GREMLIN Database
T0936_1_125 - T0936 1-125
ID: 104 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 125 (103)
Sequences: 1736 (1302)
Seq/√Len: 128.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_A94_M4.9451.00
11_C26_C3.4831.00
37_E107_R3.2691.00
19_S22_G2.6821.00
71_E98_P2.4241.00
58_Q62_R2.3031.00
41_A103_A1.9991.00
46_V58_Q1.9561.00
34_W96_L1.9071.00
20_T85_T1.7981.00
63_R70_D1.7601.00
79_Y90_A1.6781.00
86_M90_A1.6491.00
76_R87_Y1.6401.00
39_D65_L1.6251.00
46_V54_R1.5691.00
30_A96_L1.5601.00
23_Q89_M1.5561.00
67_W71_E1.5351.00
31_R95_R1.5021.00
34_W103_A1.4711.00
63_R66_A1.4581.00
101_E105_A1.4421.00
71_E75_V1.3061.00
39_D42_Y1.2551.00
97_Q101_E1.2531.00
72_A99_V1.2481.00
18_S22_G1.2431.00
20_T89_M1.2331.00
20_T24_I1.2220.99
42_Y58_Q1.1890.99
24_I89_M1.1670.99
25_Q29_E1.1650.99
40_A44_R1.1430.99
62_R65_L1.1420.99
20_T84_G1.1380.99
34_W37_E1.1340.99
60_S67_W1.1310.99
76_R91_S1.1210.99
41_A107_R1.1170.99
41_A110_A1.1120.99
28_D32_Q1.0940.99
65_L68_R1.0940.99
41_A106_L1.0790.99
43_Q47_K1.0770.99
36_G40_A1.0660.99
42_Y65_L1.0530.98
68_R99_V1.0530.98
35_Q62_R1.0400.98
35_Q65_L1.0380.98
67_W105_A1.0330.98
35_Q39_D1.0270.98
50_P54_R1.0270.98
45_L110_A1.0160.98
66_A70_D1.0120.98
31_R99_V1.0040.98
79_Y86_M0.9920.98
37_E41_A0.9910.98
77_A80_E0.9890.98
39_D62_R0.9640.97
55_R58_Q0.9620.97
32_Q36_G0.9500.97
24_I92_A0.9440.97
100_R104_L0.9340.97
13_A18_S0.9270.97
5_D8_M0.9240.97
35_Q99_V0.9150.96
93_D97_Q0.9110.96
96_L100_R0.8990.96
35_Q68_R0.8920.96
55_R59_E0.8870.96
61_Q64_W0.8830.96
61_Q102_R0.8730.95
27_M92_A0.8700.95
60_S71_E0.8520.95
102_R105_A0.8450.94
34_W104_L0.8440.94
30_A34_W0.8320.94
19_S86_M0.8300.94
38_V65_L0.8210.93
20_T23_Q0.8170.93
12_L22_G0.8170.93
14_R18_S0.8050.93
67_W98_P0.8040.93
94_M99_V0.7900.92
37_E100_R0.7800.92
65_L69_K0.7730.91
26_C94_M0.7730.91
35_Q38_V0.7660.91
5_D34_W0.7490.90
81_T87_Y0.7470.90
41_A45_L0.7460.90
34_W99_V0.7400.89
56_G77_A0.7400.89
71_E102_R0.7300.89
91_S95_R0.7290.89
86_M89_M0.7280.89
42_Y57_W0.7270.88
35_Q42_Y0.7240.88
80_E90_A0.7230.88
75_V97_Q0.7210.88
8_M12_L0.7200.88
44_R110_A0.7180.88
104_L108_G0.7160.88
34_W100_R0.7140.88
60_S102_R0.7090.87
67_W74_L0.7010.87
73_H91_S0.7000.87
71_E109_A0.6960.86
26_C72_A0.6890.86
27_M96_L0.6890.86
9_R13_A0.6870.86
42_Y61_Q0.6840.85
23_Q84_G0.6810.85
54_R58_Q0.6750.85
59_E63_R0.6740.84
79_Y87_Y0.6660.84
43_Q46_V0.6580.83
21_A25_Q0.6570.83
53_A77_A0.6490.82
24_I88_A0.6460.82
37_E40_A0.6390.81
100_R103_A0.6240.80
35_Q58_Q0.6230.79
59_E70_D0.6180.79
58_Q65_L0.6080.78
45_L48_T0.6020.77
57_W74_L0.5930.76
42_Y64_W0.5920.76
45_L106_L0.5880.75
48_T110_A0.5840.75
42_Y62_R0.5800.75
28_D92_A0.5750.74
29_E36_G0.5660.73
52_D80_E0.5620.72
49_A53_A0.5580.72
8_M30_A0.5550.71
31_R96_L0.5520.71
14_R23_Q0.5520.71
59_E73_H0.5410.69
103_A107_R0.5390.69
43_Q70_D0.5330.68
35_Q57_W0.5330.68
33_Q36_G0.5310.68
38_V61_Q0.5260.67
60_S109_A0.5260.67
14_R22_G0.5200.66
47_K50_P0.5160.66
42_Y46_V0.5130.65
20_T86_M0.5050.64
10_Q14_R0.5050.64
29_E33_Q0.5040.64
66_A91_S0.5020.64
59_E66_A0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gi7_A 1 0.768 99.9 0.256 Contact Map
4noo_B 1 0.76 65 0.859 Contact Map
4nso_B 1 0.752 56 0.867 Contact Map
2ej7_A 1 0.568 4.8 0.921 Contact Map
2cug_A 1 0.632 4.3 0.923 Contact Map
5bqm_B 1 0.296 4.2 0.923 Contact Map
1sb0_B 1 0.2 3.9 0.925 Contact Map
2ctp_A 1 0.576 3.8 0.925 Contact Map
2dn9_A 1 0.576 3.7 0.925 Contact Map
1wjz_A 1 0.624 2.2 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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