GREMLIN Database
T0806_1_258 - T0806 1-258 (CASP11)
ID: 1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 258 (251)
Sequences: 2075 (1372)
Seq/√Len: 86.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_N150_I4.8331.00
52_I56_L3.6871.00
92_Q95_T3.2761.00
142_D145_Q3.0941.00
100_D221_E3.0691.00
60_N63_R3.0041.00
241_D244_S3.0021.00
217_R221_E2.8691.00
81_L101_F2.7981.00
168_I219_I2.7871.00
187_E248_G2.5991.00
47_S54_D2.5771.00
17_L77_R2.5601.00
97_S100_D2.5581.00
226_K229_Q2.3751.00
3_I219_I2.3311.00
10_T84_K2.3201.00
100_D223_R2.3191.00
149_D153_N2.3001.00
104_A220_I2.2901.00
61_A65_H2.2611.00
109_R158_A2.1281.00
4_L167_V2.0791.00
26_E154_K2.0761.00
103_F107_H2.0711.00
26_E158_A2.0491.00
96_F104_A1.9711.00
59_I63_R1.9691.00
52_I57_A1.9641.00
228_E231_T1.9451.00
38_A64_F1.9411.00
96_F217_R1.9171.00
105_Q121_L1.9011.00
241_D253_K1.8661.00
219_I230_L1.8611.00
151_I178_S1.8601.00
194_L253_K1.8251.00
244_S253_K1.8121.00
13_Y82_A1.8051.00
15_S77_R1.7921.00
192_V249_E1.7771.00
103_F220_I1.7591.00
96_F100_D1.7571.00
141_K145_Q1.7421.00
227_P250_L1.7221.00
154_K157_E1.7041.00
224_L229_Q1.6521.00
196_E255_Y1.6491.00
5_I87_V1.5941.00
5_I216_S1.5711.00
5_I108_L1.5711.00
131_M178_S1.5671.00
190_K249_E1.5651.00
42_T45_Q1.5511.00
62_A66_D1.5491.00
37_E135_L1.5461.00
214_L236_E1.5351.00
58_G62_A1.5331.00
96_F101_F1.4961.00
27_L154_K1.4910.99
231_T250_L1.4890.99
91_L216_S1.4340.99
246_S249_E1.4280.99
86_D206_F1.4080.99
76_A123_L1.3960.99
229_Q232_G1.3830.99
219_I224_L1.3810.99
118_L124_M1.3660.99
148_G180_K1.3580.99
31_S67_W1.3580.99
95_T221_E1.3540.99
207_Y254_R1.3540.99
247_N250_L1.3480.99
104_A216_S1.3360.99
151_I179_V1.3250.99
90_G210_K1.3210.99
37_E41_L1.3020.99
191_P250_L1.2870.98
149_D180_K1.2830.98
8_A11_L1.2800.98
240_F250_L1.2640.98
231_T240_F1.2560.98
201_F253_K1.2370.98
75_N125_Q1.2320.98
32_Q36_H1.2250.98
168_I191_P1.2210.98
201_F241_D1.2190.98
77_R82_A1.2180.98
100_D220_I1.2140.98
194_L201_F1.2010.98
31_S146_F1.1980.98
95_T217_R1.1950.98
195_D205_S1.1780.97
47_S52_I1.1680.97
99_D223_R1.1660.97
84_K94_E1.1650.97
137_N140_G1.1560.97
196_E201_F1.1560.97
203_I208_A1.1450.97
30_N146_F1.1320.97
113_G131_M1.1260.96
208_A212_R1.1200.96
80_I104_A1.1100.96
109_R120_P1.0970.96
46_I52_I1.0880.96
152_T186_A1.0850.96
144_Y177_K1.0830.96
221_E235_S1.0810.96
239_F255_Y1.0760.95
166_V187_E1.0710.95
192_V203_I1.0580.95
47_S57_A1.0550.95
226_K250_L1.0520.95
12_D84_K1.0490.95
117_V154_K1.0490.95
166_V227_P1.0410.95
83_F118_L1.0280.94
18_T81_L1.0260.94
225_T229_Q1.0240.94
33_Q146_F1.0160.94
80_I91_L1.0040.93
168_I230_L1.0010.93
43_P61_A0.9980.93
108_L216_S0.9950.93
96_F221_E0.9920.93
23_T105_Q0.9890.93
22_Y78_Q0.9860.93
43_P58_G0.9810.93
250_L253_K0.9780.92
84_K89_T0.9700.92
86_D90_G0.9570.92
2_L165_N0.9570.92
80_I101_F0.9550.92
14_Q82_A0.9440.91
159_L186_A0.9350.91
245_S251_V0.9280.90
113_G175_Y0.9180.90
119_R122_D0.9110.90
101_F121_L0.9070.89
4_L155_L0.9040.89
35_I114_L0.8970.89
87_V170_L0.8970.89
169_N190_K0.8920.89
165_N187_E0.8910.88
136_E141_K0.8880.88
28_L70_D0.8860.88
2_L109_R0.8840.88
130_E133_I0.8810.88
13_Y124_M0.8770.88
50_M64_F0.8760.88
97_S221_E0.8720.87
115_Y125_Q0.8700.87
131_M175_Y0.8690.87
41_L46_I0.8690.87
6_S169_N0.8690.87
35_I46_I0.8650.87
149_D183_K0.8630.87
134_R142_D0.8570.86
205_S208_A0.8540.86
180_K183_K0.8470.86
194_L203_I0.8450.86
28_L31_S0.8340.85
91_L96_F0.8320.85
89_T206_F0.8310.85
196_E199_G0.8310.85
39_R65_H0.8310.85
10_T89_T0.8270.84
214_L235_S0.8240.84
210_K214_L0.8210.84
11_L83_F0.8150.84
9_K130_E0.8150.84
30_N33_Q0.8050.83
173_D177_K0.8030.83
80_I120_P0.8000.82
98_E102_D0.7990.82
27_L117_V0.7980.82
72_T75_N0.7970.82
103_F223_R0.7960.82
168_I189_I0.7940.82
216_S220_I0.7890.82
4_L176_F0.7860.81
12_D15_S0.7850.81
218_F222_N0.7850.81
67_W201_F0.7850.81
81_L96_F0.7830.81
26_E119_R0.7820.81
62_A65_H0.7820.81
131_M174_E0.7800.81
34_L143_L0.7790.81
49_L135_L0.7760.81
44_P48_T0.7740.80
194_L244_S0.7700.80
102_D106_Q0.7690.80
195_D204_I0.7660.80
68_Q74_A0.7610.79
173_D190_K0.7550.79
146_F150_I0.7520.78
53_S56_L0.7480.78
58_G61_A0.7480.78
169_N172_S0.7480.78
87_V206_F0.7450.78
13_Y77_R0.7430.78
218_F233_F0.7410.77
49_L132_G0.7370.77
169_N176_F0.7320.77
245_S250_L0.7320.77
8_A88_Y0.7240.76
63_R126_P0.7220.76
171_A175_Y0.7220.76
190_K250_L0.7220.76
160_A163_G0.7160.75
12_D77_R0.7110.74
194_L249_E0.7100.74
91_L217_R0.7100.74
111_L179_V0.7080.74
227_P232_G0.7050.74
38_A129_L0.7050.74
152_T180_K0.7020.73
218_F232_G0.7010.73
37_E138_A0.7010.73
18_T101_F0.6980.73
29_D33_Q0.6970.73
37_E40_K0.6970.73
43_P47_S0.6920.72
224_L227_P0.6910.72
190_K194_L0.6900.72
19_T76_A0.6900.72
83_F127_Y0.6900.72
117_V151_I0.6900.72
4_L188_I0.6850.72
219_I250_L0.6850.72
83_F132_G0.6850.72
130_E175_Y0.6830.71
76_A125_Q0.6800.71
3_I168_I0.6790.71
38_A135_L0.6790.71
87_V204_I0.6770.71
113_G130_E0.6770.71
107_H220_I0.6750.71
45_Q48_T0.6740.70
7_P175_Y0.6710.70
27_L150_I0.6710.70
67_W125_Q0.6700.70
91_L220_I0.6700.70
79_A88_Y0.6700.70
105_Q119_R0.6670.70
24_L71_F0.6660.70
113_G144_Y0.6650.69
109_R117_V0.6630.69
178_S181_P0.6610.69
52_I187_E0.6600.69
93_A96_F0.6550.68
51_R229_Q0.6540.68
111_L131_M0.6530.68
239_F253_K0.6520.68
27_L30_N0.6510.68
54_D58_G0.6460.67
189_I218_F0.6450.67
140_G145_Q0.6450.67
100_D222_N0.6430.67
244_S251_V0.6420.67
28_L67_W0.6420.67
103_F224_L0.6410.67
84_K219_I0.6400.66
36_H40_K0.6370.66
6_S171_A0.6370.66
82_A126_P0.6360.66
152_T156_N0.6340.66
55_K58_G0.6340.66
19_T115_Y0.6320.65
28_L32_Q0.6290.65
90_G132_G0.6290.65
154_K158_A0.6290.65
35_I68_Q0.6280.65
131_M144_Y0.6280.65
15_S82_A0.6260.65
181_P188_I0.6240.65
2_L158_A0.6210.64
157_E247_N0.6200.64
181_P190_K0.6180.64
34_L148_G0.6170.64
153_N183_K0.6170.64
41_L45_Q0.6140.63
11_L206_F0.6140.63
164_D189_I0.6130.63
105_Q120_P0.6100.63
31_S114_L0.6090.63
38_A42_T0.6080.63
113_G178_S0.6070.62
152_T181_P0.6060.62
230_L250_L0.6060.62
34_L137_N0.6010.62
36_H153_N0.6000.61
191_P215_M0.6000.61
195_D254_R0.5990.61
41_L65_H0.5990.61
24_L123_L0.5980.61
103_F219_I0.5940.61
164_D187_E0.5910.60
231_T242_E0.5880.60
222_N234_N0.5850.60
170_L212_R0.5830.59
128_R147_W0.5800.59
10_T52_I0.5800.59
101_F105_Q0.5800.59
99_D102_D0.5790.59
38_A133_I0.5750.58
6_S172_S0.5740.58
46_I64_F0.5730.58
46_I61_A0.5730.58
244_S249_E0.5720.58
131_M208_A0.5680.57
67_W114_L0.5670.57
130_E174_E0.5670.57
54_D66_D0.5640.57
155_L184_L0.5640.57
111_L144_Y0.5630.57
152_T183_K0.5620.57
7_P172_S0.5580.56
103_F225_T0.5580.56
113_G132_G0.5570.56
143_L147_W0.5560.56
9_K174_E0.5560.56
242_E245_S0.5550.56
32_Q68_Q0.5550.56
36_H51_R0.5530.55
168_I190_K0.5530.55
147_W172_S0.5530.55
80_I93_A0.5520.55
43_P57_A0.5510.55
12_D82_A0.5500.55
98_E149_D0.5450.54
241_D245_S0.5440.54
37_E137_N0.5430.54
48_T55_K0.5430.54
206_F210_K0.5430.54
71_F75_N0.5420.54
37_E140_G0.5410.54
157_E226_K0.5390.53
68_Q125_Q0.5390.53
31_S35_I0.5370.53
36_H39_R0.5370.53
35_I64_F0.5360.53
131_M143_L0.5340.53
71_F125_Q0.5330.53
34_L114_L0.5310.52
111_L238_Y0.5310.52
82_A124_M0.5290.52
144_Y175_Y0.5290.52
201_F244_S0.5290.52
195_D207_Y0.5290.52
13_Y63_R0.5280.52
11_L86_D0.5270.52
23_T104_A0.5240.51
219_I255_Y0.5240.51
230_L252_F0.5220.51
38_A41_L0.5210.51
249_E253_K0.5170.51
40_K247_N0.5160.50
48_T150_I0.5160.50
52_I230_L0.5160.50
201_F225_T0.5130.50
218_F221_E0.5120.50
219_I244_S0.5100.50
100_D104_A0.5100.50
196_E239_F0.5090.49
33_Q138_A0.5080.49
86_D210_K0.5040.49
24_L70_D0.5030.49
228_E250_L0.5030.49
156_N176_F0.5020.48
144_Y179_V0.5020.48
189_I227_P0.5010.48
195_D238_Y0.5010.48
194_L241_D0.5010.48
224_L235_S0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5caj_A 1 0.9922 100 0.029 Contact Map
3eyi_A 1 0.2287 12.4 0.964 Contact Map
4glx_A 1 0.3256 11.7 0.965 Contact Map
2duy_A 1 0.2481 10.8 0.965 Contact Map
3wu2_U 1 0.3605 9.1 0.966 Contact Map
4uel_C 1 0.2868 7.2 0.968 Contact Map
4wlr_B 1 0.2868 6.2 0.969 Contact Map
3c65_A 1 0.031 5.9 0.969 Contact Map
4ou0_A 1 0.2287 5 0.97 Contact Map
4rgp_A 1 0.3217 4.4 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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