T0806_1_258 - CASP12 - GREMLIN Contacts

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T0806_1_258 - T0806 1-258 (CASP11)

ID:	1	Sequences: MLILISPAKTLDYQSPLTTTRYTLPELLDNSQQLIHEARKLTPPQISTLMRISDKLAGINAARFHDWQPDFTPANARQAILAFKGDVYTGLQAETFSEDDFDFAQQHLRMLSGLYGVLRPLDLMQPYRLEMGIRLENARGKDLYQFWGDIITNKLNEALAAQGDNVVINLASDEYFKSVKPKKLNAEIIKPVFLDEKNGKFKIISFYAKKARGLMSRFIIENRLTKPEQLTGFNSEGYFFDEDSSSNGELVFKRYEQR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	258 (251)
Sequences:	2075 (1372)
Seq/√Len:	86.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
30_N	150_I	4.833	1.00
52_I	56_L	3.687	1.00
92_Q	95_T	3.276	1.00
142_D	145_Q	3.094	1.00
100_D	221_E	3.069	1.00
60_N	63_R	3.004	1.00
241_D	244_S	3.002	1.00
217_R	221_E	2.869	1.00
81_L	101_F	2.798	1.00
168_I	219_I	2.787	1.00
187_E	248_G	2.599	1.00
47_S	54_D	2.577	1.00
17_L	77_R	2.560	1.00
97_S	100_D	2.558	1.00
226_K	229_Q	2.375	1.00
3_I	219_I	2.331	1.00
10_T	84_K	2.320	1.00
100_D	223_R	2.319	1.00
149_D	153_N	2.300	1.00
104_A	220_I	2.290	1.00
61_A	65_H	2.261	1.00
109_R	158_A	2.128	1.00
4_L	167_V	2.079	1.00
26_E	154_K	2.076	1.00
103_F	107_H	2.071	1.00
26_E	158_A	2.049	1.00
96_F	104_A	1.971	1.00
59_I	63_R	1.969	1.00
52_I	57_A	1.964	1.00
228_E	231_T	1.945	1.00
38_A	64_F	1.941	1.00
96_F	217_R	1.917	1.00
105_Q	121_L	1.901	1.00
241_D	253_K	1.866	1.00
219_I	230_L	1.861	1.00
151_I	178_S	1.860	1.00
194_L	253_K	1.825	1.00
244_S	253_K	1.812	1.00
13_Y	82_A	1.805	1.00
15_S	77_R	1.792	1.00
192_V	249_E	1.777	1.00
103_F	220_I	1.759	1.00
96_F	100_D	1.757	1.00
141_K	145_Q	1.742	1.00
227_P	250_L	1.722	1.00
154_K	157_E	1.704	1.00
224_L	229_Q	1.652	1.00
196_E	255_Y	1.649	1.00
5_I	87_V	1.594	1.00
5_I	216_S	1.571	1.00
5_I	108_L	1.571	1.00
131_M	178_S	1.567	1.00
190_K	249_E	1.565	1.00
42_T	45_Q	1.551	1.00
62_A	66_D	1.549	1.00
37_E	135_L	1.546	1.00
214_L	236_E	1.535	1.00
58_G	62_A	1.533	1.00
96_F	101_F	1.496	1.00
27_L	154_K	1.491	0.99
231_T	250_L	1.489	0.99
91_L	216_S	1.434	0.99
246_S	249_E	1.428	0.99
86_D	206_F	1.408	0.99
76_A	123_L	1.396	0.99
229_Q	232_G	1.383	0.99
219_I	224_L	1.381	0.99
118_L	124_M	1.366	0.99
148_G	180_K	1.358	0.99
31_S	67_W	1.358	0.99
95_T	221_E	1.354	0.99
207_Y	254_R	1.354	0.99
247_N	250_L	1.348	0.99
104_A	216_S	1.336	0.99
151_I	179_V	1.325	0.99
90_G	210_K	1.321	0.99
37_E	41_L	1.302	0.99
191_P	250_L	1.287	0.98
149_D	180_K	1.283	0.98
8_A	11_L	1.280	0.98
240_F	250_L	1.264	0.98
231_T	240_F	1.256	0.98
201_F	253_K	1.237	0.98
75_N	125_Q	1.232	0.98
32_Q	36_H	1.225	0.98
168_I	191_P	1.221	0.98
201_F	241_D	1.219	0.98
77_R	82_A	1.218	0.98
100_D	220_I	1.214	0.98
194_L	201_F	1.201	0.98
31_S	146_F	1.198	0.98
95_T	217_R	1.195	0.98
195_D	205_S	1.178	0.97
47_S	52_I	1.168	0.97
99_D	223_R	1.166	0.97
84_K	94_E	1.165	0.97
137_N	140_G	1.156	0.97
196_E	201_F	1.156	0.97
203_I	208_A	1.145	0.97
30_N	146_F	1.132	0.97
113_G	131_M	1.126	0.96
208_A	212_R	1.120	0.96
80_I	104_A	1.110	0.96
109_R	120_P	1.097	0.96
46_I	52_I	1.088	0.96
152_T	186_A	1.085	0.96
144_Y	177_K	1.083	0.96
221_E	235_S	1.081	0.96
239_F	255_Y	1.076	0.95
166_V	187_E	1.071	0.95
192_V	203_I	1.058	0.95
47_S	57_A	1.055	0.95
226_K	250_L	1.052	0.95
12_D	84_K	1.049	0.95
117_V	154_K	1.049	0.95
166_V	227_P	1.041	0.95
83_F	118_L	1.028	0.94
18_T	81_L	1.026	0.94
225_T	229_Q	1.024	0.94
33_Q	146_F	1.016	0.94
80_I	91_L	1.004	0.93
168_I	230_L	1.001	0.93
43_P	61_A	0.998	0.93
108_L	216_S	0.995	0.93
96_F	221_E	0.992	0.93
23_T	105_Q	0.989	0.93
22_Y	78_Q	0.986	0.93
43_P	58_G	0.981	0.93
250_L	253_K	0.978	0.92
84_K	89_T	0.970	0.92
86_D	90_G	0.957	0.92
2_L	165_N	0.957	0.92
80_I	101_F	0.955	0.92
14_Q	82_A	0.944	0.91
159_L	186_A	0.935	0.91
245_S	251_V	0.928	0.90
113_G	175_Y	0.918	0.90
119_R	122_D	0.911	0.90
101_F	121_L	0.907	0.89
4_L	155_L	0.904	0.89
35_I	114_L	0.897	0.89
87_V	170_L	0.897	0.89
169_N	190_K	0.892	0.89
165_N	187_E	0.891	0.88
136_E	141_K	0.888	0.88
28_L	70_D	0.886	0.88
2_L	109_R	0.884	0.88
130_E	133_I	0.881	0.88
13_Y	124_M	0.877	0.88
50_M	64_F	0.876	0.88
97_S	221_E	0.872	0.87
115_Y	125_Q	0.870	0.87
131_M	175_Y	0.869	0.87
41_L	46_I	0.869	0.87
6_S	169_N	0.869	0.87
35_I	46_I	0.865	0.87
149_D	183_K	0.863	0.87
134_R	142_D	0.857	0.86
205_S	208_A	0.854	0.86
180_K	183_K	0.847	0.86
194_L	203_I	0.845	0.86
28_L	31_S	0.834	0.85
91_L	96_F	0.832	0.85
89_T	206_F	0.831	0.85
196_E	199_G	0.831	0.85
39_R	65_H	0.831	0.85
10_T	89_T	0.827	0.84
214_L	235_S	0.824	0.84
210_K	214_L	0.821	0.84
11_L	83_F	0.815	0.84
9_K	130_E	0.815	0.84
30_N	33_Q	0.805	0.83
173_D	177_K	0.803	0.83
80_I	120_P	0.800	0.82
98_E	102_D	0.799	0.82
27_L	117_V	0.798	0.82
72_T	75_N	0.797	0.82
103_F	223_R	0.796	0.82
168_I	189_I	0.794	0.82
216_S	220_I	0.789	0.82
4_L	176_F	0.786	0.81
12_D	15_S	0.785	0.81
218_F	222_N	0.785	0.81
67_W	201_F	0.785	0.81
81_L	96_F	0.783	0.81
26_E	119_R	0.782	0.81
62_A	65_H	0.782	0.81
131_M	174_E	0.780	0.81
34_L	143_L	0.779	0.81
49_L	135_L	0.776	0.81
44_P	48_T	0.774	0.80
194_L	244_S	0.770	0.80
102_D	106_Q	0.769	0.80
195_D	204_I	0.766	0.80
68_Q	74_A	0.761	0.79
173_D	190_K	0.755	0.79
146_F	150_I	0.752	0.78
53_S	56_L	0.748	0.78
58_G	61_A	0.748	0.78
169_N	172_S	0.748	0.78
87_V	206_F	0.745	0.78
13_Y	77_R	0.743	0.78
218_F	233_F	0.741	0.77
49_L	132_G	0.737	0.77
169_N	176_F	0.732	0.77
245_S	250_L	0.732	0.77
8_A	88_Y	0.724	0.76
63_R	126_P	0.722	0.76
171_A	175_Y	0.722	0.76
190_K	250_L	0.722	0.76
160_A	163_G	0.716	0.75
12_D	77_R	0.711	0.74
194_L	249_E	0.710	0.74
91_L	217_R	0.710	0.74
111_L	179_V	0.708	0.74
227_P	232_G	0.705	0.74
38_A	129_L	0.705	0.74
152_T	180_K	0.702	0.73
218_F	232_G	0.701	0.73
37_E	138_A	0.701	0.73
18_T	101_F	0.698	0.73
29_D	33_Q	0.697	0.73
37_E	40_K	0.697	0.73
43_P	47_S	0.692	0.72
224_L	227_P	0.691	0.72
190_K	194_L	0.690	0.72
19_T	76_A	0.690	0.72
83_F	127_Y	0.690	0.72
117_V	151_I	0.690	0.72
4_L	188_I	0.685	0.72
219_I	250_L	0.685	0.72
83_F	132_G	0.685	0.72
130_E	175_Y	0.683	0.71
76_A	125_Q	0.680	0.71
3_I	168_I	0.679	0.71
38_A	135_L	0.679	0.71
87_V	204_I	0.677	0.71
113_G	130_E	0.677	0.71
107_H	220_I	0.675	0.71
45_Q	48_T	0.674	0.70
7_P	175_Y	0.671	0.70
27_L	150_I	0.671	0.70
67_W	125_Q	0.670	0.70
91_L	220_I	0.670	0.70
79_A	88_Y	0.670	0.70
105_Q	119_R	0.667	0.70
24_L	71_F	0.666	0.70
113_G	144_Y	0.665	0.69
109_R	117_V	0.663	0.69
178_S	181_P	0.661	0.69
52_I	187_E	0.660	0.69
93_A	96_F	0.655	0.68
51_R	229_Q	0.654	0.68
111_L	131_M	0.653	0.68
239_F	253_K	0.652	0.68
27_L	30_N	0.651	0.68
54_D	58_G	0.646	0.67
189_I	218_F	0.645	0.67
140_G	145_Q	0.645	0.67
100_D	222_N	0.643	0.67
244_S	251_V	0.642	0.67
28_L	67_W	0.642	0.67
103_F	224_L	0.641	0.67
84_K	219_I	0.640	0.66
36_H	40_K	0.637	0.66
6_S	171_A	0.637	0.66
82_A	126_P	0.636	0.66
152_T	156_N	0.634	0.66
55_K	58_G	0.634	0.66
19_T	115_Y	0.632	0.65
28_L	32_Q	0.629	0.65
90_G	132_G	0.629	0.65
154_K	158_A	0.629	0.65
35_I	68_Q	0.628	0.65
131_M	144_Y	0.628	0.65
15_S	82_A	0.626	0.65
181_P	188_I	0.624	0.65
2_L	158_A	0.621	0.64
157_E	247_N	0.620	0.64
181_P	190_K	0.618	0.64
34_L	148_G	0.617	0.64
153_N	183_K	0.617	0.64
41_L	45_Q	0.614	0.63
11_L	206_F	0.614	0.63
164_D	189_I	0.613	0.63
105_Q	120_P	0.610	0.63
31_S	114_L	0.609	0.63
38_A	42_T	0.608	0.63
113_G	178_S	0.607	0.62
152_T	181_P	0.606	0.62
230_L	250_L	0.606	0.62
34_L	137_N	0.601	0.62
36_H	153_N	0.600	0.61
191_P	215_M	0.600	0.61
195_D	254_R	0.599	0.61
41_L	65_H	0.599	0.61
24_L	123_L	0.598	0.61
103_F	219_I	0.594	0.61
164_D	187_E	0.591	0.60
231_T	242_E	0.588	0.60
222_N	234_N	0.585	0.60
170_L	212_R	0.583	0.59
128_R	147_W	0.580	0.59
10_T	52_I	0.580	0.59
101_F	105_Q	0.580	0.59
99_D	102_D	0.579	0.59
38_A	133_I	0.575	0.58
6_S	172_S	0.574	0.58
46_I	64_F	0.573	0.58
46_I	61_A	0.573	0.58
244_S	249_E	0.572	0.58
131_M	208_A	0.568	0.57
67_W	114_L	0.567	0.57
130_E	174_E	0.567	0.57
54_D	66_D	0.564	0.57
155_L	184_L	0.564	0.57
111_L	144_Y	0.563	0.57
152_T	183_K	0.562	0.57
7_P	172_S	0.558	0.56
103_F	225_T	0.558	0.56
113_G	132_G	0.557	0.56
143_L	147_W	0.556	0.56
9_K	174_E	0.556	0.56
242_E	245_S	0.555	0.56
32_Q	68_Q	0.555	0.56
36_H	51_R	0.553	0.55
168_I	190_K	0.553	0.55
147_W	172_S	0.553	0.55
80_I	93_A	0.552	0.55
43_P	57_A	0.551	0.55
12_D	82_A	0.550	0.55
98_E	149_D	0.545	0.54
241_D	245_S	0.544	0.54
37_E	137_N	0.543	0.54
48_T	55_K	0.543	0.54
206_F	210_K	0.543	0.54
71_F	75_N	0.542	0.54
37_E	140_G	0.541	0.54
157_E	226_K	0.539	0.53
68_Q	125_Q	0.539	0.53
31_S	35_I	0.537	0.53
36_H	39_R	0.537	0.53
35_I	64_F	0.536	0.53
131_M	143_L	0.534	0.53
71_F	125_Q	0.533	0.53
34_L	114_L	0.531	0.52
111_L	238_Y	0.531	0.52
82_A	124_M	0.529	0.52
144_Y	175_Y	0.529	0.52
201_F	244_S	0.529	0.52
195_D	207_Y	0.529	0.52
13_Y	63_R	0.528	0.52
11_L	86_D	0.527	0.52
23_T	104_A	0.524	0.51
219_I	255_Y	0.524	0.51
230_L	252_F	0.522	0.51
38_A	41_L	0.521	0.51
249_E	253_K	0.517	0.51
40_K	247_N	0.516	0.50
48_T	150_I	0.516	0.50
52_I	230_L	0.516	0.50
201_F	225_T	0.513	0.50
218_F	221_E	0.512	0.50
219_I	244_S	0.510	0.50
100_D	104_A	0.510	0.50
196_E	239_F	0.509	0.49
33_Q	138_A	0.508	0.49
86_D	210_K	0.504	0.49
24_L	70_D	0.503	0.49
228_E	250_L	0.503	0.49
156_N	176_F	0.502	0.48
144_Y	179_V	0.502	0.48
189_I	227_P	0.501	0.48
195_D	238_Y	0.501	0.48
194_L	241_D	0.501	0.48
224_L	235_S	0.500	0.48

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
5caj_A	1	0.9922	100	0.029	Contact Map
3eyi_A	1	0.2287	12.4	0.964	Contact Map
4glx_A	1	0.3256	11.7	0.965	Contact Map
2duy_A	1	0.2481	10.8	0.965	Contact Map
3wu2_U	1	0.3605	9.1	0.966	Contact Map
4uel_C	1	0.2868	7.2	0.968	Contact Map
4wlr_B	1	0.2868	6.2	0.969	Contact Map
3c65_A	1	0.031	5.9	0.969	Contact Map
4ou0_A	1	0.2287	5	0.97	Contact Map
4rgp_A	1	0.3217	4.4	0.971	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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