GREMLIN Database
T0918_280-420_1_141 - T0918_280-420 1-141
ID: 113 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 141 (128)
Sequences: 2128 (1469)
Seq/√Len: 129.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_M60_I5.7771.00
11_M130_T5.0541.00
15_D136_A2.8571.00
8_D61_R2.7841.00
35_T61_R2.6191.00
94_K106_D2.4261.00
37_S61_R2.3411.00
89_L107_L2.2221.00
29_R108_D2.1911.00
17_V56_I2.1461.00
32_R35_T2.1451.00
18_R27_E2.1321.00
26_V60_I2.0421.00
82_G86_K2.0151.00
13_F58_V1.9991.00
9_Y60_I1.9611.00
91_G105_V1.9381.00
18_R96_G1.7541.00
10_L59_L1.7501.00
12_F127_I1.7401.00
8_D37_S1.7151.00
37_S59_L1.6911.00
20_L24_A1.6651.00
110_Y131_V1.6301.00
83_E86_K1.5541.00
96_G104_Y1.5501.00
79_E83_E1.4801.00
82_G121_E1.4601.00
14_K53_D1.4501.00
23_G35_T1.4411.00
38_K59_L1.4161.00
11_M91_G1.3781.00
22_P39_V1.3621.00
78_V82_G1.3551.00
21_Q102_A1.3541.00
76_D79_E1.3331.00
27_E104_Y1.3251.00
79_E82_G1.3251.00
63_E66_R1.3191.00
74_N78_V1.3181.00
10_L57_P1.3071.00
42_F55_R1.2851.00
60_I128_I1.2661.00
94_K104_Y1.2501.00
12_F57_P1.2261.00
59_L125_Y1.2201.00
27_E32_R1.2040.99
18_R104_Y1.2030.99
90_R131_V1.1950.99
92_S106_D1.1700.99
13_F130_T1.1540.99
121_E126_Q1.1530.99
12_F55_R1.1510.99
10_L125_Y1.1490.99
24_A104_Y1.1310.99
106_D110_Y1.0980.99
92_S110_Y1.0960.99
9_Y62_I1.0610.99
11_M105_V1.0600.99
27_E96_G1.0590.99
137_Q140_Q1.0490.99
52_D83_E1.0390.98
93_L103_L1.0290.98
45_N69_M0.9940.98
8_D59_L0.9910.98
122_F127_I0.9900.98
93_L105_V0.9700.98
75_A79_E0.9700.98
57_P60_I0.9630.97
94_K110_Y0.9530.97
20_L91_G0.9480.97
45_N53_D0.9470.97
78_V128_I0.9420.97
39_V74_N0.9420.97
29_R56_I0.9360.97
75_A80_H0.9060.96
77_V80_H0.8990.96
10_L127_I0.8860.96
32_R63_E0.8850.96
120_R124_G0.8780.96
29_R109_F0.8780.96
110_Y113_T0.8760.95
17_V39_V0.8670.95
33_L62_I0.8460.95
136_A139_Q0.8410.94
22_P38_K0.8310.94
9_Y81_L0.8300.94
6_H61_R0.8290.94
120_R127_I0.8120.93
43_A54_Y0.8110.93
75_A78_V0.8020.93
28_F84_L0.7880.92
76_D80_H0.7850.92
80_H83_E0.7640.91
32_R40_P0.7530.90
62_I77_V0.7530.90
97_N102_A0.7370.89
90_R113_T0.7370.89
78_V119_I0.7330.89
69_M74_N0.7320.89
12_F42_F0.7320.89
53_D87_R0.7280.89
96_G102_A0.7250.89
46_M51_N0.7250.89
75_A83_E0.7130.88
83_E87_R0.7090.88
90_R129_P0.7090.88
69_M77_V0.7010.87
13_F88_G0.6980.87
88_G111_P0.6970.87
88_G110_Y0.6960.87
7_I65_E0.6930.86
20_L93_L0.6930.86
58_V108_D0.6860.86
69_M82_G0.6790.85
21_Q69_M0.6780.85
27_E97_N0.6760.85
92_S131_V0.6760.85
51_N128_I0.6750.85
63_E102_A0.6710.85
11_M128_I0.6650.84
88_G129_P0.6480.82
69_M79_E0.6460.82
31_I96_G0.6420.82
91_G107_L0.6410.82
115_A118_G0.6350.81
13_F23_G0.6280.80
31_I123_N0.6210.80
70_Q82_G0.6150.79
41_F67_L0.6150.79
74_N135_L0.6120.79
69_M76_D0.6100.78
15_D137_Q0.6070.78
46_M70_Q0.6060.78
20_L105_V0.6030.78
78_V121_E0.6000.77
28_F67_L0.5990.77
86_K112_N0.5990.77
51_N76_D0.5960.77
45_N74_N0.5960.77
16_S100_T0.5930.77
15_D133_G0.5900.76
46_M112_N0.5890.76
75_A118_G0.5820.75
41_F56_I0.5810.75
36_V93_L0.5770.75
120_R123_N0.5720.74
69_M75_A0.5710.74
45_N76_D0.5710.74
23_G90_R0.5700.74
28_F56_I0.5660.73
19_G99_V0.5650.73
96_G103_L0.5640.73
44_P51_N0.5630.73
62_I84_L0.5620.73
18_R36_V0.5620.73
46_M74_N0.5620.73
51_N80_H0.5600.72
70_Q77_V0.5580.72
13_F93_L0.5530.71
12_F61_R0.5490.71
24_A105_V0.5460.71
33_L77_V0.5460.71
57_P62_I0.5430.70
75_A122_F0.5420.70
17_V93_L0.5400.70
77_V83_E0.5370.69
27_E106_D0.5360.69
31_I84_L0.5300.68
40_P57_P0.5290.68
86_K118_G0.5270.68
7_I64_P0.5270.68
95_T103_L0.5260.68
14_K55_R0.5240.67
22_P25_P0.5210.67
82_G119_I0.5180.67
52_D79_E0.5180.67
16_S22_P0.5170.66
43_A52_D0.5160.66
77_V82_G0.5160.66
95_T99_V0.5110.65
46_M79_E0.5100.65
75_A114_P0.5090.65
17_V74_N0.5070.65
88_G99_V0.5060.65
94_K107_L0.5060.65
9_Y74_N0.5030.64
70_Q74_N0.5030.64
32_R55_R0.5030.64
32_R139_Q0.5020.64
20_L58_V0.5000.64
74_N77_V0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2der_A 1 0.3262 12.3 0.918 Contact Map
4tko_B 1 0.4894 10.1 0.922 Contact Map
2jv8_A 1 0.234 6.8 0.927 Contact Map
2j5u_A 1 0.7092 3.9 0.935 Contact Map
4d6g_A 1 0.844 3.9 0.935 Contact Map
1d3y_A 1 0.8014 3.9 0.935 Contact Map
1pj5_A 1 0.6525 3.5 0.936 Contact Map
2gag_A 1 0.6596 3.5 0.937 Contact Map
1wsr_A 1 0.6241 3.2 0.938 Contact Map
1yx2_A 1 0.5745 3.2 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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