GREMLIN Database
T0940_1_271 - T0940 1-271
ID: 110 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 271 (247)
Sequences: 268 (253)
Seq/√Len: 16.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
132_R221_D5.6401.00
128_R223_D5.3441.00
257_Q265_K4.8521.00
130_G223_D4.5431.00
135_L222_I3.4740.99
11_Q257_Q3.4700.99
24_R223_D2.9610.98
11_Q265_K2.7840.97
87_S96_E2.6710.96
221_D256_F2.5930.96
18_L96_E2.5800.96
260_I265_K2.5190.95
133_F256_F2.4510.94
84_T109_V2.4150.94
249_Y253_Q2.4110.94
249_Y265_K2.3900.93
128_R225_F2.2890.92
130_G221_D2.2770.92
40_K43_L2.2590.91
88_L131_L2.2560.91
132_R223_D2.2530.91
40_K88_L2.2410.91
128_R221_D2.2140.90
15_P133_F2.2110.90
192_Y218_F2.1930.90
29_D77_Y2.0540.87
48_P133_F2.0040.85
113_V137_I1.9870.85
22_E94_V1.9840.85
22_E92_A1.9770.84
111_M241_L1.9220.83
12_P45_N1.9010.82
16_V114_V1.8850.81
139_V152_W1.7870.78
136_E217_F1.7200.75
100_Y221_D1.7180.75
97_T106_F1.7160.75
20_T131_L1.7090.74
106_F256_F1.6570.72
29_D38_E1.6540.72
41_H44_I1.6490.72
103_F246_Q1.6420.71
15_P256_F1.6000.69
47_L109_V1.5950.69
246_Q249_Y1.5860.69
107_T246_Q1.5760.68
64_G220_L1.5360.66
85_A96_E1.5010.64
31_L41_H1.4980.64
103_F268_L1.4980.64
46_D262_S1.4980.64
28_T95_V1.4960.64
54_Q73_R1.4890.63
16_V269_L1.4870.63
128_R132_R1.4790.63
19_V131_L1.4540.62
129_I241_L1.4350.60
88_L115_D1.4240.60
14_A220_L1.4210.60
176_A221_D1.4150.59
93_I112_R1.3950.58
218_F264_L1.3820.58
42_L119_Q1.3820.58
38_E222_I1.3760.57
89_K92_A1.3660.57
8_D253_Q1.3460.55
28_T175_G1.3370.55
86_A113_V1.3160.54
152_W265_K1.3150.54
46_D180_R1.3140.54
14_A268_L1.3080.53
92_A110_V1.3010.53
172_E176_A1.2760.51
193_G220_L1.2750.51
63_P151_N1.2330.49
100_Y256_F1.2270.49
48_P261_T1.2260.48
41_H77_Y1.2160.48
126_L237_N1.1610.45
131_L264_L1.1570.45
61_T135_L1.1450.44
15_P18_L1.1350.43
12_P269_L1.1280.43
149_W193_G1.1240.43
188_L249_Y1.1120.42
141_A266_D1.1100.42
79_N83_T1.1000.41
111_M262_S1.0860.40
135_L257_Q1.0840.40
153_I254_V1.0650.39
191_R236_Y1.0640.39
140_P152_W1.0640.39
53_A76_R1.0560.39
137_I154_D1.0550.39
129_I132_R1.0540.39
100_Y133_F1.0520.39
151_N263_R1.0490.38
172_E178_V1.0470.38
15_P22_E1.0430.38
138_R219_L1.0350.38
103_F249_Y1.0340.38
265_K268_L1.0300.37
102_S265_K1.0300.37
228_P250_G1.0280.37
74_F87_S1.0250.37
129_I156_Q1.0250.37
16_V19_V1.0180.37
61_T104_E1.0160.37
132_R256_F1.0140.37
18_L117_R1.0110.36
120_V137_I1.0040.36
184_P241_L1.0030.36
43_L48_P1.0030.36
16_V50_E0.9950.35
246_Q250_G0.9940.35
15_P137_I0.9850.35
15_P268_L0.9850.35
11_Q92_A0.9830.35
103_F270_R0.9830.35
149_W264_L0.9820.35
20_T94_V0.9810.35
218_F249_Y0.9810.35
43_L224_S0.9750.34
119_Q176_A0.9750.34
15_P76_R0.9550.33
93_I97_T0.9490.33
37_R121_S0.9450.33
22_E110_V0.9430.33
15_P24_R0.9380.33
135_L253_Q0.9330.32
197_G217_F0.9330.32
25_H31_L0.9310.32
77_Y262_S0.9280.32
115_D151_N0.9220.32
100_Y249_Y0.9160.31
88_L99_A0.9150.31
103_F224_S0.9150.31
25_H100_Y0.9140.31
47_L178_V0.9120.31
121_S220_L0.9050.31
19_V218_F0.9040.31
95_V109_V0.9020.31
9_E269_L0.9010.31
115_D238_R0.8970.30
100_Y135_L0.8970.30
264_L268_L0.8950.30
25_H40_K0.8930.30
33_E119_Q0.8910.30
135_L171_T0.8880.30
42_L219_L0.8860.30
103_F110_V0.8780.30
103_F159_G0.8760.29
186_K245_F0.8760.29
20_T168_L0.8750.29
14_A253_Q0.8670.29
111_M245_F0.8630.29
260_I268_L0.8620.29
74_F110_V0.8590.29
86_A262_S0.8560.28
43_L136_E0.8550.28
119_Q238_R0.8550.28
77_Y152_W0.8530.28
95_V113_V0.8520.28
14_A252_A0.8440.28
155_E188_L0.8420.28
15_P106_F0.8400.28
244_T248_L0.8280.27
47_L189_I0.8230.27
48_P151_N0.8220.27
65_G105_A0.8220.27
84_T95_V0.8110.26
127_E260_I0.8110.26
137_I256_F0.8100.26
134_V256_F0.8100.26
199_A270_R0.8070.26
130_G225_F0.8020.26
103_F137_I0.7990.26
11_Q260_I0.7980.26
10_V102_S0.7880.25
51_R82_N0.7880.25
132_R225_F0.7860.25
19_V133_F0.7860.25
22_E223_D0.7850.25
21_V252_A0.7840.25
239_D266_D0.7840.25
240_A243_S0.7800.25
93_I141_A0.7780.25
62_A235_E0.7730.25
149_W170_L0.7720.25
23_I45_N0.7680.24
31_L75_V0.7630.24
70_V136_E0.7620.24
80_R117_R0.7610.24
20_T176_A0.7570.24
246_Q266_D0.7560.24
26_P123_I0.7540.24
54_Q137_I0.7540.24
58_W72_D0.7540.24
23_I111_M0.7480.24
90_N190_V0.7460.24
23_I268_L0.7390.23
135_L194_P0.7360.23
33_E241_L0.7350.23
34_S126_L0.7340.23
263_R266_D0.7330.23
104_E269_L0.7320.23
24_R106_F0.7290.23
131_L249_Y0.7280.23
180_R225_F0.7240.23
149_W218_F0.7230.23
23_I228_P0.7180.22
93_I119_Q0.7160.22
100_Y220_L0.7120.22
106_F132_R0.7120.22
109_V117_R0.7070.22
25_H110_V0.7010.22
17_A24_R0.7010.22
104_E110_V0.6990.22
97_T253_Q0.6970.22
31_L224_S0.6970.22
191_R260_I0.6970.22
43_L177_A0.6960.22
153_I176_A0.6950.21
44_I50_E0.6940.21
16_V67_P0.6930.21
45_N182_L0.6920.21
58_W263_R0.6910.21
117_R198_Q0.6910.21
38_E41_H0.6830.21
60_M260_I0.6790.21
16_V134_V0.6760.21
155_E186_K0.6740.21
91_Q250_G0.6730.21
108_D158_L0.6720.21
9_E34_S0.6670.20
188_L260_I0.6650.20
40_K130_G0.6640.20
235_E241_L0.6630.20
255_V268_L0.6620.20
23_I118_A0.6620.20
25_H245_F0.6590.20
90_N149_W0.6580.20
123_I233_I0.6570.20
114_V214_T0.6560.20
106_F221_D0.6540.20
261_T265_K0.6530.20
15_P135_L0.6520.20
37_R76_R0.6510.20
13_N187_S0.6490.20
153_I259_M0.6490.20
19_V129_I0.6480.20
182_L261_T0.6430.20
75_V220_L0.6420.19
16_V97_T0.6410.19
76_R224_S0.6410.19
19_V264_L0.6370.19
83_T242_V0.6370.19
224_S249_Y0.6340.19
178_V269_L0.6330.19
137_I171_T0.6320.19
88_L104_E0.6300.19
91_Q266_D0.6290.19
42_L123_I0.6290.19
249_Y252_A0.6260.19
50_E77_Y0.6240.19
25_H28_T0.6240.19
95_V152_W0.6210.19
220_L253_Q0.6200.19
133_F252_A0.6190.19
14_A260_I0.6180.19
43_L250_G0.6180.19
113_V228_P0.6170.19
43_L57_S0.6170.19
23_I65_G0.6160.19
90_N108_D0.6140.18
179_Y259_M0.6130.18
15_P186_K0.6120.18
134_V233_I0.6110.18
111_M227_T0.6110.18
249_Y258_E0.6080.18
122_S190_V0.6080.18
181_E248_L0.6070.18
17_A135_L0.6040.18
19_V82_N0.6040.18
74_F89_K0.6030.18
17_A40_K0.6030.18
75_V260_I0.6030.18
117_R191_R0.6030.18
22_E132_R0.6030.18
6_N179_Y0.6010.18
44_I110_V0.6000.18
108_D115_D0.5970.18
110_V176_A0.5970.18
201_D218_F0.5960.18
93_I113_V0.5950.18
29_D41_H0.5940.18
184_P255_V0.5940.18
130_G142_G0.5890.18
198_Q202_P0.5840.17
18_L98_T0.5840.17
140_P267_E0.5830.17
25_H268_L0.5810.17
243_S246_Q0.5800.17
197_G226_W0.5780.17
17_A136_E0.5780.17
181_E189_I0.5770.17
102_S249_Y0.5750.17
60_M73_R0.5740.17
35_A78_V0.5740.17
13_N186_K0.5730.17
40_K117_R0.5720.17
88_L159_G0.5700.17
79_N97_T0.5680.17
114_V129_I0.5670.17
93_I121_S0.5670.17
176_A189_I0.5660.17
47_L213_Q0.5650.17
108_D242_V0.5640.17
29_D95_V0.5620.17
96_E223_D0.5600.17
86_A185_G0.5600.17
44_I157_L0.5590.17
163_F266_D0.5590.17
111_M114_V0.5590.17
35_A38_E0.5550.16
80_R153_I0.5550.16
15_P253_Q0.5540.16
9_E258_E0.5470.16
10_V46_D0.5460.16
15_P270_R0.5450.16
25_H252_A0.5430.16
94_V97_T0.5430.16
153_I173_W0.5420.16
102_S123_I0.5370.16
101_R105_A0.5370.16
70_V121_S0.5350.16
237_N243_S0.5350.16
19_V137_I0.5310.16
108_D113_V0.5300.16
126_L178_V0.5290.16
30_S243_S0.5270.16
41_H123_I0.5260.16
85_A219_L0.5260.16
47_L228_P0.5250.16
27_T246_Q0.5220.15
27_T241_L0.5210.15
33_E154_D0.5210.15
91_Q165_P0.5190.15
46_D202_P0.5180.15
167_G241_L0.5160.15
106_F223_D0.5160.15
38_E110_V0.5150.15
102_S255_V0.5140.15
22_E106_F0.5130.15
9_E102_S0.5130.15
24_R113_V0.5120.15
93_I243_S0.5100.15
106_F119_Q0.5100.15
107_T111_M0.5090.15
179_Y248_L0.5090.15
15_P171_T0.5080.15
82_N159_G0.5080.15
91_Q178_V0.5070.15
110_V160_P0.5060.15
131_L202_P0.5040.15
18_L87_S0.5020.15
79_N90_N0.5010.15
41_H97_T0.5010.15
91_Q225_F0.5000.15
36_N41_H0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yht_A 1 0.1771 3.6 0.955 Contact Map
1q1o_A 1 0.3579 2.6 0.958 Contact Map
2ltm_A 1 0.3801 2.1 0.96 Contact Map
1j3e_A 1 0.203 2.1 0.961 Contact Map
3vz9_B 1 0.3616 1.9 0.961 Contact Map
5c5g_A 1 0.3653 1.8 0.962 Contact Map
2k1h_A 1 0.3137 1.7 0.962 Contact Map
2wbm_A 1 0.428 1.5 0.963 Contact Map
1ip9_A 1 0.3137 1.5 0.963 Contact Map
1pqs_A 1 0.2657 1.5 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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