
234_F238_G0.9790.89
175_G179_V0.9670.88
207_I211_L0.9630.88
198_Q283_Q0.9620.88
121_L227_Y0.9610.88
64_G258_F0.9560.87
146_G150_I0.9480.87
50_T53_Q0.9400.86
186_N253_D0.9390.86
22_G234_F0.9340.86
275_T278_L0.9260.86
155_P160_L0.9260.86
114_F118_V0.9100.85
393_A397_S0.9060.84
134_S175_G0.9010.84
101_G105_A0.8950.84
205_S279_F0.8910.83
282_P395_T0.8890.83
26_T30_I0.8830.83
45_Q48_N0.8820.83
378_R382_L0.8720.82
200_L237_L0.8710.82
167_G170_Y0.8700.82
111_F114_F0.8690.82
44_G47_L0.8680.82
130_P192_N0.8620.81
71_L277_L0.8620.81
164_L169_L0.8570.81
65_A139_M0.8540.81
34_R249_V0.8480.80
364_L372_L0.8430.80
109_M133_A0.8420.80
251_V256_C0.8390.79
151_V154_K0.8370.79
34_R242_H0.8350.79
105_A258_F0.8340.79
48_N51_S0.8260.78
66_V69_I0.8220.78
266_V272_F0.8210.78
131_T179_V0.8200.78
181_C267_G0.8130.77
129_L212_V0.8080.77
208_V212_V0.8080.77
106_I265_G0.8060.77
36_H40_A0.8020.76
45_Q49_K0.7980.76
182_T257_Y0.7950.76
42_L58_S0.7940.76
164_L167_G0.7880.75
212_V220_D0.7860.75
63_S255_F0.7830.75
57_E254_T0.7810.74
236_T239_L0.7760.74
24_V28_T0.7740.74
177_L180_F0.7710.73
130_P187_I0.7690.73
30_I228_F0.7690.73
203_S236_T0.7680.73
59_Q249_V0.7610.72
137_L265_G0.7590.72
188_L289_Y0.7500.71
35_G201_V0.7500.71
210_N226_L0.7500.71
44_G48_N0.7470.71
153_P170_Y0.7470.71
112_L128_L0.7440.71
383_L387_L0.7440.71
127_L184_A0.7420.71
152_V155_P0.7360.70
201_V396_F0.7350.70
67_F71_L0.7350.70
371_V376_H0.7350.70
282_P388_Q0.7320.70
185_I259_A0.7320.70
37_F57_E0.7300.69
279_F391_G0.7290.69
130_P183_N0.7270.69
130_P257_Y0.7220.68
251_V255_F0.7210.68
204_A230_I0.7200.68
253_D257_Y0.7180.68
25_A35_G0.7180.68
182_T187_I0.7170.68
95_E98_A0.7170.68
142_F146_G0.7160.68
160_L164_L0.7150.68
57_E195_E0.7130.68
101_G142_F0.7130.68
182_T261_M0.7110.67
137_L141_Y0.7100.67
19_S69_I0.7060.67
224_F266_V0.7030.66
187_I192_N0.7030.66
208_V227_Y0.7020.66
174_M178_A0.7010.66
235_T238_G0.7000.66
205_S229_M0.7000.66
192_N257_Y0.6990.66
387_L391_G0.6980.66
61_V254_T0.6960.66
46_D250_F0.6930.65
185_I195_E0.6930.65
26_T31_P0.6880.65
67_F194_L0.6850.64
200_L204_A0.6810.64
141_Y146_G0.6790.64
41_R52_R0.6790.64
364_L384_L0.6780.64
392_S396_F0.6730.63
71_L231_P0.6730.63
74_F257_Y0.6720.63
63_S235_T0.6690.63
227_Y235_T0.6690.63
110_I114_F0.6690.63
196_A244_W0.6680.62
189_A255_F0.6670.62
254_T258_F0.6660.62
30_I34_R0.6580.61
30_I197_G0.6570.61
170_Y273_S0.6540.61
98_A115_A0.6530.61
182_T264_A0.6510.60
56_P60_G0.6510.60
196_A199_S0.6390.59
123_W126_K0.6390.59
195_E249_V0.6370.59
174_M177_L0.6370.59
391_G394_I0.6360.59
126_K254_T0.6350.59
188_L387_L0.6340.58
123_W295_L0.6310.58
18_V104_L0.6300.58
23_F27_V0.6300.58
27_V31_P0.6300.58
138_L175_G0.6290.58
40_A58_S0.6290.58
114_F254_T0.6250.57
109_M130_P0.6250.57
178_A181_C0.6250.57
127_L179_V0.6230.57
15_N25_A0.6220.57
252_G260_G0.6210.57
102_A106_I0.6210.57
62_I263_F0.6200.57
23_F237_L0.6200.57
22_G36_H0.6190.57
71_L228_F0.6150.56
18_V73_C0.6110.56
368_L372_L0.6110.56
129_L247_S0.6090.55
73_C375_I0.6080.55
127_L131_T0.6070.55
149_T161_G0.6070.55
114_F233_F0.6060.55
364_L371_V0.6020.55
123_W187_I0.5980.54
21_L95_E0.5960.54
17_I21_L0.5940.54
112_L133_A0.5930.53
238_G241_Y0.5920.53
206_I262_T0.5880.53
155_P161_G0.5870.53
250_F380_L0.5860.53
122_R394_I0.5850.52
127_L183_N0.5800.52
151_V155_P0.5800.52
135_L245_Y0.5780.52
167_G172_V0.5760.51
230_I304_R0.5750.51
65_A110_I0.5730.51
192_N245_Y0.5710.51
15_N19_S0.5710.51
314_K374_P0.5710.51
37_F259_A0.5670.50
50_T250_F0.5670.50
38_I43_C0.5670.50
267_G273_S0.5670.50
129_L178_A0.5660.50
124_R249_V0.5660.50
196_A313_G0.5650.50
147_N150_I0.5640.50
12_L152_V0.5630.50
206_I210_N0.5630.50
264_A267_G0.5620.50
115_A118_V0.5620.50
19_S22_G0.5610.50
30_I62_I0.5580.49
182_T262_T0.5580.49
248_R268_I0.5570.49
192_N195_E0.5560.49
113_G126_K0.5560.49
222_H225_S0.5550.49
268_I272_F0.5540.49
185_I257_Y0.5530.49
376_H380_L0.5510.48
120_N125_H0.5500.48
112_L203_S0.5490.48
262_T389_I0.5490.48
122_R126_K0.5490.48
18_V103_L0.5480.48
68_L103_L0.5450.48
68_L107_C0.5450.48
380_L388_Q0.5440.47
208_V396_F0.5440.47
101_G164_L0.5430.47
150_I166_L0.5420.47
278_L282_P0.5410.47
21_L73_C0.5390.47
28_T394_I0.5380.47
277_L397_S0.5380.47
210_N272_F0.5380.47
201_V392_S0.5350.46
364_L387_L0.5340.46
63_S239_L0.5330.46
239_L255_F0.5320.46
203_S207_I0.5320.46
70_I73_C0.5320.46
38_I56_P0.5320.46
231_P235_T0.5310.46
233_F393_A0.5290.46
244_W266_V0.5270.45
240_L246_P0.5270.45
203_S263_F0.5260.45
202_I392_S0.5260.45
153_P167_G0.5250.45
240_L243_N0.5250.45
194_L247_S0.5240.45
61_V263_F0.5220.45
71_L99_L0.5220.45
392_S395_T0.5210.45
390_L394_I0.5210.45
27_V30_I0.5210.45
102_A228_F0.5210.45
149_T163_H0.5180.44
107_C204_A0.5160.44
34_R56_P0.5160.44
229_M232_F0.5160.44
21_L80_L0.5150.44
194_L197_G0.5140.44
146_G170_Y0.5130.44
48_N192_N0.5120.44
386_L390_L0.5120.44
264_A268_I0.5090.43
263_F282_P0.5080.43
193_G246_P0.5070.43
192_N377_E0.5060.43
152_V176_L0.5040.43
16_L51_S0.5030.42
147_N393_A0.5030.42
172_V176_L0.5030.42
184_A232_F0.5010.42
288_L390_L0.5010.42
244_W373_G0.5010.42
108_C112_L0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5ckr_A 1 0.7604 100 0.516 Contact Map
2ls4_A 1 0.0587 10.6 0.976 Contact Map
4hw9_A 1 0.0611 5.6 0.979 Contact Map
3sya_A 1 0.1687 4.4 0.98 Contact Map
4dx5_A 1 0.1271 4.2 0.98 Contact Map
2i68_A 1 0.1883 3.9 0.98 Contact Map
4j7c_I 1 0.0831 3.4 0.981 Contact Map
3spc_A 1 0.1614 3.2 0.981 Contact Map
3w9i_A 1 0.1027 2.6 0.982 Contact Map
2kv5_A 1 0.0807 2.3 0.982 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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