T0945_1_409 - CASP12 - GREMLIN Contacts

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T0945_1_409 - T0945 1-409

ID:	119	Sequences: SMWAFSELPMPLLINLIVSLLGFVATVTLIPAFRGHFIAARLCGQDLNKTSRQQIPESQGVISGAVFLIILFCFIPFPFLNCFVKEQCKAFPHHEFVALIGALLAICCMIFLGFADDVLNLRWRHKLLLPTAASLPLLMVYFTNFGNTTIVVPKPFRPILGLHLDLGILYYVYMGLLAVFCTNAINILAGINGLEAGQSLVISASIIVFNLVELEGDCRDDHVFSLYFMIPFFFTTLGLLYHNWYPSRVFVGDTFCYFAGMTFAGVGILGHFSKTMLLFFMPQVFNFLYSLPQLLHIIPCPRHRIPRLNIKTGKLEMSYSKFKTKSLSFLGTFILKVAESLQLVTVHQSETEDGEFTECNNMTLINLLLKVLGPIHERNLTLLLLLLQILGSAITFSIRYQLVRLFYDV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	409 (333)
Sequences:	1678 (1319)
Seq/√Len:	72.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
240_L	244_W	5.584	1.00
207_I	230_I	4.686	1.00
200_L	233_F	3.584	1.00
23_F	238_G	3.163	1.00
197_G	385_L	3.066	1.00
189_A	195_E	3.058	1.00
229_M	266_V	2.871	1.00
196_A	236_T	2.851	1.00
204_A	233_F	2.807	1.00
26_T	66_V	2.739	1.00
44_G	57_E	2.728	1.00
239_L	251_V	2.702	1.00
26_T	238_G	2.689	1.00
207_I	229_M	2.686	1.00
27_V	241_Y	2.626	1.00
196_A	240_L	2.616	1.00
376_H	379_N	2.612	1.00
45_Q	54_Q	2.585	1.00
207_I	226_L	2.579	1.00
181_C	264_A	2.578	1.00
185_I	199_S	2.406	1.00
27_V	238_G	2.403	1.00
64_G	110_I	2.245	1.00
106_I	258_F	2.158	1.00
110_I	254_T	2.035	1.00
58_S	114_F	2.033	1.00
200_L	236_T	1.988	1.00
64_G	107_C	1.967	1.00
267_G	276_M	1.952	1.00
67_F	258_F	1.929	1.00
189_A	256_C	1.885	1.00
126_K	253_D	1.847	1.00
206_I	229_M	1.834	1.00
232_F	262_T	1.828	1.00
67_F	232_F	1.825	1.00
33_F	37_F	1.820	1.00
205_S	392_S	1.818	1.00
375_I	383_L	1.788	1.00
46_D	49_K	1.783	1.00
30_I	249_V	1.770	1.00
201_V	385_L	1.769	1.00
244_W	382_L	1.742	1.00
369_L	373_G	1.728	1.00
31_P	35_G	1.713	1.00
31_P	242_H	1.710	1.00
23_F	241_Y	1.686	1.00
34_R	38_I	1.678	1.00
122_R	125_H	1.676	1.00
199_S	236_T	1.642	1.00
66_V	70_I	1.633	0.99
34_R	248_R	1.629	0.99
16_L	20_L	1.619	0.99
25_A	66_V	1.593	0.99
22_G	70_I	1.584	0.99
22_G	235_T	1.575	0.99
203_S	232_F	1.530	0.99
197_G	201_V	1.527	0.99
126_K	257_Y	1.513	0.99
134_S	138_L	1.507	0.99
207_I	233_F	1.495	0.99
203_S	229_M	1.468	0.99
115_A	119_L	1.459	0.99
196_A	239_L	1.458	0.99
381_T	385_L	1.453	0.99
231_P	234_F	1.439	0.99
36_H	39_A	1.429	0.99
240_L	382_L	1.425	0.99
33_F	62_I	1.419	0.99
102_A	262_T	1.419	0.99
199_S	259_A	1.380	0.98
236_T	259_A	1.379	0.98
105_A	261_M	1.376	0.98
130_P	179_V	1.349	0.98
183_N	186_N	1.346	0.98
178_A	264_A	1.336	0.98
199_S	203_S	1.334	0.98
236_T	255_F	1.332	0.98
59_Q	62_I	1.330	0.98
45_Q	52_R	1.329	0.98
59_Q	63_S	1.328	0.98
382_L	386_L	1.304	0.97
112_L	129_L	1.290	0.97
367_L	371_V	1.258	0.97
30_I	238_G	1.254	0.97
102_A	269_L	1.224	0.96
232_F	259_A	1.207	0.96
205_S	396_F	1.193	0.96
255_F	259_A	1.176	0.95
137_L	178_A	1.174	0.95
190_G	194_L	1.167	0.95
240_L	385_L	1.159	0.95
189_A	251_V	1.155	0.95
63_S	251_V	1.147	0.95
195_E	251_V	1.139	0.94
251_V	259_A	1.134	0.94
194_L	384_L	1.133	0.94
19_S	234_F	1.132	0.94
258_F	261_M	1.129	0.94
123_W	127_L	1.110	0.94
127_L	130_P	1.091	0.93
279_F	395_T	1.080	0.93
191_I	381_T	1.074	0.92
19_S	23_F	1.069	0.92
126_K	187_I	1.064	0.92
196_A	251_V	1.060	0.92
204_A	208_V	1.059	0.92
150_I	155_P	1.051	0.92
108_C	133_A	1.046	0.91
203_S	233_F	1.045	0.91
43_C	54_Q	1.043	0.91
180_F	287_F	1.037	0.91
150_I	153_P	1.034	0.91
233_F	240_L	1.020	0.90
221_D	226_L	1.020	0.90
375_I	379_N	1.010	0.90
126_K	183_N	1.008	0.90
237_L	241_Y	1.005	0.90
170_Y	174_M	1.005	0.90
194_L	381_T	0.994	0.89
62_I	66_V	0.992	0.89
195_E	256_C	0.991	0.89
135_L	139_M	0.983	0.89
234_F	238_G	0.979	0.89
175_G	179_V	0.967	0.88
207_I	211_L	0.963	0.88
198_Q	283_Q	0.962	0.88
121_L	227_Y	0.961	0.88
64_G	258_F	0.956	0.87
146_G	150_I	0.948	0.87
50_T	53_Q	0.940	0.86
186_N	253_D	0.939	0.86
22_G	234_F	0.934	0.86
275_T	278_L	0.926	0.86
155_P	160_L	0.926	0.86
114_F	118_V	0.910	0.85
393_A	397_S	0.906	0.84
134_S	175_G	0.901	0.84
101_G	105_A	0.895	0.84
205_S	279_F	0.891	0.83
282_P	395_T	0.889	0.83
26_T	30_I	0.883	0.83
45_Q	48_N	0.882	0.83
378_R	382_L	0.872	0.82
200_L	237_L	0.871	0.82
167_G	170_Y	0.870	0.82
111_F	114_F	0.869	0.82
44_G	47_L	0.868	0.82
130_P	192_N	0.862	0.81
71_L	277_L	0.862	0.81
164_L	169_L	0.857	0.81
65_A	139_M	0.854	0.81
34_R	249_V	0.848	0.80
364_L	372_L	0.843	0.80
109_M	133_A	0.842	0.80
251_V	256_C	0.839	0.79
151_V	154_K	0.837	0.79
34_R	242_H	0.835	0.79
105_A	258_F	0.834	0.79
48_N	51_S	0.826	0.78
66_V	69_I	0.822	0.78
266_V	272_F	0.821	0.78
131_T	179_V	0.820	0.78
181_C	267_G	0.813	0.77
129_L	212_V	0.808	0.77
208_V	212_V	0.808	0.77
106_I	265_G	0.806	0.77
36_H	40_A	0.802	0.76
45_Q	49_K	0.798	0.76
182_T	257_Y	0.795	0.76
42_L	58_S	0.794	0.76
164_L	167_G	0.788	0.75
212_V	220_D	0.786	0.75
63_S	255_F	0.783	0.75
57_E	254_T	0.781	0.74
236_T	239_L	0.776	0.74
24_V	28_T	0.774	0.74
177_L	180_F	0.771	0.73
130_P	187_I	0.769	0.73
30_I	228_F	0.769	0.73
203_S	236_T	0.768	0.73
59_Q	249_V	0.761	0.72
137_L	265_G	0.759	0.72
188_L	289_Y	0.750	0.71
35_G	201_V	0.750	0.71
210_N	226_L	0.750	0.71
44_G	48_N	0.747	0.71
153_P	170_Y	0.747	0.71
112_L	128_L	0.744	0.71
383_L	387_L	0.744	0.71
127_L	184_A	0.742	0.71
152_V	155_P	0.736	0.70
201_V	396_F	0.735	0.70
67_F	71_L	0.735	0.70
371_V	376_H	0.735	0.70
282_P	388_Q	0.732	0.70
185_I	259_A	0.732	0.70
37_F	57_E	0.730	0.69
279_F	391_G	0.729	0.69
130_P	183_N	0.727	0.69
130_P	257_Y	0.722	0.68
251_V	255_F	0.721	0.68
204_A	230_I	0.720	0.68
253_D	257_Y	0.718	0.68
25_A	35_G	0.718	0.68
182_T	187_I	0.717	0.68
95_E	98_A	0.717	0.68
142_F	146_G	0.716	0.68
160_L	164_L	0.715	0.68
57_E	195_E	0.713	0.68
101_G	142_F	0.713	0.68
182_T	261_M	0.711	0.67
137_L	141_Y	0.710	0.67
19_S	69_I	0.706	0.67
224_F	266_V	0.703	0.66
187_I	192_N	0.703	0.66
208_V	227_Y	0.702	0.66
174_M	178_A	0.701	0.66
235_T	238_G	0.700	0.66
205_S	229_M	0.700	0.66
192_N	257_Y	0.699	0.66
387_L	391_G	0.698	0.66
61_V	254_T	0.696	0.66
46_D	250_F	0.693	0.65
185_I	195_E	0.693	0.65
26_T	31_P	0.688	0.65
67_F	194_L	0.685	0.64
200_L	204_A	0.681	0.64
141_Y	146_G	0.679	0.64
41_R	52_R	0.679	0.64
364_L	384_L	0.678	0.64
392_S	396_F	0.673	0.63
71_L	231_P	0.673	0.63
74_F	257_Y	0.672	0.63
63_S	235_T	0.669	0.63
227_Y	235_T	0.669	0.63
110_I	114_F	0.669	0.63
196_A	244_W	0.668	0.62
189_A	255_F	0.667	0.62
254_T	258_F	0.666	0.62
30_I	34_R	0.658	0.61
30_I	197_G	0.657	0.61
170_Y	273_S	0.654	0.61
98_A	115_A	0.653	0.61
182_T	264_A	0.651	0.60
56_P	60_G	0.651	0.60
196_A	199_S	0.639	0.59
123_W	126_K	0.639	0.59
195_E	249_V	0.637	0.59
174_M	177_L	0.637	0.59
391_G	394_I	0.636	0.59
126_K	254_T	0.635	0.59
188_L	387_L	0.634	0.58
123_W	295_L	0.631	0.58
18_V	104_L	0.630	0.58
23_F	27_V	0.630	0.58
27_V	31_P	0.630	0.58
138_L	175_G	0.629	0.58
40_A	58_S	0.629	0.58
114_F	254_T	0.625	0.57
109_M	130_P	0.625	0.57
178_A	181_C	0.625	0.57
127_L	179_V	0.623	0.57
15_N	25_A	0.622	0.57
252_G	260_G	0.621	0.57
102_A	106_I	0.621	0.57
62_I	263_F	0.620	0.57
23_F	237_L	0.620	0.57
22_G	36_H	0.619	0.57
71_L	228_F	0.615	0.56
18_V	73_C	0.611	0.56
368_L	372_L	0.611	0.56
129_L	247_S	0.609	0.55
73_C	375_I	0.608	0.55
127_L	131_T	0.607	0.55
149_T	161_G	0.607	0.55
114_F	233_F	0.606	0.55
364_L	371_V	0.602	0.55
123_W	187_I	0.598	0.54
21_L	95_E	0.596	0.54
17_I	21_L	0.594	0.54
112_L	133_A	0.593	0.53
238_G	241_Y	0.592	0.53
206_I	262_T	0.588	0.53
155_P	161_G	0.587	0.53
250_F	380_L	0.586	0.53
122_R	394_I	0.585	0.52
127_L	183_N	0.580	0.52
151_V	155_P	0.580	0.52
135_L	245_Y	0.578	0.52
167_G	172_V	0.576	0.51
230_I	304_R	0.575	0.51
65_A	110_I	0.573	0.51
192_N	245_Y	0.571	0.51
15_N	19_S	0.571	0.51
314_K	374_P	0.571	0.51
37_F	259_A	0.567	0.50
50_T	250_F	0.567	0.50
38_I	43_C	0.567	0.50
267_G	273_S	0.567	0.50
129_L	178_A	0.566	0.50
124_R	249_V	0.566	0.50
196_A	313_G	0.565	0.50
147_N	150_I	0.564	0.50
12_L	152_V	0.563	0.50
206_I	210_N	0.563	0.50
264_A	267_G	0.562	0.50
115_A	118_V	0.562	0.50
19_S	22_G	0.561	0.50
30_I	62_I	0.558	0.49
182_T	262_T	0.558	0.49
248_R	268_I	0.557	0.49
192_N	195_E	0.556	0.49
113_G	126_K	0.556	0.49
222_H	225_S	0.555	0.49
268_I	272_F	0.554	0.49
185_I	257_Y	0.553	0.49
376_H	380_L	0.551	0.48
120_N	125_H	0.550	0.48
112_L	203_S	0.549	0.48
262_T	389_I	0.549	0.48
122_R	126_K	0.549	0.48
18_V	103_L	0.548	0.48
68_L	103_L	0.545	0.48
68_L	107_C	0.545	0.48
380_L	388_Q	0.544	0.47
208_V	396_F	0.544	0.47
101_G	164_L	0.543	0.47
150_I	166_L	0.542	0.47
278_L	282_P	0.541	0.47
21_L	73_C	0.539	0.47
28_T	394_I	0.538	0.47
277_L	397_S	0.538	0.47
210_N	272_F	0.538	0.47
201_V	392_S	0.535	0.46
364_L	387_L	0.534	0.46
63_S	239_L	0.533	0.46
239_L	255_F	0.532	0.46
203_S	207_I	0.532	0.46
70_I	73_C	0.532	0.46
38_I	56_P	0.532	0.46
231_P	235_T	0.531	0.46
233_F	393_A	0.529	0.46
244_W	266_V	0.527	0.45
240_L	246_P	0.527	0.45
203_S	263_F	0.526	0.45
202_I	392_S	0.526	0.45
153_P	167_G	0.525	0.45
240_L	243_N	0.525	0.45
194_L	247_S	0.524	0.45
61_V	263_F	0.522	0.45
71_L	99_L	0.522	0.45
392_S	395_T	0.521	0.45
390_L	394_I	0.521	0.45
27_V	30_I	0.521	0.45
102_A	228_F	0.521	0.45
149_T	163_H	0.518	0.44
107_C	204_A	0.516	0.44
34_R	56_P	0.516	0.44
229_M	232_F	0.516	0.44
21_L	80_L	0.515	0.44
194_L	197_G	0.514	0.44
146_G	170_Y	0.513	0.44
48_N	192_N	0.512	0.44
386_L	390_L	0.512	0.44
264_A	268_I	0.509	0.43
263_F	282_P	0.508	0.43
193_G	246_P	0.507	0.43
192_N	377_E	0.506	0.43
152_V	176_L	0.504	0.43
16_L	51_S	0.503	0.42
147_N	393_A	0.503	0.42
172_V	176_L	0.503	0.42
184_A	232_F	0.501	0.42
288_L	390_L	0.501	0.42
244_W	373_G	0.501	0.42
108_C	112_L	0.500	0.42

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
5ckr_A	1	0.7604	100	0.516	Contact Map
2ls4_A	1	0.0587	10.6	0.976	Contact Map
4hw9_A	1	0.0611	5.6	0.979	Contact Map
3sya_A	1	0.1687	4.4	0.98	Contact Map
4dx5_A	1	0.1271	4.2	0.98	Contact Map
2i68_A	1	0.1883	3.9	0.98	Contact Map
4j7c_I	1	0.0831	3.4	0.981	Contact Map
3spc_A	1	0.1614	3.2	0.981	Contact Map
3w9i_A	1	0.1027	2.6	0.982	Contact Map
2kv5_A	1	0.0807	2.3	0.982	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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