GREMLIN Database
T0937_1_369 - T0937 1-369
ID: 108 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 369 (343)
Sequences: 571 (395)
Seq/√Len: 21.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
142_A146_S9.3101.00
268_E361_K5.2911.00
272_I321_V4.5741.00
21_D24_K4.4751.00
102_R190_E4.3931.00
312_N316_G4.1601.00
273_D318_T4.0491.00
106_R146_S3.9971.00
267_D324_T3.9141.00
267_D361_K3.8131.00
265_A268_E3.8121.00
152_S160_W3.7541.00
80_K84_D3.5591.00
93_A189_I3.1031.00
312_N318_T2.8530.99
103_V151_L2.7500.99
102_R148_E2.7180.99
304_V308_S2.5730.98
104_T188_K2.5230.98
153_A165_P2.4950.98
84_D294_S2.4860.98
273_D358_R2.4450.97
269_A360_V2.3650.97
38_D41_T2.3630.97
327_G331_W2.3610.97
102_R150_V2.2670.96
326_P331_W2.2640.96
103_V170_L2.2240.96
151_L163_M2.2100.95
289_N293_E2.1980.95
287_L321_V2.1370.94
88_N175_T2.1200.94
177_L306_K2.1180.94
264_L359_V2.1110.94
174_Q185_A2.0770.94
265_A338_R1.9920.92
109_T182_E1.8850.90
105_G147_V1.8750.89
44_E289_N1.8520.89
87_D305_N1.8470.89
51_R293_E1.8440.89
140_E158_G1.8280.88
207_Q322_A1.8120.88
71_F103_V1.8020.87
269_A328_S1.7960.87
263_S339_T1.7920.87
17_A24_K1.7780.87
143_P146_S1.7760.87
71_F172_V1.7220.85
252_D255_I1.7090.84
273_D316_G1.7050.84
99_C191_R1.7050.84
269_A320_I1.6970.84
320_I328_S1.6920.84
324_T362_L1.6690.83
238_L251_G1.6580.82
51_R62_E1.6460.82
172_V189_I1.6450.82
325_R331_W1.6360.82
80_K294_S1.6300.81
71_F189_I1.6240.81
44_E337_H1.6210.81
150_V160_W1.5560.78
106_R186_Q1.5320.77
10_L13_G1.5190.76
153_A163_M1.4720.74
20_C27_G1.4700.74
47_R293_E1.4600.73
103_V263_S1.4400.72
323_A334_T1.4230.72
303_C308_S1.4210.71
266_A323_A1.4140.71
151_L207_Q1.4010.70
148_E190_E1.3630.68
100_E191_R1.3520.67
311_P317_V1.3430.67
97_G167_T1.3430.67
115_F172_V1.3400.67
102_R192_I1.3310.66
100_E193_D1.3280.66
85_N346_W1.3240.66
266_A338_R1.3240.66
320_I326_P1.3020.64
265_A324_T1.2980.64
18_D211_M1.2950.64
140_E159_N1.2950.64
79_A175_T1.2940.64
260_S321_V1.2760.63
114_S133_F1.2510.61
304_V330_N1.2440.61
286_Q294_S1.2430.61
117_T163_M1.2420.61
175_T257_Y1.2340.60
265_A361_K1.2250.60
262_W295_L1.2200.59
147_V189_I1.2100.59
43_A47_R1.2060.58
271_V328_S1.2040.58
184_P198_P1.2020.58
139_L149_I1.2000.58
175_T254_N1.1970.58
50_S62_E1.1790.57
301_D304_V1.1730.56
45_G289_N1.1730.56
249_V252_D1.1610.55
106_R142_A1.1590.55
327_G333_D1.1560.55
142_A159_N1.1550.55
151_L161_V1.1520.55
48_Y251_G1.1460.54
269_A322_A1.1450.54
39_P203_P1.1440.54
270_L340_G1.1440.54
279_D350_A1.1410.54
274_V309_A1.1400.54
99_C193_D1.1370.54
28_E32_R1.1360.54
146_S159_N1.1350.54
256_Y322_A1.1280.53
209_G289_N1.1270.53
84_D297_Y1.1240.53
83_A288_N1.1190.53
80_K297_Y1.1180.53
174_Q294_S1.1180.53
142_A147_V1.1130.52
82_G259_H1.1120.52
285_V321_V1.1110.52
251_G286_Q1.1100.52
104_T148_E1.1030.52
175_T252_D1.1020.52
84_D302_I1.0990.51
236_N270_L1.0950.51
141_I159_N1.0920.51
152_S158_G1.0800.50
270_L359_V1.0700.49
47_R51_R1.0690.49
182_E307_H1.0660.49
112_Y255_I1.0630.49
110_V113_L1.0610.49
67_A96_D1.0500.48
25_R218_E1.0450.48
103_V115_F1.0440.48
83_A175_T1.0400.47
110_V174_Q1.0360.47
44_E47_R1.0260.46
150_V158_G1.0230.46
100_E359_V1.0050.45
20_C24_K0.9990.45
103_V150_V0.9940.44
22_T314_D0.9810.43
51_R193_D0.9790.43
67_A271_V0.9700.43
177_L182_E0.9680.43
259_H284_N0.9660.42
152_S162_R0.9650.42
285_V332_L0.9650.42
100_E152_S0.9610.42
109_T202_D0.9610.42
318_T328_S0.9550.42
142_A155_P0.9540.42
85_N348_G0.9440.41
255_I347_V0.9430.41
266_A361_K0.9430.41
202_D208_G0.9370.41
91_Q174_Q0.9330.40
16_W20_C0.9320.40
203_P207_Q0.9300.40
257_Y277_V0.9300.40
257_Y347_V0.9260.40
268_E359_V0.9230.40
97_G166_D0.9210.40
192_I362_L0.9210.40
69_P101_Y0.9210.40
85_N296_D0.9200.39
112_Y254_N0.9180.39
82_G317_V0.9150.39
263_S338_R0.9130.39
282_F291_W0.9120.39
155_P304_V0.9070.39
139_L147_V0.9040.38
42_R50_S0.9040.38
115_F187_L0.9030.38
103_V269_A0.8980.38
149_I321_V0.8980.38
284_N343_C0.8970.38
98_R149_I0.8960.38
104_T159_N0.8890.38
219_Q271_V0.8850.37
38_D67_A0.8850.37
83_A286_Q0.8820.37
55_I344_W0.8800.37
112_Y347_V0.8780.37
238_L260_S0.8750.37
114_S297_Y0.8740.37
117_T167_T0.8720.36
184_P213_A0.8690.36
155_P160_W0.8690.36
273_D312_N0.8670.36
117_T131_T0.8650.36
194_A198_P0.8630.36
326_P336_G0.8560.35
175_T255_I0.8560.35
287_L333_D0.8560.35
183_T313_A0.8550.35
70_G272_I0.8540.35
163_M167_T0.8510.35
143_P149_I0.8510.35
104_T214_A0.8490.35
36_P139_L0.8480.35
212_R262_W0.8460.35
285_V342_I0.8450.35
240_P321_V0.8450.35
88_N255_I0.8430.35
75_S251_G0.8400.35
129_L166_D0.8400.35
144_D332_L0.8380.34
178_D276_T0.8360.34
65_D315_G0.8350.34
39_P262_W0.8350.34
106_R144_D0.8330.34
44_E253_P0.8310.34
271_V360_V0.8310.34
275_D316_G0.8200.33
82_G250_G0.8200.33
153_A162_R0.8180.33
97_G165_P0.8160.33
16_W27_G0.8150.33
54_R148_E0.8130.33
280_C284_N0.8110.33
71_F304_V0.8010.32
73_S184_P0.8000.32
44_E342_I0.7980.32
48_Y83_A0.7980.32
154_T201_L0.7970.32
17_A202_D0.7940.32
167_T287_L0.7910.32
174_Q346_W0.7890.31
269_A362_L0.7870.31
150_V192_I0.7870.31
128_M302_I0.7790.31
119_K166_D0.7790.31
96_D99_C0.7720.31
149_I324_T0.7710.30
142_A332_L0.7710.30
207_Q211_M0.7710.30
147_V180_R0.7700.30
24_K27_G0.7680.30
147_V332_L0.7680.30
115_F146_S0.7650.30
14_Q329_A0.7650.30
204_L310_R0.7640.30
148_E159_N0.7630.30
257_Y284_N0.7620.30
118_Q250_G0.7610.30
165_P206_L0.7600.30
235_V261_C0.7590.30
357_T362_L0.7590.30
296_D343_C0.7570.30
18_D37_D0.7560.30
323_A362_L0.7530.29
305_N308_S0.7480.29
76_H80_K0.7480.29
201_L206_L0.7470.29
262_W308_S0.7460.29
47_R289_N0.7450.29
107_R283_W0.7440.29
30_I42_R0.7440.29
19_F22_T0.7370.29
85_N284_N0.7360.29
269_A358_R0.7350.28
93_A138_Q0.7340.28
331_W336_G0.7340.28
9_Q13_G0.7330.28
117_T151_L0.7310.28
146_S322_A0.7300.28
227_W262_W0.7290.28
141_I196_A0.7280.28
220_T282_F0.7280.28
200_P337_H0.7280.28
281_D348_G0.7260.28
76_H175_T0.7260.28
58_E217_V0.7240.28
274_V317_V0.7240.28
273_D276_T0.7230.28
268_E323_A0.7220.28
135_D238_L0.7210.28
144_D156_R0.7210.28
149_I307_H0.7110.27
197_R313_A0.7100.27
11_L14_Q0.7090.27
56_A216_F0.7080.27
138_Q356_R0.7070.27
149_I159_N0.7070.27
39_P43_A0.7040.27
136_A281_D0.7040.27
150_V188_K0.7030.27
266_A324_T0.7020.27
200_P238_L0.7010.27
134_L161_V0.7000.27
180_R211_M0.6990.27
90_Y322_A0.6970.26
267_D323_A0.6950.26
100_E192_I0.6950.26
52_L81_I0.6950.26
283_W309_A0.6920.26
193_D274_V0.6910.26
53_M218_E0.6910.26
269_A331_W0.6910.26
247_Q250_G0.6890.26
55_I79_A0.6870.26
82_G251_G0.6850.26
116_G133_F0.6840.26
134_L149_I0.6840.26
16_W23_L0.6830.26
85_N257_Y0.6830.26
43_A206_L0.6830.26
67_A183_T0.6820.26
71_F312_N0.6800.26
14_Q322_A0.6790.26
66_G149_I0.6770.25
232_R272_I0.6760.25
95_V271_V0.6760.25
274_V355_P0.6760.25
113_L185_A0.6740.25
270_L360_V0.6710.25
340_G345_R0.6710.25
289_N305_N0.6690.25
182_E267_D0.6640.25
93_A176_F0.6640.25
150_V272_I0.6630.25
154_T266_A0.6620.25
283_W353_V0.6620.25
95_V170_L0.6610.25
111_A279_D0.6610.25
92_Y171_L0.6600.25
113_L346_W0.6600.25
113_L232_R0.6600.25
18_D360_V0.6590.25
104_T205_A0.6580.24
180_R266_A0.6570.24
105_G145_G0.6560.24
161_V302_I0.6560.24
78_T217_V0.6540.24
226_D277_V0.6540.24
257_Y355_P0.6530.24
44_E294_S0.6530.24
189_I209_G0.6520.24
179_R308_S0.6490.24
45_G51_R0.6480.24
83_A116_G0.6480.24
282_F348_G0.6450.24
68_W196_A0.6410.24
30_I45_G0.6400.24
114_S252_D0.6390.24
289_N337_H0.6390.24
325_R333_D0.6370.23
192_I266_A0.6370.23
44_E293_E0.6370.23
325_R353_V0.6360.23
255_I259_H0.6360.23
54_R79_A0.6350.23
310_R361_K0.6320.23
186_Q279_D0.6320.23
303_C342_I0.6310.23
179_R223_L0.6300.23
24_K352_P0.6300.23
49_L296_D0.6290.23
151_L334_T0.6280.23
150_V217_V0.6270.23
27_G262_W0.6260.23
100_E190_E0.6240.23
16_W210_L0.6220.23
178_D272_I0.6190.23
294_S343_C0.6180.23
284_N288_N0.6180.23
107_R160_W0.6170.22
24_K198_P0.6170.22
152_S156_R0.6150.22
284_N294_S0.6140.22
175_T288_N0.6140.22
138_Q321_V0.6130.22
85_N258_Y0.6120.22
82_G108_G0.6120.22
197_R204_L0.6110.22
179_R328_S0.6100.22
30_I36_P0.6080.22
79_A254_N0.6060.22
177_L307_H0.6050.22
34_D332_L0.6040.22
44_E200_P0.6020.22
44_E198_P0.6010.22
305_N330_N0.6000.22
18_D195_Q0.6000.22
53_M56_A0.5990.22
170_L217_V0.5970.22
32_R357_T0.5970.22
95_V151_L0.5960.22
184_P276_T0.5960.22
144_D315_G0.5930.21
170_L281_D0.5920.21
224_F255_I0.5910.21
65_D188_K0.5900.21
268_E358_R0.5880.21
189_I344_W0.5870.21
58_E72_F0.5860.21
279_D360_V0.5830.21
14_Q17_A0.5830.21
43_A262_W0.5820.21
207_Q214_A0.5800.21
156_R195_Q0.5780.21
87_D308_S0.5760.21
85_N114_S0.5760.21
284_N295_L0.5750.21
250_G274_V0.5740.21
246_C250_G0.5730.21
320_I331_W0.5720.20
139_L303_C0.5710.20
103_V148_E0.5700.20
192_I285_V0.5690.20
109_T183_T0.5680.20
24_K95_V0.5680.20
26_S214_A0.5680.20
115_F341_T0.5680.20
179_R302_I0.5680.20
301_D308_S0.5660.20
149_I188_K0.5650.20
139_L238_L0.5650.20
19_F53_M0.5650.20
69_P296_D0.5640.20
186_Q192_I0.5640.20
71_F332_L0.5640.20
141_I146_S0.5630.20
257_Y283_W0.5620.20
254_N257_Y0.5620.20
333_D343_C0.5600.20
149_I310_R0.5590.20
262_W303_C0.5590.20
216_F280_C0.5580.20
320_I360_V0.5540.20
188_K192_I0.5530.20
260_S295_L0.5520.20
257_Y293_E0.5520.20
134_L159_N0.5510.20
99_C329_A0.5500.20
266_A272_I0.5490.19
103_V189_I0.5490.19
256_Y292_M0.5490.19
158_G340_G0.5490.19
109_T118_Q0.5480.19
149_I332_L0.5470.19
110_V115_F0.5460.19
152_S166_D0.5440.19
163_M355_P0.5430.19
287_L308_S0.5410.19
84_D114_S0.5390.19
219_Q270_L0.5370.19
267_D360_V0.5370.19
38_D338_R0.5350.19
255_I258_Y0.5340.19
29_Q351_Q0.5330.19
185_A283_W0.5330.19
330_N345_R0.5330.19
155_P271_V0.5330.19
42_R217_V0.5320.19
48_Y294_S0.5320.19
265_A356_R0.5310.19
229_A301_D0.5310.19
117_T249_V0.5310.19
158_G217_V0.5310.19
41_T51_R0.5290.19
178_D181_T0.5280.19
23_L53_M0.5280.19
88_N341_T0.5270.19
17_A356_R0.5270.19
19_F57_L0.5270.19
190_E212_R0.5260.19
182_E325_R0.5240.18
180_R204_L0.5240.18
95_V263_S0.5230.18
113_L264_L0.5230.18
175_T292_M0.5220.18
49_L238_L0.5210.18
255_I293_E0.5210.18
224_F284_N0.5210.18
83_A252_D0.5200.18
80_K302_I0.5190.18
302_I314_D0.5190.18
92_Y169_A0.5180.18
84_D347_V0.5170.18
190_E359_V0.5170.18
176_F294_S0.5170.18
104_T162_R0.5160.18
18_D271_V0.5160.18
296_D330_N0.5150.18
305_N344_W0.5140.18
30_I37_D0.5120.18
17_A28_E0.5110.18
264_L357_T0.5110.18
17_A21_D0.5100.18
22_T215_Q0.5090.18
63_F114_S0.5090.18
85_N282_F0.5080.18
307_H361_K0.5070.18
179_R330_N0.5070.18
199_A221_S0.5060.18
63_F71_F0.5060.18
100_E204_L0.5060.18
305_N319_V0.5060.18
40_L188_K0.5050.18
90_Y264_L0.5030.18
28_E207_Q0.5020.18
110_V281_D0.5010.18
272_I287_L0.5000.17
87_D271_V0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2p3y_A 1 0.8943 98.8 0.894 Contact Map
3u07_A 1 0.5041 98.7 0.898 Contact Map
1noa_A 1 0.2737 16.8 0.973 Contact Map
3lnd_A 1 0.5041 16.8 0.973 Contact Map
2omz_B 1 0.2737 16 0.973 Contact Map
1zvn_A 1 0.2683 13.9 0.974 Contact Map
1zxk_A 1 0.2602 13.1 0.974 Contact Map
3ppe_A 1 0.5203 11.7 0.975 Contact Map
2a4e_A 1 0.542 9.9 0.976 Contact Map
1wuz_A 1 0.2575 7.8 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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