GREMLIN Database
T0942_1_487 - T0942 1-487
ID: 115 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 487 (417)
Sequences: 3688 (2614)
Seq/√Len: 128.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
358_K361_E5.5051.00
324_K327_E5.0721.00
129_Q224_T4.3001.00
125_D228_K4.0321.00
391_Q394_E3.9401.00
382_L386_Y3.5651.00
425_N428_Q3.5641.00
194_I197_T3.1641.00
333_Q349_A3.1141.00
367_K394_E3.0021.00
132_S221_A3.0021.00
435_E470_R2.8741.00
227_E257_R2.7751.00
163_G185_T2.7601.00
363_I382_L2.7231.00
312_Q331_T2.6681.00
129_Q228_K2.6681.00
116_L134_M2.6361.00
434_A450_L2.5961.00
413_W432_A2.5861.00
103_E117_H2.5791.00
124_S130_L2.4841.00
442_R445_Q2.4381.00
319_A327_E2.4001.00
329_R353_D2.3591.00
363_I385_A2.3401.00
309_R345_Y2.2801.00
366_L381_N2.2781.00
241_E251_S2.2661.00
121_F130_L2.2081.00
80_G96_F2.1741.00
312_Q338_A2.1591.00
339_E342_N2.1551.00
396_A419_A2.1481.00
83_L138_I2.1171.00
223_P256_A2.0851.00
393_Q423_L2.0711.00
396_A420_E2.0661.00
272_E276_L2.0601.00
128_S221_A2.0471.00
239_P244_L2.0471.00
367_K382_L2.0461.00
368_N371_D2.0041.00
396_A423_L1.9951.00
101_N117_H1.9751.00
354_L385_A1.9731.00
191_Q195_S1.9651.00
76_I98_L1.9631.00
80_G134_M1.9301.00
312_Q334_P1.8781.00
72_L98_L1.8651.00
210_Q214_R1.8401.00
139_S211_V1.8361.00
379_Q398_I1.8291.00
370_R378_L1.8231.00
142_T211_V1.8141.00
396_A416_L1.7731.00
420_E425_N1.7681.00
87_A90_V1.7651.00
315_R319_A1.7531.00
386_Y394_E1.7431.00
79_L217_F1.7241.00
295_D299_E1.7161.00
353_D361_E1.7081.00
403_T412_G1.6931.00
451_S475_R1.6911.00
125_D129_Q1.6671.00
132_S222_M1.6571.00
336_L346_L1.6541.00
83_L211_V1.6521.00
319_A324_K1.6411.00
135_A212_L1.6411.00
351_D355_G1.6351.00
208_G222_M1.6191.00
353_D365_R1.6091.00
430_L449_L1.5981.00
387_L419_A1.5961.00
84_V114_V1.5941.00
319_A331_T1.5941.00
336_L349_A1.5901.00
216_G265_P1.5711.00
295_D314_G1.5671.00
278_K282_L1.5601.00
386_Y398_I1.5591.00
329_R356_Q1.5581.00
84_V138_I1.5471.00
454_S468_D1.5461.00
120_L133_V1.5221.00
447_I471_I1.5171.00
418_Q422_A1.5161.00
329_R349_A1.5071.00
124_S274_F1.5051.00
86_H215_S1.5031.00
202_Q251_S1.4821.00
292_L318_Q1.4781.00
65_P100_N1.4771.00
181_A184_G1.4711.00
271_S275_Y1.4661.00
349_A365_R1.4611.00
349_A353_D1.4481.00
209_I256_A1.4371.00
291_Q295_D1.4331.00
257_R261_N1.4231.00
420_E428_Q1.3931.00
350_T366_L1.3931.00
72_L275_Y1.3801.00
270_S274_F1.3771.00
190_R193_M1.3581.00
329_R352_I1.3581.00
400_N420_E1.3571.00
167_S182_L1.3531.00
199_Q202_Q1.3481.00
430_L452_S1.3461.00
97_F115_V1.3331.00
109_F146_L1.3211.00
70_P375_N1.3191.00
436_G440_A1.3101.00
320_M352_I1.3091.00
329_R333_Q1.2921.00
75_Y277_A1.2841.00
331_T334_P1.2821.00
363_I389_G1.2801.00
309_R338_A1.2781.00
186_L190_R1.2771.00
305_V308_Q1.2771.00
292_L315_R1.2621.00
272_E275_Y1.2581.00
400_N416_L1.2581.00
124_S225_F1.2491.00
131_A217_F1.2491.00
72_L277_A1.2401.00
94_F142_T1.2401.00
296_L327_E1.2301.00
143_Q207_I1.2291.00
220_Q261_N1.2261.00
149_A200_N1.2220.99
124_S272_E1.2130.99
353_D358_K1.2120.99
166_G170_L1.2070.99
197_T200_N1.2060.99
226_L256_A1.2050.99
275_Y278_K1.2020.99
392_P422_A1.1980.99
171_A178_G1.1950.99
180_A184_G1.1910.99
277_A295_D1.1860.99
224_T228_K1.1840.99
332_L348_L1.1740.99
334_P337_A1.1740.99
175_P178_G1.1710.99
75_Y79_L1.1700.99
438_A477_L1.1690.99
310_A314_G1.1620.99
299_E305_V1.1590.99
468_D472_D1.1590.99
167_S178_G1.1520.99
126_N129_Q1.1520.99
249_P253_L1.1440.99
461_S465_A1.1410.99
96_F138_I1.1400.99
333_Q337_A1.1340.99
383_A399_L1.1320.99
196_F200_N1.1240.99
76_I96_F1.1240.99
208_G215_S1.1220.99
268_V272_E1.1220.99
403_T413_W1.1200.99
369_A378_L1.1130.99
160_T189_T1.1090.99
206_R255_D1.1070.99
339_E345_Y1.1060.99
291_Q321_E1.1050.99
382_L398_I1.1040.99
275_Y279_A1.1040.99
176_Q179_M1.1020.99
359_A385_A1.1010.99
67_I118_S1.0950.99
274_F345_Y1.0930.99
359_A362_A1.0810.99
139_S142_T1.0800.99
276_L279_A1.0740.99
471_I474_L1.0700.99
346_L365_R1.0690.99
292_L319_A1.0650.99
268_V273_D1.0650.99
222_M226_L1.0630.99
159_L163_G1.0620.99
80_G138_I1.0590.99
167_S185_T1.0550.99
270_S273_D1.0540.98
225_F249_P1.0480.98
167_S181_A1.0450.98
79_L130_L1.0420.98
352_I356_Q1.0410.98
367_K371_D1.0340.98
78_S273_D1.0330.98
104_I123_Y1.0310.98
361_E364_N1.0270.98
417_A433_R1.0200.98
133_V225_F1.0190.98
225_F229_L1.0140.98
316_A332_L1.0090.98
274_F279_A1.0040.98
88_N91_K1.0000.98
320_M355_G0.9960.98
220_Q224_T0.9900.98
76_I116_L0.9890.98
421_A433_R0.9860.98
213_Q219_P0.9820.98
387_L392_P0.9800.98
223_P260_A0.9800.98
363_I367_K0.9790.98
458_K465_A0.9770.98
346_L369_A0.9770.98
464_Q468_D0.9750.97
222_M260_A0.9740.97
380_L412_G0.9720.97
269_Q272_E0.9670.97
95_H113_N0.9670.97
108_A112_G0.9630.97
98_L121_F0.9530.97
80_G114_V0.9530.97
360_N391_Q0.9520.97
248_L253_L0.9470.97
304_N307_Q0.9470.97
399_L403_T0.9470.97
385_A389_G0.9460.97
128_S217_F0.9460.97
271_S276_L0.9430.97
122_R282_L0.9410.97
108_A141_V0.9410.97
77_N81_M0.9390.97
274_F277_A0.9370.97
359_A388_Q0.9360.97
280_R283_G0.9360.97
447_I474_L0.9310.97
384_N388_Q0.9290.97
448_S452_S0.9260.97
320_M348_L0.9250.97
152_D155_R0.9190.96
470_R473_Q0.9120.96
202_Q255_D0.9100.96
179_M183_T0.9100.96
406_N409_D0.9090.96
233_A249_P0.9090.96
141_V146_L0.9040.96
84_V94_F0.9030.96
431_A435_E0.9020.96
272_E281_T0.9000.96
97_F113_N0.8970.96
420_E432_A0.8970.96
353_D356_Q0.8950.96
320_M325_Y0.8950.96
427_D457_V0.8890.96
114_V138_I0.8890.96
143_Q203_E0.8840.96
126_N224_T0.8830.96
427_D456_Q0.8830.96
296_L299_E0.8820.95
312_Q335_L0.8810.95
177_A181_A0.8810.95
268_V271_S0.8810.95
364_N368_N0.8800.95
87_A91_K0.8800.95
244_L249_P0.8790.95
256_A260_A0.8750.95
108_A115_V0.8740.95
290_N293_T0.8720.95
431_A471_I0.8700.95
230_L253_L0.8700.95
226_L253_L0.8690.95
258_N262_Q0.8690.95
360_N389_G0.8660.95
451_S455_S0.8640.95
351_D381_N0.8640.95
325_Y352_I0.8640.95
118_S279_A0.8630.95
113_N146_L0.8630.95
325_Y356_Q0.8630.95
421_A426_R0.8600.95
433_R436_G0.8600.95
463_Q466_R0.8590.95
354_L359_A0.8580.95
187_A190_R0.8570.95
184_G188_G0.8560.95
327_E331_T0.8530.95
156_S189_T0.8510.95
99_I117_H0.8510.95
139_S207_I0.8440.94
273_D276_L0.8430.94
186_L189_T0.8380.94
450_L467_Y0.8360.94
233_A244_L0.8360.94
276_L280_R0.8350.94
438_A474_L0.8340.94
332_L349_A0.8330.94
187_A191_Q0.8320.94
273_D277_A0.8270.94
79_L131_A0.8260.94
471_I475_R0.8250.94
359_A363_I0.8240.94
219_P260_A0.8220.93
107_F115_V0.8170.93
308_Q311_A0.8160.93
80_G94_F0.8140.93
392_P419_A0.8080.93
188_G192_G0.8080.93
64_A99_I0.8060.93
230_L250_E0.8040.93
433_R437_Y0.8030.93
131_A212_L0.7990.92
414_D436_G0.7980.92
238_R250_E0.7960.92
400_N403_T0.7950.92
415_L418_Q0.7910.92
387_L415_L0.7910.92
437_Y442_R0.7900.92
241_E244_L0.7890.92
330_K334_P0.7890.92
317_L320_M0.7880.92
158_P161_W0.7880.92
444_D478_Q0.7820.92
202_Q206_R0.7800.92
447_I451_S0.7790.91
478_Q481_F0.7790.91
222_M256_A0.7770.91
224_T227_E0.7770.91
213_Q263_M0.7770.91
390_G422_A0.7740.91
393_Q397_N0.7700.91
104_I241_E0.7700.91
118_S281_T0.7700.91
268_V274_F0.7670.91
416_L420_E0.7610.91
316_A320_M0.7590.90
277_A280_R0.7570.90
326_D330_K0.7560.90
183_T186_L0.7550.90
447_I478_Q0.7550.90
219_P263_M0.7520.90
457_V467_Y0.7520.90
81_M85_S0.7490.90
437_Y449_L0.7490.90
313_Y317_L0.7460.90
327_E330_K0.7450.90
346_L368_N0.7440.90
280_R284_M0.7420.89
100_N285_Y0.7410.89
207_I211_V0.7380.89
281_T284_M0.7380.89
367_K386_Y0.7380.89
379_Q401_R0.7370.89
258_N261_N0.7360.89
336_L345_Y0.7330.89
275_Y344_W0.7320.89
215_S219_P0.7320.89
276_L342_N0.7310.89
248_L256_A0.7300.89
123_Y228_K0.7280.88
120_L130_L0.7280.88
461_S464_Q0.7260.88
466_R471_I0.7240.88
270_S275_Y0.7240.88
475_R478_Q0.7240.88
213_Q259_R0.7230.88
149_A196_F0.7210.88
349_A352_I0.7210.88
221_A226_L0.7200.88
127_E271_S0.7200.88
296_L315_R0.7190.88
203_E207_I0.7190.88
478_Q482_K0.7160.88
359_A389_G0.7150.88
341_G368_N0.7140.88
101_N119_A0.7140.88
419_A423_L0.7130.87
394_E397_N0.7080.87
220_Q223_P0.7050.87
450_L454_S0.7030.87
401_R404_F0.7030.87
469_A473_Q0.6970.86
364_N367_K0.6950.86
67_I98_L0.6950.86
467_Y470_R0.6920.86
104_I225_F0.6920.86
194_I245_T0.6900.86
384_N387_L0.6870.85
435_E439_L0.6860.85
146_L196_F0.6850.85
294_S298_D0.6840.85
309_R339_E0.6840.85
148_R203_E0.6830.85
269_Q275_Y0.6830.85
206_R210_Q0.6820.85
465_A472_D0.6810.85
149_A197_T0.6810.85
272_E279_A0.6800.85
284_M351_D0.6780.85
303_G308_Q0.6760.85
268_V276_L0.6760.85
286_N290_N0.6750.84
152_D192_G0.6730.84
163_G169_L0.6720.84
341_G397_N0.6680.84
284_M321_E0.6680.84
72_L75_Y0.6670.84
453_A457_V0.6670.84
466_R469_A0.6660.84
127_E274_F0.6650.84
304_N308_Q0.6630.83
114_V134_M0.6630.83
221_A244_L0.6630.83
401_R405_N0.6620.83
402_Y412_G0.6620.83
409_D412_G0.6620.83
470_R474_L0.6600.83
431_A467_Y0.6590.83
376_P379_Q0.6560.83
398_I402_Y0.6550.83
465_A468_D0.6550.83
334_P338_A0.6530.82
70_P74_Q0.6530.82
477_L480_R0.6520.82
185_T189_T0.6510.82
289_R293_T0.6510.82
83_L134_M0.6500.82
187_A243_L0.6490.82
276_L281_T0.6490.82
164_A167_S0.6490.82
299_E307_Q0.6480.82
75_Y127_E0.6480.82
292_L322_A0.6470.82
464_Q467_Y0.6460.82
279_A310_A0.6460.82
344_W347_D0.6460.82
354_L388_Q0.6450.82
110_F146_L0.6430.81
209_I219_P0.6420.81
149_A242_I0.6400.81
332_L352_I0.6390.81
71_L351_D0.6370.81
83_L221_A0.6350.81
308_Q312_Q0.6330.80
171_A182_L0.6330.80
467_Y471_I0.6330.80
292_L299_E0.6310.80
363_I386_Y0.6300.80
401_R416_L0.6300.80
335_L345_Y0.6250.80
242_I256_A0.6250.80
274_F278_K0.6230.79
431_A466_R0.6230.79
203_E206_R0.6210.79
104_I229_L0.6210.79
143_Q148_R0.6200.79
110_F113_N0.6190.79
254_A257_R0.6180.79
132_S256_A0.6170.79
451_S479_E0.6170.79
255_D258_N0.6160.79
269_Q273_D0.6160.79
115_V226_L0.6160.79
135_A139_S0.6140.78
211_V215_S0.6140.78
384_N415_L0.6140.78
437_Y445_Q0.6110.78
451_S454_S0.6090.78
127_E130_L0.6080.78
238_R244_L0.6080.78
437_Y440_A0.6080.78
380_L402_Y0.6080.78
95_H408_D0.6070.78
94_F138_I0.6070.78
209_I260_A0.6070.78
345_Y434_A0.6060.78
139_S143_Q0.6050.77
282_L288_G0.6050.77
354_L384_N0.6040.77
237_S244_L0.6040.77
167_S171_A0.6030.77
255_D259_R0.6010.77
331_T335_L0.5990.77
146_L150_M0.5960.76
284_M348_L0.5930.76
370_R382_L0.5910.76
109_F113_N0.5890.76
272_E283_G0.5870.75
413_W435_E0.5860.75
414_D418_Q0.5850.75
388_Q415_L0.5830.75
173_A378_L0.5830.75
131_A215_S0.5820.75
379_Q402_Y0.5810.75
272_E339_E0.5790.74
208_G216_G0.5790.74
318_Q322_A0.5790.74
73_T76_I0.5780.74
230_L249_P0.5780.74
191_Q243_L0.5780.74
132_S226_L0.5760.74
276_L283_G0.5740.74
229_L249_P0.5720.73
393_Q396_A0.5720.73
216_G248_L0.5720.73
421_A429_E0.5710.73
121_F278_K0.5710.73
429_E432_A0.5700.73
150_M154_Q0.5700.73
387_L395_A0.5690.73
387_L399_L0.5680.73
396_A400_N0.5680.73
260_A441_G0.5680.73
394_E398_I0.5670.73
323_N356_Q0.5670.73
376_P402_Y0.5670.73
229_L233_A0.5670.73
220_Q260_A0.5660.73
177_A438_A0.5650.73
403_T416_L0.5640.72
149_A152_D0.5640.72
272_E278_K0.5630.72
426_R456_Q0.5620.72
420_E423_L0.5600.72
299_E311_A0.5570.71
231_D234_R0.5570.71
191_Q194_I0.5560.71
128_S274_F0.5560.71
130_L229_L0.5540.71
429_E433_R0.5520.71
328_A352_I0.5520.71
320_M356_Q0.5510.71
384_N418_Q0.5510.71
158_P162_V0.5510.71
476_Q479_E0.5500.71
209_I480_R0.5500.71
240_P244_L0.5500.71
279_A283_G0.5490.70
383_A416_L0.5480.70
68_N73_T0.5470.70
466_R472_D0.5460.70
123_Y232_Q0.5450.70
79_L83_L0.5450.70
473_Q477_L0.5450.70
414_D433_R0.5450.70
320_M347_D0.5450.70
143_Q259_R0.5450.70
72_L156_S0.5450.70
169_L422_A0.5440.70
315_R331_T0.5430.70
386_Y391_Q0.5430.70
80_G97_F0.5420.69
73_T419_A0.5420.69
267_V270_S0.5410.69
434_A441_G0.5410.69
84_V90_V0.5400.69
73_T77_N0.5390.69
99_I229_L0.5380.69
79_L274_F0.5380.69
199_Q203_E0.5370.69
438_A470_R0.5370.69
468_D474_L0.5370.69
74_Q78_S0.5370.69
71_L278_K0.5360.69
72_L279_A0.5360.69
169_L172_M0.5350.68
452_S455_S0.5350.68
126_N228_K0.5350.68
200_N203_E0.5350.68
452_S456_Q0.5340.68
75_Y130_L0.5330.68
454_S467_Y0.5320.68
96_F114_V0.5320.68
324_K330_K0.5300.68
363_I370_R0.5290.68
377_V381_N0.5280.67
283_G321_E0.5270.67
445_Q449_L0.5260.67
332_L353_D0.5260.67
292_L296_L0.5260.67
150_M153_Q0.5250.67
293_T308_Q0.5250.67
462_L465_A0.5240.67
366_L385_A0.5240.67
326_D356_Q0.5240.67
86_H214_R0.5230.67
227_E230_L0.5230.67
316_A349_A0.5230.67
364_N371_D0.5220.67
119_A407_K0.5220.67
111_G196_F0.5190.66
105_N247_P0.5180.66
289_R326_D0.5170.66
299_E315_R0.5170.66
354_L381_N0.5170.66
299_E303_G0.5160.66
165_L168_I0.5160.66
475_R479_E0.5150.66
205_D252_R0.5150.66
117_H203_E0.5150.66
277_A281_T0.5140.65
197_T245_T0.5140.65
326_D358_K0.5140.65
380_L406_N0.5130.65
171_A177_A0.5130.65
432_A435_E0.5130.65
158_P166_G0.5120.65
375_N379_Q0.5120.65
299_E308_Q0.5120.65
209_I242_I0.5100.65
383_A398_I0.5100.65
348_L351_D0.5090.65
466_R470_R0.5090.65
289_R322_A0.5080.64
105_N252_R0.5070.64
132_S347_D0.5070.64
439_L450_L0.5070.64
117_H245_T0.5060.64
213_Q264_R0.5050.64
246_H252_R0.5050.64
233_A236_S0.5050.64
159_L162_V0.5040.64
428_Q463_Q0.5030.64
109_F112_G0.5030.64
108_A144_R0.5030.64
149_A193_M0.5020.64
106_A252_R0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c37_A 1 0.4559 100 0.639 Contact Map
4aw6_A 1 0.4887 99.9 0.788 Contact Map
4il3_A 1 0.4764 99.9 0.789 Contact Map
3ieg_A 1 0.4394 99.7 0.853 Contact Map
3as5_A 1 0.3737 99.7 0.853 Contact Map
2y4t_A 1 0.4415 99.7 0.854 Contact Map
1w3b_A 1 0.5708 99.7 0.858 Contact Map
4gyw_A 1 0.3717 99.7 0.86 Contact Map
2pl2_A 1 0.3409 99.7 0.861 Contact Map
2ho1_A 1 0.4148 99.6 0.861 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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