GREMLIN Database
T0918_150-280_1_131 - T0918_150-280 1-131
ID: 112 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 131 (125)
Sequences: 2315 (1450)
Seq/√Len: 129.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_V53_L4.9901.00
13_L53_L4.9411.00
34_V101_F3.9101.00
26_P33_R3.1501.00
11_V53_L2.8571.00
13_L121_L2.7201.00
14_D48_N2.5131.00
15_S121_L2.4101.00
55_I63_V2.3471.00
15_S51_Y2.1421.00
72_D100_S2.0391.00
37_V53_L2.0271.00
27_V55_I1.9991.00
14_D118_A1.9501.00
18_A40_S1.8391.00
124_D127_S1.8161.00
10_R52_Q1.8031.00
57_A60_D1.8021.00
38_E54_F1.8001.00
37_V51_Y1.7621.00
17_K31_G1.7521.00
43_D50_S1.7101.00
43_D48_N1.7001.00
12_I118_A1.6671.00
76_A87_E1.6521.00
41_T52_Q1.6141.00
14_D50_S1.5831.00
113_V117_T1.5641.00
10_R38_E1.5131.00
79_L84_M1.4931.00
78_D85_R1.4771.00
80_T83_G1.4511.00
12_I50_S1.4121.00
14_D120_V1.4121.00
12_I52_Q1.3971.00
39_T52_Q1.3881.00
68_R122_Y1.3611.00
59_Y121_L1.3421.00
66_N107_L1.3371.00
65_N114_A1.2931.00
63_V102_D1.2481.00
91_L94_L1.2301.00
24_G36_S1.2201.00
77_V86_V1.1860.99
72_D89_G1.1690.99
10_R54_F1.1610.99
36_S56_N1.1310.99
21_L40_S1.1260.99
19_G73_S1.1240.99
9_I55_I1.0700.99
9_I60_D1.0660.99
55_I59_Y1.0660.99
22_S92_T1.0600.99
31_G89_G1.0340.98
13_L27_V1.0290.98
64_T103_V1.0090.98
25_D96_S1.0030.98
88_M94_L1.0010.98
122_Y126_K1.0010.98
63_V67_V0.9920.98
11_V46_K0.9900.98
21_L51_Y0.9640.97
72_D90_S0.9620.97
68_R103_V0.9380.97
41_T58_P0.9360.97
26_P98_G0.9200.97
43_D47_R0.9190.97
65_N116_K0.9150.96
27_V101_F0.8900.96
45_Q48_N0.8480.95
42_F98_G0.8470.95
70_W102_D0.8450.95
72_D76_A0.8300.94
28_L99_V0.8280.94
27_V99_V0.8260.94
64_T104_P0.8220.94
4_P7_K0.8210.94
22_S26_P0.8200.94
29_F101_F0.8180.94
28_L32_Y0.8140.93
75_I126_K0.8130.93
90_S93_T0.8110.93
87_E96_S0.8050.93
78_D123_D0.8020.93
16_K123_D0.7890.92
73_S121_L0.7830.92
18_A51_Y0.7810.92
58_P61_R0.7790.92
34_V62_L0.7770.92
113_V119_F0.7770.92
79_L90_S0.7640.91
51_Y121_L0.7620.91
24_G42_F0.7560.91
32_Y49_I0.7450.90
66_N109_L0.7400.90
65_N117_T0.7360.89
24_G91_L0.7320.89
19_G31_G0.7310.89
80_T98_G0.7280.89
93_T96_S0.7270.89
42_F62_L0.7200.88
78_D125_Q0.7190.88
76_A112_P0.7180.88
9_I62_L0.7110.88
55_I62_L0.7100.88
41_T50_S0.7050.87
34_V102_D0.6910.86
40_S51_Y0.6900.86
120_V123_D0.6890.86
85_R126_K0.6740.85
25_D97_G0.6640.84
75_I94_L0.6610.84
41_T65_N0.6600.84
20_Q71_K0.6580.83
107_L114_A0.6560.83
33_R36_S0.6560.83
72_D93_T0.6560.83
89_G93_T0.6550.83
84_M90_S0.6520.83
34_V100_S0.6460.82
71_K121_L0.6460.82
19_G101_F0.6410.82
76_A119_F0.6400.82
106_G120_V0.6310.81
52_Q78_D0.6310.81
79_L83_G0.6250.80
62_L102_D0.6250.80
73_S98_G0.6240.80
76_A88_M0.6190.79
93_T98_G0.6180.79
20_Q49_I0.6170.79
72_D91_L0.6170.79
27_V108_D0.6140.79
105_E126_K0.6140.79
43_D46_K0.6110.79
66_N113_V0.6070.78
18_A25_D0.6060.78
56_N94_L0.6010.77
81_S124_D0.5990.77
125_Q129_Q0.5960.77
20_Q40_S0.5930.76
52_Q116_K0.5910.76
104_P129_Q0.5880.76
18_A100_S0.5860.76
28_L31_G0.5850.76
15_S126_K0.5850.76
26_P36_S0.5850.76
8_G57_A0.5840.75
67_V103_V0.5830.75
108_D117_T0.5780.75
65_N113_V0.5770.75
63_V66_N0.5750.74
32_Y92_T0.5710.74
64_T116_K0.5670.73
42_F49_I0.5660.73
58_P79_L0.5660.73
78_D126_K0.5640.73
50_S118_A0.5620.73
19_G55_I0.5610.72
76_A79_L0.5600.72
21_L98_G0.5590.72
65_N107_L0.5540.72
11_V113_V0.5480.71
37_V121_L0.5460.70
98_G101_F0.5460.70
105_E112_P0.5430.70
18_A71_K0.5430.70
28_L53_L0.5350.69
25_D99_V0.5350.69
79_L124_D0.5340.69
20_Q88_M0.5340.69
25_D40_S0.5310.68
33_R56_N0.5290.68
64_T113_V0.5280.68
70_W100_S0.5230.67
17_K124_D0.5230.67
3_P36_S0.5230.67
84_M128_I0.5220.67
73_S83_G0.5200.67
41_T114_A0.5190.67
87_E125_Q0.5180.66
76_A86_V0.5150.66
59_Y73_S0.5110.65
54_F127_S0.5060.65
33_R67_V0.5050.65
24_G68_R0.5030.64
25_D92_T0.5000.64
7_K21_L0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yx2_A 1 0.6336 41 0.898 Contact Map
2gag_A 1 0.7023 35.5 0.902 Contact Map
3gir_A 1 0.6947 31.7 0.904 Contact Map
1pj5_A 1 0.7099 27 0.907 Contact Map
1vlo_A 1 0.7023 23.9 0.91 Contact Map
1wsr_A 1 0.6947 21.4 0.911 Contact Map
3ttg_A 1 0.6031 20.8 0.912 Contact Map
3tfi_A 1 0.6412 20.3 0.912 Contact Map
1vly_A 1 0.6336 17.4 0.915 Contact Map
1wos_A 1 0.687 16.7 0.916 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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