GREMLIN Database
T0938_1_259 - T0938 1-259
ID: 107 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 259 (242)
Sequences: 2485 (1973)
Seq/√Len: 126.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
225_C236_F5.6601.00
51_A72_I4.9351.00
237_T250_S3.6741.00
241_F245_A3.4151.00
162_S188_S3.3071.00
197_L238_H3.0261.00
151_L183_V3.0021.00
150_A229_A2.9481.00
226_Q230_L2.8351.00
183_V251_L2.8071.00
19_H23_E2.7181.00
102_Q144_R2.6131.00
19_H22_A2.5111.00
104_F142_A2.4841.00
186_G248_T2.4751.00
162_S166_N2.4391.00
55_E70_A2.3991.00
55_E73_R2.3901.00
182_H252_A2.3881.00
229_A251_L2.0081.00
238_H249_L1.9761.00
48_H76_I1.9731.00
184_T248_T1.9191.00
150_A228_V1.8941.00
118_R123_D1.8741.00
193_A196_A1.8581.00
193_A243_D1.8481.00
15_E19_H1.8251.00
166_N188_S1.8101.00
182_H250_S1.7991.00
155_L170_F1.7581.00
18_A22_A1.7441.00
117_V159_V1.7411.00
230_L235_T1.7391.00
142_A232_H1.7381.00
132_T171_A1.7341.00
161_A206_R1.7221.00
146_R149_Q1.7111.00
235_T252_A1.6701.00
105_A108_P1.6661.00
103_P141_S1.6191.00
27_F31_Q1.6101.00
130_D169_T1.6041.00
47_M72_I1.6011.00
110_L151_L1.5841.00
101_A141_S1.5691.00
171_A184_T1.5411.00
21_A24_A1.5371.00
142_A147_V1.5121.00
122_A159_V1.4901.00
190_A215_A1.4891.00
122_A168_V1.4831.00
57_Q65_L1.4771.00
47_M76_I1.4761.00
239_A248_T1.4171.00
173_T184_T1.4031.00
150_A225_C1.3991.00
206_R213_R1.3901.00
150_A251_L1.3861.00
120_A124_A1.3731.00
171_A186_G1.3671.00
50_W68_A1.3651.00
196_A207_R1.3551.00
184_T250_S1.3531.00
169_T186_G1.3521.00
196_A199_H1.3401.00
187_V191_A1.3351.00
175_D182_H1.3351.00
15_E18_A1.3211.00
52_Y73_R1.3161.00
66_Q70_A1.2981.00
50_W72_I1.2921.00
154_M251_L1.2911.00
130_D167_R1.2881.00
220_W224_L1.2871.00
192_L198_P1.2671.00
192_L200_A1.2611.00
132_T169_T1.2411.00
167_R188_S1.2361.00
173_T182_H1.2361.00
24_A28_L1.2250.99
26_L29_R1.2120.99
73_R77_D1.2060.99
211_R216_K1.2060.99
51_A55_E1.1980.99
192_L196_A1.1940.99
127_V159_V1.1900.99
114_L131_A1.1780.99
55_E66_Q1.1600.99
110_L183_V1.1570.99
46_A75_G1.1440.99
211_R215_A1.1390.99
140_L255_C1.1280.99
201_F236_F1.1250.99
18_A23_E1.1150.99
210_L213_R1.1140.99
107_R111_D1.1050.99
76_I79_Q1.1040.99
237_T252_A1.1000.99
39_D42_S1.0980.99
197_L240_A1.0960.99
54_L65_L1.0950.99
97_L146_R1.0950.99
190_A207_R1.0940.99
88_D146_R1.0790.99
194_D197_L1.0730.99
126_Q164_A1.0660.99
169_T188_S1.0550.98
52_Y77_D1.0490.98
229_A236_F1.0460.98
127_V161_A1.0390.98
106_L179_C1.0280.98
117_V155_L1.0250.98
175_D252_A1.0190.98
182_H237_T1.0120.98
132_T173_T1.0120.98
85_D149_Q1.0110.98
178_Q252_A1.0020.98
113_T155_L0.9980.98
127_V168_V0.9910.98
213_R216_K0.9860.98
208_E212_S0.9860.98
91_R218_V0.9720.97
228_V232_H0.9690.97
79_Q83_I0.9650.97
36_A86_V0.9640.97
112_D144_R0.9640.97
22_A28_L0.9500.97
30_D40_L0.9500.97
18_A21_A0.9470.97
67_R70_A0.9440.97
23_E26_L0.9420.97
117_V152_W0.9390.97
236_F251_L0.9370.97
161_A215_A0.9310.97
114_L129_I0.9300.97
206_R210_L0.9270.96
192_L197_L0.9190.96
208_E213_R0.9180.96
109_L113_T0.9130.96
101_A142_A0.9120.96
48_H52_Y0.9110.96
54_L69_L0.9110.96
172_C183_V0.9040.96
110_L172_C0.9010.96
40_L50_W0.8950.96
199_H205_A0.8930.96
104_F109_L0.8910.96
192_L240_A0.8910.96
88_D149_Q0.8910.96
240_A244_G0.8840.95
203_A220_W0.8800.95
42_S45_N0.8750.95
26_L30_D0.8750.95
35_T203_A0.8700.95
47_M51_A0.8700.95
237_T251_L0.8680.95
156_T170_F0.8660.95
16_R19_H0.8610.95
50_W71_G0.8550.95
81_A145_E0.8510.94
239_A250_S0.8500.94
71_G75_G0.8500.94
106_L183_V0.8460.94
172_C179_C0.8460.94
78_Q148_A0.8400.94
103_P139_S0.8400.94
20_Y24_A0.8370.94
78_Q203_A0.8370.94
64_S67_R0.8330.94
112_D148_A0.8250.93
107_R172_C0.8150.93
187_V246_V0.8110.93
151_L185_C0.8100.93
201_F249_L0.8050.93
62_D65_L0.8010.92
67_R71_G0.7970.92
22_A26_L0.7960.92
238_H247_V0.7910.92
29_R33_L0.7880.92
174_R255_C0.7860.92
35_T212_S0.7840.92
196_A205_A0.7810.91
127_V162_S0.7800.91
78_Q145_E0.7790.91
17_A21_A0.7750.91
147_V183_V0.7740.91
40_L44_L0.7630.90
138_P174_R0.7620.90
240_A245_A0.7580.90
57_Q60_S0.7570.90
31_Q209_M0.7510.90
24_A27_F0.7510.90
78_Q82_L0.7490.90
160_E206_R0.7440.89
49_S53_V0.7420.89
251_L254_P0.7410.89
200_A203_A0.7360.89
74_T112_D0.7320.89
51_A69_L0.7320.89
44_L83_I0.7290.88
161_A214_D0.7280.88
128_S167_R0.7280.88
151_L155_L0.7260.88
30_D93_E0.7250.88
113_T117_V0.7250.88
104_F147_V0.7230.88
149_Q228_V0.7190.88
113_T159_V0.7170.87
228_V231_A0.7160.87
50_W75_G0.7150.87
192_L238_H0.7140.87
39_D79_Q0.7130.87
199_H202_D0.7120.87
232_H254_P0.7110.87
122_A129_I0.7110.87
140_L253_V0.7040.87
36_A46_A0.7030.86
42_S220_W0.7030.86
65_L68_A0.7020.86
48_H77_D0.7010.86
104_F140_L0.7010.86
178_Q182_H0.6990.86
197_L200_A0.6970.86
29_R39_D0.6950.86
191_A246_V0.6930.86
37_S42_S0.6910.86
46_A71_G0.6850.85
200_A205_A0.6840.85
203_A227_R0.6820.85
208_E215_A0.6770.84
86_V218_V0.6760.84
25_A33_L0.6750.84
162_S206_R0.6740.84
141_S256_K0.6730.84
51_A73_R0.6720.84
194_D243_D0.6700.84
198_P207_R0.6690.84
105_A137_E0.6660.83
169_T184_T0.6650.83
67_R115_A0.6630.83
207_R211_R0.6620.83
84_D218_V0.6610.83
157_T191_A0.6590.83
209_M212_S0.6530.82
157_T246_V0.6500.82
23_E27_F0.6480.82
227_R230_L0.6460.81
57_Q62_D0.6450.81
225_C229_A0.6430.81
229_A235_T0.6430.81
25_A97_L0.6420.81
127_V188_S0.6410.81
125_R163_A0.6360.80
125_R159_V0.6360.80
110_L113_T0.6350.80
29_R90_P0.6340.80
16_R20_Y0.6340.80
46_A49_S0.6320.80
70_A74_T0.6310.80
157_T187_V0.6270.80
151_L251_L0.6240.79
200_A238_H0.6220.79
191_A217_R0.6220.79
227_R231_A0.6220.79
162_S165_G0.6220.79
105_A138_P0.6190.79
31_Q227_R0.6190.79
157_T219_A0.6190.79
206_R215_A0.6140.78
212_S216_K0.6120.78
154_M249_L0.6110.78
212_S215_A0.6110.78
34_S206_R0.6110.78
49_S76_I0.6100.78
106_L181_A0.6080.77
92_A116_L0.6060.77
106_L172_C0.6050.77
51_A76_I0.6040.77
81_A96_T0.6040.77
63_P66_Q0.6030.77
138_P255_C0.6010.77
83_I89_A0.5990.76
140_L256_K0.5980.76
41_R206_R0.5980.76
179_C257_A0.5940.76
210_L216_K0.5930.76
181_A255_C0.5910.75
120_A159_V0.5900.75
125_R162_S0.5890.75
81_A89_A0.5860.75
63_P67_R0.5840.75
54_L72_I0.5820.74
85_D146_R0.5800.74
108_P111_D0.5780.74
157_T221_V0.5750.73
45_N75_G0.5750.73
48_H73_R0.5750.73
225_C251_L0.5740.73
155_L158_A0.5730.73
32_A160_E0.5700.73
54_L68_A0.5690.73
35_T207_R0.5690.73
107_R134_P0.5690.73
41_R162_S0.5670.72
173_T245_A0.5660.72
144_R148_A0.5630.72
14_R18_A0.5620.72
107_R133_L0.5620.72
82_L86_V0.5610.72
29_R32_A0.5610.72
15_E20_Y0.5590.71
68_A72_I0.5580.71
49_S79_Q0.5570.71
106_L171_A0.5540.71
14_R17_A0.5540.71
21_A70_A0.5540.71
46_A76_I0.5540.71
36_A206_R0.5530.71
42_S49_S0.5510.70
52_Y148_A0.5500.70
143_D146_R0.5480.70
117_V129_I0.5470.70
189_A246_V0.5460.70
167_R171_A0.5450.69
36_A215_A0.5430.69
187_V217_R0.5420.69
225_C232_H0.5420.69
46_A82_L0.5420.69
42_S86_V0.5400.69
96_T206_R0.5370.68
229_A234_G0.5360.68
157_T217_R0.5360.68
82_L218_V0.5340.68
187_V221_V0.5330.68
122_A127_V0.5310.67
40_L88_D0.5280.67
31_Q223_A0.5270.67
80_V84_D0.5270.67
134_P137_E0.5250.67
104_F144_R0.5240.66
146_R228_V0.5230.66
208_E214_D0.5190.66
129_I170_F0.5170.65
191_A221_V0.5150.65
173_T176_G0.5140.65
36_A156_T0.5140.65
200_A249_L0.5130.65
179_C182_H0.5120.65
37_S45_N0.5080.64
153_T157_T0.5080.64
41_R224_L0.5080.64
120_A156_T0.5070.64
123_D128_S0.5070.64
72_I80_V0.5050.64
194_D241_F0.5050.64
17_A20_Y0.5050.64
182_H248_T0.5040.63
155_L168_V0.5040.63
30_D218_V0.5040.63
84_D91_R0.5030.63
142_A253_V0.5020.63
150_A224_L0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4u7o_A 1 0.8842 100 0.357 Contact Map
4i5s_A 1 0.8726 100 0.358 Contact Map
3a0r_A 1 0.8958 100 0.362 Contact Map
4q20_A 1 0.8919 100 0.37 Contact Map
4gcz_A 1 0.9382 100 0.374 Contact Map
2e0a_A 1 0.9691 100 0.384 Contact Map
4mpc_A 1 0.9266 100 0.386 Contact Map
4e01_A 1 0.9421 100 0.392 Contact Map
3jz3_A 1 0.583 100 0.394 Contact Map
2c2a_A 1 0.9073 100 0.4 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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