T0938_1_259 - CASP12 - GREMLIN Contacts

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T0938_1_259 - T0938 1-259

ID:	107	Sequences: MTSIPVDPAADLLRERAAHYAAEAALFLRDQALSTASHDLRSPLNAMHSWAYVLERQLASADPSLQRALAGIRTGIDQQVALIDDVLDAPRAETRTLAITAQPFALRPLLDDTLALVRFALADARQVSIDATLPDGEPSLSADRERVAQALWTMLTTAVEASAAGNRVTFACTRDGAQCVAHVTCGVSAAALADPALPHAFDAFARREMLRSRDAKRVAWVLALCQRVALAHGGTFTHAAFADGAVVTLSLAVPCKAAG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	259 (242)
Sequences:	2485 (1973)
Seq/√Len:	126.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
225_C	236_F	5.660	1.00
51_A	72_I	4.935	1.00
237_T	250_S	3.674	1.00
241_F	245_A	3.415	1.00
162_S	188_S	3.307	1.00
197_L	238_H	3.026	1.00
151_L	183_V	3.002	1.00
150_A	229_A	2.948	1.00
226_Q	230_L	2.835	1.00
183_V	251_L	2.807	1.00
19_H	23_E	2.718	1.00
102_Q	144_R	2.613	1.00
19_H	22_A	2.511	1.00
104_F	142_A	2.484	1.00
186_G	248_T	2.475	1.00
162_S	166_N	2.439	1.00
55_E	70_A	2.399	1.00
55_E	73_R	2.390	1.00
182_H	252_A	2.388	1.00
229_A	251_L	2.008	1.00
238_H	249_L	1.976	1.00
48_H	76_I	1.973	1.00
184_T	248_T	1.919	1.00
150_A	228_V	1.894	1.00
118_R	123_D	1.874	1.00
193_A	196_A	1.858	1.00
193_A	243_D	1.848	1.00
15_E	19_H	1.825	1.00
166_N	188_S	1.810	1.00
182_H	250_S	1.799	1.00
155_L	170_F	1.758	1.00
18_A	22_A	1.744	1.00
117_V	159_V	1.741	1.00
230_L	235_T	1.739	1.00
142_A	232_H	1.738	1.00
132_T	171_A	1.734	1.00
161_A	206_R	1.722	1.00
146_R	149_Q	1.711	1.00
235_T	252_A	1.670	1.00
105_A	108_P	1.666	1.00
103_P	141_S	1.619	1.00
27_F	31_Q	1.610	1.00
130_D	169_T	1.604	1.00
47_M	72_I	1.601	1.00
110_L	151_L	1.584	1.00
101_A	141_S	1.569	1.00
171_A	184_T	1.541	1.00
21_A	24_A	1.537	1.00
142_A	147_V	1.512	1.00
122_A	159_V	1.490	1.00
190_A	215_A	1.489	1.00
122_A	168_V	1.483	1.00
57_Q	65_L	1.477	1.00
47_M	76_I	1.476	1.00
239_A	248_T	1.417	1.00
173_T	184_T	1.403	1.00
150_A	225_C	1.399	1.00
206_R	213_R	1.390	1.00
150_A	251_L	1.386	1.00
120_A	124_A	1.373	1.00
171_A	186_G	1.367	1.00
50_W	68_A	1.365	1.00
196_A	207_R	1.355	1.00
184_T	250_S	1.353	1.00
169_T	186_G	1.352	1.00
196_A	199_H	1.340	1.00
187_V	191_A	1.335	1.00
175_D	182_H	1.335	1.00
15_E	18_A	1.321	1.00
52_Y	73_R	1.316	1.00
66_Q	70_A	1.298	1.00
50_W	72_I	1.292	1.00
154_M	251_L	1.291	1.00
130_D	167_R	1.288	1.00
220_W	224_L	1.287	1.00
192_L	198_P	1.267	1.00
192_L	200_A	1.261	1.00
132_T	169_T	1.241	1.00
167_R	188_S	1.236	1.00
173_T	182_H	1.236	1.00
24_A	28_L	1.225	0.99
26_L	29_R	1.212	0.99
73_R	77_D	1.206	0.99
211_R	216_K	1.206	0.99
51_A	55_E	1.198	0.99
192_L	196_A	1.194	0.99
127_V	159_V	1.190	0.99
114_L	131_A	1.178	0.99
55_E	66_Q	1.160	0.99
110_L	183_V	1.157	0.99
46_A	75_G	1.144	0.99
211_R	215_A	1.139	0.99
140_L	255_C	1.128	0.99
201_F	236_F	1.125	0.99
18_A	23_E	1.115	0.99
210_L	213_R	1.114	0.99
107_R	111_D	1.105	0.99
76_I	79_Q	1.104	0.99
237_T	252_A	1.100	0.99
39_D	42_S	1.098	0.99
197_L	240_A	1.096	0.99
54_L	65_L	1.095	0.99
97_L	146_R	1.095	0.99
190_A	207_R	1.094	0.99
88_D	146_R	1.079	0.99
194_D	197_L	1.073	0.99
126_Q	164_A	1.066	0.99
169_T	188_S	1.055	0.98
52_Y	77_D	1.049	0.98
229_A	236_F	1.046	0.98
127_V	161_A	1.039	0.98
106_L	179_C	1.028	0.98
117_V	155_L	1.025	0.98
175_D	252_A	1.019	0.98
182_H	237_T	1.012	0.98
132_T	173_T	1.012	0.98
85_D	149_Q	1.011	0.98
178_Q	252_A	1.002	0.98
113_T	155_L	0.998	0.98
127_V	168_V	0.991	0.98
213_R	216_K	0.986	0.98
208_E	212_S	0.986	0.98
91_R	218_V	0.972	0.97
228_V	232_H	0.969	0.97
79_Q	83_I	0.965	0.97
36_A	86_V	0.964	0.97
112_D	144_R	0.964	0.97
22_A	28_L	0.950	0.97
30_D	40_L	0.950	0.97
18_A	21_A	0.947	0.97
67_R	70_A	0.944	0.97
23_E	26_L	0.942	0.97
117_V	152_W	0.939	0.97
236_F	251_L	0.937	0.97
161_A	215_A	0.931	0.97
114_L	129_I	0.930	0.97
206_R	210_L	0.927	0.96
192_L	197_L	0.919	0.96
208_E	213_R	0.918	0.96
109_L	113_T	0.913	0.96
101_A	142_A	0.912	0.96
48_H	52_Y	0.911	0.96
54_L	69_L	0.911	0.96
172_C	183_V	0.904	0.96
110_L	172_C	0.901	0.96
40_L	50_W	0.895	0.96
199_H	205_A	0.893	0.96
104_F	109_L	0.891	0.96
192_L	240_A	0.891	0.96
88_D	149_Q	0.891	0.96
240_A	244_G	0.884	0.95
203_A	220_W	0.880	0.95
42_S	45_N	0.875	0.95
26_L	30_D	0.875	0.95
35_T	203_A	0.870	0.95
47_M	51_A	0.870	0.95
237_T	251_L	0.868	0.95
156_T	170_F	0.866	0.95
16_R	19_H	0.861	0.95
50_W	71_G	0.855	0.95
81_A	145_E	0.851	0.94
239_A	250_S	0.850	0.94
71_G	75_G	0.850	0.94
106_L	183_V	0.846	0.94
172_C	179_C	0.846	0.94
78_Q	148_A	0.840	0.94
103_P	139_S	0.840	0.94
20_Y	24_A	0.837	0.94
78_Q	203_A	0.837	0.94
64_S	67_R	0.833	0.94
112_D	148_A	0.825	0.93
107_R	172_C	0.815	0.93
187_V	246_V	0.811	0.93
151_L	185_C	0.810	0.93
201_F	249_L	0.805	0.93
62_D	65_L	0.801	0.92
67_R	71_G	0.797	0.92
22_A	26_L	0.796	0.92
238_H	247_V	0.791	0.92
29_R	33_L	0.788	0.92
174_R	255_C	0.786	0.92
35_T	212_S	0.784	0.92
196_A	205_A	0.781	0.91
127_V	162_S	0.780	0.91
78_Q	145_E	0.779	0.91
17_A	21_A	0.775	0.91
147_V	183_V	0.774	0.91
40_L	44_L	0.763	0.90
138_P	174_R	0.762	0.90
240_A	245_A	0.758	0.90
57_Q	60_S	0.757	0.90
31_Q	209_M	0.751	0.90
24_A	27_F	0.751	0.90
78_Q	82_L	0.749	0.90
160_E	206_R	0.744	0.89
49_S	53_V	0.742	0.89
251_L	254_P	0.741	0.89
200_A	203_A	0.736	0.89
74_T	112_D	0.732	0.89
51_A	69_L	0.732	0.89
44_L	83_I	0.729	0.88
161_A	214_D	0.728	0.88
128_S	167_R	0.728	0.88
151_L	155_L	0.726	0.88
30_D	93_E	0.725	0.88
113_T	117_V	0.725	0.88
104_F	147_V	0.723	0.88
149_Q	228_V	0.719	0.88
113_T	159_V	0.717	0.87
228_V	231_A	0.716	0.87
50_W	75_G	0.715	0.87
192_L	238_H	0.714	0.87
39_D	79_Q	0.713	0.87
199_H	202_D	0.712	0.87
232_H	254_P	0.711	0.87
122_A	129_I	0.711	0.87
140_L	253_V	0.704	0.87
36_A	46_A	0.703	0.86
42_S	220_W	0.703	0.86
65_L	68_A	0.702	0.86
48_H	77_D	0.701	0.86
104_F	140_L	0.701	0.86
178_Q	182_H	0.699	0.86
197_L	200_A	0.697	0.86
29_R	39_D	0.695	0.86
191_A	246_V	0.693	0.86
37_S	42_S	0.691	0.86
46_A	71_G	0.685	0.85
200_A	205_A	0.684	0.85
203_A	227_R	0.682	0.85
208_E	215_A	0.677	0.84
86_V	218_V	0.676	0.84
25_A	33_L	0.675	0.84
162_S	206_R	0.674	0.84
141_S	256_K	0.673	0.84
51_A	73_R	0.672	0.84
194_D	243_D	0.670	0.84
198_P	207_R	0.669	0.84
105_A	137_E	0.666	0.83
169_T	184_T	0.665	0.83
67_R	115_A	0.663	0.83
207_R	211_R	0.662	0.83
84_D	218_V	0.661	0.83
157_T	191_A	0.659	0.83
209_M	212_S	0.653	0.82
157_T	246_V	0.650	0.82
23_E	27_F	0.648	0.82
227_R	230_L	0.646	0.81
57_Q	62_D	0.645	0.81
225_C	229_A	0.643	0.81
229_A	235_T	0.643	0.81
25_A	97_L	0.642	0.81
127_V	188_S	0.641	0.81
125_R	163_A	0.636	0.80
125_R	159_V	0.636	0.80
110_L	113_T	0.635	0.80
29_R	90_P	0.634	0.80
16_R	20_Y	0.634	0.80
46_A	49_S	0.632	0.80
70_A	74_T	0.631	0.80
157_T	187_V	0.627	0.80
151_L	251_L	0.624	0.79
200_A	238_H	0.622	0.79
191_A	217_R	0.622	0.79
227_R	231_A	0.622	0.79
162_S	165_G	0.622	0.79
105_A	138_P	0.619	0.79
31_Q	227_R	0.619	0.79
157_T	219_A	0.619	0.79
206_R	215_A	0.614	0.78
212_S	216_K	0.612	0.78
154_M	249_L	0.611	0.78
212_S	215_A	0.611	0.78
34_S	206_R	0.611	0.78
49_S	76_I	0.610	0.78
106_L	181_A	0.608	0.77
92_A	116_L	0.606	0.77
106_L	172_C	0.605	0.77
51_A	76_I	0.604	0.77
81_A	96_T	0.604	0.77
63_P	66_Q	0.603	0.77
138_P	255_C	0.601	0.77
83_I	89_A	0.599	0.76
140_L	256_K	0.598	0.76
41_R	206_R	0.598	0.76
179_C	257_A	0.594	0.76
210_L	216_K	0.593	0.76
181_A	255_C	0.591	0.75
120_A	159_V	0.590	0.75
125_R	162_S	0.589	0.75
81_A	89_A	0.586	0.75
63_P	67_R	0.584	0.75
54_L	72_I	0.582	0.74
85_D	146_R	0.580	0.74
108_P	111_D	0.578	0.74
157_T	221_V	0.575	0.73
45_N	75_G	0.575	0.73
48_H	73_R	0.575	0.73
225_C	251_L	0.574	0.73
155_L	158_A	0.573	0.73
32_A	160_E	0.570	0.73
54_L	68_A	0.569	0.73
35_T	207_R	0.569	0.73
107_R	134_P	0.569	0.73
41_R	162_S	0.567	0.72
173_T	245_A	0.566	0.72
144_R	148_A	0.563	0.72
14_R	18_A	0.562	0.72
107_R	133_L	0.562	0.72
82_L	86_V	0.561	0.72
29_R	32_A	0.561	0.72
15_E	20_Y	0.559	0.71
68_A	72_I	0.558	0.71
49_S	79_Q	0.557	0.71
106_L	171_A	0.554	0.71
14_R	17_A	0.554	0.71
21_A	70_A	0.554	0.71
46_A	76_I	0.554	0.71
36_A	206_R	0.553	0.71
42_S	49_S	0.551	0.70
52_Y	148_A	0.550	0.70
143_D	146_R	0.548	0.70
117_V	129_I	0.547	0.70
189_A	246_V	0.546	0.70
167_R	171_A	0.545	0.69
36_A	215_A	0.543	0.69
187_V	217_R	0.542	0.69
225_C	232_H	0.542	0.69
46_A	82_L	0.542	0.69
42_S	86_V	0.540	0.69
96_T	206_R	0.537	0.68
229_A	234_G	0.536	0.68
157_T	217_R	0.536	0.68
82_L	218_V	0.534	0.68
187_V	221_V	0.533	0.68
122_A	127_V	0.531	0.67
40_L	88_D	0.528	0.67
31_Q	223_A	0.527	0.67
80_V	84_D	0.527	0.67
134_P	137_E	0.525	0.67
104_F	144_R	0.524	0.66
146_R	228_V	0.523	0.66
208_E	214_D	0.519	0.66
129_I	170_F	0.517	0.65
191_A	221_V	0.515	0.65
173_T	176_G	0.514	0.65
36_A	156_T	0.514	0.65
200_A	249_L	0.513	0.65
179_C	182_H	0.512	0.65
37_S	45_N	0.508	0.64
153_T	157_T	0.508	0.64
41_R	224_L	0.508	0.64
120_A	156_T	0.507	0.64
123_D	128_S	0.507	0.64
72_I	80_V	0.505	0.64
194_D	241_F	0.505	0.64
17_A	20_Y	0.505	0.64
182_H	248_T	0.504	0.63
155_L	168_V	0.504	0.63
30_D	218_V	0.504	0.63
84_D	91_R	0.503	0.63
142_A	253_V	0.502	0.63
150_A	224_L	0.500	0.63

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4u7o_A	1	0.8842	100	0.357	Contact Map
4i5s_A	1	0.8726	100	0.358	Contact Map
3a0r_A	1	0.8958	100	0.362	Contact Map
4q20_A	1	0.8919	100	0.37	Contact Map
4gcz_A	1	0.9382	100	0.374	Contact Map
2e0a_A	1	0.9691	100	0.384	Contact Map
4mpc_A	1	0.9266	100	0.386	Contact Map
4e01_A	1	0.9421	100	0.392	Contact Map
3jz3_A	1	0.583	100	0.394	Contact Map
2c2a_A	1	0.9073	100	0.4	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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