GREMLIN Database
T0918_20-160_1_141 - T0918_20-160 1-141
ID: 111 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 141 (123)
Sequences: 2237 (1424)
Seq/√Len: 128.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_L69_A5.3761.00
43_I69_A4.9371.00
42_T49_D3.3991.00
28_L125_L3.1441.00
29_I64_H2.9281.00
30_T125_L2.8891.00
43_I71_L2.2491.00
50_V110_E2.1771.00
30_T67_I2.1021.00
27_T122_K2.0901.00
54_E70_R2.0261.00
81_K120_M1.9551.00
53_V69_A1.9541.00
53_V67_I1.9271.00
71_L79_L1.8981.00
59_A64_H1.7861.00
36_I56_A1.7611.00
25_E68_K1.7601.00
26_V69_A1.7281.00
57_T68_K1.6981.00
29_I122_K1.6231.00
59_A66_E1.5991.00
28_L43_I1.5991.00
29_I66_E1.5391.00
128_S131_L1.5241.00
27_T68_K1.5221.00
24_P71_L1.4911.00
84_V126_L1.4831.00
81_K118_S1.4801.00
93_G96_G1.4461.00
29_I124_D1.4021.00
88_V109_I1.3931.00
79_L111_L1.3481.00
27_T66_E1.3301.00
44_K47_S1.2851.00
73_S76_E1.2621.00
25_E70_R1.2481.00
84_V112_Q1.2311.00
33_A41_T1.2261.00
58_L78_L1.2060.99
82_D116_K1.2030.99
55_S68_K1.1970.99
71_L75_M1.1770.99
99_G102_T1.1630.99
79_L83_T1.1390.99
88_V102_T1.1130.99
34_E89_K1.1070.99
42_T107_V1.1070.99
33_A56_A1.1050.99
126_L130_P1.1030.99
42_T52_V1.0880.99
57_T74_G1.0770.99
38_G55_S1.0730.99
25_E54_E1.0360.98
75_M125_L1.0340.98
45_S116_K1.0210.98
24_P76_E1.0150.98
103_L106_G1.0140.98
89_K107_V1.0140.98
137_K140_R1.0120.98
88_V108_Y0.9990.98
80_H114_G0.9950.98
58_L65_V0.9920.98
36_I53_V0.9770.98
36_I107_V0.9690.97
120_M123_Y0.9680.97
49_D52_V0.9580.97
56_A67_I0.9580.97
132_A141_V0.9410.97
48_V65_V0.9270.97
57_T121_D0.9110.96
104_L107_V0.9080.96
67_I125_L0.8990.96
87_V125_L0.8930.96
133_P136_A0.8850.96
50_V111_L0.8820.96
32_N47_S0.8750.95
80_H120_M0.8300.94
31_A127_D0.8300.94
41_T105_S0.8270.94
50_V78_L0.8260.94
35_G56_A0.8250.94
100_L103_L0.8240.94
24_P78_L0.8030.93
91_Q98_S0.7880.92
44_K108_Y0.7780.91
87_V102_T0.7750.91
46_R102_T0.7730.91
79_L85_F0.7680.91
90_P108_Y0.7680.91
92_I97_I0.7630.91
33_A67_I0.7630.91
100_L104_L0.7550.90
82_D118_S0.7470.90
36_I67_I0.7450.90
82_D115_A0.7320.89
71_L78_L0.7270.88
136_A139_I0.7260.88
90_P109_I0.7260.88
61_D64_H0.7230.88
78_L111_L0.7210.88
52_V72_N0.7210.88
90_P102_T0.7180.88
57_T66_E0.7160.88
31_A77_K0.7110.87
107_V110_E0.7110.87
29_I139_I0.7070.87
36_I41_T0.7060.87
38_G56_A0.7030.87
44_K88_V0.6960.86
39_G52_V0.6950.86
131_L134_P0.6930.86
48_V129_P0.6880.86
129_P133_P0.6850.85
23_G113_P0.6670.84
98_S103_L0.6650.84
34_E47_S0.6650.84
45_S110_E0.6650.84
132_A135_D0.6630.83
35_G65_V0.6590.83
37_E101_G0.6580.83
96_G107_V0.6570.83
19_Y22_Q0.6550.83
90_P99_G0.6490.82
90_P110_E0.6450.82
53_V105_S0.6430.82
91_Q129_P0.6430.82
30_T109_I0.6420.81
34_E110_E0.6420.81
97_I100_L0.6390.81
115_A128_S0.6380.81
131_L140_R0.6380.81
44_K49_D0.6280.80
93_G107_V0.6190.79
94_R111_L0.6100.78
70_R76_E0.6070.78
134_P137_K0.6030.77
34_E101_G0.6010.77
80_H111_L0.5960.76
108_Y111_L0.5920.76
23_G73_S0.5910.76
103_L130_P0.5910.76
42_T45_S0.5900.76
62_L67_I0.5880.76
79_L82_D0.5850.75
50_V109_I0.5790.74
49_D72_N0.5780.74
83_T111_L0.5780.74
69_A115_A0.5760.74
49_D71_L0.5750.74
134_P140_R0.5740.74
20_S80_H0.5710.73
35_G87_V0.5700.73
66_E81_K0.5650.73
30_T87_V0.5650.73
35_G41_T0.5620.72
59_A63_T0.5540.71
21_H72_N0.5520.71
92_I96_G0.5500.71
22_Q131_L0.5490.70
20_S74_G0.5490.70
26_V62_L0.5480.70
125_L139_I0.5440.70
49_D135_D0.5440.70
126_L137_K0.5400.69
18_H137_K0.5390.69
49_D110_E0.5310.68
62_L89_K0.5260.67
49_D69_A0.5250.67
133_P137_K0.5220.67
80_H113_P0.5220.67
124_D128_S0.5220.67
50_V71_L0.5210.67
117_G120_M0.5160.66
37_E42_T0.5160.66
115_A124_D0.5150.66
88_V100_L0.5120.65
130_P138_G0.5090.65
126_L132_A0.5080.65
35_G101_G0.5060.64
23_G70_R0.5020.64
30_T93_G0.5020.64
57_T81_K0.5010.64
133_P141_V0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1v5v_A 1 0.7801 27.2 0.912 Contact Map
1yx2_A 1 0.7021 18.3 0.919 Contact Map
3ttg_A 1 0.6667 11.2 0.926 Contact Map
3tfi_A 1 0.7021 10.9 0.927 Contact Map
2na6_A 1 0.1702 10.5 0.927 Contact Map
1vlo_A 1 0.7589 7.9 0.931 Contact Map
1wos_A 1 0.7376 7.8 0.931 Contact Map
1pj5_A 1 0.766 7.7 0.931 Contact Map
2gag_A 1 0.766 6.9 0.933 Contact Map
1wsr_A 1 0.7518 5.6 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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