T0933_1_346 - CASP12 - GREMLIN Contacts

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T0933_1_346 - T0933 1-346

ID:	101	Sequences: MGHHHHHHGGSENLYFQGNEDILKASATQSAVAGTYQIQVNSLATSSKIALQAIADPANAKFNSGTLNISVGDTKLPAITVDSSNNTLAGMRDAINQAGKEAGVSATIITDNSGSRLVLSSTKTGDGKDIKVEVSDDGSGGNTSLSQLAFDPATAPKLSDGAAAGYVTKAANGEITVDGLKRSIASNSVSDVIDGVSFDVKAVTEAGKPITLTVSRDDAGVKDNVKKFVEAYNTLTKFINEQTVVTKVGEDKNPVTGALLGDASVRALVNTMRSELIASNENGSVRNLAALGITTTKDGTLEIDEKKLDKAISADFEGVASYFTGDTGLAKRLGDKMKPYTDAQGI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	346 (308)
Sequences:	2908 (2246)
Seq/√Len:	128.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
172_N	183_S	4.546	1.00
42_S	174_E	4.211	1.00
42_S	171_A	3.710	1.00
48_K	178_D	3.667	1.00
222_K	309_D	3.508	1.00
226_K	230_E	3.325	1.00
174_E	181_K	3.054	1.00
303_I	308_L	2.945	1.00
315_D	318_G	2.935	1.00
237_K	300_T	2.879	1.00
226_K	305_E	2.768	1.00
296_T	302_E	2.733	1.00
175_I	189_V	2.730	1.00
257_G	260_L	2.702	1.00
184_I	191_D	2.628	1.00
189_V	200_V	2.566	1.00
175_I	182_R	2.541	1.00
95_I	119_L	2.537	1.00
86_N	94_A	2.496	1.00
45_T	171_A	2.491	1.00
291_L	322_Y	2.481	1.00
296_T	300_T	2.443	1.00
23_L	38_I	2.439	1.00
39_Q	176_T	2.438	1.00
41_N	174_E	2.418	1.00
85_N	90_G	2.387	1.00
223_D	227_K	2.386	1.00
304_D	307_K	2.382	1.00
226_K	303_I	2.371	1.00
22_I	204_T	2.304	1.00
238_F	242_Q	2.275	1.00
166_Y	169_K	2.188	1.00
86_N	90_G	2.173	1.00
322_Y	329_L	2.166	1.00
92_R	108_I	2.116	1.00
23_L	212_L	2.092	1.00
35_T	213_T	2.083	1.00
176_T	181_K	2.067	1.00
174_E	183_S	2.066	1.00
204_T	210_I	2.051	1.00
188_S	199_D	2.035	1.00
222_K	305_E	2.003	1.00
23_L	210_I	2.002	1.00
172_N	185_A	1.950	1.00
111_D	116_R	1.941	1.00
47_S	130_I	1.896	1.00
310_K	314_A	1.884	1.00
230_E	234_T	1.872	1.00
308_L	312_I	1.827	1.00
105_S	122_T	1.810	1.00
41_N	176_T	1.792	1.00
66_T	78_A	1.718	1.00
286_R	290_A	1.718	1.00
245_V	254_P	1.706	1.00
43_L	200_V	1.670	1.00
243_T	265_V	1.658	1.00
225_V	308_L	1.634	1.00
189_V	198_F	1.601	1.00
77_P	102_A	1.600	1.00
287_N	290_A	1.579	1.00
18_G	210_I	1.572	1.00
90_G	94_A	1.548	1.00
19_N	22_I	1.546	1.00
39_Q	204_T	1.541	1.00
108_I	115_S	1.531	1.00
68_N	78_A	1.478	1.00
70_S	131_K	1.469	1.00
313_S	316_F	1.452	1.00
235_L	239_I	1.440	1.00
19_N	202_A	1.435	1.00
66_T	80_T	1.434	1.00
237_K	241_E	1.433	1.00
36_Y	178_D	1.433	1.00
41_N	181_K	1.430	1.00
204_T	207_G	1.414	1.00
38_I	177_V	1.412	1.00
46_S	124_T	1.408	1.00
222_K	226_K	1.405	1.00
225_V	303_I	1.397	1.00
49_I	130_I	1.395	1.00
219_A	223_D	1.394	1.00
145_L	148_L	1.393	1.00
295_T	301_L	1.377	1.00
221_V	224_N	1.372	1.00
119_L	132_V	1.362	1.00
177_V	192_V	1.355	1.00
87_T	90_G	1.333	1.00
89_A	93_D	1.328	1.00
22_I	202_A	1.294	1.00
236_T	240_N	1.290	1.00
193_I	196_V	1.288	1.00
236_T	269_V	1.279	1.00
42_S	203_V	1.263	1.00
24_K	201_K	1.257	1.00
175_I	181_K	1.256	1.00
175_I	200_V	1.246	1.00
309_D	313_S	1.246	1.00
338_K	342_D	1.245	1.00
24_K	199_D	1.245	1.00
229_V	303_I	1.244	1.00
25_A	212_L	1.244	1.00
305_E	309_D	1.242	1.00
70_S	133_E	1.241	1.00
224_N	227_K	1.232	1.00
145_L	150_F	1.231	1.00
236_T	300_T	1.229	1.00
221_V	316_F	1.211	0.99
225_V	323_F	1.204	0.99
293_I	301_L	1.198	0.99
246_T	249_G	1.195	0.99
271_T	336_K	1.191	0.99
184_I	189_V	1.186	0.99
39_Q	206_A	1.185	0.99
81_V	86_N	1.173	0.99
189_V	192_V	1.168	0.99
68_N	135_S	1.144	0.99
70_S	76_L	1.138	0.99
245_V	260_L	1.130	0.99
88_L	108_I	1.113	0.99
128_K	185_A	1.112	0.99
246_T	254_P	1.110	0.99
110_T	115_S	1.108	0.99
227_K	230_E	1.095	0.99
312_I	319_V	1.095	0.99
219_A	309_D	1.092	0.99
91_M	148_L	1.089	0.99
177_V	182_R	1.086	0.99
38_I	212_L	1.075	0.99
49_I	166_Y	1.073	0.99
50_A	167_V	1.067	0.99
123_K	128_K	1.067	0.99
268_L	340_Y	1.065	0.99
241_E	244_V	1.052	0.98
56_D	60_A	1.049	0.98
95_I	106_A	1.045	0.98
173_G	200_V	1.043	0.98
47_S	170_A	1.043	0.98
67_L	134_V	1.036	0.98
25_A	198_F	1.035	0.98
294_T	304_D	1.025	0.98
182_R	192_V	1.022	0.98
68_N	76_L	1.020	0.98
69_I	79_I	1.016	0.98
81_V	94_A	1.006	0.98
218_D	313_S	0.994	0.98
238_F	241_E	0.994	0.98
231_A	234_T	0.993	0.98
126_D	183_S	0.981	0.98
83_S	86_N	0.981	0.98
48_K	118_V	0.969	0.97
49_I	164_A	0.963	0.97
51_L	54_I	0.957	0.97
129_D	170_A	0.955	0.97
288_L	293_I	0.954	0.97
47_S	166_Y	0.949	0.97
43_L	203_V	0.946	0.97
50_A	118_V	0.943	0.97
93_D	97_Q	0.932	0.97
126_D	172_N	0.931	0.97
23_L	198_F	0.929	0.97
235_L	272_M	0.925	0.97
291_L	319_V	0.923	0.97
239_I	269_V	0.923	0.97
229_V	308_L	0.923	0.97
64_S	86_N	0.922	0.96
84_S	90_G	0.919	0.96
39_Q	205_E	0.917	0.96
269_V	273_R	0.917	0.96
311_A	319_V	0.913	0.96
112_N	115_S	0.904	0.96
81_V	91_M	0.899	0.96
89_A	108_I	0.897	0.96
21_D	202_A	0.895	0.96
175_I	184_I	0.892	0.96
69_I	102_A	0.891	0.96
38_I	198_F	0.891	0.96
96_N	106_A	0.890	0.96
47_S	129_D	0.888	0.96
219_A	222_K	0.886	0.96
223_D	226_K	0.885	0.96
149_A	152_P	0.884	0.96
184_I	190_S	0.882	0.95
130_I	166_Y	0.881	0.95
134_V	149_A	0.874	0.95
35_T	211_T	0.872	0.95
128_K	170_A	0.870	0.95
69_I	95_I	0.870	0.95
234_T	238_F	0.868	0.95
126_D	185_A	0.867	0.95
239_I	265_V	0.866	0.95
45_T	168_T	0.865	0.95
173_G	187_N	0.862	0.95
136_D	139_S	0.861	0.95
217_D	220_G	0.860	0.95
306_K	310_K	0.857	0.95
328_G	332_R	0.856	0.95
110_T	184_I	0.856	0.95
221_V	312_I	0.851	0.95
337_M	341_T	0.843	0.94
189_V	197_S	0.837	0.94
31_A	214_V	0.835	0.94
307_K	310_K	0.833	0.94
21_D	201_K	0.831	0.94
222_K	303_I	0.830	0.94
274_S	277_I	0.827	0.94
111_D	114_G	0.825	0.94
41_N	175_I	0.820	0.93
92_R	117_L	0.817	0.93
275_E	332_R	0.817	0.93
334_G	338_K	0.817	0.93
335_D	338_K	0.817	0.93
171_A	174_E	0.815	0.93
317_E	321_S	0.809	0.93
184_I	192_V	0.809	0.93
229_V	293_I	0.803	0.93
38_I	175_I	0.803	0.93
193_I	198_F	0.794	0.92
285_V	311_A	0.789	0.92
310_K	313_S	0.789	0.92
245_V	249_G	0.788	0.92
52_Q	165_G	0.788	0.92
134_V	137_D	0.783	0.92
127_G	185_A	0.781	0.92
50_A	116_R	0.781	0.92
175_I	192_V	0.780	0.92
69_I	132_V	0.778	0.91
80_T	84_S	0.771	0.91
276_L	301_L	0.769	0.91
106_A	119_L	0.768	0.91
146_S	150_F	0.760	0.90
220_G	223_D	0.760	0.90
37_Q	211_T	0.755	0.90
294_T	302_E	0.752	0.90
126_D	129_D	0.752	0.90
86_N	91_M	0.747	0.90
69_I	104_V	0.746	0.90
239_I	242_Q	0.743	0.89
246_T	260_L	0.743	0.89
289_A	294_T	0.740	0.89
45_T	203_V	0.737	0.89
64_S	90_G	0.735	0.89
103_G	122_T	0.735	0.89
38_I	191_D	0.734	0.89
146_S	149_A	0.733	0.89
246_T	255_V	0.731	0.89
191_D	194_D	0.731	0.89
125_G	172_N	0.727	0.88
90_G	93_D	0.722	0.88
318_G	321_S	0.721	0.88
271_T	275_E	0.719	0.88
128_K	172_N	0.719	0.88
131_K	151_D	0.719	0.88
265_V	269_V	0.716	0.88
23_L	204_T	0.716	0.88
249_G	256_T	0.715	0.88
334_G	337_M	0.713	0.87
231_A	236_T	0.713	0.87
232_Y	301_L	0.712	0.87
41_N	203_V	0.712	0.87
127_G	172_N	0.711	0.87
27_A	31_A	0.707	0.87
175_I	198_F	0.706	0.87
24_K	27_A	0.705	0.87
71_V	130_I	0.703	0.87
198_F	201_K	0.702	0.87
173_G	186_S	0.700	0.86
260_L	266_R	0.699	0.86
203_V	207_G	0.697	0.86
216_R	221_V	0.692	0.86
317_E	320_A	0.690	0.86
107_T	118_V	0.689	0.86
17_Q	20_E	0.688	0.86
223_D	230_E	0.683	0.85
218_D	309_D	0.679	0.85
198_F	212_L	0.677	0.85
118_V	178_D	0.677	0.85
107_T	111_D	0.677	0.85
64_S	85_N	0.676	0.85
243_T	260_L	0.676	0.85
263_A	266_R	0.672	0.84
275_E	336_K	0.672	0.84
65_G	72_G	0.666	0.84
61_K	87_T	0.665	0.84
25_A	32_V	0.664	0.83
279_S	287_N	0.664	0.83
249_G	260_L	0.662	0.83
144_S	149_A	0.662	0.83
87_T	91_M	0.660	0.83
123_K	186_S	0.659	0.83
335_D	339_P	0.657	0.83
31_A	36_Y	0.656	0.83
225_V	293_I	0.652	0.82
245_V	256_T	0.650	0.82
57_P	89_A	0.649	0.82
249_G	254_P	0.648	0.82
228_F	293_I	0.648	0.82
256_T	260_L	0.645	0.82
17_Q	210_I	0.644	0.82
285_V	291_L	0.644	0.82
196_V	212_L	0.644	0.82
69_I	77_P	0.643	0.81
36_Y	214_V	0.642	0.81
48_K	170_A	0.642	0.81
245_V	261_G	0.642	0.81
329_L	332_R	0.637	0.81
100_K	103_G	0.635	0.81
33_A	216_R	0.634	0.81
71_V	74_T	0.634	0.81
266_R	270_N	0.632	0.80
45_T	126_D	0.632	0.80
63_N	114_G	0.631	0.80
294_T	307_K	0.630	0.80
285_V	290_A	0.629	0.80
131_K	152_P	0.628	0.80
146_S	151_D	0.628	0.80
323_F	328_G	0.627	0.80
139_S	144_S	0.627	0.80
240_N	300_T	0.626	0.80
235_L	269_V	0.625	0.80
75_K	135_S	0.623	0.79
39_Q	207_G	0.620	0.79
79_I	102_A	0.619	0.79
53_A	114_G	0.618	0.79
104_V	224_N	0.617	0.79
327_T	335_D	0.616	0.79
77_P	100_K	0.616	0.79
249_G	255_V	0.613	0.78
229_V	233_N	0.613	0.78
337_M	340_Y	0.613	0.78
85_N	94_A	0.612	0.78
64_S	80_T	0.612	0.78
34_G	177_V	0.612	0.78
92_R	106_A	0.611	0.78
22_I	39_Q	0.611	0.78
180_L	314_A	0.610	0.78
31_A	196_V	0.610	0.78
228_F	323_F	0.608	0.78
284_S	318_G	0.607	0.78
285_V	315_D	0.607	0.78
48_K	120_S	0.607	0.78
164_A	167_V	0.606	0.78
22_I	201_K	0.605	0.77
316_F	320_A	0.602	0.77
280_N	332_R	0.602	0.77
64_S	84_S	0.601	0.77
109_I	118_V	0.601	0.77
70_S	73_D	0.599	0.77
51_L	164_A	0.597	0.76
336_K	340_Y	0.597	0.76
268_L	338_K	0.596	0.76
276_L	290_A	0.596	0.76
46_S	168_T	0.592	0.76
229_V	301_L	0.591	0.76
246_T	256_T	0.591	0.76
144_S	147_Q	0.591	0.76
91_M	95_I	0.591	0.76
76_L	79_I	0.590	0.76
331_K	335_D	0.590	0.76
306_K	309_D	0.588	0.75
243_T	261_G	0.587	0.75
22_I	40_V	0.584	0.75
232_Y	236_T	0.584	0.75
203_V	206_A	0.581	0.75
22_I	210_I	0.578	0.74
87_T	94_A	0.578	0.74
23_L	175_I	0.578	0.74
247_K	258_A	0.578	0.74
190_S	199_D	0.576	0.74
124_T	172_N	0.575	0.74
196_V	214_V	0.575	0.74
280_N	329_L	0.574	0.74
40_V	44_A	0.573	0.74
119_L	130_I	0.573	0.74
46_S	121_S	0.572	0.73
81_V	85_N	0.571	0.73
42_S	45_T	0.569	0.73
69_I	78_A	0.569	0.73
311_A	315_D	0.569	0.73
318_G	322_Y	0.566	0.73
117_L	121_S	0.564	0.72
33_A	213_T	0.563	0.72
144_S	151_D	0.563	0.72
108_I	117_L	0.563	0.72
239_I	336_K	0.561	0.72
111_D	121_S	0.561	0.72
240_N	269_V	0.560	0.72
80_T	83_S	0.560	0.72
20_E	24_K	0.559	0.72
109_I	335_D	0.557	0.71
240_N	313_S	0.556	0.71
112_N	183_S	0.555	0.71
70_S	130_I	0.554	0.71
134_V	148_L	0.552	0.71
44_A	187_N	0.551	0.71
232_Y	273_R	0.551	0.71
184_I	200_V	0.550	0.71
220_G	224_N	0.550	0.71
47_S	128_K	0.550	0.71
23_L	232_Y	0.549	0.70
230_E	305_E	0.549	0.70
244_V	260_L	0.549	0.70
126_D	170_A	0.549	0.70
248_V	255_V	0.547	0.70
260_L	268_L	0.547	0.70
72_G	81_V	0.547	0.70
268_L	336_K	0.546	0.70
307_K	311_A	0.544	0.70
336_K	339_P	0.543	0.70
177_V	193_I	0.542	0.69
313_S	317_E	0.541	0.69
73_D	76_L	0.541	0.69
52_Q	164_A	0.540	0.69
240_N	244_V	0.540	0.69
92_R	194_D	0.538	0.69
65_G	69_I	0.538	0.69
103_G	123_K	0.537	0.69
335_D	342_D	0.536	0.69
227_K	235_L	0.534	0.68
37_Q	45_T	0.531	0.68
145_L	151_D	0.531	0.68
248_V	253_N	0.531	0.68
150_F	164_A	0.529	0.68
247_K	255_V	0.529	0.68
291_L	330_A	0.529	0.68
215_S	223_D	0.528	0.67
121_S	125_G	0.527	0.67
237_K	298_D	0.526	0.67
227_K	231_A	0.524	0.67
57_P	60_A	0.523	0.67
109_I	179_G	0.522	0.67
168_T	265_V	0.522	0.67
297_K	302_E	0.521	0.66
47_S	169_K	0.518	0.66
109_I	180_L	0.518	0.66
275_E	278_A	0.517	0.66
38_I	173_G	0.517	0.66
256_T	261_G	0.516	0.66
107_T	194_D	0.516	0.66
59_N	89_A	0.515	0.66
79_I	100_K	0.514	0.65
130_I	295_T	0.513	0.65
145_L	149_A	0.513	0.65
303_I	311_A	0.512	0.65
298_D	302_E	0.512	0.65
104_V	119_L	0.510	0.65
48_K	184_I	0.508	0.64
66_T	133_E	0.508	0.64
242_Q	258_A	0.507	0.64
261_G	330_A	0.505	0.64
67_L	117_L	0.505	0.64
51_L	116_R	0.504	0.64
24_K	198_F	0.504	0.64
95_I	104_V	0.502	0.64
36_Y	184_I	0.502	0.64
93_D	108_I	0.502	0.64
111_D	180_L	0.502	0.64
291_L	303_I	0.502	0.64
290_A	311_A	0.502	0.64
247_K	254_P	0.502	0.64
193_I	239_I	0.502	0.64
215_S	310_K	0.501	0.63
274_S	293_I	0.500	0.63

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1jql_B	1	0.1358	7.1	0.965	Contact Map
1pc2_A	1	0.3439	4.4	0.968	Contact Map
3qml_C	1	0.3208	2.9	0.971	Contact Map
3f1i_S	1	0.1301	2.7	0.971	Contact Map
3gfz_A	1	0.2399	2.7	0.971	Contact Map
1yj7_A	1	0.2081	2.5	0.972	Contact Map
3or1_C	1	0.159	2.4	0.972	Contact Map
1uhr_A	1	0.1301	2.1	0.973	Contact Map
1lyq_A	1	0.1705	2.1	0.973	Contact Map
2k9m_A	1	0.2023	2.1	0.973	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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