GREMLIN Database
T0871_1_375 - T0871 1-375
ID: 11 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 375 (318)
Sequences: 1613 (1238)
Seq/√Len: 69.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
199_C265_E4.4231.00
62_L113_E4.2831.00
194_E198_E4.2041.00
55_D109_K4.1431.00
192_R207_Y4.0801.00
194_E197_W3.4731.00
76_F120_G3.4691.00
55_D108_D3.3761.00
50_E84_R3.2951.00
110_S113_E3.2291.00
198_E276_R3.2221.00
179_Q306_A3.0591.00
244_I268_N2.9261.00
90_D94_N2.9051.00
190_A279_L2.7101.00
122_G319_M2.6091.00
174_R315_H2.5881.00
140_D315_H2.5171.00
251_Q258_R2.4441.00
205_A263_Q2.3691.00
244_I248_L2.3641.00
191_V274_A2.3191.00
283_M291_Q2.2781.00
195_M269_K2.1591.00
182_T303_T2.1401.00
58_L113_E2.1361.00
199_C202_L2.1281.00
184_L282_P2.1111.00
242_F271_E2.0821.00
115_R140_D2.0761.00
54_I117_L2.0591.00
244_I271_E2.0581.00
91_S96_P2.0531.00
178_S306_A2.0521.00
132_N136_S2.0001.00
260_T263_Q1.9461.00
186_V279_L1.9131.00
178_S308_E1.9121.00
185_V293_I1.8711.00
170_T292_M1.8631.00
26_G193_R1.8511.00
57_A120_G1.8191.00
109_K117_L1.8181.00
102_R289_D1.7851.00
98_F185_V1.7841.00
191_V273_I1.7621.00
184_L280_V1.7371.00
204_S208_E1.7061.00
152_V159_I1.6981.00
193_R196_S1.6941.00
51_A55_D1.6871.00
183_S291_Q1.6871.00
44_H50_E1.6560.99
60_V64_S1.6260.99
199_C269_K1.6210.99
159_I301_G1.6170.99
46_L101_V1.6040.99
182_T284_Q1.5640.99
24_M196_S1.5550.99
58_L117_L1.5540.99
24_M197_W1.5420.99
53_E79_P1.5060.99
176_A287_P1.4900.99
88_I99_A1.4900.99
195_M270_V1.4530.99
102_R286_E1.4350.98
235_E328_S1.4170.98
27_G30_M1.4110.98
233_R238_T1.4070.98
57_A76_F1.4040.98
331_P334_E1.3980.98
309_E312_E1.3910.98
240_T299_L1.3760.98
103_G289_D1.3690.98
121_L290_L1.3660.98
61_L116_R1.3610.98
255_D258_R1.3570.98
176_A286_E1.3570.98
60_V77_P1.3570.98
273_I279_L1.3400.98
100_L283_M1.3290.97
239_T327_R1.3280.97
257_P263_Q1.3260.97
201_E265_E1.3240.97
50_E80_T1.3180.97
307_S313_G1.3160.97
169_V291_Q1.3140.97
106_V114_V1.3120.97
29_Q189_E1.3110.97
285_F291_Q1.3060.97
122_G292_M1.2890.97
75_D119_W1.2890.97
53_E78_L1.2810.97
175_R311_G1.2810.97
269_K273_I1.2790.97
57_A78_L1.2760.97
120_G124_Y1.2700.97
262_R265_E1.2450.96
45_R286_E1.2410.96
308_E312_E1.2370.96
192_R203_L1.2360.96
276_R279_L1.2350.96
211_P227_L1.2320.96
32_R190_A1.2260.96
196_S203_L1.2230.96
139_V153_H1.2180.96
53_E80_T1.2140.96
205_A208_E1.2140.96
194_E279_L1.2100.96
55_D58_L1.2100.96
30_M189_E1.2100.96
47_D50_E1.2100.96
176_A284_Q1.2090.95
195_M203_L1.2070.95
231_F240_T1.2070.95
248_L264_L1.2000.95
203_L207_Y1.1990.95
84_R87_G1.1980.95
269_K272_E1.1970.95
211_P256_A1.1970.95
192_R233_R1.1950.95
214_D217_S1.1950.95
59_D113_E1.1910.95
169_V283_M1.1890.95
268_N272_E1.1880.95
107_G287_P1.1860.95
46_L51_A1.1840.95
242_F267_I1.1820.95
237_L328_S1.1810.95
295_N298_V1.1770.95
175_R287_P1.1550.94
190_A194_E1.1540.94
113_E116_R1.1390.94
82_G124_Y1.1360.94
123_M128_P1.1260.93
128_P321_F1.1190.93
174_R317_L1.1180.93
51_A108_D1.1160.93
58_L62_L1.1090.93
188_A240_T1.0950.92
55_D104_V1.0880.92
265_E272_E1.0840.92
192_R231_F1.0760.92
114_V172_L1.0740.92
36_F98_F1.0680.91
94_N237_L1.0510.91
264_L271_E1.0480.91
208_E262_R1.0450.91
261_E264_L1.0400.90
175_R315_H1.0400.90
119_W128_P1.0390.90
43_L102_R1.0360.90
136_S139_V1.0290.90
168_V323_V1.0220.90
62_L112_D1.0180.89
33_G281_T1.0070.89
61_L66_K1.0060.89
213_A252_D1.0050.89
208_E263_Q1.0040.89
109_K114_V1.0000.89
45_R102_R0.9960.88
231_F266_A0.9940.88
152_V243_Y0.9910.88
215_V249_R0.9750.87
268_N271_E0.9720.87
41_P96_P0.9700.87
48_P52_A0.9660.87
165_S243_Y0.9600.86
114_V174_R0.9600.86
52_A56_D0.9570.86
273_I276_R0.9500.86
205_A262_R0.9480.86
185_V291_Q0.9450.86
73_P123_M0.9420.85
150_L155_S0.9410.85
44_H84_R0.9300.85
86_R124_Y0.9200.84
125_I170_T0.9170.84
51_A105_P0.9160.84
118_Y316_L0.9140.84
30_M190_A0.9130.84
60_V63_K0.9130.84
59_D62_L0.9130.84
64_S75_D0.9100.83
261_E265_E0.9080.83
32_R35_E0.9030.83
38_S41_P0.9020.83
22_A196_S0.8860.82
111_E174_R0.8790.81
44_H101_V0.8770.81
248_L268_N0.8730.81
183_S283_M0.8670.80
92_I125_I0.8590.80
76_F124_Y0.8580.80
79_P82_G0.8580.80
62_L116_R0.8570.79
173_C176_A0.8560.79
98_F281_T0.8550.79
195_M199_C0.8550.79
264_L268_N0.8550.79
285_F290_L0.8510.79
198_E269_K0.8510.79
85_L121_L0.8480.79
210_L263_Q0.8470.79
218_P224_D0.8440.78
152_V246_R0.8440.78
118_Y170_T0.8370.78
80_T83_P0.8370.78
119_W123_M0.8330.77
189_E238_T0.8320.77
285_F316_L0.8300.77
158_H304_A0.8270.77
178_S309_E0.8260.77
75_D123_M0.8260.77
30_M193_R0.8250.77
44_H47_D0.8220.77
43_L100_L0.8200.76
244_I267_I0.8190.76
251_Q257_P0.8170.76
254_P257_P0.8150.76
32_R194_E0.8150.76
72_S75_D0.8150.76
159_I243_Y0.8140.76
93_E294_N0.8110.76
66_K75_D0.8100.75
53_E82_G0.8070.75
195_M210_L0.8000.75
132_N139_V0.7990.74
118_Y172_L0.7960.74
71_A123_M0.7960.74
36_F42_W0.7930.74
246_R249_R0.7890.74
326_S329_L0.7880.73
89_V323_V0.7870.73
86_R89_V0.7840.73
163_I274_A0.7830.73
202_L205_A0.7820.73
115_R138_M0.7810.73
182_T282_P0.7770.72
259_L264_L0.7770.72
213_A253_N0.7670.71
247_V259_L0.7660.71
142_R315_H0.7640.71
92_I170_T0.7630.71
102_R285_F0.7630.71
81_L85_L0.7620.71
244_I247_V0.7610.71
49_A80_T0.7590.71
215_V252_D0.7590.71
205_A210_L0.7570.70
106_V172_L0.7560.70
272_E276_R0.7530.70
209_P227_L0.7510.70
308_E311_G0.7480.70
207_Y231_F0.7350.68
215_V246_R0.7330.68
338_G343_G0.7250.67
188_A274_A0.7250.67
195_M266_A0.7250.67
160_G301_G0.7240.67
32_R279_L0.7230.67
231_F270_V0.7220.67
33_G279_L0.7210.67
152_V301_G0.7200.67
69_F119_W0.7200.67
202_L265_E0.7190.66
73_P86_R0.7180.66
169_V183_S0.7170.66
191_V269_K0.7160.66
195_M273_I0.7160.66
61_L71_A0.7140.66
213_A249_R0.7120.66
142_R305_F0.7120.66
212_F241_R0.7100.66
25_T189_E0.7090.65
171_L291_Q0.7020.65
213_A224_D0.7020.65
69_F137_S0.7020.65
25_T193_R0.7020.65
47_D84_R0.6980.64
160_G243_Y0.6980.64
250_S254_P0.6970.64
201_E269_K0.6960.64
49_A52_A0.6920.64
161_F184_L0.6910.63
79_P83_P0.6900.63
93_E325_S0.6900.63
78_L82_G0.6890.63
42_W291_Q0.6870.63
58_L108_D0.6860.63
209_P228_S0.6850.63
219_D222_R0.6850.63
160_G245_R0.6850.63
161_F301_G0.6810.62
121_L156_N0.6800.62
121_L191_V0.6790.62
132_N173_C0.6790.62
75_D124_Y0.6780.62
53_E81_L0.6780.62
253_N258_R0.6750.62
251_Q259_L0.6730.61
182_T285_F0.6690.61
84_R88_I0.6660.61
155_S171_L0.6660.61
91_S95_E0.6660.61
134_N144_E0.6660.61
254_P258_R0.6650.60
271_E274_A0.6650.60
212_F230_V0.6640.60
139_V246_R0.6630.60
212_F243_Y0.6590.60
159_I304_A0.6580.60
133_N142_R0.6560.59
161_F209_P0.6550.59
87_G90_D0.6530.59
118_Y290_L0.6530.59
169_V172_L0.6460.58
33_G37_M0.6450.58
205_A260_T0.6450.58
166_T323_V0.6430.58
104_V121_L0.6430.58
293_I298_V0.6410.58
122_G153_H0.6410.58
214_D218_P0.6390.57
185_V285_F0.6390.57
101_V249_R0.6380.57
53_E56_D0.6380.57
92_I168_V0.6370.57
151_R155_S0.6370.57
79_P124_Y0.6370.57
105_P108_D0.6360.57
241_R294_N0.6360.57
309_E313_G0.6330.57
33_G36_F0.6320.57
39_D43_L0.6320.57
216_A259_L0.6290.56
48_P108_D0.6270.56
165_S305_F0.6270.56
202_L269_K0.6260.56
26_G47_D0.6250.56
56_D121_L0.6250.56
271_E275_A0.6240.56
130_I135_D0.6180.55
212_F247_V0.6170.55
194_E276_R0.6150.55
145_R151_R0.6130.54
314_R318_R0.6120.54
140_D174_R0.6120.54
44_H99_A0.6110.54
186_V191_V0.6110.54
109_K113_E0.6090.54
242_F270_V0.6070.54
198_E273_I0.6070.54
50_E81_L0.6060.53
185_V281_T0.6050.53
173_C320_W0.6030.53
104_V117_L0.6020.53
333_Y338_G0.6010.53
175_R312_E0.6000.53
340_R343_G0.5990.53
230_V266_A0.5970.52
202_L273_I0.5970.52
82_G86_R0.5960.52
123_M127_V0.5930.52
161_F186_V0.5920.52
184_L303_T0.5910.52
154_K246_R0.5880.51
51_A56_D0.5880.51
77_P120_G0.5860.51
209_P263_Q0.5840.51
195_M202_L0.5830.51
206_L266_A0.5810.50
77_P124_Y0.5810.50
232_G330_P0.5810.50
61_L64_S0.5760.50
35_E90_D0.5740.50
153_H319_M0.5740.50
212_F336_A0.5730.50
217_S222_R0.5720.49
212_F228_S0.5720.49
294_N297_L0.5710.49
111_E175_R0.5710.49
48_P51_A0.5710.49
110_S114_V0.5700.49
127_V324_P0.5700.49
152_V157_Q0.5680.49
266_A270_V0.5680.49
171_L183_S0.5660.49
230_V247_V0.5660.49
245_R292_M0.5650.49
265_E287_P0.5640.48
241_R250_S0.5640.48
83_P197_W0.5630.48
146_R154_K0.5630.48
167_D289_D0.5620.48
45_R48_P0.5600.48
237_L327_R0.5590.48
160_G275_A0.5590.48
206_L230_V0.5570.48
67_P70_A0.5570.48
58_L109_K0.5570.48
208_E227_L0.5560.47
57_A124_Y0.5560.47
191_V270_V0.5560.47
50_E59_D0.5550.47
185_V298_V0.5540.47
211_P225_V0.5540.47
37_M47_D0.5540.47
83_P265_E0.5530.47
72_S116_R0.5520.47
183_S320_W0.5510.47
226_F246_R0.5510.47
93_E327_R0.5510.47
48_P261_E0.5510.47
58_L137_S0.5500.47
183_S285_F0.5490.47
190_A276_R0.5490.47
83_P87_G0.5480.46
322_S329_L0.5470.46
143_D313_G0.5460.46
331_P340_R0.5460.46
56_D80_T0.5450.46
40_Q45_R0.5440.46
143_D281_T0.5440.46
40_Q43_L0.5420.46
67_P71_A0.5420.46
244_I264_L0.5410.46
132_N217_S0.5410.46
265_E268_N0.5400.46
270_V299_L0.5400.46
253_N256_A0.5390.45
252_D257_P0.5380.45
240_T270_V0.5370.45
46_L113_E0.5340.45
36_F281_T0.5340.45
145_R155_S0.5330.45
82_G85_L0.5330.45
159_I245_R0.5330.45
122_G128_P0.5320.45
294_N326_S0.5320.45
50_E274_A0.5320.45
115_R192_R0.5300.44
249_R253_N0.5300.44
53_E77_P0.5270.44
101_V290_L0.5220.43
276_R280_V0.5220.43
211_P250_S0.5200.43
112_D116_R0.5200.43
55_D113_E0.5200.43
85_L88_I0.5190.43
133_N154_K0.5190.43
182_T305_F0.5170.43
45_R86_R0.5170.43
250_S256_A0.5170.43
93_E326_S0.5170.43
123_M129_M0.5170.43
230_V240_T0.5160.43
139_V170_T0.5160.43
176_A185_V0.5160.43
51_A109_K0.5150.43
126_G153_H0.5150.43
110_S116_R0.5130.42
42_W155_S0.5120.42
41_P98_F0.5120.42
154_K215_V0.5120.42
169_V217_S0.5100.42
205_A266_A0.5100.42
83_P86_R0.5090.42
119_W241_R0.5050.41
160_G244_I0.5050.41
186_V274_A0.5050.41
213_A217_S0.5040.41
159_I246_R0.5040.41
26_G309_E0.5020.41
61_L72_S0.5020.41
65_G236_G0.5000.41
44_H190_A0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2og5_A 1 0.7547 100 0.581 Contact Map
2wbq_A 1 0.744 100 0.631 Contact Map
4m23_A 1 0.7547 100 0.659 Contact Map
4c5w_A 1 0.8453 100 0.721 Contact Map
1ds1_A 1 0.7707 100 0.727 Contact Map
3pvj_A 1 0.6587 100 0.748 Contact Map
4oj8_A 1 0.632 100 0.751 Contact Map
1otj_A 1 0.6747 100 0.751 Contact Map
4ylm_X 1 0.6853 100 0.752 Contact Map
5hsx_A 1 0.6613 100 0.753 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0091 seconds.