GREMLIN Database
T0870_1_138 - T0870 1-138
ID: 10 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 138 (112)
Sequences: 66 (54)
Seq/√Len: 5.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_L46_A3.9950.90
23_L74_Y2.8740.68
38_L52_C2.5350.58
69_L76_G2.4290.54
46_A52_C2.3240.51
60_V79_I2.0060.40
17_P83_S1.9930.40
68_P76_G1.9350.38
41_E44_C1.9270.38
13_M31_I1.9000.37
67_E76_G1.8800.37
45_R50_N1.8790.36
42_D68_P1.8780.36
34_P58_P1.8720.36
13_M28_E1.8300.35
70_A74_Y1.7310.32
53_I107_L1.7000.31
74_Y78_L1.6860.31
26_W40_V1.6540.30
42_D76_G1.5710.28
22_P45_R1.5490.27
30_I33_V1.5420.27
7_L56_L1.5350.27
35_L91_K1.5290.27
45_R75_D1.5070.26
31_I115_D1.4890.26
8_I100_I1.4380.24
71_G74_Y1.4220.24
43_L47_I1.4150.24
10_N53_I1.4130.24
5_R46_A1.3770.23
30_I42_D1.3660.23
29_R61_L1.3520.22
24_E57_M1.3370.22
64_L78_L1.3330.22
51_L62_E1.3120.21
51_L54_D1.2930.21
57_M60_V1.2800.21
95_S101_R1.2580.20
6_K61_L1.2490.20
20_Q51_L1.2060.19
35_L58_P1.1870.19
38_L45_R1.1850.19
30_I59_R1.1380.18
30_I79_I1.1330.18
68_P111_D1.1060.17
30_I60_V1.1010.17
34_P83_S1.0720.17
49_Q76_G1.0680.17
7_L52_C1.0620.16
70_A106_Q1.0590.16
23_L78_L1.0530.16
39_T89_D1.0460.16
34_P43_L1.0360.16
11_I24_E1.0210.16
83_S115_D1.0200.16
18_E100_I1.0090.16
66_K72_E1.0080.16
49_Q78_L0.9990.15
24_E53_I0.9980.15
6_K43_L0.9900.15
10_N95_S0.9790.15
83_S113_N0.9560.15
24_E77_E0.9530.15
57_M97_F0.9440.14
6_K59_R0.9340.14
47_I71_G0.9220.14
37_K88_E0.9180.14
31_I81_A0.9170.14
49_Q64_L0.9080.14
86_K99_Q0.8940.14
13_M32_D0.8880.14
64_L76_G0.8820.13
25_L102_Q0.8760.13
29_R62_E0.8680.13
57_M111_D0.8670.13
37_K104_I0.8650.13
31_I90_L0.8610.13
47_I53_I0.8470.13
60_V64_L0.8370.13
9_G104_I0.8320.13
62_E102_Q0.8310.13
63_V70_A0.8260.13
88_E102_Q0.8230.13
47_I74_Y0.8020.12
44_C77_E0.8010.12
8_I60_V0.7990.12
93_Q104_I0.7950.12
50_N102_Q0.7920.12
12_N94_K0.7920.12
66_K106_Q0.7880.12
40_V91_K0.7840.12
26_W48_R0.7800.12
59_R89_D0.7800.12
82_L85_I0.7770.12
61_L70_A0.7760.12
11_I81_A0.7730.12
7_L73_Y0.7700.12
42_D47_I0.7520.12
41_E66_K0.7510.12
75_D88_E0.7490.12
65_T84_T0.7430.11
12_N61_L0.7330.11
47_I78_L0.7300.11
33_V39_T0.7280.11
22_P38_L0.7270.11
8_I103_L0.7240.11
63_V85_I0.7210.11
40_V54_D0.7210.11
5_R15_K0.7200.11
77_E90_L0.7170.11
25_L38_L0.7170.11
20_Q100_I0.7130.11
26_W45_R0.7080.11
33_V97_F0.7020.11
85_I108_E0.7020.11
18_E88_E0.7010.11
48_R91_K0.6990.11
25_L86_K0.6920.11
56_L73_Y0.6890.11
73_Y81_A0.6860.11
23_L35_L0.6830.11
18_E108_E0.6810.11
20_Q43_L0.6700.11
30_I46_A0.6700.11
35_L95_S0.6670.11
41_E45_R0.6610.10
41_E56_L0.6570.10
28_E31_I0.6570.10
22_P46_A0.6500.10
44_C75_D0.6500.10
25_L85_I0.6490.10
75_D86_K0.6490.10
43_L68_P0.6480.10
40_V43_L0.6440.10
58_P96_T0.6440.10
57_M61_L0.6380.10
23_L104_I0.6380.10
71_G78_L0.6370.10
96_T99_Q0.6280.10
54_D94_K0.6210.10
39_T44_C0.6150.10
34_P47_I0.6050.10
77_E89_D0.6030.10
8_I37_K0.5980.10
24_E110_S0.5930.10
49_Q60_V0.5880.10
53_I77_E0.5880.10
47_I56_L0.5780.09
10_N44_C0.5710.09
18_E33_V0.5660.09
40_V70_A0.5650.09
10_N96_T0.5620.09
88_E106_Q0.5570.09
60_V77_E0.5420.09
45_R82_L0.5400.09
5_R37_K0.5340.09
25_L51_L0.5310.09
51_L87_G0.5290.09
35_L96_T0.5260.09
57_M79_I0.5230.09
47_I105_N0.5220.09
13_M81_A0.5220.09
50_N104_I0.5160.09
67_E92_D0.5110.09
18_E54_D0.5070.09
23_L49_Q0.5050.09
16_E19_Q0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g5h_A 1 0.4348 24.6 0.929 Contact Map
4j2o_A 1 0.2681 13.9 0.936 Contact Map
3ffv_A 1 0.7971 13 0.937 Contact Map
4hdh_A 1 0.4203 9.7 0.941 Contact Map
3bs7_A 1 0.5 9.3 0.941 Contact Map
2gle_A 1 0.5072 8.2 0.942 Contact Map
4ov4_A 1 0.3406 8 0.943 Contact Map
1t98_A 1 0.6812 7.6 0.943 Contact Map
1pn5_A 1 0.6014 7 0.945 Contact Map
4xqk_A 1 0.9348 6.7 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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