GREMLIN Database
HTRB - Serine protease Do-like HtrB
UniProt: Q9R9I1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 458 (360)
Sequences: 4711 (3695)
Seq/√Len: 194.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
304_N308_Q6.0531.00
406_K435_Q4.6671.00
436_V445_L4.6411.00
133_E241_R4.6201.00
408_N426_L3.8571.00
236_D332_N3.8481.00
431_K446_N3.6441.00
236_D239_Q3.4711.00
233_S308_Q3.3991.00
186_N212_S3.3841.00
433_T444_T3.3011.00
207_A221_L3.1091.00
238_S332_N2.9841.00
232_A309_V2.9771.00
195_L209_L2.9701.00
138_T231_V2.9581.00
435_Q442_T2.9231.00
433_T446_N2.7881.00
293_I326_G2.7421.00
406_K409_G2.5221.00
208_K224_S2.4791.00
220_V342_L2.4781.00
436_V443_K2.3931.00
194_K206_T2.3171.00
390_N394_E2.2681.00
384_V398_I2.2441.00
196_T204_T2.2301.00
183_I334_V2.2171.00
398_I434_I2.2131.00
355_Q386_E2.1901.00
205_E223_I2.1731.00
266_I287_L2.1111.00
352_L447_A2.0881.00
129_A244_E2.0811.00
431_K448_T2.0751.00
90_G93_P2.0511.00
356_M415_S2.0251.00
171_V309_V2.0241.00
225_G228_V2.0191.00
234_F331_S2.0131.00
171_V301_P2.0111.00
340_Q344_N1.9821.00
234_F335_E1.9811.00
171_V312_I1.9591.00
406_K411_D1.9561.00
301_P309_V1.9461.00
435_Q444_T1.8971.00
402_D438_R1.8801.00
145_I194_K1.8561.00
427_K430_D1.8221.00
240_L310_I1.8201.00
183_I338_V1.8141.00
413_E417_D1.7981.00
339_D343_Q1.7971.00
245_K263_Q1.7751.00
398_I436_V1.7741.00
348_D451_K1.7601.00
171_V232_A1.7531.00
199_L205_E1.7451.00
398_I445_L1.7301.00
350_P428_V1.6801.00
410_K421_I1.6631.00
132_V261_V1.6401.00
414_S417_D1.6321.00
426_L449_L1.6321.00
144_N195_L1.6321.00
218_L312_I1.6281.00
196_T206_T1.6231.00
246_V266_I1.6161.00
358_D415_S1.6101.00
384_V404_I1.5931.00
405_V437_L1.5931.00
426_L430_D1.5751.00
172_I199_L1.5491.00
405_V442_T1.5231.00
143_S198_T1.5081.00
181_Y222_E1.5041.00
129_A241_R1.4761.00
335_E339_D1.4681.00
351_F392_P1.4681.00
405_V435_Q1.4651.00
135_L303_I1.4591.00
128_I263_Q1.4561.00
232_A303_I1.4521.00
392_P450_T1.4101.00
426_L432_T1.4091.00
235_G331_S1.4081.00
245_K305_A1.4011.00
389_A394_E1.3981.00
174_K181_Y1.3841.00
346_K451_K1.3791.00
380_K413_E1.3781.00
432_T449_L1.3761.00
127_N244_E1.3741.00
247_I305_A1.3701.00
208_K222_E1.3531.00
253_L317_V1.3481.00
438_R443_K1.3421.00
181_Y342_L1.3411.00
351_F453_T1.3311.00
128_I245_K1.3301.00
383_Y401_E1.3211.00
80_G84_G1.3191.00
135_L232_A1.3171.00
240_L287_L1.3131.00
81_G85_G1.2931.00
437_L442_T1.2701.00
181_Y210_V1.2621.00
138_T232_A1.2611.00
84_G88_M1.2541.00
344_N348_D1.2421.00
380_K411_D1.2361.00
388_Q391_S1.2281.00
169_S301_P1.2271.00
237_S332_N1.2251.00
182_I223_I1.2251.00
395_K450_T1.2211.00
199_L223_I1.2171.00
213_D216_T1.2171.00
199_L203_E1.2101.00
240_L269_L1.2091.00
140_V182_I1.2091.00
387_V391_S1.2091.00
246_V305_A1.2031.00
312_I334_V1.2021.00
142_I221_L1.2011.00
334_V338_V1.2001.00
134_D233_S1.1961.00
130_D241_R1.1861.00
127_N130_D1.1841.00
242_T269_L1.1841.00
253_L322_V1.1721.00
131_M303_I1.1631.00
205_E225_G1.1581.00
270_N285_N1.1511.00
192_A195_L1.1461.00
316_K323_E1.1401.00
128_I247_I1.1311.00
358_D414_S1.1301.00
225_G229_K1.1281.00
289_T302_L1.1221.00
357_I385_K1.1221.00
331_S334_V1.1201.00
142_I197_V1.1171.00
316_K322_V1.1031.00
269_L287_L1.0951.00
88_M92_A1.0861.00
408_N421_I1.0821.00
176_D222_E1.0821.00
386_E400_S1.0751.00
85_G88_M1.0671.00
434_I445_L1.0591.00
434_I447_A1.0571.00
216_T349_R1.0521.00
88_M91_I1.0381.00
263_Q290_D1.0261.00
399_K438_R1.0261.00
223_I228_V1.0221.00
189_V195_L1.0131.00
408_N433_T1.0121.00
209_L212_S1.0101.00
198_T204_T1.0091.00
86_G89_L1.0091.00
84_G92_A1.0071.00
136_E259_G1.0021.00
180_A222_E0.9971.00
240_L266_I0.9860.99
354_V382_V0.9840.99
393_A396_A0.9820.99
172_I223_I0.9800.99
421_I426_L0.9780.99
350_P449_L0.9770.99
407_L426_L0.9680.99
407_L432_T0.9650.99
176_D181_Y0.9630.99
319_E323_E0.9620.99
211_G341_L0.9610.99
257_F325_L0.9480.99
351_F388_Q0.9460.99
182_I221_L0.9440.99
360_S367_Q0.9420.99
234_F309_V0.9410.99
248_A302_L0.9400.99
186_N214_T0.9330.99
251_N258_S0.9310.99
128_I132_V0.9300.99
226_K229_K0.9290.99
83_I86_G0.9290.99
174_K180_A0.9260.99
437_L440_G0.9220.99
173_F338_V0.9180.99
340_Q347_V0.9150.99
186_N190_E0.9120.99
76_S79_L0.9110.99
253_L323_E0.9090.99
355_Q388_Q0.9080.99
146_Q164_E0.9080.99
336_P340_Q0.9050.99
91_I95_L0.9040.99
248_A313_N0.9010.99
295_P319_E0.8990.99
358_D382_V0.8940.99
131_M135_L0.8940.99
355_Q385_K0.8900.99
235_G240_L0.8880.99
77_P80_G0.8880.99
293_I313_N0.8860.99
131_M247_I0.8850.99
241_R244_E0.8830.99
344_N347_V0.8790.99
73_A76_S0.8780.99
220_V341_L0.8740.99
89_L93_P0.8720.99
356_M382_V0.8690.99
220_V338_V0.8690.99
399_K439_K0.8650.99
170_G182_I0.8630.99
407_L422_L0.8620.99
91_I94_Y0.8550.99
141_G251_N0.8520.99
77_P81_G0.8520.99
89_L92_A0.8510.99
406_K442_T0.8500.98
183_I218_L0.8500.98
80_G88_M0.8480.98
132_V247_I0.8480.98
145_I165_S0.8420.98
266_I310_I0.8400.98
358_D416_A0.8380.98
135_L249_I0.8310.98
140_V170_G0.8300.98
172_I229_K0.8260.98
318_S321_G0.8240.98
76_S80_G0.8240.98
147_T193_N0.8210.98
131_M134_D0.8190.98
338_V342_L0.8190.98
240_L246_V0.8120.98
71_R75_L0.8070.98
382_V412_V0.8070.98
147_T161_S0.8070.98
171_V303_I0.8060.98
197_V207_A0.8040.98
77_P83_I0.8030.98
189_V212_S0.7960.98
421_I425_D0.7960.98
172_I231_V0.7910.98
149_Q153_F0.7890.98
175_K228_V0.7880.98
145_I163_S0.7880.98
174_K342_L0.7850.97
395_K448_T0.7790.97
132_V303_I0.7770.97
422_L426_L0.7750.97
197_V223_I0.7720.97
252_P257_F0.7690.97
139_I301_P0.7680.97
260_T325_L0.7670.97
90_G94_Y0.7570.97
145_I196_T0.7550.97
247_I263_Q0.7550.97
108_A111_Q0.7530.97
387_V397_G0.7530.97
356_M419_R0.7530.97
153_F157_G0.7510.97
351_F452_Q0.7510.97
273_I282_V0.7480.97
407_L434_I0.7440.97
409_G433_T0.7420.96
82_I85_G0.7410.96
381_G403_V0.7410.96
273_I286_V0.7390.96
143_S196_T0.7380.96
410_K425_D0.7380.96
309_V331_S0.7380.96
211_G220_V0.7370.96
339_D342_L0.7370.96
387_V400_S0.7360.96
85_G90_G0.7330.96
302_L313_N0.7310.96
434_I444_T0.7310.96
87_L90_G0.7250.96
288_Q327_F0.7240.96
187_H298_S0.7210.96
141_G166_G0.7210.96
215_I452_Q0.7170.96
74_W80_G0.7160.96
384_V445_L0.7150.96
396_A447_A0.7150.96
340_Q345_G0.7130.96
368_E371_L0.7130.96
391_S394_E0.7120.96
144_N167_T0.7120.96
412_V421_I0.7120.96
271_R288_Q0.7110.95
131_M249_I0.7100.95
132_V136_E0.7100.95
430_D449_L0.7090.95
407_L418_I0.7070.95
294_N297_N0.7070.95
244_E304_N0.7050.95
352_L434_I0.7030.95
148_S151_N0.7030.95
79_L82_I0.7020.95
168_G188_V0.7010.95
253_L316_K0.7010.95
195_L221_L0.7010.95
110_K113_Q0.7000.95
332_N335_E0.7000.95
78_I84_G0.6990.95
386_E389_A0.6980.95
91_I97_S0.6970.95
213_D349_R0.6950.95
359_M373_L0.6930.95
417_D421_I0.6920.95
85_G91_I0.6920.95
130_D134_D0.6890.95
166_G295_P0.6890.95
183_I331_S0.6870.95
271_R327_F0.6840.94
173_F183_I0.6820.94
185_N329_I0.6820.94
173_F342_L0.6810.94
378_L437_L0.6800.94
284_M333_D0.6800.94
350_P430_D0.6800.94
80_G87_L0.6790.94
232_A331_S0.6790.94
124_N245_K0.6790.94
146_Q193_N0.6780.94
353_G391_S0.6720.94
91_I96_P0.6710.94
77_P85_G0.6670.94
237_S240_L0.6670.94
93_P96_P0.6670.94
83_I88_M0.6640.94
246_V310_I0.6630.93
72_A76_S0.6620.93
317_V322_V0.6610.93
73_A77_P0.6610.93
75_L85_G0.6590.93
187_H217_D0.6570.93
157_G160_S0.6560.93
93_P97_S0.6550.93
187_H296_G0.6540.93
77_P91_I0.6530.93
261_V265_I0.6520.93
436_V444_T0.6520.93
190_E214_T0.6510.93
399_K443_K0.6460.93
76_S84_G0.6440.92
409_G444_T0.6440.92
331_S335_E0.6430.92
73_A79_L0.6420.92
407_L412_V0.6410.92
356_M418_I0.6400.92
88_M93_P0.6400.92
291_A326_G0.6390.92
171_V218_L0.6380.92
404_I418_I0.6380.92
75_L86_G0.6380.92
382_V415_S0.6370.92
124_N127_N0.6350.92
218_L331_S0.6350.92
354_V398_I0.6330.92
184_T219_A0.6310.92
74_W79_L0.6310.92
126_S130_D0.6290.92
88_M95_L0.6280.92
217_D298_S0.6250.91
86_G90_G0.6240.91
259_G301_P0.6230.91
142_I207_A0.6220.91
438_R445_L0.6200.91
216_T337_I0.6190.91
249_I260_T0.6190.91
143_S167_T0.6180.91
262_T267_S0.6150.91
318_S322_V0.6150.91
141_G167_T0.6140.91
257_F327_F0.6130.91
419_R422_L0.6120.90
128_I261_V0.6120.90
173_F220_V0.6110.90
393_A397_G0.6100.90
75_L78_I0.6070.90
136_E309_V0.6060.90
354_V384_V0.6050.90
368_E372_G0.6050.90
124_N305_A0.6020.90
141_G258_S0.6020.90
246_V263_Q0.6010.90
175_K231_V0.6000.90
82_I89_L0.6000.90
74_W77_P0.5980.89
249_I303_I0.5980.89
252_P327_F0.5980.89
144_N164_E0.5970.89
289_T292_A0.5970.89
341_L347_V0.5960.89
428_V450_T0.5960.89
142_I195_L0.5950.89
316_K324_S0.5950.89
138_T230_K0.5950.89
95_L99_Q0.5950.89
146_Q166_G0.5940.89
286_V314_S0.5920.89
393_A398_I0.5910.89
190_E212_S0.5910.89
218_L329_I0.5910.89
185_N217_D0.5890.89
188_V298_S0.5890.89
359_M379_G0.5880.89
75_L80_G0.5880.89
274_D281_T0.5870.89
360_S368_E0.5870.89
83_I91_I0.5870.89
136_E200_Y0.5850.88
431_K449_L0.5840.88
387_V398_I0.5840.88
206_T224_S0.5830.88
200_Y259_G0.5830.88
107_S110_K0.5820.88
348_D449_L0.5810.88
285_N333_D0.5770.88
83_I87_L0.5760.88
149_Q161_S0.5750.88
127_N245_K0.5740.87
359_M383_Y0.5740.87
135_L309_V0.5740.87
352_L392_P0.5730.87
82_I87_L0.5730.87
382_V419_R0.5720.87
189_V221_L0.5710.87
282_V419_R0.5700.87
267_S294_N0.5690.87
216_T347_V0.5690.87
144_N189_V0.5690.87
407_L421_I0.5690.87
73_A91_I0.5690.87
111_Q114_S0.5680.87
87_L91_I0.5680.87
87_L92_A0.5670.87
79_L83_I0.5670.87
173_F231_V0.5660.87
372_G377_Q0.5650.87
295_P316_K0.5650.87
176_D231_V0.5650.87
288_Q297_N0.5640.87
272_T286_V0.5630.86
302_L328_A0.5630.86
286_V315_L0.5620.86
75_L79_L0.5620.86
421_I432_T0.5610.86
89_L94_Y0.5600.86
79_L85_G0.5590.86
144_N166_G0.5590.86
408_N432_T0.5590.86
76_S82_I0.5590.86
399_K402_D0.5550.86
429_G448_T0.5550.86
273_I315_L0.5540.86
284_M314_S0.5540.86
358_D361_Q0.5540.86
408_N434_I0.5520.85
135_L301_P0.5520.85
148_S164_E0.5510.85
247_I261_V0.5490.85
77_P89_L0.5490.85
137_P230_K0.5480.85
75_L88_M0.5480.85
412_V418_I0.5480.85
409_G435_Q0.5470.85
183_I234_F0.5470.85
357_I383_Y0.5470.85
131_M202_G0.5470.85
218_L338_V0.5460.85
78_I85_G0.5460.85
368_E373_L0.5460.85
353_G392_P0.5460.85
368_E379_G0.5430.84
188_V296_G0.5430.84
96_P99_Q0.5420.84
153_F158_G0.5420.84
340_Q427_K0.5420.84
174_K231_V0.5410.84
173_F181_Y0.5400.84
367_Q371_L0.5400.84
382_V418_I0.5390.84
166_G192_A0.5390.84
187_H288_Q0.5390.84
75_L82_I0.5370.84
134_D230_K0.5370.84
292_A322_V0.5360.84
236_D335_E0.5360.84
409_G421_I0.5350.84
262_T297_N0.5340.83
239_Q306_S0.5340.83
253_L318_S0.5310.83
359_M403_V0.5310.83
185_N297_N0.5300.83
72_A79_L0.5290.83
246_V289_T0.5290.83
246_V303_I0.5290.83
408_N430_D0.5290.83
294_N324_S0.5270.83
146_Q165_S0.5260.83
417_D420_Q0.5260.83
180_A225_G0.5260.83
234_F338_V0.5250.82
267_S271_R0.5250.82
211_G337_I0.5250.82
119_T134_D0.5240.82
167_T258_S0.5230.82
384_V387_V0.5220.82
114_S117_F0.5220.82
387_V394_E0.5210.82
87_L94_Y0.5210.82
251_N254_G0.5200.82
77_P93_P0.5200.82
144_N192_A0.5200.82
333_D337_I0.5200.82
272_T283_E0.5190.82
106_A109_N0.5150.81
370_T373_L0.5150.81
136_E258_S0.5150.81
168_G187_H0.5120.81
216_T284_M0.5090.80
291_A314_S0.5090.80
125_A129_A0.5080.80
92_A95_L0.5080.80
356_M422_L0.5070.80
362_V367_Q0.5070.80
419_R423_Y0.5060.80
322_V325_L0.5050.80
112_V117_F0.5040.80
301_P313_N0.5040.80
211_G345_G0.5040.80
198_T259_G0.5030.80
257_F273_I0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ky9A 5 0.6769 100 0.428 Contact Map
3pv2A 6 0.6376 100 0.441 Contact Map
3stjA 6 0.6528 100 0.454 Contact Map
4a8cA 5 0.6681 100 0.457 Contact Map
1lcyA 3 0.6397 100 0.491 Contact Map
3qo6A 5 0.6921 100 0.494 Contact Map
4ic6A 4 0.6856 100 0.497 Contact Map
4ri0A 3 0.6703 100 0.503 Contact Map
4flnA 5 0.6594 100 0.514 Contact Map
1te0A 6 0.6856 100 0.515 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0116 seconds.