GREMLIN Database
T0932_1_246 - T0932 1-246
ID: 100 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 246 (241)
Sequences: 467 (332)
Seq/√Len: 21.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_N61_D6.5501.00
129_E132_K5.3921.00
65_C105_D4.6831.00
148_D151_H4.6351.00
209_S213_S3.7161.00
168_S192_Y3.3881.00
135_E167_S3.3011.00
61_D109_T3.2661.00
103_T183_L3.2371.00
12_A141_E3.1531.00
49_H52_G3.1101.00
26_L60_T2.7420.99
158_L173_L2.6370.99
124_D199_Y2.6280.98
46_R56_E2.5660.98
104_T146_F2.5030.98
47_I171_L2.4290.97
131_L137_I2.3760.97
207_R229_S2.3510.97
169_F193_H2.2690.96
122_T201_L2.1930.95
9_K48_Q2.0710.94
29_E60_T1.9790.92
142_E159_S1.9670.92
74_K240_E1.9460.91
130_K194_E1.9370.91
4_A9_K1.9120.90
107_K202_R1.9020.90
38_M149_E1.8250.88
136_Q146_F1.7800.87
185_R208_E1.7710.87
60_T101_T1.7280.85
103_T229_S1.6840.84
55_I191_L1.6780.83
130_K192_Y1.6690.83
142_E160_V1.6250.81
18_M30_L1.6030.80
22_D42_D1.5710.79
137_I165_M1.5650.79
48_Q54_G1.5280.77
17_I149_E1.5210.77
106_Y109_T1.5200.77
135_E168_S1.5090.76
13_S44_V1.4960.75
11_T48_Q1.4960.75
184_I214_L1.4540.73
98_Y103_T1.4540.73
176_F228_I1.4410.73
229_S233_P1.4350.72
119_V122_T1.4350.72
234_I237_A1.4340.72
77_C181_G1.4200.72
187_N206_S1.3930.70
133_A136_Q1.3760.69
143_V160_V1.3650.68
19_K22_D1.3580.68
124_D201_L1.3310.66
184_I227_E1.3250.66
40_F147_E1.3070.65
24_E158_L1.3050.65
103_T121_P1.2950.64
215_M218_P1.2920.64
140_F161_K1.2920.64
25_K29_E1.2800.63
58_N155_V1.2660.62
47_I169_F1.2600.62
91_S98_Y1.2470.61
32_M98_Y1.2270.60
110_L122_T1.2220.60
12_A158_L1.2070.59
228_I232_L1.2050.59
137_I152_D1.2040.58
3_M184_I1.1890.57
45_L171_L1.1850.57
132_K201_L1.1830.57
5_S16_H1.1730.56
160_V173_L1.1700.56
144_L156_S1.1690.56
106_Y145_L1.1680.56
46_R181_G1.1630.56
23_V98_Y1.1510.55
131_L165_M1.1460.55
8_W47_I1.1460.55
12_A176_F1.1430.54
66_V97_P1.1420.54
72_M179_I1.1400.54
29_E64_R1.1310.54
12_A45_L1.1280.53
204_Y239_C1.1200.53
99_D108_G1.1150.53
128_T167_S1.1110.52
107_K204_Y1.1080.52
27_A124_D1.1020.52
14_K141_E1.0980.51
151_H156_S1.0920.51
210_K213_S1.0900.51
20_S199_Y1.0650.49
123_T181_G1.0500.48
75_V185_R1.0490.48
59_A84_S1.0480.48
15_T18_M1.0440.48
141_E161_K1.0380.47
199_Y241_K1.0330.47
20_S124_D1.0300.47
55_I200_M1.0250.47
38_M101_T1.0180.46
18_M148_D1.0110.46
144_L155_V0.9980.45
131_L152_D0.9970.45
10_L47_I0.9940.44
35_L179_I0.9890.44
62_A78_A0.9840.44
146_F198_T0.9780.43
22_D41_G0.9780.43
58_N109_T0.9730.43
60_T78_A0.9700.43
33_P102_Y0.9660.43
104_T186_M0.9650.43
149_E177_L0.9550.42
16_H32_M0.9530.42
185_R189_T0.9420.41
109_T145_L0.9400.41
104_T109_T0.9390.41
18_M41_G0.9370.41
31_H102_Y0.9340.41
184_I216_H0.9340.41
140_F207_R0.9330.40
138_K195_A0.9330.40
127_D181_G0.9320.40
74_K102_Y0.9280.40
45_L162_I0.9270.40
126_I232_L0.9270.40
186_M225_P0.9250.40
203_E237_A0.9220.40
194_E242_L0.9160.39
189_T202_R0.9160.39
211_I227_E0.9130.39
93_E96_K0.9130.39
168_S193_H0.9110.39
110_L121_P0.9010.38
104_T158_L0.8990.38
179_I207_R0.8970.38
206_S236_E0.8950.38
147_E150_L0.8950.38
39_M126_I0.8800.37
146_F160_V0.8790.37
16_H188_D0.8770.37
28_D113_E0.8740.37
6_G123_T0.8730.37
29_E144_L0.8710.37
18_M98_Y0.8700.36
79_E83_E0.8470.35
241_K244_F0.8460.35
143_V201_L0.8440.35
107_K238_V0.8410.35
54_G129_E0.8390.35
101_T130_K0.8390.35
152_D190_R0.8370.34
7_P52_G0.8360.34
163_R180_D0.8360.34
7_P238_V0.8340.34
72_M222_F0.8280.34
34_S37_E0.8270.34
45_L49_H0.8220.34
62_A75_V0.8200.33
73_L207_R0.8200.33
55_I171_L0.8180.33
31_H87_E0.8100.33
130_K176_F0.8080.33
38_M66_V0.8070.33
163_R190_R0.8020.32
183_L213_S0.8010.32
42_D102_Y0.7950.32
41_G211_I0.7940.32
148_D167_S0.7870.31
43_N74_K0.7860.31
77_C127_D0.7860.31
231_Y234_I0.7840.31
78_A98_Y0.7740.31
3_M162_I0.7710.31
206_S228_I0.7700.31
181_G194_E0.7700.31
162_I171_L0.7680.30
55_I221_L0.7660.30
156_S175_F0.7630.30
3_M10_L0.7490.29
53_F192_Y0.7490.29
43_N96_K0.7460.29
74_K177_L0.7460.29
149_E152_D0.7430.29
155_V170_F0.7410.29
77_C153_H0.7400.29
174_R188_D0.7400.29
197_K234_I0.7360.29
110_L201_L0.7360.29
3_M219_P0.7340.29
27_A77_C0.7310.28
14_K41_G0.7280.28
240_E244_F0.7280.28
122_T238_V0.7280.28
154_G172_L0.7270.28
26_L30_L0.7270.28
47_I120_V0.7240.28
74_K77_C0.7220.28
173_L179_I0.7200.28
145_L185_R0.7190.28
74_K225_P0.7130.27
58_N138_K0.7110.27
93_E161_K0.7060.27
181_G241_K0.7060.27
6_G203_E0.7040.27
27_A35_L0.7020.27
223_T229_S0.7010.27
131_L139_F0.7000.27
225_P242_L0.6970.27
149_E182_V0.6960.26
41_G143_V0.6950.26
77_C222_F0.6940.26
83_E166_P0.6920.26
149_E156_S0.6890.26
108_G154_G0.6890.26
31_H219_P0.6870.26
150_L185_R0.6860.26
207_R234_I0.6820.26
152_D180_D0.6820.26
225_P228_I0.6800.26
45_L202_R0.6750.25
8_W177_L0.6730.25
45_L169_F0.6690.25
201_L240_E0.6690.25
109_T129_E0.6670.25
223_T226_N0.6640.25
9_K50_G0.6640.25
103_T185_R0.6600.25
54_G196_D0.6600.25
13_S162_I0.6570.24
81_W152_D0.6550.24
186_M231_Y0.6540.24
4_A125_H0.6530.24
8_W90_H0.6520.24
221_L243_I0.6520.24
172_L180_D0.6520.24
24_E47_I0.6500.24
188_D192_Y0.6440.24
10_L63_L0.6420.24
73_L204_Y0.6410.24
142_E161_K0.6410.24
87_E220_S0.6410.24
15_T162_I0.6390.24
61_D186_M0.6390.24
57_F189_T0.6380.24
66_V96_K0.6380.24
96_K176_F0.6370.24
3_M218_P0.6360.23
84_S183_L0.6360.23
158_L184_I0.6350.23
67_N176_F0.6350.23
45_L144_L0.6340.23
53_F188_D0.6340.23
18_M141_E0.6320.23
74_K166_P0.6310.23
240_E245_P0.6290.23
80_E85_R0.6290.23
51_S201_L0.6280.23
8_W165_M0.6230.23
41_G98_Y0.6200.23
99_D154_G0.6180.23
9_K123_T0.6180.23
84_S192_Y0.6160.23
125_H161_K0.6150.22
98_Y241_K0.6140.22
80_E213_S0.6140.22
18_M35_L0.6120.22
151_H211_I0.6110.22
230_Q243_I0.6100.22
18_M60_T0.6090.22
45_L173_L0.6050.22
51_S231_Y0.6050.22
121_P238_V0.6040.22
221_L229_S0.6010.22
32_M87_E0.5970.22
16_H22_D0.5950.22
46_R54_G0.5930.21
89_E160_V0.5930.21
222_F227_E0.5860.21
15_T128_T0.5840.21
152_D165_M0.5830.21
47_I233_P0.5830.21
68_N200_M0.5820.21
34_S173_L0.5820.21
37_E59_A0.5810.21
142_E157_S0.5790.21
119_V140_F0.5780.21
196_D244_F0.5760.21
224_E229_S0.5760.21
50_G122_T0.5750.21
221_L233_P0.5740.21
97_P139_F0.5730.21
130_K168_S0.5720.21
80_E165_M0.5710.20
105_D183_L0.5700.20
28_D196_D0.5690.20
47_I55_I0.5690.20
2_H104_T0.5690.20
16_H33_P0.5690.20
239_C242_L0.5670.20
35_L68_N0.5660.20
77_C151_H0.5650.20
127_D194_E0.5650.20
78_A134_R0.5640.20
128_T237_A0.5630.20
120_V123_T0.5620.20
140_F143_V0.5580.20
17_I38_M0.5580.20
22_D98_Y0.5570.20
76_A182_V0.5560.20
8_W166_P0.5550.20
16_H127_D0.5520.20
165_M180_D0.5510.20
61_D106_Y0.5510.20
148_D216_H0.5480.19
56_E111_L0.5470.19
187_N204_Y0.5460.19
45_L214_L0.5440.19
151_H175_F0.5440.19
31_H192_Y0.5430.19
25_K28_D0.5420.19
43_N169_F0.5400.19
218_P245_P0.5400.19
125_H156_S0.5400.19
12_A20_S0.5390.19
66_V100_W0.5370.19
54_G79_E0.5370.19
110_L237_A0.5340.19
82_Q148_D0.5320.19
123_T210_K0.5310.19
191_L200_M0.5300.19
110_L242_L0.5290.19
15_T171_L0.5280.19
184_I217_V0.5240.19
198_T209_S0.5210.18
47_I96_K0.5210.18
90_H146_F0.5210.18
125_H239_C0.5190.18
9_K120_V0.5190.18
45_L191_L0.5180.18
82_Q89_E0.5160.18
171_L195_A0.5150.18
169_F199_Y0.5150.18
47_I208_E0.5140.18
102_Y127_D0.5130.18
124_D241_K0.5120.18
142_E162_I0.5100.18
127_D135_E0.5060.18
105_D162_I0.5050.18
69_Y96_K0.5050.18
215_M237_A0.5040.18
61_D110_L0.5040.18
193_H197_K0.5030.18
74_K91_S0.5030.18
91_S196_D0.5000.18
142_E209_S0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3og2_A 1 0.3171 31.6 0.964 Contact Map
3ke2_A 1 0.1463 16.1 0.968 Contact Map
4e6n_A 1 0.2154 16 0.968 Contact Map
1tg7_A 1 0.3171 10.6 0.971 Contact Map
2kts_A 1 0.252 5.9 0.974 Contact Map
4kgm_A 1 0.3415 5.8 0.974 Contact Map
1gu3_A 1 0.5325 5.6 0.974 Contact Map
1nkg_A 1 0.2683 4.7 0.975 Contact Map
1kcq_A 1 0.2276 4.3 0.976 Contact Map
2la7_A 1 0.248 3.7 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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