T0871_1_375 - CASP12 - GREMLIN Contacts

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T0871_1_375 - T0871 1-375

ID:	11	Sequences: MGSSHHHHHHSSGLVPRGSHMASMTGGQQMGRGSEFMSDQPWLHRLDPAEAAEIDDALDVLLKSGKPNFAASPADFPLPTLGPRLRGIVDSIENEPGFALVRGVPVGDKSEDEVRRLYWGLGMYIGVPMIQNNNDSSMVDIRDERRAGKLRVHKSNQHIGFHIDSTDVVTLLCRRAASQGGTSLVVSAEAVRREMSWECPELLSALYEPLPFADVASPDDERPDVFLSPVFGRHEGLTTTRFYIRRVLRSQDNPDAPRLTERQLEAINKVEEIAARPGLVTPMQFEPGDLQMINNHLVLHGRTAFASEEPGEGRHLLRMWFSVPSSRSLPPGYEAAWGTREGGTLRGAGPRWQLQGEFGEFQRRQAEELGVAIPA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	375 (318)
Sequences:	1613 (1238)
Seq/√Len:	69.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
199_C	265_E	4.423	1.00
62_L	113_E	4.283	1.00
194_E	198_E	4.204	1.00
55_D	109_K	4.143	1.00
192_R	207_Y	4.080	1.00
194_E	197_W	3.473	1.00
76_F	120_G	3.469	1.00
55_D	108_D	3.376	1.00
50_E	84_R	3.295	1.00
110_S	113_E	3.229	1.00
198_E	276_R	3.222	1.00
179_Q	306_A	3.059	1.00
244_I	268_N	2.926	1.00
90_D	94_N	2.905	1.00
190_A	279_L	2.710	1.00
122_G	319_M	2.609	1.00
174_R	315_H	2.588	1.00
140_D	315_H	2.517	1.00
251_Q	258_R	2.444	1.00
205_A	263_Q	2.369	1.00
244_I	248_L	2.364	1.00
191_V	274_A	2.319	1.00
283_M	291_Q	2.278	1.00
195_M	269_K	2.159	1.00
182_T	303_T	2.140	1.00
58_L	113_E	2.136	1.00
199_C	202_L	2.128	1.00
184_L	282_P	2.111	1.00
242_F	271_E	2.082	1.00
115_R	140_D	2.076	1.00
54_I	117_L	2.059	1.00
244_I	271_E	2.058	1.00
91_S	96_P	2.053	1.00
178_S	306_A	2.052	1.00
132_N	136_S	2.000	1.00
260_T	263_Q	1.946	1.00
186_V	279_L	1.913	1.00
178_S	308_E	1.912	1.00
185_V	293_I	1.871	1.00
170_T	292_M	1.863	1.00
26_G	193_R	1.851	1.00
57_A	120_G	1.819	1.00
109_K	117_L	1.818	1.00
102_R	289_D	1.785	1.00
98_F	185_V	1.784	1.00
191_V	273_I	1.762	1.00
184_L	280_V	1.737	1.00
204_S	208_E	1.706	1.00
152_V	159_I	1.698	1.00
193_R	196_S	1.694	1.00
51_A	55_D	1.687	1.00
183_S	291_Q	1.687	1.00
44_H	50_E	1.656	0.99
60_V	64_S	1.626	0.99
199_C	269_K	1.621	0.99
159_I	301_G	1.617	0.99
46_L	101_V	1.604	0.99
182_T	284_Q	1.564	0.99
24_M	196_S	1.555	0.99
58_L	117_L	1.554	0.99
24_M	197_W	1.542	0.99
53_E	79_P	1.506	0.99
176_A	287_P	1.490	0.99
88_I	99_A	1.490	0.99
195_M	270_V	1.453	0.99
102_R	286_E	1.435	0.98
235_E	328_S	1.417	0.98
27_G	30_M	1.411	0.98
233_R	238_T	1.407	0.98
57_A	76_F	1.404	0.98
331_P	334_E	1.398	0.98
309_E	312_E	1.391	0.98
240_T	299_L	1.376	0.98
103_G	289_D	1.369	0.98
121_L	290_L	1.366	0.98
61_L	116_R	1.361	0.98
255_D	258_R	1.357	0.98
176_A	286_E	1.357	0.98
60_V	77_P	1.357	0.98
273_I	279_L	1.340	0.98
100_L	283_M	1.329	0.97
239_T	327_R	1.328	0.97
257_P	263_Q	1.326	0.97
201_E	265_E	1.324	0.97
50_E	80_T	1.318	0.97
307_S	313_G	1.316	0.97
169_V	291_Q	1.314	0.97
106_V	114_V	1.312	0.97
29_Q	189_E	1.311	0.97
285_F	291_Q	1.306	0.97
122_G	292_M	1.289	0.97
75_D	119_W	1.289	0.97
53_E	78_L	1.281	0.97
175_R	311_G	1.281	0.97
269_K	273_I	1.279	0.97
57_A	78_L	1.276	0.97
120_G	124_Y	1.270	0.97
262_R	265_E	1.245	0.96
45_R	286_E	1.241	0.96
308_E	312_E	1.237	0.96
192_R	203_L	1.236	0.96
276_R	279_L	1.235	0.96
211_P	227_L	1.232	0.96
32_R	190_A	1.226	0.96
196_S	203_L	1.223	0.96
139_V	153_H	1.218	0.96
53_E	80_T	1.214	0.96
205_A	208_E	1.214	0.96
194_E	279_L	1.210	0.96
55_D	58_L	1.210	0.96
30_M	189_E	1.210	0.96
47_D	50_E	1.210	0.96
176_A	284_Q	1.209	0.95
195_M	203_L	1.207	0.95
231_F	240_T	1.207	0.95
248_L	264_L	1.200	0.95
203_L	207_Y	1.199	0.95
84_R	87_G	1.198	0.95
269_K	272_E	1.197	0.95
211_P	256_A	1.197	0.95
192_R	233_R	1.195	0.95
214_D	217_S	1.195	0.95
59_D	113_E	1.191	0.95
169_V	283_M	1.189	0.95
268_N	272_E	1.188	0.95
107_G	287_P	1.186	0.95
46_L	51_A	1.184	0.95
242_F	267_I	1.182	0.95
237_L	328_S	1.181	0.95
295_N	298_V	1.177	0.95
175_R	287_P	1.155	0.94
190_A	194_E	1.154	0.94
113_E	116_R	1.139	0.94
82_G	124_Y	1.136	0.94
123_M	128_P	1.126	0.93
128_P	321_F	1.119	0.93
174_R	317_L	1.118	0.93
51_A	108_D	1.116	0.93
58_L	62_L	1.109	0.93
188_A	240_T	1.095	0.92
55_D	104_V	1.088	0.92
265_E	272_E	1.084	0.92
192_R	231_F	1.076	0.92
114_V	172_L	1.074	0.92
36_F	98_F	1.068	0.91
94_N	237_L	1.051	0.91
264_L	271_E	1.048	0.91
208_E	262_R	1.045	0.91
261_E	264_L	1.040	0.90
175_R	315_H	1.040	0.90
119_W	128_P	1.039	0.90
43_L	102_R	1.036	0.90
136_S	139_V	1.029	0.90
168_V	323_V	1.022	0.90
62_L	112_D	1.018	0.89
33_G	281_T	1.007	0.89
61_L	66_K	1.006	0.89
213_A	252_D	1.005	0.89
208_E	263_Q	1.004	0.89
109_K	114_V	1.000	0.89
45_R	102_R	0.996	0.88
231_F	266_A	0.994	0.88
152_V	243_Y	0.991	0.88
215_V	249_R	0.975	0.87
268_N	271_E	0.972	0.87
41_P	96_P	0.970	0.87
48_P	52_A	0.966	0.87
165_S	243_Y	0.960	0.86
114_V	174_R	0.960	0.86
52_A	56_D	0.957	0.86
273_I	276_R	0.950	0.86
205_A	262_R	0.948	0.86
185_V	291_Q	0.945	0.86
73_P	123_M	0.942	0.85
150_L	155_S	0.941	0.85
44_H	84_R	0.930	0.85
86_R	124_Y	0.920	0.84
125_I	170_T	0.917	0.84
51_A	105_P	0.916	0.84
118_Y	316_L	0.914	0.84
30_M	190_A	0.913	0.84
60_V	63_K	0.913	0.84
59_D	62_L	0.913	0.84
64_S	75_D	0.910	0.83
261_E	265_E	0.908	0.83
32_R	35_E	0.903	0.83
38_S	41_P	0.902	0.83
22_A	196_S	0.886	0.82
111_E	174_R	0.879	0.81
44_H	101_V	0.877	0.81
248_L	268_N	0.873	0.81
183_S	283_M	0.867	0.80
92_I	125_I	0.859	0.80
76_F	124_Y	0.858	0.80
79_P	82_G	0.858	0.80
62_L	116_R	0.857	0.79
173_C	176_A	0.856	0.79
98_F	281_T	0.855	0.79
195_M	199_C	0.855	0.79
264_L	268_N	0.855	0.79
285_F	290_L	0.851	0.79
198_E	269_K	0.851	0.79
85_L	121_L	0.848	0.79
210_L	263_Q	0.847	0.79
218_P	224_D	0.844	0.78
152_V	246_R	0.844	0.78
118_Y	170_T	0.837	0.78
80_T	83_P	0.837	0.78
119_W	123_M	0.833	0.77
189_E	238_T	0.832	0.77
285_F	316_L	0.830	0.77
158_H	304_A	0.827	0.77
178_S	309_E	0.826	0.77
75_D	123_M	0.826	0.77
30_M	193_R	0.825	0.77
44_H	47_D	0.822	0.77
43_L	100_L	0.820	0.76
244_I	267_I	0.819	0.76
251_Q	257_P	0.817	0.76
254_P	257_P	0.815	0.76
32_R	194_E	0.815	0.76
72_S	75_D	0.815	0.76
159_I	243_Y	0.814	0.76
93_E	294_N	0.811	0.76
66_K	75_D	0.810	0.75
53_E	82_G	0.807	0.75
195_M	210_L	0.800	0.75
132_N	139_V	0.799	0.74
118_Y	172_L	0.796	0.74
71_A	123_M	0.796	0.74
36_F	42_W	0.793	0.74
246_R	249_R	0.789	0.74
326_S	329_L	0.788	0.73
89_V	323_V	0.787	0.73
86_R	89_V	0.784	0.73
163_I	274_A	0.783	0.73
202_L	205_A	0.782	0.73
115_R	138_M	0.781	0.73
182_T	282_P	0.777	0.72
259_L	264_L	0.777	0.72
213_A	253_N	0.767	0.71
247_V	259_L	0.766	0.71
142_R	315_H	0.764	0.71
92_I	170_T	0.763	0.71
102_R	285_F	0.763	0.71
81_L	85_L	0.762	0.71
244_I	247_V	0.761	0.71
49_A	80_T	0.759	0.71
215_V	252_D	0.759	0.71
205_A	210_L	0.757	0.70
106_V	172_L	0.756	0.70
272_E	276_R	0.753	0.70
209_P	227_L	0.751	0.70
308_E	311_G	0.748	0.70
207_Y	231_F	0.735	0.68
215_V	246_R	0.733	0.68
338_G	343_G	0.725	0.67
188_A	274_A	0.725	0.67
195_M	266_A	0.725	0.67
160_G	301_G	0.724	0.67
32_R	279_L	0.723	0.67
231_F	270_V	0.722	0.67
33_G	279_L	0.721	0.67
152_V	301_G	0.720	0.67
69_F	119_W	0.720	0.67
202_L	265_E	0.719	0.66
73_P	86_R	0.718	0.66
169_V	183_S	0.717	0.66
191_V	269_K	0.716	0.66
195_M	273_I	0.716	0.66
61_L	71_A	0.714	0.66
213_A	249_R	0.712	0.66
142_R	305_F	0.712	0.66
212_F	241_R	0.710	0.66
25_T	189_E	0.709	0.65
171_L	291_Q	0.702	0.65
213_A	224_D	0.702	0.65
69_F	137_S	0.702	0.65
25_T	193_R	0.702	0.65
47_D	84_R	0.698	0.64
160_G	243_Y	0.698	0.64
250_S	254_P	0.697	0.64
201_E	269_K	0.696	0.64
49_A	52_A	0.692	0.64
161_F	184_L	0.691	0.63
79_P	83_P	0.690	0.63
93_E	325_S	0.690	0.63
78_L	82_G	0.689	0.63
42_W	291_Q	0.687	0.63
58_L	108_D	0.686	0.63
209_P	228_S	0.685	0.63
219_D	222_R	0.685	0.63
160_G	245_R	0.685	0.63
161_F	301_G	0.681	0.62
121_L	156_N	0.680	0.62
121_L	191_V	0.679	0.62
132_N	173_C	0.679	0.62
75_D	124_Y	0.678	0.62
53_E	81_L	0.678	0.62
253_N	258_R	0.675	0.62
251_Q	259_L	0.673	0.61
182_T	285_F	0.669	0.61
84_R	88_I	0.666	0.61
155_S	171_L	0.666	0.61
91_S	95_E	0.666	0.61
134_N	144_E	0.666	0.61
254_P	258_R	0.665	0.60
271_E	274_A	0.665	0.60
212_F	230_V	0.664	0.60
139_V	246_R	0.663	0.60
212_F	243_Y	0.659	0.60
159_I	304_A	0.658	0.60
133_N	142_R	0.656	0.59
161_F	209_P	0.655	0.59
87_G	90_D	0.653	0.59
118_Y	290_L	0.653	0.59
169_V	172_L	0.646	0.58
33_G	37_M	0.645	0.58
205_A	260_T	0.645	0.58
166_T	323_V	0.643	0.58
104_V	121_L	0.643	0.58
293_I	298_V	0.641	0.58
122_G	153_H	0.641	0.58
214_D	218_P	0.639	0.57
185_V	285_F	0.639	0.57
101_V	249_R	0.638	0.57
53_E	56_D	0.638	0.57
92_I	168_V	0.637	0.57
151_R	155_S	0.637	0.57
79_P	124_Y	0.637	0.57
105_P	108_D	0.636	0.57
241_R	294_N	0.636	0.57
309_E	313_G	0.633	0.57
33_G	36_F	0.632	0.57
39_D	43_L	0.632	0.57
216_A	259_L	0.629	0.56
48_P	108_D	0.627	0.56
165_S	305_F	0.627	0.56
202_L	269_K	0.626	0.56
26_G	47_D	0.625	0.56
56_D	121_L	0.625	0.56
271_E	275_A	0.624	0.56
130_I	135_D	0.618	0.55
212_F	247_V	0.617	0.55
194_E	276_R	0.615	0.55
145_R	151_R	0.613	0.54
314_R	318_R	0.612	0.54
140_D	174_R	0.612	0.54
44_H	99_A	0.611	0.54
186_V	191_V	0.611	0.54
109_K	113_E	0.609	0.54
242_F	270_V	0.607	0.54
198_E	273_I	0.607	0.54
50_E	81_L	0.606	0.53
185_V	281_T	0.605	0.53
173_C	320_W	0.603	0.53
104_V	117_L	0.602	0.53
333_Y	338_G	0.601	0.53
175_R	312_E	0.600	0.53
340_R	343_G	0.599	0.53
230_V	266_A	0.597	0.52
202_L	273_I	0.597	0.52
82_G	86_R	0.596	0.52
123_M	127_V	0.593	0.52
161_F	186_V	0.592	0.52
184_L	303_T	0.591	0.52
154_K	246_R	0.588	0.51
51_A	56_D	0.588	0.51
77_P	120_G	0.586	0.51
209_P	263_Q	0.584	0.51
195_M	202_L	0.583	0.51
206_L	266_A	0.581	0.50
77_P	124_Y	0.581	0.50
232_G	330_P	0.581	0.50
61_L	64_S	0.576	0.50
35_E	90_D	0.574	0.50
153_H	319_M	0.574	0.50
212_F	336_A	0.573	0.50
217_S	222_R	0.572	0.49
212_F	228_S	0.572	0.49
294_N	297_L	0.571	0.49
111_E	175_R	0.571	0.49
48_P	51_A	0.571	0.49
110_S	114_V	0.570	0.49
127_V	324_P	0.570	0.49
152_V	157_Q	0.568	0.49
266_A	270_V	0.568	0.49
171_L	183_S	0.566	0.49
230_V	247_V	0.566	0.49
245_R	292_M	0.565	0.49
265_E	287_P	0.564	0.48
241_R	250_S	0.564	0.48
83_P	197_W	0.563	0.48
146_R	154_K	0.563	0.48
167_D	289_D	0.562	0.48
45_R	48_P	0.560	0.48
237_L	327_R	0.559	0.48
160_G	275_A	0.559	0.48
206_L	230_V	0.557	0.48
67_P	70_A	0.557	0.48
58_L	109_K	0.557	0.48
208_E	227_L	0.556	0.47
57_A	124_Y	0.556	0.47
191_V	270_V	0.556	0.47
50_E	59_D	0.555	0.47
185_V	298_V	0.554	0.47
211_P	225_V	0.554	0.47
37_M	47_D	0.554	0.47
83_P	265_E	0.553	0.47
72_S	116_R	0.552	0.47
183_S	320_W	0.551	0.47
226_F	246_R	0.551	0.47
93_E	327_R	0.551	0.47
48_P	261_E	0.551	0.47
58_L	137_S	0.550	0.47
183_S	285_F	0.549	0.47
190_A	276_R	0.549	0.47
83_P	87_G	0.548	0.46
322_S	329_L	0.547	0.46
143_D	313_G	0.546	0.46
331_P	340_R	0.546	0.46
56_D	80_T	0.545	0.46
40_Q	45_R	0.544	0.46
143_D	281_T	0.544	0.46
40_Q	43_L	0.542	0.46
67_P	71_A	0.542	0.46
244_I	264_L	0.541	0.46
132_N	217_S	0.541	0.46
265_E	268_N	0.540	0.46
270_V	299_L	0.540	0.46
253_N	256_A	0.539	0.45
252_D	257_P	0.538	0.45
240_T	270_V	0.537	0.45
46_L	113_E	0.534	0.45
36_F	281_T	0.534	0.45
145_R	155_S	0.533	0.45
82_G	85_L	0.533	0.45
159_I	245_R	0.533	0.45
122_G	128_P	0.532	0.45
294_N	326_S	0.532	0.45
50_E	274_A	0.532	0.45
115_R	192_R	0.530	0.44
249_R	253_N	0.530	0.44
53_E	77_P	0.527	0.44
101_V	290_L	0.522	0.43
276_R	280_V	0.522	0.43
211_P	250_S	0.520	0.43
112_D	116_R	0.520	0.43
55_D	113_E	0.520	0.43
85_L	88_I	0.519	0.43
133_N	154_K	0.519	0.43
182_T	305_F	0.517	0.43
45_R	86_R	0.517	0.43
250_S	256_A	0.517	0.43
93_E	326_S	0.517	0.43
123_M	129_M	0.517	0.43
230_V	240_T	0.516	0.43
139_V	170_T	0.516	0.43
176_A	185_V	0.516	0.43
51_A	109_K	0.515	0.43
126_G	153_H	0.515	0.43
110_S	116_R	0.513	0.42
42_W	155_S	0.512	0.42
41_P	98_F	0.512	0.42
154_K	215_V	0.512	0.42
169_V	217_S	0.510	0.42
205_A	266_A	0.510	0.42
83_P	86_R	0.509	0.42
119_W	241_R	0.505	0.41
160_G	244_I	0.505	0.41
186_V	274_A	0.505	0.41
213_A	217_S	0.504	0.41
159_I	246_R	0.504	0.41
26_G	309_E	0.502	0.41
61_L	72_S	0.502	0.41
65_G	236_G	0.500	0.41
44_H	190_A	0.500	0.41

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2og5_A	1	0.7547	100	0.581	Contact Map
2wbq_A	1	0.744	100	0.631	Contact Map
4m23_A	1	0.7547	100	0.659	Contact Map
4c5w_A	1	0.8453	100	0.721	Contact Map
1ds1_A	1	0.7707	100	0.727	Contact Map
3pvj_A	1	0.6587	100	0.748	Contact Map
4oj8_A	1	0.632	100	0.751	Contact Map
1otj_A	1	0.6747	100	0.751	Contact Map
4ylm_X	1	0.6853	100	0.752	Contact Map
5hsx_A	1	0.6613	100	0.753	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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