GREMLIN Database
T0933_1_346 - T0933 1-346
ID: 101 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 346 (308)
Sequences: 2908 (2246)
Seq/√Len: 128.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
172_N183_S4.5461.00
42_S174_E4.2111.00
42_S171_A3.7101.00
48_K178_D3.6671.00
222_K309_D3.5081.00
226_K230_E3.3251.00
174_E181_K3.0541.00
303_I308_L2.9451.00
315_D318_G2.9351.00
237_K300_T2.8791.00
226_K305_E2.7681.00
296_T302_E2.7331.00
175_I189_V2.7301.00
257_G260_L2.7021.00
184_I191_D2.6281.00
189_V200_V2.5661.00
175_I182_R2.5411.00
95_I119_L2.5371.00
86_N94_A2.4961.00
45_T171_A2.4911.00
291_L322_Y2.4811.00
296_T300_T2.4431.00
23_L38_I2.4391.00
39_Q176_T2.4381.00
41_N174_E2.4181.00
85_N90_G2.3871.00
223_D227_K2.3861.00
304_D307_K2.3821.00
226_K303_I2.3711.00
22_I204_T2.3041.00
238_F242_Q2.2751.00
166_Y169_K2.1881.00
86_N90_G2.1731.00
322_Y329_L2.1661.00
92_R108_I2.1161.00
23_L212_L2.0921.00
35_T213_T2.0831.00
176_T181_K2.0671.00
174_E183_S2.0661.00
204_T210_I2.0511.00
188_S199_D2.0351.00
222_K305_E2.0031.00
23_L210_I2.0021.00
172_N185_A1.9501.00
111_D116_R1.9411.00
47_S130_I1.8961.00
310_K314_A1.8841.00
230_E234_T1.8721.00
308_L312_I1.8271.00
105_S122_T1.8101.00
41_N176_T1.7921.00
66_T78_A1.7181.00
286_R290_A1.7181.00
245_V254_P1.7061.00
43_L200_V1.6701.00
243_T265_V1.6581.00
225_V308_L1.6341.00
189_V198_F1.6011.00
77_P102_A1.6001.00
287_N290_A1.5791.00
18_G210_I1.5721.00
90_G94_A1.5481.00
19_N22_I1.5461.00
39_Q204_T1.5411.00
108_I115_S1.5311.00
68_N78_A1.4781.00
70_S131_K1.4691.00
313_S316_F1.4521.00
235_L239_I1.4401.00
19_N202_A1.4351.00
66_T80_T1.4341.00
237_K241_E1.4331.00
36_Y178_D1.4331.00
41_N181_K1.4301.00
204_T207_G1.4141.00
38_I177_V1.4121.00
46_S124_T1.4081.00
222_K226_K1.4051.00
225_V303_I1.3971.00
49_I130_I1.3951.00
219_A223_D1.3941.00
145_L148_L1.3931.00
295_T301_L1.3771.00
221_V224_N1.3721.00
119_L132_V1.3621.00
177_V192_V1.3551.00
87_T90_G1.3331.00
89_A93_D1.3281.00
22_I202_A1.2941.00
236_T240_N1.2901.00
193_I196_V1.2881.00
236_T269_V1.2791.00
42_S203_V1.2631.00
24_K201_K1.2571.00
175_I181_K1.2561.00
175_I200_V1.2461.00
309_D313_S1.2461.00
338_K342_D1.2451.00
24_K199_D1.2451.00
229_V303_I1.2441.00
25_A212_L1.2441.00
305_E309_D1.2421.00
70_S133_E1.2411.00
224_N227_K1.2321.00
145_L150_F1.2311.00
236_T300_T1.2291.00
221_V316_F1.2110.99
225_V323_F1.2040.99
293_I301_L1.1980.99
246_T249_G1.1950.99
271_T336_K1.1910.99
184_I189_V1.1860.99
39_Q206_A1.1850.99
81_V86_N1.1730.99
189_V192_V1.1680.99
68_N135_S1.1440.99
70_S76_L1.1380.99
245_V260_L1.1300.99
88_L108_I1.1130.99
128_K185_A1.1120.99
246_T254_P1.1100.99
110_T115_S1.1080.99
227_K230_E1.0950.99
312_I319_V1.0950.99
219_A309_D1.0920.99
91_M148_L1.0890.99
177_V182_R1.0860.99
38_I212_L1.0750.99
49_I166_Y1.0730.99
50_A167_V1.0670.99
123_K128_K1.0670.99
268_L340_Y1.0650.99
241_E244_V1.0520.98
56_D60_A1.0490.98
95_I106_A1.0450.98
173_G200_V1.0430.98
47_S170_A1.0430.98
67_L134_V1.0360.98
25_A198_F1.0350.98
294_T304_D1.0250.98
182_R192_V1.0220.98
68_N76_L1.0200.98
69_I79_I1.0160.98
81_V94_A1.0060.98
218_D313_S0.9940.98
238_F241_E0.9940.98
231_A234_T0.9930.98
126_D183_S0.9810.98
83_S86_N0.9810.98
48_K118_V0.9690.97
49_I164_A0.9630.97
51_L54_I0.9570.97
129_D170_A0.9550.97
288_L293_I0.9540.97
47_S166_Y0.9490.97
43_L203_V0.9460.97
50_A118_V0.9430.97
93_D97_Q0.9320.97
126_D172_N0.9310.97
23_L198_F0.9290.97
235_L272_M0.9250.97
291_L319_V0.9230.97
239_I269_V0.9230.97
229_V308_L0.9230.97
64_S86_N0.9220.96
84_S90_G0.9190.96
39_Q205_E0.9170.96
269_V273_R0.9170.96
311_A319_V0.9130.96
112_N115_S0.9040.96
81_V91_M0.8990.96
89_A108_I0.8970.96
21_D202_A0.8950.96
175_I184_I0.8920.96
69_I102_A0.8910.96
38_I198_F0.8910.96
96_N106_A0.8900.96
47_S129_D0.8880.96
219_A222_K0.8860.96
223_D226_K0.8850.96
149_A152_P0.8840.96
184_I190_S0.8820.95
130_I166_Y0.8810.95
134_V149_A0.8740.95
35_T211_T0.8720.95
128_K170_A0.8700.95
69_I95_I0.8700.95
234_T238_F0.8680.95
126_D185_A0.8670.95
239_I265_V0.8660.95
45_T168_T0.8650.95
173_G187_N0.8620.95
136_D139_S0.8610.95
217_D220_G0.8600.95
306_K310_K0.8570.95
328_G332_R0.8560.95
110_T184_I0.8560.95
221_V312_I0.8510.95
337_M341_T0.8430.94
189_V197_S0.8370.94
31_A214_V0.8350.94
307_K310_K0.8330.94
21_D201_K0.8310.94
222_K303_I0.8300.94
274_S277_I0.8270.94
111_D114_G0.8250.94
41_N175_I0.8200.93
92_R117_L0.8170.93
275_E332_R0.8170.93
334_G338_K0.8170.93
335_D338_K0.8170.93
171_A174_E0.8150.93
317_E321_S0.8090.93
184_I192_V0.8090.93
229_V293_I0.8030.93
38_I175_I0.8030.93
193_I198_F0.7940.92
285_V311_A0.7890.92
310_K313_S0.7890.92
245_V249_G0.7880.92
52_Q165_G0.7880.92
134_V137_D0.7830.92
127_G185_A0.7810.92
50_A116_R0.7810.92
175_I192_V0.7800.92
69_I132_V0.7780.91
80_T84_S0.7710.91
276_L301_L0.7690.91
106_A119_L0.7680.91
146_S150_F0.7600.90
220_G223_D0.7600.90
37_Q211_T0.7550.90
294_T302_E0.7520.90
126_D129_D0.7520.90
86_N91_M0.7470.90
69_I104_V0.7460.90
239_I242_Q0.7430.89
246_T260_L0.7430.89
289_A294_T0.7400.89
45_T203_V0.7370.89
64_S90_G0.7350.89
103_G122_T0.7350.89
38_I191_D0.7340.89
146_S149_A0.7330.89
246_T255_V0.7310.89
191_D194_D0.7310.89
125_G172_N0.7270.88
90_G93_D0.7220.88
318_G321_S0.7210.88
271_T275_E0.7190.88
128_K172_N0.7190.88
131_K151_D0.7190.88
265_V269_V0.7160.88
23_L204_T0.7160.88
249_G256_T0.7150.88
334_G337_M0.7130.87
231_A236_T0.7130.87
232_Y301_L0.7120.87
41_N203_V0.7120.87
127_G172_N0.7110.87
27_A31_A0.7070.87
175_I198_F0.7060.87
24_K27_A0.7050.87
71_V130_I0.7030.87
198_F201_K0.7020.87
173_G186_S0.7000.86
260_L266_R0.6990.86
203_V207_G0.6970.86
216_R221_V0.6920.86
317_E320_A0.6900.86
107_T118_V0.6890.86
17_Q20_E0.6880.86
223_D230_E0.6830.85
218_D309_D0.6790.85
198_F212_L0.6770.85
118_V178_D0.6770.85
107_T111_D0.6770.85
64_S85_N0.6760.85
243_T260_L0.6760.85
263_A266_R0.6720.84
275_E336_K0.6720.84
65_G72_G0.6660.84
61_K87_T0.6650.84
25_A32_V0.6640.83
279_S287_N0.6640.83
249_G260_L0.6620.83
144_S149_A0.6620.83
87_T91_M0.6600.83
123_K186_S0.6590.83
335_D339_P0.6570.83
31_A36_Y0.6560.83
225_V293_I0.6520.82
245_V256_T0.6500.82
57_P89_A0.6490.82
249_G254_P0.6480.82
228_F293_I0.6480.82
256_T260_L0.6450.82
17_Q210_I0.6440.82
285_V291_L0.6440.82
196_V212_L0.6440.82
69_I77_P0.6430.81
36_Y214_V0.6420.81
48_K170_A0.6420.81
245_V261_G0.6420.81
329_L332_R0.6370.81
100_K103_G0.6350.81
33_A216_R0.6340.81
71_V74_T0.6340.81
266_R270_N0.6320.80
45_T126_D0.6320.80
63_N114_G0.6310.80
294_T307_K0.6300.80
285_V290_A0.6290.80
131_K152_P0.6280.80
146_S151_D0.6280.80
323_F328_G0.6270.80
139_S144_S0.6270.80
240_N300_T0.6260.80
235_L269_V0.6250.80
75_K135_S0.6230.79
39_Q207_G0.6200.79
79_I102_A0.6190.79
53_A114_G0.6180.79
104_V224_N0.6170.79
327_T335_D0.6160.79
77_P100_K0.6160.79
249_G255_V0.6130.78
229_V233_N0.6130.78
337_M340_Y0.6130.78
85_N94_A0.6120.78
64_S80_T0.6120.78
34_G177_V0.6120.78
92_R106_A0.6110.78
22_I39_Q0.6110.78
180_L314_A0.6100.78
31_A196_V0.6100.78
228_F323_F0.6080.78
284_S318_G0.6070.78
285_V315_D0.6070.78
48_K120_S0.6070.78
164_A167_V0.6060.78
22_I201_K0.6050.77
316_F320_A0.6020.77
280_N332_R0.6020.77
64_S84_S0.6010.77
109_I118_V0.6010.77
70_S73_D0.5990.77
51_L164_A0.5970.76
336_K340_Y0.5970.76
268_L338_K0.5960.76
276_L290_A0.5960.76
46_S168_T0.5920.76
229_V301_L0.5910.76
246_T256_T0.5910.76
144_S147_Q0.5910.76
91_M95_I0.5910.76
76_L79_I0.5900.76
331_K335_D0.5900.76
306_K309_D0.5880.75
243_T261_G0.5870.75
22_I40_V0.5840.75
232_Y236_T0.5840.75
203_V206_A0.5810.75
22_I210_I0.5780.74
87_T94_A0.5780.74
23_L175_I0.5780.74
247_K258_A0.5780.74
190_S199_D0.5760.74
124_T172_N0.5750.74
196_V214_V0.5750.74
280_N329_L0.5740.74
40_V44_A0.5730.74
119_L130_I0.5730.74
46_S121_S0.5720.73
81_V85_N0.5710.73
42_S45_T0.5690.73
69_I78_A0.5690.73
311_A315_D0.5690.73
318_G322_Y0.5660.73
117_L121_S0.5640.72
33_A213_T0.5630.72
144_S151_D0.5630.72
108_I117_L0.5630.72
239_I336_K0.5610.72
111_D121_S0.5610.72
240_N269_V0.5600.72
80_T83_S0.5600.72
20_E24_K0.5590.72
109_I335_D0.5570.71
240_N313_S0.5560.71
112_N183_S0.5550.71
70_S130_I0.5540.71
134_V148_L0.5520.71
44_A187_N0.5510.71
232_Y273_R0.5510.71
184_I200_V0.5500.71
220_G224_N0.5500.71
47_S128_K0.5500.71
23_L232_Y0.5490.70
230_E305_E0.5490.70
244_V260_L0.5490.70
126_D170_A0.5490.70
248_V255_V0.5470.70
260_L268_L0.5470.70
72_G81_V0.5470.70
268_L336_K0.5460.70
307_K311_A0.5440.70
336_K339_P0.5430.70
177_V193_I0.5420.69
313_S317_E0.5410.69
73_D76_L0.5410.69
52_Q164_A0.5400.69
240_N244_V0.5400.69
92_R194_D0.5380.69
65_G69_I0.5380.69
103_G123_K0.5370.69
335_D342_D0.5360.69
227_K235_L0.5340.68
37_Q45_T0.5310.68
145_L151_D0.5310.68
248_V253_N0.5310.68
150_F164_A0.5290.68
247_K255_V0.5290.68
291_L330_A0.5290.68
215_S223_D0.5280.67
121_S125_G0.5270.67
237_K298_D0.5260.67
227_K231_A0.5240.67
57_P60_A0.5230.67
109_I179_G0.5220.67
168_T265_V0.5220.67
297_K302_E0.5210.66
47_S169_K0.5180.66
109_I180_L0.5180.66
275_E278_A0.5170.66
38_I173_G0.5170.66
256_T261_G0.5160.66
107_T194_D0.5160.66
59_N89_A0.5150.66
79_I100_K0.5140.65
130_I295_T0.5130.65
145_L149_A0.5130.65
303_I311_A0.5120.65
298_D302_E0.5120.65
104_V119_L0.5100.65
48_K184_I0.5080.64
66_T133_E0.5080.64
242_Q258_A0.5070.64
261_G330_A0.5050.64
67_L117_L0.5050.64
51_L116_R0.5040.64
24_K198_F0.5040.64
95_I104_V0.5020.64
36_Y184_I0.5020.64
93_D108_I0.5020.64
111_D180_L0.5020.64
291_L303_I0.5020.64
290_A311_A0.5020.64
247_K254_P0.5020.64
193_I239_I0.5020.64
215_S310_K0.5010.63
274_S293_I0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jql_B 1 0.1358 7.1 0.965 Contact Map
1pc2_A 1 0.3439 4.4 0.968 Contact Map
3qml_C 1 0.3208 2.9 0.971 Contact Map
3f1i_S 1 0.1301 2.7 0.971 Contact Map
3gfz_A 1 0.2399 2.7 0.971 Contact Map
1yj7_A 1 0.2081 2.5 0.972 Contact Map
3or1_C 1 0.159 2.4 0.972 Contact Map
1uhr_A 1 0.1301 2.1 0.973 Contact Map
1lyq_A 1 0.1705 2.1 0.973 Contact Map
2k9m_A 1 0.2023 2.1 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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