GREMLIN Database
T0944_1_277 - T0944 1-277
ID: 117 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 277 (225)
Sequences: 2666 (1917)
Seq/√Len: 127.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
102_V198_I4.4261.00
41_S262_N4.2301.00
50_S195_Y3.7711.00
52_V73_M3.4591.00
179_I196_T3.4281.00
111_P181_D3.3921.00
18_C175_T2.9831.00
122_A176_M2.7761.00
218_D222_A2.7601.00
255_V263_T2.7131.00
138_Q251_A2.6531.00
144_F147_I2.5881.00
143_Y248_T2.5461.00
17_A223_V2.5431.00
78_V192_L2.2961.00
124_G141_F2.2891.00
47_Q92_F2.1591.00
7_C44_K2.1491.00
44_K50_S2.1141.00
147_I172_R2.0921.00
6_S141_F2.0221.00
54_L71_A2.0081.00
99_S198_I1.9661.00
116_R181_D1.9391.00
142_I209_I1.9391.00
255_V266_C1.9091.00
51_P70_I1.8981.00
176_M197_I1.8961.00
136_Q254_S1.8781.00
142_I206_L1.7661.00
143_Y250_H1.7581.00
9_L123_D1.7531.00
265_E268_A1.7501.00
182_C193_Y1.7321.00
119_V175_T1.7161.00
103_M238_L1.6951.00
202_S211_H1.6891.00
41_S48_S1.6811.00
120_V195_Y1.6471.00
187_E190_D1.6461.00
205_G247_I1.6221.00
144_F247_I1.5941.00
132_Q136_Q1.5641.00
174_L247_I1.5411.00
94_T107_S1.5401.00
255_V265_E1.5261.00
119_V223_V1.4961.00
54_L193_Y1.4711.00
142_I249_F1.4671.00
50_S120_V1.4651.00
88_S92_F1.4501.00
141_F250_H1.4461.00
82_F90_L1.4131.00
145_P248_T1.4071.00
99_S241_I1.4051.00
125_F203_C1.4001.00
54_L73_M1.3821.00
253_S257_N1.3801.00
52_V195_Y1.3651.00
41_S44_K1.3641.00
5_T50_S1.3471.00
144_F174_L1.3461.00
216_I247_I1.3341.00
182_C191_V1.3061.00
52_V120_V1.3011.00
7_C51_P1.2861.00
94_T108_F1.2831.00
240_L243_P1.2821.00
144_F172_R1.2751.00
112_L237_A1.2751.00
110_V113_G1.2721.00
119_V217_L1.2691.00
111_P116_R1.2641.00
78_V87_P1.2461.00
71_A193_Y1.2251.00
118_C178_G1.2210.99
55_S68_R1.2170.99
21_Q67_E1.2000.99
131_C136_Q1.1970.99
74_R87_P1.1920.99
5_T51_P1.1920.99
80_S110_V1.1910.99
174_L223_V1.1890.99
14_L121_L1.1880.99
204_K207_S1.1790.99
228_D231_E1.1720.99
110_V114_K1.1690.99
106_R109_K1.1660.99
17_A172_R1.1640.99
102_V112_L1.1580.99
185_P190_D1.1530.99
225_K231_E1.1510.99
209_I249_F1.1510.99
73_M193_Y1.1330.99
45_S259_S1.1140.99
84_E88_S1.1130.99
74_R194_S1.1040.99
184_E191_V1.1010.99
11_R15_T1.1000.99
203_C243_P1.0950.99
141_F267_L1.0870.99
68_R224_S1.0850.99
82_F91_Q1.0830.99
90_L93_N1.0810.99
200_V215_A1.0740.99
132_Q135_N1.0720.99
225_K239_K1.0700.99
185_P191_V1.0630.99
125_F206_L1.0590.99
5_T122_A1.0420.98
129_Q208_D1.0330.98
47_Q259_S1.0290.98
120_V178_G1.0260.98
15_T20_Y1.0190.98
103_M112_L1.0130.98
138_Q270_V1.0090.98
254_S257_N0.9940.98
54_L69_I0.9890.98
5_T195_Y0.9820.98
129_Q140_Y0.9740.97
43_N128_W0.9730.97
9_L173_L0.9630.97
263_T266_C0.9620.97
13_V16_R0.9570.97
201_D211_H0.9540.97
120_V197_I0.9490.97
200_V243_P0.9460.97
110_V181_D0.9450.97
203_C208_D0.9440.97
175_T223_V0.9400.97
233_S236_E0.9180.96
10_P13_V0.9150.96
222_A225_K0.9070.96
248_T269_P0.9070.96
91_Q94_T0.9030.96
87_P192_L0.8950.96
84_E93_N0.8940.96
202_S205_G0.8920.96
80_S181_D0.8920.96
9_L13_V0.8910.96
38_Y72_P0.8890.96
1_M4_R0.8860.96
90_L94_T0.8860.96
130_R137_R0.8820.95
112_L238_L0.8810.95
143_Y171_W0.8750.95
225_K236_E0.8740.95
51_P72_P0.8680.95
77_L181_D0.8640.95
206_L209_I0.8580.95
250_H269_P0.8480.94
116_R180_F0.8400.94
20_Y70_I0.8400.94
253_S261_N0.8390.94
219_G223_V0.8390.94
84_E90_L0.8360.94
127_E210_H0.8320.94
56_R69_I0.8320.94
8_H123_D0.8320.94
261_N266_C0.8300.94
94_T111_P0.8270.94
121_L195_Y0.8270.94
82_F93_N0.8180.93
131_C135_N0.8110.93
205_G208_D0.8040.93
38_Y51_P0.8030.93
125_F205_G0.8020.93
9_L14_L0.7940.92
252_V256_V0.7940.92
102_V238_L0.7910.92
185_P188_G0.7850.92
78_V91_Q0.7830.92
95_T259_S0.7770.91
130_R211_H0.7750.91
94_T196_T0.7650.91
133_G136_Q0.7590.90
5_T197_I0.7580.90
100_D201_D0.7580.90
6_S267_L0.7570.90
18_C53_L0.7520.90
204_K244_T0.7470.90
49_N74_R0.7470.90
198_I215_A0.7460.90
222_A242_H0.7450.90
264_P268_A0.7420.89
177_A215_A0.7400.89
4_R128_W0.7370.89
18_C223_V0.7330.89
14_L173_L0.7300.89
129_Q138_Q0.7270.88
125_F208_D0.7230.88
144_F173_L0.7220.88
7_C41_S0.7200.88
180_F193_Y0.7160.88
205_G249_F0.7150.88
261_N265_E0.7150.88
252_V267_L0.7110.87
46_P128_W0.7050.87
84_E91_Q0.7020.87
6_S124_G0.7020.87
95_T257_N0.7010.87
4_R43_N0.6990.86
206_L249_F0.6980.86
218_D246_N0.6980.86
94_T98_R0.6880.85
103_M113_G0.6860.85
232_V237_A0.6850.85
201_D207_S0.6790.85
218_D223_V0.6770.85
54_L182_C0.6760.84
205_G245_E0.6760.84
112_L241_I0.6730.84
102_V179_I0.6710.84
56_R67_E0.6680.84
77_L94_T0.6640.83
101_T105_K0.6630.83
77_L196_T0.6630.83
8_H141_F0.6600.83
99_S200_V0.6530.82
203_C247_I0.6520.82
104_E107_S0.6520.82
202_S207_S0.6490.82
54_L180_F0.6440.82
78_V194_S0.6440.82
118_C180_F0.6430.81
215_A237_A0.6410.81
45_S48_S0.6350.81
87_P194_S0.6350.81
73_M195_Y0.6340.81
110_V116_R0.6330.80
3_G46_P0.6330.80
123_D141_F0.6300.80
236_E239_K0.6280.80
3_G128_W0.6270.80
53_L119_V0.6220.79
222_A240_L0.6220.79
252_V266_C0.6180.79
49_N72_P0.6180.79
43_N46_P0.6170.79
200_V213_M0.6130.78
130_R254_S0.6130.78
121_L173_L0.6130.78
15_T22_D0.6120.78
93_N199_T0.6090.78
217_L223_V0.6090.78
244_T247_I0.6070.78
251_A270_V0.6060.77
6_S266_C0.6060.77
126_Y266_C0.6050.77
203_C213_M0.6040.77
22_D36_D0.6030.77
124_G143_Y0.6010.77
80_S116_R0.6000.77
77_L111_P0.5970.76
45_S95_T0.5960.76
255_V261_N0.5960.76
5_T176_M0.5960.76
225_K228_D0.5880.75
186_P189_G0.5870.75
204_K208_D0.5860.75
23_R70_I0.5840.75
125_F216_I0.5840.75
106_R111_P0.5830.75
94_T199_T0.5820.75
201_D242_H0.5800.74
184_E190_D0.5790.74
119_V174_L0.5760.74
202_S249_F0.5740.74
97_C196_T0.5720.73
15_T23_R0.5700.73
53_L121_L0.5700.73
3_G43_N0.5680.73
15_T21_Q0.5660.73
3_G95_T0.5650.72
8_H38_Y0.5630.72
215_A243_P0.5600.72
137_R254_S0.5580.72
20_Y68_R0.5570.71
208_D249_F0.5560.71
203_C216_I0.5560.71
114_K232_V0.5550.71
80_S83_K0.5530.71
96_N210_H0.5500.70
130_R135_N0.5490.70
4_R46_P0.5490.70
84_E194_S0.5490.70
114_K181_D0.5460.70
137_R258_N0.5450.70
69_I193_Y0.5450.70
131_C138_Q0.5420.69
90_L196_T0.5420.69
250_H267_L0.5420.69
171_W248_T0.5410.69
84_E95_T0.5400.69
80_S107_S0.5400.69
144_F246_N0.5390.69
51_P195_Y0.5390.69
184_E193_Y0.5380.69
123_D180_F0.5380.69
178_G196_T0.5370.69
57_L66_S0.5310.68
234_T239_K0.5290.67
46_P97_C0.5290.67
228_D233_S0.5260.67
55_S138_Q0.5260.67
55_S66_S0.5250.67
144_F216_I0.5240.67
139_P173_L0.5220.66
126_Y205_G0.5210.66
198_I225_K0.5200.66
12_D16_R0.5200.66
213_M243_P0.5190.66
187_E270_V0.5170.66
74_R192_L0.5170.66
254_S261_N0.5150.65
76_G95_T0.5150.65
139_P254_S0.5130.65
6_S126_Y0.5130.65
130_R136_Q0.5130.65
75_W97_C0.5120.65
52_V71_A0.5120.65
113_G137_R0.5110.65
200_V203_C0.5100.65
12_D15_T0.5090.65
94_T105_K0.5090.65
113_G232_V0.5080.64
203_C244_T0.5070.64
259_S266_C0.5070.64
220_E268_A0.5070.64
251_A269_P0.5060.64
92_F199_T0.5060.64
138_Q257_N0.5050.64
183_W186_P0.5050.64
8_H11_R0.5020.63
205_G211_H0.5010.63
174_L216_I0.5010.63
87_P228_D0.5000.63
19_A68_R0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2icu_A 1 0.7437 100 0.227 Contact Map
2bdv_A 1 0.7437 100 0.228 Contact Map
2f20_A 1 0.8123 100 0.237 Contact Map
2aeg_A 1 0.7365 100 0.278 Contact Map
1zn6_A 1 0.7148 100 0.31 Contact Map
2jd3_A 1 0.3249 23.7 0.963 Contact Map
5dgg_A 1 0.1877 5.8 0.972 Contact Map
2ovr_B 1 0.2491 4.6 0.973 Contact Map
2b3g_B 1 0.0866 4.5 0.973 Contact Map
3epw_A 1 0.2058 4.1 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0078 seconds.