GREMLIN Database
T0936_126_205 - T0936 126-205
ID: 105 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 80 (66)
Sequences: 1366 (1003)
Seq/√Len: 123.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_D71_K3.4611.00
50_M62_L2.8681.00
20_Y67_V2.3191.00
13_A60_V2.2711.00
25_R37_V2.2281.00
37_V41_R2.0961.00
18_N21_Y1.7711.00
20_Y71_K1.7671.00
22_E26_A1.7431.00
20_Y74_S1.7431.00
18_N44_A1.7021.00
15_F19_R1.6591.00
39_A46_F1.6271.00
61_D65_A1.4451.00
46_F50_M1.3981.00
45_A49_A1.3941.00
42_E49_A1.3671.00
65_A69_T1.3111.00
16_D20_Y1.3051.00
42_E45_A1.2581.00
25_R33_R1.2140.99
29_P32_S1.1590.99
13_A67_V1.1490.99
58_E63_I1.1370.99
16_D64_G1.1260.99
56_E59_R1.1140.99
14_L48_D1.1080.99
29_P33_R1.1080.99
21_Y37_V1.1050.99
37_V44_A1.1030.99
18_N41_R1.0770.99
20_Y24_L1.0270.98
14_L63_I1.0130.98
51_T54_V0.9940.98
19_R23_K0.9840.97
24_L28_M0.9830.97
44_A63_I0.9610.97
44_A48_D0.9410.97
13_A64_G0.9330.96
66_R69_T0.9220.96
28_M32_S0.8950.95
68_A72_R0.8870.95
53_L57_G0.8850.95
20_Y70_L0.8810.95
14_L44_A0.8790.95
46_F62_L0.8750.95
19_R34_Q0.8670.95
52_P60_V0.8660.94
21_Y25_R0.8600.94
21_Y44_A0.8490.94
18_N63_I0.8490.94
39_A50_M0.8480.94
60_V64_G0.8420.94
64_G68_A0.8380.93
62_L65_A0.8290.93
24_L74_S0.8170.93
14_L17_M0.8090.92
14_L41_R0.8040.92
46_F69_T0.8010.92
40_Q66_R0.7810.91
21_Y28_M0.7790.91
13_A63_I0.7790.91
55_S59_R0.7710.90
13_A16_D0.7700.90
71_K75_E0.7520.89
34_Q38_A0.7420.89
14_L18_N0.7360.88
52_P56_E0.7180.87
57_G61_D0.7000.85
23_K74_S0.6950.85
24_L73_F0.6890.85
59_R63_I0.6810.84
44_A47_S0.6810.84
17_M40_Q0.6650.82
39_A66_R0.6610.82
34_Q37_V0.6400.80
15_F22_E0.6150.77
12_H16_D0.6120.77
68_A71_K0.6020.76
27_R56_E0.5910.74
17_M41_R0.5900.74
46_F73_F0.5830.73
21_Y36_L0.5730.72
57_G65_A0.5640.71
62_L69_T0.5590.70
38_A72_R0.5550.70
56_E67_V0.5530.70
23_K27_R0.5530.70
38_A49_A0.5490.69
27_R30_A0.5400.68
12_H41_R0.5320.67
14_L36_L0.5270.66
41_R44_A0.5270.66
16_D19_R0.5220.65
53_L56_E0.5200.65
48_D59_R0.5160.64
33_R37_V0.5080.63
21_Y41_R0.5020.62
51_T55_S0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gi7_A 1 0.95 99.2 0.364 Contact Map
3lxu_X 1 0.975 13 0.869 Contact Map
2yay_A 1 0.25 4.7 0.893 Contact Map
2y9m_A 1 0.3375 2.7 0.906 Contact Map
3csk_A 1 1 2.7 0.906 Contact Map
2rno_A 1 0.4125 2.5 0.907 Contact Map
3jb6_A 1 0.35 2 0.912 Contact Map
4p72_A 1 0.4625 1.9 0.913 Contact Map
3pco_B 1 0.475 1.9 0.913 Contact Map
1deq_A 1 0.9875 1.8 0.915 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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