GREMLIN Database
T0942_c90_1_487 - T0942_c90 1-487
ID: 116 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 487 (469)
Sequences: 1681 (1202)
Seq/√Len: 55.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
391_Q394_E5.1961.00
324_K327_E5.0311.00
434_A450_L4.9311.00
194_I197_T4.8051.00
125_D228_K4.7641.00
272_E276_L4.7501.00
358_K361_E4.4301.00
382_L386_Y3.8251.00
293_T297_L3.6241.00
435_E470_R3.5861.00
191_Q195_S3.3981.00
103_E117_H3.3561.00
276_L279_A3.3441.00
223_P256_A3.3281.00
132_S221_A3.2841.00
56_Y109_F3.2081.00
272_E275_Y3.1551.00
447_I471_I3.0651.00
86_H215_S2.9611.00
270_S274_F2.9551.00
294_S297_L2.9381.00
139_S211_V2.9301.00
297_L301_A2.8841.00
76_I98_L2.8321.00
249_P253_L2.7321.00
80_G96_F2.7071.00
329_R353_D2.6811.00
319_A327_E2.6321.00
274_F279_A2.5841.00
461_S465_A2.5791.00
116_L134_M2.4761.00
129_Q228_K2.4381.00
241_E251_S2.3631.00
312_Q331_T2.2911.00
275_Y279_A2.2821.00
72_L275_Y2.2751.00
239_P244_L2.2621.00
353_D365_R2.2311.00
363_I382_L2.2271.00
163_G185_T2.2191.00
79_L217_F2.1801.00
329_R356_Q2.1691.00
135_A212_L2.1601.00
272_E279_A2.1521.00
315_R319_A2.0841.00
190_R193_M2.0351.00
271_S274_F1.9951.00
124_S272_E1.9751.00
24_P27_A1.9741.00
354_L385_A1.9531.00
126_N129_Q1.9251.00
454_S468_D1.9081.00
370_R378_L1.9041.00
50_M54_D1.8801.00
269_Q272_E1.8450.99
167_S182_L1.8020.99
101_N117_H1.7940.99
272_E277_A1.7930.99
97_F115_V1.7910.99
438_A477_L1.7860.99
38_T41_G1.7850.99
196_F200_N1.7770.99
223_P260_A1.7750.99
319_A331_T1.7740.99
392_P419_A1.7700.99
425_N428_Q1.7650.99
129_Q224_T1.7560.99
277_A280_R1.7550.99
369_A378_L1.7260.99
339_E345_Y1.7220.99
54_D113_N1.7140.99
72_L98_L1.7140.99
447_I474_L1.7120.99
430_L452_S1.7110.99
94_F142_T1.6970.99
451_S475_R1.6810.99
309_R338_A1.6630.99
278_K282_L1.6480.99
202_Q251_S1.6450.99
431_A466_R1.6310.99
319_A324_K1.6270.99
139_S142_T1.6260.99
39_S151_E1.6180.98
274_F283_G1.6160.98
67_I118_S1.5970.98
104_I123_Y1.5920.98
294_S298_D1.5800.98
273_D276_L1.5780.98
57_V113_N1.5730.98
163_G167_S1.5520.98
320_M325_Y1.5510.98
128_S221_A1.5430.98
276_L283_G1.5410.98
76_I96_F1.5120.98
274_F277_A1.5040.98
179_M183_T1.5020.98
131_A212_L1.4990.98
159_L163_G1.4830.97
167_S181_A1.4830.97
329_R333_Q1.4830.97
396_A420_E1.4730.97
50_M113_N1.4690.97
290_N293_T1.4670.97
180_A184_G1.4490.97
349_A353_D1.4420.97
227_E257_R1.4340.97
57_V61_R1.4300.97
336_L349_A1.4020.96
276_L280_R1.3800.96
238_R244_L1.3750.96
387_L419_A1.3710.96
197_T200_N1.3680.96
367_K382_L1.3640.96
438_A474_L1.3580.96
162_V178_G1.3540.95
14_I17_M1.3500.95
363_I385_A1.3490.95
186_L190_R1.3430.95
209_I256_A1.3360.95
199_Q202_Q1.3350.95
121_F130_L1.3300.95
406_N409_D1.3290.95
403_T412_G1.3190.95
413_W432_A1.3160.95
114_V138_I1.3090.95
367_K394_E1.3050.94
305_V308_Q1.2930.94
272_E281_T1.2910.94
79_L130_L1.2880.94
98_L121_F1.2860.94
442_R445_Q1.2840.94
350_T366_L1.2820.94
176_Q179_M1.2770.94
83_L138_I1.2700.94
37_G148_R1.2660.93
396_A416_L1.2640.93
156_S159_L1.2580.93
148_R203_E1.2550.93
49_E144_R1.2540.93
430_L449_L1.2530.93
19_I24_P1.2450.93
76_I116_L1.2440.93
444_D478_Q1.2420.93
97_F113_N1.2410.93
353_D361_E1.2400.93
309_R345_Y1.2380.93
202_Q255_D1.2290.92
470_R474_L1.2270.92
271_S276_L1.2010.92
209_I260_A1.2010.92
279_A283_G1.1980.91
72_L279_A1.1910.91
87_A90_V1.1890.91
216_G248_L1.1800.91
124_S130_L1.1750.91
297_L300_W1.1720.91
333_Q337_A1.1670.90
450_L467_Y1.1660.90
460_G465_A1.1620.90
152_D155_R1.1600.90
83_L211_V1.1580.90
62_G221_A1.1560.90
276_L281_T1.1550.90
149_A200_N1.1530.90
138_I141_V1.1520.90
290_N294_S1.1520.90
80_G225_F1.1480.90
56_Y60_L1.1480.90
209_I213_Q1.1480.90
57_V97_F1.1460.90
71_L351_D1.1460.90
109_F146_L1.1370.89
420_E425_N1.1360.89
349_A352_I1.1350.89
23_A26_F1.1340.89
351_D381_N1.1320.89
385_A389_G1.1320.89
382_L398_I1.1270.89
276_L290_N1.1180.88
392_P422_A1.1180.88
317_L348_L1.1160.88
13_L17_M1.1150.88
363_I389_G1.1120.88
331_T334_P1.1060.88
475_R478_Q1.1040.88
403_T416_L1.1040.88
339_E342_N1.0980.87
275_Y344_W1.0980.87
387_L392_P1.0970.87
220_Q261_N1.0970.87
56_Y64_A1.0930.87
366_L381_N1.0850.87
289_R293_T1.0840.87
269_Q275_Y1.0820.87
313_Y317_L1.0760.86
213_Q263_M1.0750.86
329_R352_I1.0650.86
333_Q349_A1.0640.86
12_T15_A1.0630.86
386_Y394_E1.0590.85
421_A429_E1.0550.85
107_F115_V1.0540.85
166_G170_L1.0500.85
79_L83_L1.0430.85
50_M93_P1.0420.84
256_A260_A1.0410.84
332_L348_L1.0400.84
191_Q197_T1.0330.84
272_E283_G1.0330.84
384_N415_L1.0310.84
348_L352_I1.0250.84
191_Q194_I1.0230.83
273_D279_A1.0230.83
293_T296_L1.0190.83
27_A30_A1.0120.83
175_P178_G1.0120.83
248_L256_A1.0120.83
96_F225_F1.0110.83
171_A177_A1.0050.82
376_P409_D1.0050.82
298_D302_K1.0030.82
274_F345_Y1.0030.82
318_Q322_A1.0030.82
174_S177_A1.0020.82
320_M355_G0.9960.82
188_G229_L0.9940.82
383_A399_L0.9910.81
320_M352_I0.9870.81
325_Y352_I0.9790.81
167_S171_A0.9770.80
72_L277_A0.9730.80
213_Q219_P0.9720.80
271_S275_Y0.9690.80
276_L285_Y0.9670.80
206_R255_D0.9630.79
281_T284_M0.9630.79
135_A215_S0.9620.79
400_N420_E0.9620.79
132_S222_M0.9580.79
276_L287_S0.9570.79
147_A432_A0.9560.79
229_L233_A0.9490.78
158_P161_W0.9460.78
13_L16_A0.9440.78
460_G463_Q0.9400.78
453_A467_Y0.9390.78
276_L284_M0.9390.78
96_F138_I0.9360.78
175_P183_T0.9320.77
415_L419_A0.9310.77
125_D129_Q0.9290.77
150_M153_Q0.9260.77
167_S185_T0.9230.77
346_L369_A0.9210.76
316_A320_M0.9200.76
109_F113_N0.9190.76
470_R473_Q0.9180.76
177_A181_A0.9170.76
238_R250_E0.9160.76
274_F280_R0.9130.76
314_G318_Q0.9110.76
296_L300_W0.9110.76
162_V254_A0.9090.75
15_A18_T0.9070.75
115_V226_L0.9070.75
360_N391_Q0.9070.75
224_T229_L0.9060.75
447_I478_Q0.9030.75
116_L249_P0.8980.75
353_D356_Q0.8950.74
169_L194_I0.8930.74
384_N388_Q0.8930.74
329_R349_A0.8910.74
124_S196_F0.8890.74
387_L415_L0.8880.74
223_P255_D0.8830.73
133_V259_R0.8830.73
80_G138_I0.8800.73
230_L253_L0.8800.73
312_Q334_P0.8730.72
289_R294_S0.8720.72
403_T413_W0.8600.71
39_S163_G0.8560.71
478_Q482_K0.8540.71
471_I475_R0.8530.71
342_N345_Y0.8500.70
48_Q51_Q0.8480.70
297_L314_G0.8480.70
320_M348_L0.8470.70
230_L249_P0.8460.70
52_M55_Y0.8460.70
170_L185_T0.8450.70
273_D277_A0.8450.70
74_Q207_I0.8420.70
398_I402_Y0.8410.70
349_A365_R0.8410.70
57_V60_L0.8380.69
153_Q157_A0.8360.69
478_Q481_F0.8350.69
84_V94_F0.8330.69
241_E244_L0.8300.69
167_S178_G0.8280.68
353_D358_K0.8280.68
430_L453_A0.8270.68
71_L377_V0.8270.68
248_L253_L0.8270.68
275_Y281_T0.8270.68
272_E285_Y0.8270.68
379_Q398_I0.8250.68
99_I207_I0.8210.68
58_R62_G0.8190.68
379_Q402_Y0.8150.67
359_A385_A0.8140.67
434_A441_G0.8120.67
287_S291_Q0.8120.67
270_S275_Y0.8120.67
185_T382_L0.8100.67
291_Q294_S0.8090.67
449_L452_S0.8090.67
471_I474_L0.8090.67
463_Q466_R0.8080.66
308_Q311_A0.8070.66
316_A348_L0.8070.66
417_A471_I0.8020.66
194_I200_N0.8020.66
89_S142_T0.8000.66
274_F285_Y0.7990.66
363_I386_Y0.7960.65
281_T304_N0.7960.65
126_N228_K0.7950.65
466_R471_I0.7930.65
414_D418_Q0.7910.65
80_G94_F0.7910.65
465_A472_D0.7910.65
287_S290_N0.7870.64
334_P337_A0.7860.64
139_S200_N0.7830.64
88_N214_R0.7810.64
74_Q375_N0.7800.64
469_A473_Q0.7800.64
53_G113_N0.7770.63
186_L189_T0.7760.63
263_M357_N0.7760.63
450_L454_S0.7750.63
237_S244_L0.7740.63
304_N308_Q0.7720.63
277_A281_T0.7710.63
183_T186_L0.7700.63
351_D354_L0.7680.63
100_N215_S0.7640.62
17_M190_R0.7640.62
276_L286_N0.7630.62
427_D467_Y0.7620.62
245_T390_G0.7600.62
14_I26_F0.7570.61
160_T189_T0.7540.61
71_L278_K0.7540.61
135_A222_M0.7500.61
75_Y79_L0.7480.60
279_A285_Y0.7480.60
312_Q338_A0.7470.60
382_L458_K0.7470.60
361_E364_N0.7460.60
215_S230_L0.7420.60
131_A259_R0.7410.60
54_D93_P0.7400.60
86_H211_V0.7400.60
95_H113_N0.7400.60
420_E432_A0.7350.59
134_M211_V0.7340.59
113_N146_L0.7340.59
326_D330_K0.7330.59
376_P402_Y0.7330.59
270_S276_L0.7320.59
352_I356_Q0.7320.59
400_N416_L0.7310.59
141_V146_L0.7290.58
364_N371_D0.7250.58
132_S223_P0.7250.58
226_L256_A0.7250.58
310_A314_G0.7240.58
476_Q480_R0.7230.58
368_N371_D0.7230.58
79_L134_M0.7210.58
75_Y417_A0.7200.58
50_M95_H0.7190.57
128_S225_F0.7190.57
80_G114_V0.7190.57
420_E428_Q0.7140.57
67_I98_L0.7130.57
146_L196_F0.7100.56
376_P406_N0.7100.56
97_F109_F0.7100.56
90_V188_G0.7090.56
275_Y290_N0.7060.56
215_S221_A0.7060.56
473_Q477_L0.7050.56
94_F212_L0.7040.56
209_I263_M0.7030.56
347_D381_N0.7020.56
89_S375_N0.7010.56
185_T189_T0.7010.56
300_W303_G0.7000.55
160_T188_G0.6980.55
111_G144_R0.6970.55
298_D301_A0.6950.55
165_L168_I0.6930.55
73_T76_I0.6930.55
184_G188_G0.6910.54
312_Q335_L0.6910.54
52_M478_Q0.6900.54
291_Q297_L0.6890.54
465_A470_R0.6870.54
132_S170_L0.6860.54
335_L345_Y0.6850.54
209_I242_I0.6850.54
359_A363_I0.6850.54
279_A286_N0.6850.54
74_Q86_H0.6840.54
438_A447_I0.6840.54
277_A290_N0.6820.53
12_T16_A0.6820.53
386_Y391_Q0.6810.53
380_L412_G0.6810.53
387_L395_A0.6810.53
215_S337_A0.6800.53
101_N206_R0.6800.53
36_M172_M0.6800.53
195_S242_I0.6790.53
372_L392_P0.6760.53
42_S114_V0.6750.53
220_Q260_A0.6750.53
211_V256_A0.6740.53
431_A467_Y0.6740.53
116_L150_M0.6730.53
90_V366_L0.6680.52
60_L113_N0.6640.52
161_W165_L0.6640.52
360_N371_D0.6630.51
250_E419_A0.6630.51
242_I256_A0.6620.51
292_L295_D0.6610.51
450_L474_L0.6610.51
418_Q422_A0.6600.51
325_Y356_Q0.6590.51
269_Q276_L0.6580.51
80_G413_W0.6580.51
16_A23_A0.6580.51
364_N367_K0.6570.51
129_Q244_L0.6570.51
139_S256_A0.6550.51
367_K391_Q0.6520.50
56_Y146_L0.6510.50
377_V417_A0.6510.50
240_P244_L0.6510.50
99_I109_F0.6510.50
279_A290_N0.6500.50
197_T202_Q0.6490.50
427_D459_L0.6480.50
163_G187_A0.6480.50
272_E284_M0.6470.50
101_N445_Q0.6460.50
315_R461_S0.6450.49
156_S219_P0.6450.49
57_V109_F0.6450.49
413_W416_L0.6450.49
80_G97_F0.6440.49
197_T413_W0.6430.49
71_L153_Q0.6430.49
240_P251_S0.6420.49
233_A236_S0.6420.49
245_T329_R0.6400.49
36_M306_R0.6390.49
161_W460_G0.6390.49
80_G146_L0.6380.49
251_S448_S0.6370.49
163_G377_V0.6360.49
295_D299_E0.6360.49
55_Y164_A0.6360.49
386_Y398_I0.6350.48
41_G44_L0.6340.48
96_F217_F0.6330.48
212_L343_A0.6330.48
433_R436_G0.6320.48
196_F443_L0.6320.48
277_A294_S0.6310.48
454_S467_Y0.6310.48
402_Y412_G0.6300.48
164_A480_R0.6290.48
60_L64_A0.6270.48
32_T354_L0.6270.48
181_A346_L0.6250.47
170_L231_D0.6250.47
277_A313_Y0.6230.47
120_L243_L0.6230.47
417_A433_R0.6230.47
118_S281_T0.6220.47
80_G141_V0.6220.47
350_T365_R0.6210.47
94_F138_I0.6210.47
207_I210_Q0.6210.47
222_M441_G0.6210.47
96_F127_E0.6200.47
80_G127_E0.6180.47
128_S271_S0.6170.46
286_N290_N0.6160.46
416_L432_A0.6160.46
72_L320_M0.6160.46
162_V222_M0.6160.46
271_S277_A0.6150.46
60_L99_I0.6150.46
420_E423_L0.6140.46
460_G471_I0.6140.46
118_S279_A0.6130.46
356_Q386_Y0.6130.46
52_M109_F0.6130.46
122_R279_A0.6120.46
360_N389_G0.6120.46
262_Q367_K0.6120.46
59_Q62_G0.6120.46
146_L150_M0.6110.46
35_D188_G0.6110.46
256_A441_G0.6110.46
51_Q480_R0.6100.46
117_H142_T0.6080.46
234_R243_L0.6080.46
335_L340_P0.6080.46
118_S332_L0.6070.45
170_L206_R0.6060.45
176_Q434_A0.6060.45
53_G61_R0.6060.45
292_L296_L0.6050.45
115_V465_A0.6020.45
222_M256_A0.6020.45
294_S301_A0.6010.45
193_M229_L0.6010.45
290_N297_L0.6000.45
60_L141_V0.6000.45
464_Q468_D0.6000.45
200_N259_R0.5980.44
58_R435_E0.5970.44
116_L395_A0.5970.44
160_T229_L0.5940.44
191_Q242_I0.5930.44
187_A200_N0.5920.44
61_R441_G0.5910.44
111_G242_I0.5910.44
65_P100_N0.5910.44
281_T317_L0.5910.44
86_H214_R0.5890.43
42_S45_S0.5880.43
460_G467_Y0.5880.43
164_A182_L0.5870.43
44_L138_I0.5870.43
138_I225_F0.5860.43
35_D398_I0.5850.43
414_D436_G0.5830.43
413_W438_A0.5830.43
394_E464_Q0.5820.43
468_D472_D0.5800.43
317_L320_M0.5790.42
38_T44_L0.5790.42
53_G132_S0.5790.42
157_A166_G0.5780.42
141_V274_F0.5780.42
77_N406_N0.5780.42
292_L297_L0.5770.42
394_E397_N0.5770.42
84_V138_I0.5770.42
52_M110_F0.5760.42
132_S248_L0.5760.42
431_A445_Q0.5740.42
147_A248_L0.5730.42
244_L250_E0.5720.42
99_I162_V0.5710.42
69_D278_K0.5700.41
89_S94_F0.5700.41
121_F382_L0.5690.41
344_W347_D0.5670.41
332_L349_A0.5670.41
280_R283_G0.5670.41
227_E231_D0.5650.41
80_G130_L0.5650.41
196_F248_L0.5650.41
418_Q437_Y0.5640.41
124_S153_Q0.5640.41
274_F289_R0.5630.41
16_A24_P0.5630.41
118_S130_L0.5610.41
109_F217_F0.5610.41
104_I222_M0.5610.41
242_I432_A0.5600.40
77_N408_D0.5590.40
290_N296_L0.5580.40
107_F110_F0.5580.40
192_G413_W0.5580.40
14_I371_D0.5570.40
110_F429_E0.5560.40
96_F141_V0.5560.40
40_A144_R0.5550.40
194_I256_A0.5550.40
342_N347_D0.5550.40
43_T182_L0.5540.40
99_I115_V0.5540.40
56_Y187_A0.5540.40
165_L406_N0.5530.40
130_L225_F0.5530.40
419_A424_N0.5530.40
183_T188_G0.5530.40
466_R470_R0.5530.40
59_Q466_R0.5510.39
276_L314_G0.5510.39
403_T469_A0.5510.39
350_T386_Y0.5510.39
123_Y232_Q0.5500.39
85_S138_I0.5500.39
300_W305_V0.5490.39
176_Q211_V0.5480.39
114_V192_G0.5480.39
280_R284_M0.5470.39
253_L383_A0.5470.39
366_L433_R0.5460.39
40_A115_V0.5450.39
279_A284_M0.5440.39
24_P337_A0.5440.39
436_G440_A0.5430.39
60_L173_A0.5430.39
431_A435_E0.5430.39
221_A248_L0.5420.39
396_A419_A0.5420.39
467_Y474_L0.5420.39
85_S314_G0.5400.38
396_A423_L0.5400.38
12_T22_V0.5400.38
117_H224_T0.5390.38
41_G144_R0.5380.38
160_T185_T0.5380.38
24_P182_L0.5370.38
293_T301_A0.5370.38
87_A234_R0.5350.38
409_D413_W0.5350.38
354_L359_A0.5340.38
56_Y257_R0.5310.37
357_N385_A0.5310.37
231_D234_R0.5300.37
139_S207_I0.5300.37
414_D437_Y0.5290.37
426_R429_E0.5290.37
272_E280_R0.5280.37
124_S226_L0.5280.37
80_G131_A0.5270.37
225_F396_A0.5260.37
293_T298_D0.5250.37
32_T473_Q0.5250.37
43_T150_M0.5230.37
448_S452_S0.5220.37
218_D224_T0.5220.37
310_A469_A0.5220.37
158_P450_L0.5220.37
443_L478_Q0.5210.36
167_S196_F0.5200.36
160_T420_E0.5200.36
80_G134_M0.5190.36
283_G286_N0.5180.36
279_A282_L0.5180.36
329_R371_D0.5180.36
418_Q443_L0.5160.36
143_Q259_R0.5150.36
44_L254_A0.5140.36
124_S212_L0.5140.36
414_D433_R0.5140.36
63_S66_L0.5140.36
49_E147_A0.5140.36
369_A373_R0.5130.36
331_T335_L0.5120.36
211_V471_I0.5120.36
76_I79_L0.5110.35
330_K333_Q0.5110.35
115_V196_F0.5110.35
211_V215_S0.5100.35
71_L128_S0.5090.35
149_A195_S0.5090.35
110_F166_G0.5080.35
72_L478_Q0.5070.35
332_L434_A0.5070.35
210_Q254_A0.5070.35
395_A418_Q0.5070.35
128_S217_F0.5060.35
343_A347_D0.5060.35
224_T228_K0.5060.35
200_N277_A0.5050.35
158_P162_V0.5050.35
65_P79_L0.5050.35
384_N418_Q0.5040.35
48_Q452_S0.5030.35
187_A431_A0.5020.35
132_S320_M0.5020.35
142_T175_P0.5020.35
187_A229_L0.5020.35
271_S290_N0.5010.34
142_T146_L0.5010.34
82_R217_F0.5010.34
361_E367_K0.5000.34
277_A293_T0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c37_A 1 0.4559 100 0.714 Contact Map
4aw6_A 1 0.4949 100 0.828 Contact Map
4il3_A 1 0.4805 100 0.828 Contact Map
3as5_A 1 0.3388 99.6 0.894 Contact Map
1xnf_A 1 0.4148 99.6 0.897 Contact Map
3ieg_A 1 0.4415 99.6 0.897 Contact Map
2yhc_A 1 0.3696 99.6 0.898 Contact Map
2pl2_A 1 0.3347 99.5 0.898 Contact Map
3jb9_R 1 0.0246 99.5 0.899 Contact Map
3vtx_A 1 0.3347 99.5 0.9 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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