GREMLIN Database
NADA - Quinolinate synthase A
UniProt: Q9KWZ1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 368 (301)
Sequences: 2307 (1178)
Seq/√Len: 67.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_R77_D4.9551.00
29_R336_E4.1061.00
362_N366_S3.0751.00
269_D275_Y2.9571.00
288_K309_Q2.9291.00
32_A36_K2.8281.00
351_K354_Q2.7921.00
248_D288_K2.7391.00
278_D282_Q2.7351.00
250_D288_K2.7241.00
255_V264_V2.6361.00
178_R222_K2.5181.00
122_N151_F2.5151.00
349_V354_Q2.4811.00
55_Q299_Q2.4591.00
90_T361_L2.3841.00
354_Q358_L2.3841.00
351_K355_E2.3741.00
78_Y343_P2.3521.00
105_D330_H2.3081.00
69_V72_K2.2821.00
29_R32_A2.2801.00
188_G225_L2.2761.00
100_T343_P2.2751.00
26_M332_L2.2631.00
281_N304_E2.2431.00
255_V267_S2.2401.00
100_T346_V2.2281.00
39_S343_P2.1271.00
332_L336_E2.1201.00
140_T144_S2.1171.00
358_L362_N2.1081.00
283_A289_W2.0421.00
242_H266_L2.0361.00
78_Y102_V1.9531.00
252_Q279_T1.9121.00
300_R304_E1.9041.00
29_R332_L1.9041.00
65_Q274_K1.9021.00
65_Q69_V1.8971.00
109_G114_D1.8771.00
166_K191_T1.8571.00
31_A34_K1.8481.00
281_N305_H1.7951.00
245_R268_D1.7601.00
276_I301_I1.7591.00
264_V270_N1.7491.00
140_T156_G1.7401.00
238_T266_L1.7341.00
59_Q65_Q1.7171.00
337_Q344_S1.7011.00
334_S345_G1.6440.99
127_K130_H1.6390.99
39_S78_Y1.6380.99
287_S307_D1.6360.99
71_E95_T1.6270.99
242_H246_E1.6150.99
166_K170_E1.6070.99
252_Q285_A1.5840.99
363_R366_S1.5750.99
81_F91_A1.5660.99
280_I310_I1.5590.99
166_K194_D1.5330.99
92_D346_V1.5230.99
59_Q69_V1.4950.99
252_Q283_A1.4860.99
158_A171_W1.4740.99
78_Y100_T1.4680.99
356_D359_L1.4570.98
280_I305_H1.4480.98
39_S100_T1.4480.98
80_V102_V1.4170.98
261_H265_T1.4050.98
112_M115_M1.3980.98
40_R78_Y1.3960.98
333_W337_Q1.3940.98
171_W367_I1.3800.98
169_L191_T1.3790.98
287_S309_Q1.3770.98
283_A308_K1.3640.98
82_C331_L1.3580.98
241_I253_I1.3550.98
92_D348_K1.3420.97
44_P70_A1.3350.97
127_K131_I1.3290.97
42_F76_A1.3130.97
93_M146_A1.3040.97
67_A81_F1.3010.97
45_G57_A1.2990.97
254_I280_I1.2970.97
136_I172_A1.2860.97
185_Q227_K1.2790.97
132_F178_R1.2760.96
243_D247_R1.2690.96
232_V322_T1.2680.96
111_S322_T1.2680.96
255_V292_G1.2600.96
27_E31_A1.2490.96
231_S322_T1.2330.96
333_W336_E1.2230.95
53_V331_L1.2170.95
193_Y261_H1.2160.95
93_M354_Q1.2100.95
167_K170_E1.2080.95
248_D311_E1.2050.95
67_A95_T1.2010.95
254_I291_I1.1870.95
278_D281_N1.1860.95
88_A103_L1.1780.94
193_Y265_T1.1670.94
251_I290_A1.1540.94
280_I301_I1.1530.94
40_R75_E1.1520.94
322_T325_R1.1520.94
288_K311_E1.1500.94
80_V331_L1.1430.94
236_F318_C1.1310.93
122_N130_H1.1180.93
66_L81_F1.1100.93
274_K278_D1.1090.92
102_V334_S1.1060.92
68_Q72_K1.0990.92
68_Q365_L1.0980.92
135_T178_R1.0950.92
135_T222_K1.0930.92
136_I177_K1.0860.92
85_H109_G1.0820.92
136_I176_K1.0810.91
163_S274_K1.0810.91
185_Q234_E1.0780.91
40_R76_A1.0750.91
41_L80_V1.0740.91
170_E197_I1.0720.91
245_R266_L1.0690.91
132_F224_I1.0610.91
148_I182_L1.0510.90
168_V367_I1.0490.90
115_M229_H1.0470.90
24_K28_T1.0450.90
36_K39_S1.0450.90
30_V332_L1.0370.90
103_L347_I1.0340.90
170_E195_L1.0300.89
327_D330_H1.0260.89
271_G276_I1.0220.89
140_T182_L1.0220.89
64_L68_Q1.0210.89
189_R192_A1.0210.89
297_L301_I1.0180.89
289_W308_K1.0110.89
295_M312_S1.0080.88
26_M329_P0.9970.88
142_V159_T0.9920.88
350_P353_I0.9920.88
117_D120_Q0.9910.88
238_T242_H0.9850.87
116_A148_I0.9800.87
254_I276_I0.9800.87
26_M328_L0.9750.87
290_A313_L0.9730.87
279_T289_W0.9670.86
118_M148_I0.9670.86
45_G54_I0.9660.86
191_T223_V0.9640.86
111_S229_H0.9640.86
190_N264_V0.9620.86
355_E358_L0.9610.86
156_G360_A0.9600.86
236_F313_L0.9570.86
51_D55_Q0.9540.85
106_M345_G0.9490.85
118_M147_E0.9470.85
353_I356_D0.9460.85
139_L168_V0.9450.85
41_L78_Y0.9410.85
135_T224_I0.9270.84
299_Q303_H0.9260.84
121_T182_L0.9260.84
144_S254_I0.9160.83
243_D246_E0.9140.83
49_Q53_V0.9120.83
92_D349_V0.9050.82
129_Q137_I0.9040.82
65_Q68_Q0.8990.82
134_D178_R0.8990.82
105_D325_R0.8970.82
189_R193_Y0.8960.82
189_R261_H0.8910.81
333_W344_S0.8910.81
253_I292_G0.8840.81
232_V235_K0.8840.81
239_K242_H0.8820.81
190_N270_N0.8790.80
239_K243_D0.8790.80
352_A356_D0.8790.80
118_M151_F0.8780.80
31_A35_K0.8740.80
27_E55_Q0.8730.80
292_G313_L0.8720.80
75_E78_Y0.8670.79
28_T32_A0.8650.79
355_E359_L0.8580.79
47_H271_G0.8560.79
44_P66_L0.8520.78
150_A349_V0.8520.78
174_T197_I0.8510.78
120_Q127_K0.8480.78
305_H308_K0.8480.78
244_M311_E0.8470.78
111_S231_S0.8470.78
181_F188_G0.8460.78
33_I36_K0.8460.78
47_H300_R0.8440.78
112_M322_T0.8430.78
95_T156_G0.8360.77
100_T348_K0.8330.77
144_S229_H0.8330.77
51_D299_Q0.8310.77
245_R253_I0.8300.76
54_I299_Q0.8300.76
42_F59_Q0.8290.76
359_L363_R0.8290.76
189_R264_V0.8280.76
64_L142_V0.8270.76
105_D326_I0.8260.76
305_H310_I0.8260.76
42_F74_K0.8250.76
244_M290_A0.8210.76
39_S335_L0.8190.75
130_H151_F0.8150.75
49_Q88_A0.8140.75
193_Y264_V0.8090.75
111_S232_V0.8090.75
337_Q343_P0.8040.74
139_L172_A0.8000.74
128_L180_L0.7990.74
140_T360_A0.7940.73
238_T263_V0.7920.73
165_A187_L0.7880.73
242_H245_R0.7850.72
53_V326_I0.7850.72
163_S278_D0.7820.72
300_R303_H0.7810.72
178_R224_I0.7780.72
116_A226_W0.7750.71
271_G275_Y0.7730.71
277_I297_L0.7680.71
177_K222_K0.7660.70
132_F135_T0.7640.70
151_F356_D0.7590.70
302_I309_Q0.7570.70
71_E362_N0.7530.69
231_S236_F0.7520.69
252_Q255_V0.7500.69
137_I180_L0.7500.69
254_I289_W0.7500.69
301_I310_I0.7490.69
112_M231_S0.7460.68
244_M247_R0.7440.68
65_Q163_S0.7440.68
80_V104_P0.7430.68
229_H234_E0.7430.68
250_D287_S0.7390.68
192_A223_V0.7380.68
276_I297_L0.7370.68
41_L335_L0.7360.67
279_T283_A0.7350.67
235_K321_L0.7310.67
47_H297_L0.7310.67
232_V236_F0.7280.67
93_M357_A0.7270.66
176_K197_I0.7220.66
334_S344_S0.7210.66
238_T262_E0.7190.66
163_S276_I0.7190.66
180_L224_I0.7170.65
349_V353_I0.7160.65
116_A182_L0.7150.65
176_K179_I0.7090.65
55_Q303_H0.7060.64
118_M122_N0.7050.64
337_Q345_G0.7010.64
79_I91_A0.7000.64
158_A172_A0.6980.63
251_I288_K0.6940.63
115_M228_G0.6920.63
64_L163_S0.6900.62
43_I82_C0.6840.62
353_I360_A0.6830.62
133_G180_L0.6820.62
196_G223_V0.6770.61
34_K58_D0.6770.61
112_M229_H0.6760.61
168_V366_S0.6730.60
139_L158_A0.6720.60
133_G178_R0.6700.60
28_T246_E0.6700.60
68_Q275_Y0.6670.60
107_R325_R0.6660.60
349_V360_A0.6630.59
330_H333_W0.6620.59
139_L160_V0.6580.59
25_D28_T0.6570.59
146_A349_V0.6560.59
142_V168_V0.6550.58
170_E174_T0.6550.58
28_T31_A0.6530.58
349_V358_L0.6520.58
80_V334_S0.6500.58
95_T99_Q0.6500.58
44_P81_F0.6460.57
169_L179_I0.6430.57
331_L334_S0.6360.56
232_V321_L0.6360.56
263_V268_D0.6360.56
50_K324_N0.6350.56
111_S236_F0.6350.56
190_N225_L0.6340.56
144_S156_G0.6310.56
47_H276_I0.6300.55
241_I292_G0.6300.55
298_V302_I0.6300.55
111_S115_M0.6290.55
352_A355_E0.6270.55
192_A225_L0.6270.55
128_L135_T0.6260.55
185_Q229_H0.6260.55
49_Q57_A0.6260.55
34_K43_I0.6240.55
93_M358_L0.6240.55
102_V343_P0.6230.55
121_T128_L0.6230.55
296_N324_N0.6210.54
190_N194_D0.6210.54
97_E100_T0.6160.54
103_L326_I0.6160.54
319_P324_N0.6160.54
140_T159_T0.6120.53
132_F176_K0.6080.53
192_A222_K0.6080.53
117_D121_T0.6070.53
108_A326_I0.6060.53
118_M150_A0.6030.52
128_L223_V0.6010.52
49_Q103_L0.6000.52
306_P310_I0.6000.52
148_I226_W0.5990.52
54_I296_N0.5980.52
41_L102_V0.5970.52
82_C326_I0.5970.52
158_A367_I0.5920.51
248_D309_Q0.5910.51
276_I291_I0.5910.51
109_G112_M0.5910.51
22_S25_D0.5900.51
244_M248_D0.5890.51
121_T151_F0.5870.50
29_R333_W0.5860.50
150_A353_I0.5830.50
160_V164_N0.5820.50
177_K197_I0.5800.50
130_H351_K0.5800.50
285_A308_K0.5790.49
27_E328_L0.5790.49
136_I179_I0.5780.49
74_K142_V0.5770.49
190_N193_Y0.5760.49
121_T129_Q0.5760.49
175_Q197_I0.5760.49
271_G318_C0.5740.49
35_K287_S0.5740.49
85_H113_A0.5710.48
119_Q127_K0.5700.48
85_H349_V0.5700.48
289_W310_I0.5690.48
115_M322_T0.5670.48
135_T180_L0.5640.48
156_G182_L0.5640.48
25_D29_R0.5590.47
129_Q157_G0.5570.47
275_Y280_I0.5560.47
314_N317_M0.5540.46
297_L300_R0.5540.46
150_A357_A0.5540.46
45_G53_V0.5540.46
45_G82_C0.5520.46
85_H114_D0.5500.46
180_L228_G0.5490.46
291_I301_I0.5490.46
129_Q180_L0.5480.46
229_H322_T0.5470.46
280_I289_W0.5470.46
121_T148_I0.5470.46
93_M349_V0.5450.45
23_R52_E0.5450.45
298_V312_S0.5440.45
71_E74_K0.5440.45
111_S318_C0.5420.45
49_Q109_G0.5420.45
160_V179_I0.5420.45
72_K282_Q0.5420.45
252_Q289_W0.5390.45
93_M356_D0.5370.44
314_N326_I0.5360.44
317_M321_L0.5360.44
142_V367_I0.5360.44
172_A192_A0.5340.44
291_I325_R0.5330.44
232_V318_C0.5330.44
284_P308_K0.5320.44
343_P346_V0.5320.44
97_E119_Q0.5280.43
116_A121_T0.5280.43
332_L337_Q0.5260.43
42_F78_Y0.5260.43
237_T240_N0.5260.43
169_L172_A0.5240.43
103_L106_M0.5230.43
239_K352_A0.5190.42
85_H103_L0.5170.42
104_P335_L0.5170.42
31_A43_I0.5170.42
329_P333_W0.5160.42
64_L365_L0.5150.42
64_L90_T0.5150.42
57_A60_T0.5140.42
234_E260_S0.5130.42
359_L366_S0.5130.42
166_K169_L0.5130.42
120_Q226_W0.5130.42
326_I330_H0.5120.42
314_N319_P0.5120.42
319_P322_T0.5110.41
136_I188_G0.5110.41
83_G187_L0.5100.41
51_D302_I0.5100.41
47_H116_A0.5090.41
67_A71_E0.5080.41
121_T226_W0.5080.41
88_A129_Q0.5080.41
170_E194_D0.5080.41
102_V345_G0.5060.41
47_H188_G0.5060.41
336_E344_S0.5060.41
185_Q189_R0.5050.41
172_A179_I0.5040.41
42_F134_D0.5030.40
324_N328_L0.5030.40
92_D101_V0.5010.40
113_A145_T0.5000.40
52_E55_Q0.5000.40
329_P332_L0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wzuA 1 0.7364 100 0.21 Contact Map
4p3xA 1 0.8207 100 0.221 Contact Map
2q5cA 2 0.4918 74.5 0.971 Contact Map
3gnnA 2 0.663 45 0.976 Contact Map
3v7eA 1 0.2201 44.1 0.976 Contact Map
3cg6A 3 0.3179 43.7 0.976 Contact Map
4w23M 1 0.288 38.5 0.977 Contact Map
3mw8A 1 0.5353 37.6 0.977 Contact Map
2gaiA 1 0.3668 30.2 0.978 Contact Map
2ekcA 1 0.6332 28 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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