T0940_1_271 - CASP12 - GREMLIN Contacts

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T0940_1_271 - T0940 1-271

ID:	110	Sequences: MLPETNQDEVQPNAPVALVTVEIRHPTTDSLTESANRELKHLLINDLPIERQAQDVSWGMTAPGGAPTPVADRFVRYVNRDNTTAASLKNQAIVVETTAYRSFEAFTDVVMRVVDARAQVSSIVGLERIGLRFVLEIRVPAGVDGRITWSNWIDEQLLGPQRFTPGGLVLTEWQGAAVYRELQPGKSLIVRYGPGMGQALDPNYHLRRITPAQTGPFFLLDIDSFWTPSGGSIPEYNRDALVSTFQDLYGPAQVVFQEMITSRLKDELLRQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	271 (247)
Sequences:	268 (253)
Seq/√Len:	16.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
132_R	221_D	5.640	1.00
128_R	223_D	5.344	1.00
257_Q	265_K	4.852	1.00
130_G	223_D	4.543	1.00
135_L	222_I	3.474	0.99
11_Q	257_Q	3.470	0.99
24_R	223_D	2.961	0.98
11_Q	265_K	2.784	0.97
87_S	96_E	2.671	0.96
221_D	256_F	2.593	0.96
18_L	96_E	2.580	0.96
260_I	265_K	2.519	0.95
133_F	256_F	2.451	0.94
84_T	109_V	2.415	0.94
249_Y	253_Q	2.411	0.94
249_Y	265_K	2.390	0.93
128_R	225_F	2.289	0.92
130_G	221_D	2.277	0.92
40_K	43_L	2.259	0.91
88_L	131_L	2.256	0.91
132_R	223_D	2.253	0.91
40_K	88_L	2.241	0.91
128_R	221_D	2.214	0.90
15_P	133_F	2.211	0.90
192_Y	218_F	2.193	0.90
29_D	77_Y	2.054	0.87
48_P	133_F	2.004	0.85
113_V	137_I	1.987	0.85
22_E	94_V	1.984	0.85
22_E	92_A	1.977	0.84
111_M	241_L	1.922	0.83
12_P	45_N	1.901	0.82
16_V	114_V	1.885	0.81
139_V	152_W	1.787	0.78
136_E	217_F	1.720	0.75
100_Y	221_D	1.718	0.75
97_T	106_F	1.716	0.75
20_T	131_L	1.709	0.74
106_F	256_F	1.657	0.72
29_D	38_E	1.654	0.72
41_H	44_I	1.649	0.72
103_F	246_Q	1.642	0.71
15_P	256_F	1.600	0.69
47_L	109_V	1.595	0.69
246_Q	249_Y	1.586	0.69
107_T	246_Q	1.576	0.68
64_G	220_L	1.536	0.66
85_A	96_E	1.501	0.64
31_L	41_H	1.498	0.64
103_F	268_L	1.498	0.64
46_D	262_S	1.498	0.64
28_T	95_V	1.496	0.64
54_Q	73_R	1.489	0.63
16_V	269_L	1.487	0.63
128_R	132_R	1.479	0.63
19_V	131_L	1.454	0.62
129_I	241_L	1.435	0.60
88_L	115_D	1.424	0.60
14_A	220_L	1.421	0.60
176_A	221_D	1.415	0.59
93_I	112_R	1.395	0.58
218_F	264_L	1.382	0.58
42_L	119_Q	1.382	0.58
38_E	222_I	1.376	0.57
89_K	92_A	1.366	0.57
8_D	253_Q	1.346	0.55
28_T	175_G	1.337	0.55
86_A	113_V	1.316	0.54
152_W	265_K	1.315	0.54
46_D	180_R	1.314	0.54
14_A	268_L	1.308	0.53
92_A	110_V	1.301	0.53
172_E	176_A	1.276	0.51
193_G	220_L	1.275	0.51
63_P	151_N	1.233	0.49
100_Y	256_F	1.227	0.49
48_P	261_T	1.226	0.48
41_H	77_Y	1.216	0.48
126_L	237_N	1.161	0.45
131_L	264_L	1.157	0.45
61_T	135_L	1.145	0.44
15_P	18_L	1.135	0.43
12_P	269_L	1.128	0.43
149_W	193_G	1.124	0.43
188_L	249_Y	1.112	0.42
141_A	266_D	1.110	0.42
79_N	83_T	1.100	0.41
111_M	262_S	1.086	0.40
135_L	257_Q	1.084	0.40
153_I	254_V	1.065	0.39
191_R	236_Y	1.064	0.39
140_P	152_W	1.064	0.39
53_A	76_R	1.056	0.39
137_I	154_D	1.055	0.39
129_I	132_R	1.054	0.39
100_Y	133_F	1.052	0.39
151_N	263_R	1.049	0.38
172_E	178_V	1.047	0.38
15_P	22_E	1.043	0.38
138_R	219_L	1.035	0.38
103_F	249_Y	1.034	0.38
265_K	268_L	1.030	0.37
102_S	265_K	1.030	0.37
228_P	250_G	1.028	0.37
74_F	87_S	1.025	0.37
129_I	156_Q	1.025	0.37
16_V	19_V	1.018	0.37
61_T	104_E	1.016	0.37
132_R	256_F	1.014	0.37
18_L	117_R	1.011	0.36
120_V	137_I	1.004	0.36
184_P	241_L	1.003	0.36
43_L	48_P	1.003	0.36
16_V	50_E	0.995	0.35
246_Q	250_G	0.994	0.35
15_P	137_I	0.985	0.35
15_P	268_L	0.985	0.35
11_Q	92_A	0.983	0.35
103_F	270_R	0.983	0.35
149_W	264_L	0.982	0.35
20_T	94_V	0.981	0.35
218_F	249_Y	0.981	0.35
43_L	224_S	0.975	0.34
119_Q	176_A	0.975	0.34
15_P	76_R	0.955	0.33
93_I	97_T	0.949	0.33
37_R	121_S	0.945	0.33
22_E	110_V	0.943	0.33
15_P	24_R	0.938	0.33
135_L	253_Q	0.933	0.32
197_G	217_F	0.933	0.32
25_H	31_L	0.931	0.32
77_Y	262_S	0.928	0.32
115_D	151_N	0.922	0.32
100_Y	249_Y	0.916	0.31
88_L	99_A	0.915	0.31
103_F	224_S	0.915	0.31
25_H	100_Y	0.914	0.31
47_L	178_V	0.912	0.31
121_S	220_L	0.905	0.31
19_V	218_F	0.904	0.31
95_V	109_V	0.902	0.31
9_E	269_L	0.901	0.31
115_D	238_R	0.897	0.30
100_Y	135_L	0.897	0.30
264_L	268_L	0.895	0.30
25_H	40_K	0.893	0.30
33_E	119_Q	0.891	0.30
135_L	171_T	0.888	0.30
42_L	219_L	0.886	0.30
103_F	110_V	0.878	0.30
103_F	159_G	0.876	0.29
186_K	245_F	0.876	0.29
20_T	168_L	0.875	0.29
14_A	253_Q	0.867	0.29
111_M	245_F	0.863	0.29
260_I	268_L	0.862	0.29
74_F	110_V	0.859	0.29
86_A	262_S	0.856	0.28
43_L	136_E	0.855	0.28
119_Q	238_R	0.855	0.28
77_Y	152_W	0.853	0.28
95_V	113_V	0.852	0.28
14_A	252_A	0.844	0.28
155_E	188_L	0.842	0.28
15_P	106_F	0.840	0.28
244_T	248_L	0.828	0.27
47_L	189_I	0.823	0.27
48_P	151_N	0.822	0.27
65_G	105_A	0.822	0.27
84_T	95_V	0.811	0.26
127_E	260_I	0.811	0.26
137_I	256_F	0.810	0.26
134_V	256_F	0.810	0.26
199_A	270_R	0.807	0.26
130_G	225_F	0.802	0.26
103_F	137_I	0.799	0.26
11_Q	260_I	0.798	0.26
10_V	102_S	0.788	0.25
51_R	82_N	0.788	0.25
132_R	225_F	0.786	0.25
19_V	133_F	0.786	0.25
22_E	223_D	0.785	0.25
21_V	252_A	0.784	0.25
239_D	266_D	0.784	0.25
240_A	243_S	0.780	0.25
93_I	141_A	0.778	0.25
62_A	235_E	0.773	0.25
149_W	170_L	0.772	0.25
23_I	45_N	0.768	0.24
31_L	75_V	0.763	0.24
70_V	136_E	0.762	0.24
80_R	117_R	0.761	0.24
20_T	176_A	0.757	0.24
246_Q	266_D	0.756	0.24
26_P	123_I	0.754	0.24
54_Q	137_I	0.754	0.24
58_W	72_D	0.754	0.24
23_I	111_M	0.748	0.24
90_N	190_V	0.746	0.24
23_I	268_L	0.739	0.23
135_L	194_P	0.736	0.23
33_E	241_L	0.735	0.23
34_S	126_L	0.734	0.23
263_R	266_D	0.733	0.23
104_E	269_L	0.732	0.23
24_R	106_F	0.729	0.23
131_L	249_Y	0.728	0.23
180_R	225_F	0.724	0.23
149_W	218_F	0.723	0.23
23_I	228_P	0.718	0.22
93_I	119_Q	0.716	0.22
100_Y	220_L	0.712	0.22
106_F	132_R	0.712	0.22
109_V	117_R	0.707	0.22
25_H	110_V	0.701	0.22
17_A	24_R	0.701	0.22
104_E	110_V	0.699	0.22
97_T	253_Q	0.697	0.22
31_L	224_S	0.697	0.22
191_R	260_I	0.697	0.22
43_L	177_A	0.696	0.22
153_I	176_A	0.695	0.21
44_I	50_E	0.694	0.21
16_V	67_P	0.693	0.21
45_N	182_L	0.692	0.21
58_W	263_R	0.691	0.21
117_R	198_Q	0.691	0.21
38_E	41_H	0.683	0.21
60_M	260_I	0.679	0.21
16_V	134_V	0.676	0.21
155_E	186_K	0.674	0.21
91_Q	250_G	0.673	0.21
108_D	158_L	0.672	0.21
9_E	34_S	0.667	0.20
188_L	260_I	0.665	0.20
40_K	130_G	0.664	0.20
235_E	241_L	0.663	0.20
255_V	268_L	0.662	0.20
23_I	118_A	0.662	0.20
25_H	245_F	0.659	0.20
90_N	149_W	0.658	0.20
123_I	233_I	0.657	0.20
114_V	214_T	0.656	0.20
106_F	221_D	0.654	0.20
261_T	265_K	0.653	0.20
15_P	135_L	0.652	0.20
37_R	76_R	0.651	0.20
13_N	187_S	0.649	0.20
153_I	259_M	0.649	0.20
19_V	129_I	0.648	0.20
182_L	261_T	0.643	0.20
75_V	220_L	0.642	0.19
16_V	97_T	0.641	0.19
76_R	224_S	0.641	0.19
19_V	264_L	0.637	0.19
83_T	242_V	0.637	0.19
224_S	249_Y	0.634	0.19
178_V	269_L	0.633	0.19
137_I	171_T	0.632	0.19
88_L	104_E	0.630	0.19
91_Q	266_D	0.629	0.19
42_L	123_I	0.629	0.19
249_Y	252_A	0.626	0.19
50_E	77_Y	0.624	0.19
25_H	28_T	0.624	0.19
95_V	152_W	0.621	0.19
220_L	253_Q	0.620	0.19
133_F	252_A	0.619	0.19
14_A	260_I	0.618	0.19
43_L	250_G	0.618	0.19
113_V	228_P	0.617	0.19
43_L	57_S	0.617	0.19
23_I	65_G	0.616	0.19
90_N	108_D	0.614	0.18
179_Y	259_M	0.613	0.18
15_P	186_K	0.612	0.18
134_V	233_I	0.611	0.18
111_M	227_T	0.611	0.18
249_Y	258_E	0.608	0.18
122_S	190_V	0.608	0.18
181_E	248_L	0.607	0.18
17_A	135_L	0.604	0.18
19_V	82_N	0.604	0.18
74_F	89_K	0.603	0.18
17_A	40_K	0.603	0.18
75_V	260_I	0.603	0.18
117_R	191_R	0.603	0.18
22_E	132_R	0.603	0.18
6_N	179_Y	0.601	0.18
44_I	110_V	0.600	0.18
108_D	115_D	0.597	0.18
110_V	176_A	0.597	0.18
201_D	218_F	0.596	0.18
93_I	113_V	0.595	0.18
29_D	41_H	0.594	0.18
184_P	255_V	0.594	0.18
130_G	142_G	0.589	0.18
198_Q	202_P	0.584	0.17
18_L	98_T	0.584	0.17
140_P	267_E	0.583	0.17
25_H	268_L	0.581	0.17
243_S	246_Q	0.580	0.17
197_G	226_W	0.578	0.17
17_A	136_E	0.578	0.17
181_E	189_I	0.577	0.17
102_S	249_Y	0.575	0.17
60_M	73_R	0.574	0.17
35_A	78_V	0.574	0.17
13_N	186_K	0.573	0.17
40_K	117_R	0.572	0.17
88_L	159_G	0.570	0.17
79_N	97_T	0.568	0.17
114_V	129_I	0.567	0.17
93_I	121_S	0.567	0.17
176_A	189_I	0.566	0.17
47_L	213_Q	0.565	0.17
108_D	242_V	0.564	0.17
29_D	95_V	0.562	0.17
96_E	223_D	0.560	0.17
86_A	185_G	0.560	0.17
44_I	157_L	0.559	0.17
163_F	266_D	0.559	0.17
111_M	114_V	0.559	0.17
35_A	38_E	0.555	0.16
80_R	153_I	0.555	0.16
15_P	253_Q	0.554	0.16
9_E	258_E	0.547	0.16
10_V	46_D	0.546	0.16
15_P	270_R	0.545	0.16
25_H	252_A	0.543	0.16
94_V	97_T	0.543	0.16
153_I	173_W	0.542	0.16
102_S	123_I	0.537	0.16
101_R	105_A	0.537	0.16
70_V	121_S	0.535	0.16
237_N	243_S	0.535	0.16
19_V	137_I	0.531	0.16
108_D	113_V	0.530	0.16
126_L	178_V	0.529	0.16
30_S	243_S	0.527	0.16
41_H	123_I	0.526	0.16
85_A	219_L	0.526	0.16
47_L	228_P	0.525	0.16
27_T	246_Q	0.522	0.15
27_T	241_L	0.521	0.15
33_E	154_D	0.521	0.15
91_Q	165_P	0.519	0.15
46_D	202_P	0.518	0.15
167_G	241_L	0.516	0.15
106_F	223_D	0.516	0.15
38_E	110_V	0.515	0.15
102_S	255_V	0.514	0.15
22_E	106_F	0.513	0.15
9_E	102_S	0.513	0.15
24_R	113_V	0.512	0.15
93_I	243_S	0.510	0.15
106_F	119_Q	0.510	0.15
107_T	111_M	0.509	0.15
179_Y	248_L	0.509	0.15
15_P	171_T	0.508	0.15
82_N	159_G	0.508	0.15
91_Q	178_V	0.507	0.15
110_V	160_P	0.506	0.15
131_L	202_P	0.504	0.15
18_L	87_S	0.502	0.15
79_N	90_N	0.501	0.15
41_H	97_T	0.501	0.15
91_Q	225_F	0.500	0.15
36_N	41_H	0.500	0.15

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1yht_A	1	0.1771	3.6	0.955	Contact Map
1q1o_A	1	0.3579	2.6	0.958	Contact Map
2ltm_A	1	0.3801	2.1	0.96	Contact Map
1j3e_A	1	0.203	2.1	0.961	Contact Map
3vz9_B	1	0.3616	1.9	0.961	Contact Map
5c5g_A	1	0.3653	1.8	0.962	Contact Map
2k1h_A	1	0.3137	1.7	0.962	Contact Map
2wbm_A	1	0.428	1.5	0.963	Contact Map
1ip9_A	1	0.3137	1.5	0.963	Contact Map
1pqs_A	1	0.2657	1.5	0.964	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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