GREMLIN Database
T0918_400-546_1_147 - T0918_400-546 1-147
ID: 114 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 147 (128)
Sequences: 2019 (1448)
Seq/√Len: 128.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_D86_N3.3051.00
115_E120_L3.1101.00
24_E30_N2.8161.00
128_N132_F2.6431.00
109_L113_L2.4101.00
55_L59_L2.3511.00
62_M66_L2.2091.00
54_N60_D2.1871.00
108_R117_Q2.1641.00
48_S51_T2.1451.00
98_A102_M2.0741.00
77_D83_R1.9741.00
78_M82_L1.9661.00
47_E53_K1.9301.00
54_N59_L1.8601.00
55_L58_T1.8511.00
122_T129_A1.7181.00
101_K110_D1.6971.00
58_T62_M1.6941.00
116_L120_L1.6881.00
48_S52_M1.6841.00
86_N90_Q1.6711.00
21_R26_L1.5301.00
25_A29_I1.5131.00
61_S67_A1.5081.00
40_Q45_L1.4931.00
122_T126_K1.4921.00
63_N69_Q1.4801.00
21_R27_D1.4321.00
105_D109_L1.4211.00
85_L89_M1.4061.00
127_S133_E1.3961.00
29_I32_L1.3861.00
40_Q46_S1.3631.00
65_I68_S1.3461.00
50_R56_Q1.3431.00
52_M59_L1.3061.00
61_S65_I1.2911.00
61_S66_L1.2801.00
32_L41_A1.2781.00
47_E56_Q1.2771.00
25_A30_N1.2661.00
115_E121_K1.2611.00
63_N67_A1.2331.00
105_D110_D1.2301.00
16_A19_Q1.2180.99
60_D63_N1.2010.99
112_V115_E1.1970.99
111_Q117_Q1.1680.99
117_Q120_L1.1670.99
101_K107_Q1.1660.99
123_L130_L1.1590.99
81_T85_L1.1510.99
81_T84_E1.1320.99
112_V120_L1.1300.99
51_T55_L1.1300.99
83_R86_N1.1270.99
32_L38_I1.1060.99
38_I42_T1.0920.99
40_Q49_Q1.0880.99
94_P99_Y1.0820.99
53_K57_T1.0730.99
75_P81_T1.0680.99
47_E51_T1.0630.99
65_I70_S1.0500.98
40_Q44_T1.0430.98
119_V132_F1.0330.98
12_S17_Q1.0290.98
126_K134_A1.0280.98
73_Q79_Q1.0280.98
61_S70_S1.0060.98
17_Q23_M1.0000.98
57_T63_N0.9940.98
101_K124_N0.9910.98
122_T134_A0.9800.98
121_K125_E0.9790.98
29_I38_I0.9750.97
89_M92_F0.9710.97
123_L129_A0.9710.97
96_S99_Y0.9690.97
94_P100_N0.9620.97
51_T54_N0.9590.97
98_A105_D0.9560.97
39_E43_S0.9540.97
49_Q59_L0.9540.97
43_S49_Q0.9490.97
24_E28_K0.9490.97
108_R114_R0.9480.97
110_D113_L0.9460.97
23_M32_L0.9280.97
127_S130_L0.9090.96
119_V130_L0.9070.96
63_N66_L0.8990.96
59_L62_M0.8920.96
124_N134_A0.8710.95
49_Q53_K0.8620.95
106_M119_V0.8560.95
21_R30_N0.8550.95
119_V123_L0.8380.94
78_M84_E0.8350.94
21_R28_K0.8320.94
69_Q75_P0.8280.94
108_R113_L0.8230.93
54_N57_T0.8100.93
103_V108_R0.8090.93
28_K38_I0.8000.92
62_M65_I0.7950.92
14_G19_Q0.7950.92
100_N103_V0.7820.92
58_T72_Q0.7720.91
31_K81_T0.7620.91
18_I22_L0.7560.90
22_L44_T0.7500.90
44_T48_S0.7370.89
118_P124_N0.7260.88
126_K129_A0.7260.88
41_A45_L0.7260.88
10_T22_L0.7150.88
92_F98_A0.7110.87
129_A132_F0.7070.87
50_R57_T0.7000.86
112_V116_L0.6950.86
67_A70_S0.6900.86
127_S131_V0.6870.85
115_E122_T0.6740.84
49_Q62_M0.6730.84
128_N134_A0.6730.84
77_D80_S0.6700.84
79_Q83_R0.6630.83
58_T68_S0.6590.83
111_Q119_V0.6570.83
39_E42_T0.6550.83
73_Q76_T0.6550.83
84_E88_S0.6530.82
66_L85_L0.6500.82
26_L29_I0.6410.81
127_S132_F0.6390.81
22_L28_K0.6370.81
40_Q43_S0.6350.81
80_S86_N0.6350.81
49_Q52_M0.6320.80
92_F99_Y0.6290.80
23_M116_L0.6290.80
99_Y102_M0.6240.80
119_V134_A0.6200.79
24_E27_D0.6180.79
47_E52_M0.6150.79
3_N7_I0.6140.78
17_Q45_L0.6120.78
84_E90_Q0.6120.78
76_T80_S0.6060.78
122_T125_E0.6060.78
38_I46_S0.6020.77
31_K39_E0.5970.76
51_T57_T0.5950.76
7_I85_L0.5940.76
116_L122_T0.5830.75
74_L77_D0.5760.74
7_I10_T0.5720.73
31_K53_K0.5700.73
26_L118_P0.5680.73
102_M106_M0.5610.72
113_L122_T0.5590.72
22_L26_L0.5540.71
42_T46_S0.5470.70
117_Q121_K0.5460.70
101_K125_E0.5430.70
41_A50_R0.5400.69
28_K43_S0.5400.69
59_L63_N0.5380.69
18_I118_P0.5370.69
25_A117_Q0.5310.68
105_D113_L0.5280.67
55_L69_Q0.5230.67
58_T65_I0.5230.67
85_L88_S0.5200.66
32_L51_T0.5190.66
28_K114_R0.5170.66
32_L109_L0.5160.66
114_R121_K0.5160.66
14_G22_L0.5140.65
17_Q74_L0.5110.65
125_E134_A0.5110.65
23_M108_R0.5100.65
13_G32_L0.5090.65
43_S125_E0.5090.65
18_I51_T0.5090.65
11_V108_R0.5070.64
93_Q114_R0.5060.64
27_D30_N0.5050.64
14_G26_L0.5030.64
5_Y20_Q0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ch7_A 1 0.8231 69 0.847 Contact Map
3zx6_A 1 0.7959 54.8 0.86 Contact Map
1qu7_A 1 0.8095 49 0.865 Contact Map
4hpq_C 1 0.8231 36.1 0.875 Contact Map
1tr2_A 1 0.7755 32.1 0.878 Contact Map
2ieq_A 1 0.5918 26.3 0.883 Contact Map
4i3m_A 1 0.7007 25.9 0.884 Contact Map
1io1_A 1 0.6667 20.3 0.889 Contact Map
3rf3_A 1 0.7687 19.7 0.89 Contact Map
3v47_C 1 0.6122 17.2 0.893 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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