GREMLIN Database
T0936_1_205 - T0936 1-205
ID: 103 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 205 (204)
Sequences: 43 (20)
Seq/√Len: 1.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
74_L78_V3.7000.36
111_D171_F2.8710.24
184_R194_T2.4820.19
95_R152_R2.3880.18
153_M176_T2.3330.18
41_A71_E2.3220.18
10_Q111_D2.1200.16
47_K85_T2.1050.16
88_A157_S2.0520.15
188_I199_S2.0080.15
5_D11_C2.0070.15
93_D146_Y1.9960.15
188_I192_V1.9270.14
79_Y111_D1.9180.14
20_T86_M1.8630.14
59_E63_R1.8540.13
49_A134_A1.8510.13
142_M175_M1.7900.13
190_A204_N1.7850.13
152_R203_N1.7480.13
194_T199_S1.7420.13
184_R199_S1.7420.13
79_Y91_S1.7110.12
4_I158_R1.6990.12
54_R78_V1.6890.12
54_R192_V1.6630.12
184_R200_E1.6470.12
194_T200_E1.6470.12
199_S202_V1.6350.12
2_D8_M1.6310.12
54_R74_L1.6250.12
60_S161_L1.6240.12
165_Q181_E1.6010.12
55_R89_M1.5660.11
42_Y178_L1.5490.11
79_Y171_F1.5390.11
182_G205_R1.5300.11
52_D70_D1.5230.11
200_E204_N1.5040.11
152_R202_V1.4950.11
10_Q79_Y1.4650.11
15_R42_Y1.4610.11
61_Q92_A1.4470.11
195_L204_N1.4380.10
78_V138_A1.4340.10
151_A195_L1.4080.10
19_S40_A1.4030.10
93_D153_M1.3910.10
66_A70_D1.3880.10
10_Q171_F1.3670.10
16_D149_L1.3510.10
28_D71_E1.3450.10
74_L138_A1.3260.10
133_A137_H1.3230.10
69_K123_V1.3180.10
94_M153_M1.3110.10
41_A181_E1.3110.10
4_I12_L1.3020.10
19_S45_L1.2920.10
182_G192_V1.2800.09
183_E195_L1.2790.09
19_S195_L1.2780.09
85_T91_S1.2720.09
59_E110_A1.2710.09
52_D80_E1.2670.09
68_R84_G1.2410.09
166_R173_D1.2210.09
29_E148_K1.2180.09
78_V90_A1.2170.09
138_A166_R1.2130.09
78_V192_V1.2120.09
85_T171_F1.2070.09
33_Q172_S1.2070.09
85_T111_D1.2050.09
20_T45_L1.2050.09
95_R203_N1.2030.09
163_A175_M1.1980.09
63_R73_H1.1810.09
153_M200_E1.1680.09
3_P22_G1.1650.09
62_R110_A1.1570.09
183_E192_V1.1560.09
25_Q99_V1.1550.09
128_P159_Q1.1470.09
153_M177_P1.1440.09
3_P11_C1.1380.09
20_T66_A1.1230.09
138_A143_N1.1220.09
62_R148_K1.1200.09
55_R59_E1.1190.09
39_D60_S1.1170.09
77_A141_D1.1110.09
161_L166_R1.1080.09
84_G168_W1.1060.09
74_L192_V1.1020.08
162_V188_I1.0950.08
67_W172_S1.0910.08
90_A138_A1.0880.08
74_L90_A1.0790.08
58_Q123_V1.0790.08
153_M162_V1.0680.08
109_A125_R1.0650.08
70_D154_P1.0500.08
192_V195_L1.0470.08
10_Q53_A1.0440.08
37_E79_Y1.0330.08
78_V188_I1.0210.08
182_G203_N1.0190.08
101_E167_E1.0170.08
190_A201_T1.0080.08
153_M160_T1.0080.08
34_W102_R1.0030.08
64_W102_R1.0030.08
64_W106_L1.0030.08
102_R106_L1.0030.08
34_W64_W1.0030.08
34_W106_L1.0030.08
114_A171_F0.9960.08
191_R196_K0.9830.08
189_G193_A0.9830.08
193_A197_R0.9830.08
189_G196_K0.9830.08
186_D196_K0.9830.08
193_A196_K0.9830.08
186_D193_A0.9830.08
186_D191_R0.9830.08
189_G197_R0.9830.08
191_R197_R0.9830.08
186_D197_R0.9830.08
186_D189_G0.9830.08
49_A185_V0.9780.08
133_A136_E0.9770.08
42_Y62_R0.9750.08
198_F203_N0.9740.08
23_Q135_C0.9730.08
183_E203_N0.9730.08
33_Q52_D0.9650.08
188_I202_V0.9560.08
105_A157_S0.9560.08
79_Y123_V0.9530.08
78_V140_F0.9470.08
108_G172_S0.9430.08
56_G139_L0.9380.08
3_P100_R0.9340.08
143_N161_L0.9260.08
7_A187_L0.9190.08
35_Q88_A0.9140.08
77_A87_Y0.9130.08
43_Q54_R0.9100.08
37_E80_E0.9100.08
19_S151_A0.9060.07
79_Y147_E0.9050.07
80_E128_P0.9050.07
65_L150_R0.9030.07
109_A152_R0.9020.07
74_L188_I0.9020.07
50_P61_Q0.8990.07
50_P92_A0.8990.07
84_G141_D0.8960.07
59_E185_V0.8870.07
139_L188_I0.8790.07
88_A126_V0.8770.07
37_E101_E0.8750.07
16_D41_A0.8740.07
42_Y78_V0.8690.07
65_L157_S0.8670.07
88_A180_S0.8660.07
139_L169_A0.8650.07
139_L187_L0.8520.07
49_A56_G0.8470.07
187_L203_N0.8430.07
74_L140_F0.8410.07
57_W145_Y0.8390.07
62_R85_T0.8330.07
82_T174_A0.8320.07
159_Q180_S0.8260.07
76_R187_L0.8260.07
17_R187_L0.8240.07
9_R13_A0.8220.07
183_E188_I0.8130.07
48_T147_E0.8120.07
183_E205_R0.8110.07
15_R62_R0.8080.07
109_A140_F0.8060.07
17_R148_K0.8030.07
33_Q108_G0.8020.07
132_D136_E0.7990.07
67_W178_L0.7990.07
23_Q87_Y0.7960.07
18_S27_M0.7930.07
42_Y150_R0.7920.07
71_E184_R0.7840.07
71_E194_T0.7840.07
99_V138_A0.7840.07
86_M183_E0.7820.07
49_A59_E0.7800.07
190_A200_E0.7790.07
129_C154_P0.7780.07
17_R29_E0.7760.07
194_T202_V0.7720.07
184_R202_V0.7720.07
126_V152_R0.7680.07
22_G174_A0.7660.07
138_A161_L0.7650.07
42_Y74_L0.7610.07
33_Q66_A0.7560.07
44_R93_D0.7550.07
57_W96_L0.7390.07
88_A114_A0.7390.07
190_A195_L0.7360.07
88_A139_L0.7330.07
160_T183_E0.7310.07
16_D25_Q0.7310.07
17_R67_W0.7270.07
35_Q59_E0.7220.07
22_G100_R0.7210.07
56_G187_L0.7140.07
15_R79_Y0.7090.07
86_M169_A0.7070.07
169_A205_R0.7050.07
63_R185_V0.6930.07
62_R171_F0.6880.07
25_Q104_L0.6800.06
166_R174_A0.6740.06
181_E194_T0.6720.06
181_E184_R0.6720.06
80_E154_P0.6710.06
56_G134_A0.6670.06
54_R58_Q0.6660.06
7_A72_A0.6660.06
182_G195_L0.6630.06
129_C135_C0.6620.06
188_I203_N0.6540.06
68_R77_A0.6540.06
50_P158_R0.6490.06
189_G201_T0.6470.06
197_R201_T0.6470.06
193_A201_T0.6470.06
186_D201_T0.6470.06
191_R201_T0.6470.06
196_K201_T0.6470.06
169_A187_L0.6470.06
139_L180_S0.6470.06
62_R79_Y0.6440.06
26_C68_R0.6400.06
107_R144_R0.6360.06
20_T50_P0.6340.06
192_V203_N0.6310.06
26_C74_L0.6230.06
49_A66_A0.6220.06
86_M188_I0.6200.06
179_V199_S0.6160.06
185_V192_V0.6120.06
103_A129_C0.6120.06
37_E156_D0.6110.06
98_P136_E0.6080.06
97_Q145_Y0.6060.06
142_M160_T0.6040.06
141_D157_S0.6010.06
17_R95_R0.5960.06
113_Y202_V0.5940.06
2_D9_R0.5940.06
18_S107_R0.5910.06
33_Q150_R0.5890.06
112_R126_V0.5770.06
46_V169_A0.5700.06
77_A137_H0.5690.06
41_A194_T0.5690.06
41_A184_R0.5690.06
7_A155_A0.5680.06
37_E41_A0.5670.06
104_L145_Y0.5640.06
170_A174_A0.5630.06
32_Q88_A0.5560.06
30_A103_A0.5560.06
18_S144_R0.5520.06
49_A55_R0.5510.06
168_W171_F0.5510.06
187_L194_T0.5490.06
184_R187_L0.5490.06
114_A180_S0.5490.06
1_A11_C0.5480.06
1_A5_D0.5480.06
53_A180_S0.5460.06
75_V180_S0.5430.06
99_V104_L0.5390.06
84_G87_Y0.5370.06
10_Q151_A0.5330.06
130_M159_Q0.5310.06
44_R52_D0.5290.06
162_V166_R0.5280.06
19_S65_L0.5260.06
8_M13_A0.5220.06
97_Q107_R0.5200.06
3_P8_M0.5190.06
90_A188_I0.5130.06
35_Q63_R0.5130.06
172_S175_M0.5090.06
47_K131_R0.5090.06
33_Q152_R0.5080.06
153_M199_S0.5080.06
132_D137_H0.5070.06
97_Q144_R0.5070.06
10_Q91_S0.5060.06
107_R145_Y0.5010.06
63_R78_V0.5000.06
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gi7_A 1 0.4683 98.9 0.876 Contact Map
2zae_A 1 0.1951 8.9 0.973 Contact Map
2jqe_A 1 0.3268 7.1 0.974 Contact Map
1gl2_D 1 0.1171 5.6 0.976 Contact Map
1mfq_C 1 0.2927 5.3 0.976 Contact Map
3syn_E 1 0.0683 5.2 0.976 Contact Map
3uky_C 1 0.0683 4.6 0.976 Contact Map
1aq5_A 1 0.2244 4.1 0.977 Contact Map
1qb2_A 1 0.3024 3.8 0.977 Contact Map
3b5n_D 1 0.1512 3.7 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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