T0932_1_246 - CASP12 - GREMLIN Contacts

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T0932_1_246 - T0932 1-246

ID:	100	Sequences: GHMASGPWKLTASKTHIMKSADVEKLADELHMPSLPEMMFGDNVLRIQHGSGFGIEFNATDALRCVNNYQGMLKVACAEEWQESRTEGEHSKEVIKPYDWTYTTDYKGTLLGESLKLKVVPTTDHIDTEKLKAREQIKFFEEVLLFEDELHDHGVSSLSVKIRVMPSSFFLLLRFFLRIDGVLIRMNDTRLYHEADKTYMLREYTSRESKISSLMHVPPSLFTEPNEISQYLPIKEAVCEKLIFPE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	246 (241)
Sequences:	467 (332)
Seq/√Len:	21.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
58_N	61_D	6.550	1.00
129_E	132_K	5.392	1.00
65_C	105_D	4.683	1.00
148_D	151_H	4.635	1.00
209_S	213_S	3.716	1.00
168_S	192_Y	3.388	1.00
135_E	167_S	3.301	1.00
61_D	109_T	3.266	1.00
103_T	183_L	3.237	1.00
12_A	141_E	3.153	1.00
49_H	52_G	3.110	1.00
26_L	60_T	2.742	0.99
158_L	173_L	2.637	0.99
124_D	199_Y	2.628	0.98
46_R	56_E	2.566	0.98
104_T	146_F	2.503	0.98
47_I	171_L	2.429	0.97
131_L	137_I	2.376	0.97
207_R	229_S	2.351	0.97
169_F	193_H	2.269	0.96
122_T	201_L	2.193	0.95
9_K	48_Q	2.071	0.94
29_E	60_T	1.979	0.92
142_E	159_S	1.967	0.92
74_K	240_E	1.946	0.91
130_K	194_E	1.937	0.91
4_A	9_K	1.912	0.90
107_K	202_R	1.902	0.90
38_M	149_E	1.825	0.88
136_Q	146_F	1.780	0.87
185_R	208_E	1.771	0.87
60_T	101_T	1.728	0.85
103_T	229_S	1.684	0.84
55_I	191_L	1.678	0.83
130_K	192_Y	1.669	0.83
142_E	160_V	1.625	0.81
18_M	30_L	1.603	0.80
22_D	42_D	1.571	0.79
137_I	165_M	1.565	0.79
48_Q	54_G	1.528	0.77
17_I	149_E	1.521	0.77
106_Y	109_T	1.520	0.77
135_E	168_S	1.509	0.76
13_S	44_V	1.496	0.75
11_T	48_Q	1.496	0.75
184_I	214_L	1.454	0.73
98_Y	103_T	1.454	0.73
176_F	228_I	1.441	0.73
229_S	233_P	1.435	0.72
119_V	122_T	1.435	0.72
234_I	237_A	1.434	0.72
77_C	181_G	1.420	0.72
187_N	206_S	1.393	0.70
133_A	136_Q	1.376	0.69
143_V	160_V	1.365	0.68
19_K	22_D	1.358	0.68
124_D	201_L	1.331	0.66
184_I	227_E	1.325	0.66
40_F	147_E	1.307	0.65
24_E	158_L	1.305	0.65
103_T	121_P	1.295	0.64
215_M	218_P	1.292	0.64
140_F	161_K	1.292	0.64
25_K	29_E	1.280	0.63
58_N	155_V	1.266	0.62
47_I	169_F	1.260	0.62
91_S	98_Y	1.247	0.61
32_M	98_Y	1.227	0.60
110_L	122_T	1.222	0.60
12_A	158_L	1.207	0.59
228_I	232_L	1.205	0.59
137_I	152_D	1.204	0.58
3_M	184_I	1.189	0.57
45_L	171_L	1.185	0.57
132_K	201_L	1.183	0.57
5_S	16_H	1.173	0.56
160_V	173_L	1.170	0.56
144_L	156_S	1.169	0.56
106_Y	145_L	1.168	0.56
46_R	181_G	1.163	0.56
23_V	98_Y	1.151	0.55
131_L	165_M	1.146	0.55
8_W	47_I	1.146	0.55
12_A	176_F	1.143	0.54
66_V	97_P	1.142	0.54
72_M	179_I	1.140	0.54
29_E	64_R	1.131	0.54
12_A	45_L	1.128	0.53
204_Y	239_C	1.120	0.53
99_D	108_G	1.115	0.53
128_T	167_S	1.111	0.52
107_K	204_Y	1.108	0.52
27_A	124_D	1.102	0.52
14_K	141_E	1.098	0.51
151_H	156_S	1.092	0.51
210_K	213_S	1.090	0.51
20_S	199_Y	1.065	0.49
123_T	181_G	1.050	0.48
75_V	185_R	1.049	0.48
59_A	84_S	1.048	0.48
15_T	18_M	1.044	0.48
141_E	161_K	1.038	0.47
199_Y	241_K	1.033	0.47
20_S	124_D	1.030	0.47
55_I	200_M	1.025	0.47
38_M	101_T	1.018	0.46
18_M	148_D	1.011	0.46
144_L	155_V	0.998	0.45
131_L	152_D	0.997	0.45
10_L	47_I	0.994	0.44
35_L	179_I	0.989	0.44
62_A	78_A	0.984	0.44
146_F	198_T	0.978	0.43
22_D	41_G	0.978	0.43
58_N	109_T	0.973	0.43
60_T	78_A	0.970	0.43
33_P	102_Y	0.966	0.43
104_T	186_M	0.965	0.43
149_E	177_L	0.955	0.42
16_H	32_M	0.953	0.42
185_R	189_T	0.942	0.41
109_T	145_L	0.940	0.41
104_T	109_T	0.939	0.41
18_M	41_G	0.937	0.41
31_H	102_Y	0.934	0.41
184_I	216_H	0.934	0.41
140_F	207_R	0.933	0.40
138_K	195_A	0.933	0.40
127_D	181_G	0.932	0.40
74_K	102_Y	0.928	0.40
45_L	162_I	0.927	0.40
126_I	232_L	0.927	0.40
186_M	225_P	0.925	0.40
203_E	237_A	0.922	0.40
194_E	242_L	0.916	0.39
189_T	202_R	0.916	0.39
211_I	227_E	0.913	0.39
93_E	96_K	0.913	0.39
168_S	193_H	0.911	0.39
110_L	121_P	0.901	0.38
104_T	158_L	0.899	0.38
179_I	207_R	0.897	0.38
206_S	236_E	0.895	0.38
147_E	150_L	0.895	0.38
39_M	126_I	0.880	0.37
146_F	160_V	0.879	0.37
16_H	188_D	0.877	0.37
28_D	113_E	0.874	0.37
6_G	123_T	0.873	0.37
29_E	144_L	0.871	0.37
18_M	98_Y	0.870	0.36
79_E	83_E	0.847	0.35
241_K	244_F	0.846	0.35
143_V	201_L	0.844	0.35
107_K	238_V	0.841	0.35
54_G	129_E	0.839	0.35
101_T	130_K	0.839	0.35
152_D	190_R	0.837	0.34
7_P	52_G	0.836	0.34
163_R	180_D	0.836	0.34
7_P	238_V	0.834	0.34
72_M	222_F	0.828	0.34
34_S	37_E	0.827	0.34
45_L	49_H	0.822	0.34
62_A	75_V	0.820	0.33
73_L	207_R	0.820	0.33
55_I	171_L	0.818	0.33
31_H	87_E	0.810	0.33
130_K	176_F	0.808	0.33
38_M	66_V	0.807	0.33
163_R	190_R	0.802	0.32
183_L	213_S	0.801	0.32
42_D	102_Y	0.795	0.32
41_G	211_I	0.794	0.32
148_D	167_S	0.787	0.31
43_N	74_K	0.786	0.31
77_C	127_D	0.786	0.31
231_Y	234_I	0.784	0.31
78_A	98_Y	0.774	0.31
3_M	162_I	0.771	0.31
206_S	228_I	0.770	0.31
181_G	194_E	0.770	0.31
162_I	171_L	0.768	0.30
55_I	221_L	0.766	0.30
156_S	175_F	0.763	0.30
3_M	10_L	0.749	0.29
53_F	192_Y	0.749	0.29
43_N	96_K	0.746	0.29
74_K	177_L	0.746	0.29
149_E	152_D	0.743	0.29
155_V	170_F	0.741	0.29
77_C	153_H	0.740	0.29
174_R	188_D	0.740	0.29
197_K	234_I	0.736	0.29
110_L	201_L	0.736	0.29
3_M	219_P	0.734	0.29
27_A	77_C	0.731	0.28
14_K	41_G	0.728	0.28
240_E	244_F	0.728	0.28
122_T	238_V	0.728	0.28
154_G	172_L	0.727	0.28
26_L	30_L	0.727	0.28
47_I	120_V	0.724	0.28
74_K	77_C	0.722	0.28
173_L	179_I	0.720	0.28
145_L	185_R	0.719	0.28
74_K	225_P	0.713	0.27
58_N	138_K	0.711	0.27
93_E	161_K	0.706	0.27
181_G	241_K	0.706	0.27
6_G	203_E	0.704	0.27
27_A	35_L	0.702	0.27
223_T	229_S	0.701	0.27
131_L	139_F	0.700	0.27
225_P	242_L	0.697	0.27
149_E	182_V	0.696	0.26
41_G	143_V	0.695	0.26
77_C	222_F	0.694	0.26
83_E	166_P	0.692	0.26
149_E	156_S	0.689	0.26
108_G	154_G	0.689	0.26
31_H	219_P	0.687	0.26
150_L	185_R	0.686	0.26
207_R	234_I	0.682	0.26
152_D	180_D	0.682	0.26
225_P	228_I	0.680	0.26
45_L	202_R	0.675	0.25
8_W	177_L	0.673	0.25
45_L	169_F	0.669	0.25
201_L	240_E	0.669	0.25
109_T	129_E	0.667	0.25
223_T	226_N	0.664	0.25
9_K	50_G	0.664	0.25
103_T	185_R	0.660	0.25
54_G	196_D	0.660	0.25
13_S	162_I	0.657	0.24
81_W	152_D	0.655	0.24
186_M	231_Y	0.654	0.24
4_A	125_H	0.653	0.24
8_W	90_H	0.652	0.24
221_L	243_I	0.652	0.24
172_L	180_D	0.652	0.24
24_E	47_I	0.650	0.24
188_D	192_Y	0.644	0.24
10_L	63_L	0.642	0.24
73_L	204_Y	0.641	0.24
142_E	161_K	0.641	0.24
87_E	220_S	0.641	0.24
15_T	162_I	0.639	0.24
61_D	186_M	0.639	0.24
57_F	189_T	0.638	0.24
66_V	96_K	0.638	0.24
96_K	176_F	0.637	0.24
3_M	218_P	0.636	0.23
84_S	183_L	0.636	0.23
158_L	184_I	0.635	0.23
67_N	176_F	0.635	0.23
45_L	144_L	0.634	0.23
53_F	188_D	0.634	0.23
18_M	141_E	0.632	0.23
74_K	166_P	0.631	0.23
240_E	245_P	0.629	0.23
80_E	85_R	0.629	0.23
51_S	201_L	0.628	0.23
8_W	165_M	0.623	0.23
41_G	98_Y	0.620	0.23
99_D	154_G	0.618	0.23
9_K	123_T	0.618	0.23
84_S	192_Y	0.616	0.23
125_H	161_K	0.615	0.22
98_Y	241_K	0.614	0.22
80_E	213_S	0.614	0.22
18_M	35_L	0.612	0.22
151_H	211_I	0.611	0.22
230_Q	243_I	0.610	0.22
18_M	60_T	0.609	0.22
45_L	173_L	0.605	0.22
51_S	231_Y	0.605	0.22
121_P	238_V	0.604	0.22
221_L	229_S	0.601	0.22
32_M	87_E	0.597	0.22
16_H	22_D	0.595	0.22
46_R	54_G	0.593	0.21
89_E	160_V	0.593	0.21
222_F	227_E	0.586	0.21
15_T	128_T	0.584	0.21
152_D	165_M	0.583	0.21
47_I	233_P	0.583	0.21
68_N	200_M	0.582	0.21
34_S	173_L	0.582	0.21
37_E	59_A	0.581	0.21
142_E	157_S	0.579	0.21
119_V	140_F	0.578	0.21
196_D	244_F	0.576	0.21
224_E	229_S	0.576	0.21
50_G	122_T	0.575	0.21
221_L	233_P	0.574	0.21
97_P	139_F	0.573	0.21
130_K	168_S	0.572	0.21
80_E	165_M	0.571	0.20
105_D	183_L	0.570	0.20
28_D	196_D	0.569	0.20
47_I	55_I	0.569	0.20
2_H	104_T	0.569	0.20
16_H	33_P	0.569	0.20
239_C	242_L	0.567	0.20
35_L	68_N	0.566	0.20
77_C	151_H	0.565	0.20
127_D	194_E	0.565	0.20
78_A	134_R	0.564	0.20
128_T	237_A	0.563	0.20
120_V	123_T	0.562	0.20
140_F	143_V	0.558	0.20
17_I	38_M	0.558	0.20
22_D	98_Y	0.557	0.20
76_A	182_V	0.556	0.20
8_W	166_P	0.555	0.20
16_H	127_D	0.552	0.20
165_M	180_D	0.551	0.20
61_D	106_Y	0.551	0.20
148_D	216_H	0.548	0.19
56_E	111_L	0.547	0.19
187_N	204_Y	0.546	0.19
45_L	214_L	0.544	0.19
151_H	175_F	0.544	0.19
31_H	192_Y	0.543	0.19
25_K	28_D	0.542	0.19
43_N	169_F	0.540	0.19
218_P	245_P	0.540	0.19
125_H	156_S	0.540	0.19
12_A	20_S	0.539	0.19
66_V	100_W	0.537	0.19
54_G	79_E	0.537	0.19
110_L	237_A	0.534	0.19
82_Q	148_D	0.532	0.19
123_T	210_K	0.531	0.19
191_L	200_M	0.530	0.19
110_L	242_L	0.529	0.19
15_T	171_L	0.528	0.19
184_I	217_V	0.524	0.19
198_T	209_S	0.521	0.18
47_I	96_K	0.521	0.18
90_H	146_F	0.521	0.18
125_H	239_C	0.519	0.18
9_K	120_V	0.519	0.18
45_L	191_L	0.518	0.18
82_Q	89_E	0.516	0.18
171_L	195_A	0.515	0.18
169_F	199_Y	0.515	0.18
47_I	208_E	0.514	0.18
102_Y	127_D	0.513	0.18
124_D	241_K	0.512	0.18
142_E	162_I	0.510	0.18
127_D	135_E	0.506	0.18
105_D	162_I	0.505	0.18
69_Y	96_K	0.505	0.18
215_M	237_A	0.504	0.18
61_D	110_L	0.504	0.18
193_H	197_K	0.503	0.18
74_K	91_S	0.503	0.18
91_S	196_D	0.500	0.18
142_E	209_S	0.500	0.18

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3og2_A	1	0.3171	31.6	0.964	Contact Map
3ke2_A	1	0.1463	16.1	0.968	Contact Map
4e6n_A	1	0.2154	16	0.968	Contact Map
1tg7_A	1	0.3171	10.6	0.971	Contact Map
2kts_A	1	0.252	5.9	0.974	Contact Map
4kgm_A	1	0.3415	5.8	0.974	Contact Map
1gu3_A	1	0.5325	5.6	0.974	Contact Map
1nkg_A	1	0.2683	4.7	0.975	Contact Map
1kcq_A	1	0.2276	4.3	0.976	Contact Map
2la7_A	1	0.248	3.7	0.977	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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