GREMLIN Database
T0939_1_212 - T0939 1-212
ID: 109 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 212 (195)
Sequences: 62 (34)
Seq/√Len: 2.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_D87_N5.0190.81
171_S188_L3.0010.40
49_V194_I2.9860.40
43_A166_Q2.6970.34
46_S180_L2.6240.33
31_M80_V2.6150.32
205_I209_E2.5010.30
125_H210_S2.3960.28
51_P178_R2.0670.23
45_V53_L2.0240.22
63_Y175_A2.0160.22
204_E209_E1.9780.21
202_K210_S1.9720.21
58_D170_A1.9640.21
58_D90_G1.9520.21
192_D199_S1.8800.20
24_P98_T1.8530.19
198_L206_A1.8050.19
140_P143_P1.7740.18
105_L201_L1.7470.18
64_V82_I1.7360.18
60_W99_F1.6950.17
174_L204_E1.6680.17
21_P87_N1.6610.17
118_Y194_I1.6450.17
21_P48_A1.6440.17
182_A198_L1.6290.17
106_K118_Y1.6190.16
65_F192_D1.6160.16
86_G112_G1.5740.16
140_P145_P1.5650.16
40_V166_Q1.5390.15
118_Y207_K1.5340.15
26_L39_V1.5040.15
60_W87_N1.4980.15
18_T29_D1.4890.15
20_L54_N1.4880.15
188_L204_E1.4870.15
52_P173_D1.4740.15
171_S177_M1.4710.15
125_H157_S1.4600.15
169_A194_I1.4500.14
12_V180_L1.4370.14
84_L98_T1.4370.14
155_I202_K1.4190.14
24_P55_F1.4070.14
33_D44_A1.3840.14
78_A118_Y1.3680.14
45_V196_A1.3650.13
87_N90_G1.3600.13
26_L34_T1.3480.13
93_S98_T1.3410.13
180_L210_S1.3350.13
184_A202_K1.3350.13
37_H163_V1.3230.13
78_A206_A1.3200.13
104_L132_V1.3160.13
14_Y87_N1.2980.13
145_P155_I1.2950.13
137_E182_A1.2900.13
114_A173_D1.2810.13
53_L181_S1.2800.13
34_T211_R1.2770.13
186_Q196_A1.2740.13
91_P160_M1.2630.12
115_S199_S1.2610.12
60_W93_S1.2480.12
15_L105_L1.2470.12
49_V118_Y1.2350.12
35_V102_E1.2340.12
57_A84_L1.2310.12
68_G84_L1.2300.12
78_A194_I1.2170.12
175_A197_A1.2160.12
53_L180_L1.2100.12
60_W90_G1.2050.12
78_A105_L1.1980.12
161_Y188_L1.1980.12
97_I185_R1.1930.12
44_A179_T1.1870.12
48_A71_P1.1870.12
124_W187_Q1.1860.12
15_L182_A1.1790.12
64_V177_M1.1760.12
48_A95_S1.1710.12
188_L205_I1.1660.12
163_V190_S1.1660.12
68_G104_L1.1610.11
72_R120_S1.1410.11
177_M194_I1.1310.11
184_A198_L1.1310.11
166_Q201_L1.1220.11
92_Q114_A1.1090.11
16_V202_K1.1050.11
201_L208_L1.0890.11
161_Y166_Q1.0820.11
90_G172_G1.0690.11
23_A124_W1.0670.11
51_P174_L1.0560.11
171_S204_E1.0540.11
117_R137_E1.0500.11
195_A199_S1.0440.10
7_V136_P1.0350.10
62_S72_R1.0270.10
170_A173_D1.0220.10
191_R195_A1.0170.10
79_I176_H1.0150.10
133_K137_E1.0140.10
174_L178_R1.0130.10
40_V43_A1.0030.10
187_Q208_L0.9970.10
11_P121_N0.9920.10
171_S174_L0.9800.10
174_L188_L0.9730.10
174_L205_I0.9680.10
33_D166_Q0.9640.10
38_S185_R0.9620.10
8_G59_V0.9580.10
159_A207_K0.9560.10
82_I85_Q0.9520.10
72_R180_L0.9460.10
177_M184_A0.9450.10
85_Q100_Y0.9410.10
86_G99_F0.9390.10
99_F112_G0.9390.10
171_S186_Q0.9330.10
130_V179_T0.9250.10
71_P85_Q0.9220.09
97_I115_S0.9200.09
60_W197_A0.9120.09
106_K197_A0.9090.09
68_G134_A0.9070.09
45_V194_I0.9040.09
130_V133_K0.9020.09
95_S129_N0.9000.09
63_Y200_E0.8950.09
97_I165_I0.8940.09
26_L32_V0.8930.09
21_P58_D0.8870.09
7_V18_T0.8810.09
25_Q203_A0.8780.09
198_L202_K0.8710.09
35_V87_N0.8630.09
24_P82_I0.8620.09
12_V210_S0.8610.09
120_S192_D0.8540.09
163_V206_A0.8520.09
159_A162_G0.8490.09
93_S138_L0.8460.09
64_V67_L0.8440.09
101_G203_A0.8440.09
81_Q89_G0.8370.09
89_G95_S0.8370.09
17_G33_D0.8370.09
21_P130_V0.8350.09
15_L62_S0.8340.09
51_P116_Y0.8220.09
35_V58_D0.8200.09
43_A117_R0.8150.09
67_L121_N0.8130.09
93_S96_M0.8130.09
14_Y65_F0.8120.09
67_L79_I0.8120.09
47_Q124_W0.8100.09
52_P116_Y0.8040.09
46_S53_L0.7970.09
24_P83_S0.7950.09
121_N134_A0.7950.09
11_P135_D0.7930.09
38_S130_V0.7890.09
168_A172_G0.7830.08
89_G131_P0.7780.08
64_V200_E0.7780.08
65_F170_A0.7680.08
72_R138_L0.7630.08
109_G160_M0.7590.08
65_F199_S0.7590.08
18_T184_A0.7540.08
12_V105_L0.7480.08
64_V84_L0.7450.08
26_L116_Y0.7450.08
31_M121_N0.7440.08
52_P70_P0.7420.08
32_V105_L0.7390.08
103_L165_I0.7380.08
71_P94_N0.7260.08
161_Y187_Q0.7200.08
159_A183_Y0.7190.08
20_L46_S0.7170.08
117_R201_L0.7170.08
45_V182_A0.7160.08
89_G94_N0.7150.08
166_Q188_L0.7090.08
84_L125_H0.7080.08
161_Y201_L0.7060.08
140_P144_G0.7010.08
161_Y171_S0.6980.08
16_V163_V0.6920.08
60_W91_P0.6880.08
29_D132_V0.6870.08
114_A199_S0.6850.08
111_T210_S0.6820.08
18_T115_S0.6800.08
18_T173_D0.6710.08
82_I185_R0.6660.08
54_N193_E0.6660.08
168_A187_Q0.6640.08
89_G103_L0.6610.08
7_V181_S0.6520.08
36_D71_P0.6470.08
56_H146_V0.6450.08
24_P38_S0.6410.08
171_S205_I0.6380.08
49_V64_V0.6370.07
64_V160_M0.6320.07
155_I184_A0.6300.07
54_N136_P0.6300.07
89_G104_L0.6300.07
17_G47_Q0.6290.07
10_F61_G0.6250.07
10_F41_G0.6250.07
10_F28_L0.6250.07
10_F22_G0.6250.07
9_L61_G0.6250.07
28_L61_G0.6250.07
28_L41_G0.6250.07
22_G61_G0.6250.07
9_L41_G0.6250.07
41_G61_G0.6250.07
9_L28_L0.6250.07
9_L22_G0.6250.07
22_G28_L0.6250.07
22_G41_G0.6250.07
190_S197_A0.6190.07
106_K184_A0.6190.07
48_A97_I0.6160.07
114_A180_L0.6160.07
84_L100_Y0.6100.07
168_A173_D0.6090.07
186_Q204_E0.6080.07
174_L209_E0.6060.07
7_V62_S0.6060.07
50_S180_L0.6060.07
50_S83_S0.6040.07
39_V108_D0.6030.07
171_S200_E0.5960.07
19_G190_S0.5920.07
78_A197_A0.5900.07
6_R194_I0.5890.07
174_L186_Q0.5840.07
37_H88_Q0.5840.07
53_L126_E0.5790.07
132_V175_A0.5760.07
60_W98_T0.5730.07
64_V117_R0.5720.07
39_V203_A0.5650.07
50_S193_E0.5650.07
56_H170_A0.5610.07
27_V105_L0.5600.07
176_H195_A0.5560.07
162_G176_H0.5540.07
12_V133_K0.5500.07
89_G129_N0.5480.07
138_L176_H0.5460.07
53_L114_A0.5450.07
6_R192_D0.5450.07
69_P78_A0.5450.07
14_Y58_D0.5440.07
38_S49_V0.5440.07
34_T127_V0.5440.07
176_H179_T0.5430.07
11_P131_P0.5390.07
49_V126_E0.5380.07
104_L156_G0.5360.07
177_M188_L0.5350.07
18_T194_I0.5290.07
72_R143_P0.5280.07
115_S192_D0.5280.07
78_A163_V0.5230.07
46_S72_R0.5210.07
82_I103_L0.5200.07
113_V189_E0.5160.07
21_P191_R0.5140.07
70_P128_E0.5120.07
73_R105_L0.5100.07
107_G203_A0.5060.07
72_R142_E0.5040.07
116_Y178_R0.5010.07
122_G156_G0.5010.07
85_Q113_V0.5000.07
24_P133_K0.5000.07
57_A98_T0.5000.07
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qpr_A 1 0 43 0.963 Contact Map
4jkv_A 1 0.2972 38.4 0.964 Contact Map
1r48_A 1 0.1132 31.5 0.966 Contact Map
4b86_A 1 0.1698 26.6 0.967 Contact Map
4e61_A 1 0.1934 23.5 0.968 Contact Map
2a26_A 1 0.2264 23 0.968 Contact Map
2b0t_A 1 0.4434 17.2 0.97 Contact Map
4l8j_A 1 0.5849 16.5 0.97 Contact Map
3pqa_A 1 0.3538 15.5 0.97 Contact Map
1ysm_A 1 0.2311 15.5 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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