GREMLIN Database
PYC - Pyruvate carboxylase
UniProt: Q9KWU4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 1148 (1135)
Sequences: 1096 (499)
Seq/√Len: 14.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
376_V402_T7.1371.00
1076_N1079_H7.0681.00
513_K517_D6.5481.00
108_I317_I6.3261.00
740_L761_V5.5651.00
534_V757_V5.3591.00
575_M605_V5.3131.00
98_R102_E5.2141.00
177_R209_E5.1621.00
528_V763_I4.8551.00
307_I340_T4.6951.00
154_Q179_E4.6851.00
99_R103_E4.5191.00
599_E640_S4.4181.00
69_E99_R4.3021.00
1100_N1122_S4.1821.00
1018_V1028_V4.1731.00
11_V22_F4.1271.00
522_E665_R4.0701.00
692_A696_S4.0471.00
263_A288_F3.9371.00
130_K270_N3.9051.00
67_D70_G3.8661.00
1126_K1144_E3.8571.00
766_V783_F3.8391.00
35_V55_V3.8301.00
526_N530_E3.8031.00
573_F708_I3.7331.00
601_L610_F3.7071.00
529_K731_K3.6961.00
73_D77_R3.6911.00
219_I315_T3.6610.99
475_I1005_T3.6600.99
577_M610_F3.6580.99
477_N1060_E3.5470.99
297_V312_I3.4780.99
178_S181_E3.4690.99
1125_I1145_I3.4430.99
655_K658_T3.4190.99
510_R518_E3.4030.99
766_V780_A3.3960.99
227_V338_I3.3720.99
6_I106_V3.3660.99
254_P258_D3.3470.99
69_E103_E3.2990.99
70_G73_D3.2440.99
1098_K1124_T3.2410.99
227_V332_I3.2390.99
587_Y988_Y3.2000.99
599_E973_Q3.1730.98
869_F885_M3.1450.98
258_D262_E3.1110.98
9_V108_I3.1060.98
522_E526_N3.0790.98
709_L736_I2.9950.98
219_I319_V2.9950.98
524_L670_V2.9820.98
605_V610_F2.9430.97
1078_S1145_I2.9170.97
516_L521_A2.9100.97
9_V317_I2.8070.97
536_L796_M2.7990.97
149_V204_V2.7660.96
605_V608_T2.7300.96
553_I558_L2.7170.96
227_V310_V2.6870.96
1100_N1103_D2.6630.95
631_K659_L2.6610.95
9_V25_C2.6480.95
673_A701_L2.6410.95
519_K523_G2.6400.95
1095_A1127_Q2.6350.95
785_H798_V2.6300.95
698_A730_L2.6290.95
755_K758_E2.6130.95
640_S973_Q2.6050.95
944_V948_E2.5960.95
265_V269_K2.5890.95
740_L752_M2.5830.94
422_R467_R2.5780.94
253_S286_N2.5760.94
673_A706_A2.5670.94
718_L740_L2.5300.94
98_R116_D2.5220.94
917_K939_Q2.5190.94
253_S256_L2.5130.94
411_A443_L2.4980.93
190_K200_D2.4850.93
864_R896_E2.4660.93
55_V70_G2.4620.93
661_I671_A2.4530.93
1070_L1127_Q2.4310.92
183_K187_E2.4280.92
683_D686_R2.3950.92
944_V949_L2.3910.92
514_Q517_D2.3890.92
1073_D1076_N2.3710.91
695_T729_A2.3690.91
515_I519_K2.3570.91
1095_A1128_V2.3050.90
515_I523_G2.2890.90
929_E933_K2.2850.90
519_K524_L2.2840.90
881_V920_I2.2720.90
788_E793_R2.2700.90
1037_Q1041_T2.2580.89
900_Y934_L2.2550.89
528_V708_I2.2520.89
334_E337_D2.2510.89
218_V268_A2.2440.89
132_G266_A2.2400.89
246_V303_I2.2230.88
1129_H1144_E2.2200.88
696_S700_E2.2170.88
220_G226_V2.2150.88
954_S957_A2.2100.88
223_Q324_S2.2030.88
99_R102_E2.1940.88
256_L259_Q2.1840.88
724_Y758_E2.1830.88
127_Q271_V2.1750.87
315_T319_V2.1720.87
60_K63_D2.1720.87
1104_H1116_T2.1580.87
829_I832_H2.1300.86
916_F931_L2.1200.86
1127_Q1144_E2.1170.86
929_E932_Q2.1090.86
688_K925_G2.0810.85
467_R1026_L2.0800.85
303_I401_S2.0780.85
226_V265_V2.0620.84
59_K67_D2.0210.83
160_I204_V2.0090.83
512_T609_L2.0020.82
244_I436_V1.9950.82
976_V980_L1.9870.82
632_E972_D1.9720.81
916_F935_I1.9650.81
206_K289_Y1.9620.81
194_K200_D1.9600.81
866_N872_I1.9570.81
988_Y992_T1.9410.80
440_E444_T1.9380.80
573_F644_V1.9340.80
116_D123_K1.9280.80
521_A668_G1.9210.80
439_H457_E1.9060.79
686_R871_D1.9000.79
753_Y783_F1.8960.79
958_I979_A1.8960.79
1020_I1026_L1.8930.79
74_I78_N1.8870.78
682_L725_E1.8820.78
591_K991_T1.8700.78
176_V185_A1.8690.78
647_I661_I1.8620.77
6_I30_I1.8510.77
610_F642_I1.8510.77
525_A528_V1.8480.77
1002_D1005_T1.8300.76
750_I783_F1.8270.76
474_Y998_I1.8220.76
601_L605_V1.8150.76
75_A83_I1.8150.76
632_E635_K1.8130.75
854_R857_E1.7840.74
11_V21_I1.7770.74
1094_E1097_T1.7770.74
467_R470_K1.7760.74
38_K41_S1.7700.74
527_W531_Q1.7590.73
627_D945_R1.7500.73
476_G1057_I1.7450.73
513_K782_G1.7400.72
1026_L1048_L1.7320.72
310_V332_I1.7310.72
468_G1048_L1.7220.72
854_R893_N1.7060.71
126_E130_K1.7010.71
614_L634_V1.6950.70
106_V222_K1.6950.70
711_I727_V1.6940.70
378_L398_V1.6860.70
145_T148_A1.6790.70
129_E135_V1.6770.69
959_K972_D1.6750.69
636_Q976_V1.6560.68
729_A732_E1.6560.68
436_V771_M1.6550.68
1078_S1121_F1.6480.68
674_A710_G1.6470.68
424_R467_R1.6460.68
76_K103_E1.6380.68
609_L644_V1.6360.67
101_E112_S1.6320.67
868_M896_E1.6320.67
757_V794_P1.6320.67
468_G1026_L1.6310.67
1071_K1140_D1.6310.67
575_M610_F1.6260.67
152_F156_N1.6250.67
515_I524_L1.6210.67
965_Q986_T1.6200.67
1097_T1103_D1.6170.67
1030_L1033_I1.6170.67
784_Y794_P1.6160.66
866_N871_D1.6140.66
72_I83_I1.6120.66
503_D567_A1.6080.66
647_I671_A1.6060.66
1080_I1099_V1.6040.66
888_Y892_N1.6010.66
914_E919_N1.5970.66
1036_P1062_I1.5960.65
1106_M1142_L1.5920.65
370_S383_S1.5890.65
99_R303_I1.5890.65
785_H788_E1.5830.65
966_H986_T1.5800.65
521_A525_A1.5760.64
467_R1048_L1.5690.64
498_L810_S1.5610.64
6_I757_V1.5590.64
799_Q831_E1.5580.64
563_N604_E1.5530.63
1123_G1145_I1.5480.63
718_L752_M1.5440.63
761_V792_R1.5360.62
422_R468_G1.5230.62
559_K600_D1.5200.62
663_A666_D1.5170.61
658_T662_D1.5070.61
721_Q755_K1.5070.61
861_M864_R1.5030.61
1021_E1026_L1.5020.61
1128_V1143_L1.5010.61
740_L753_Y1.4980.60
1080_I1119_A1.4970.60
1121_F1145_I1.4940.60
664_V671_A1.4940.60
441_K446_Q1.4880.60
523_G526_N1.4850.60
549_L553_I1.4830.60
661_I704_A1.4830.60
58_G64_A1.4790.59
226_V268_A1.4770.59
419_Q434_E1.4710.59
510_R514_Q1.4710.59
521_A707_H1.4690.59
525_A709_L1.4640.59
76_K796_M1.4550.58
532_K791_D1.4510.58
636_Q973_Q1.4500.58
511_G607_N1.4450.58
600_D604_E1.4380.57
653_W922_Q1.4370.57
629_V953_V1.4370.57
558_L601_L1.4330.57
687_T690_D1.4260.56
344_A401_S1.4250.56
1042_R1059_D1.4230.56
678_T873_V1.4180.56
687_T725_E1.4180.56
37_S393_Y1.4160.56
244_I1128_V1.4120.56
577_M601_L1.4090.56
122_V125_R1.4070.55
577_M642_I1.4050.55
910_D914_E1.4040.55
700_E703_A1.4020.55
708_I763_I1.3960.55
365_I1103_D1.3940.55
987_D990_K1.3880.54
863_R867_D1.3870.54
525_A763_I1.3810.54
636_Q639_Q1.3810.54
751_Y754_A1.3780.54
479_T1030_L1.3750.54
519_K670_V1.3690.53
70_G834_M1.3680.53
596_K600_D1.3670.53
127_Q267_L1.3660.53
9_V30_I1.3660.53
218_V279_V1.3660.53
218_V226_V1.3600.53
545_H585_V1.3580.53
629_V980_L1.3550.53
77_R1022_R1.3550.53
83_I105_I1.3530.52
349_V411_A1.3510.52
230_F338_I1.3420.52
534_V793_R1.3380.52
834_M844_Q1.3350.51
521_A670_V1.3350.51
150_E183_K1.3350.51
634_V663_A1.3340.51
557_D1003_T1.3320.51
1020_I1048_L1.3320.51
631_K662_D1.3300.51
681_I686_R1.3290.51
284_A793_R1.3280.51
814_Y1003_T1.3250.51
868_M900_Y1.3250.51
118_F1002_D1.3190.51
453_D459_F1.3170.50
111_K114_H1.3160.50
370_S398_V1.3160.50
150_E179_E1.3130.50
699_K734_I1.3120.50
471_M1001_L1.3100.50
861_M890_V1.3070.50
525_A529_K1.3050.50
895_T898_D1.3040.50
411_A437_A1.3040.50
699_K733_T1.2990.49
143_A149_V1.2980.49
8_K80_V1.2920.49
21_I220_G1.2900.49
8_K79_K1.2890.49
262_E266_A1.2890.49
797_N800_G1.2870.49
626_P950_L1.2860.49
78_N1022_R1.2860.49
415_V438_K1.2850.49
956_E959_K1.2850.49
575_M608_T1.2840.49
914_E917_K1.2840.49
562_A601_L1.2790.48
206_K287_E1.2760.48
230_F340_T1.2750.48
869_F1004_P1.2740.48
872_I915_L1.2740.48
898_D906_L1.2620.47
516_L670_V1.2620.47
38_K58_G1.2610.47
536_L766_V1.2600.47
869_F935_I1.2570.47
981_Y984_V1.2530.47
310_V1018_V1.2530.47
634_V660_A1.2530.47
968_L974_D1.2530.47
243_V452_I1.2510.47
665_R704_A1.2480.47
70_G74_I1.2480.47
497_P500_V1.2450.46
900_Y930_K1.2430.46
781_S801_V1.2390.46
661_I706_A1.2370.46
865_V916_F1.2340.46
158_Y179_E1.2330.46
1076_N1145_I1.2280.45
541_F558_L1.2270.45
997_D1000_V1.2260.45
753_Y766_V1.2220.45
310_V831_E1.2220.45
279_V293_V1.2210.45
467_R1021_E1.2210.45
171_R196_A1.2180.45
916_F927_F1.2180.45
847_K852_G1.2160.45
508_P566_A1.2160.45
650_S878_S1.2140.45
315_T402_T1.2140.45
709_L734_I1.2030.44
963_K969_E1.2010.44
537_T574_S1.2010.44
631_K666_D1.1980.44
111_K274_I1.1940.44
500_V503_D1.1920.44
293_V414_M1.1910.43
265_V1082_A1.1810.43
1074_R1139_G1.1810.43
26_T419_Q1.1810.43
533_S571_E1.1790.43
631_K660_A1.1790.43
72_I76_K1.1780.43
512_T527_W1.1780.43
9_V642_I1.1720.42
1105_L1142_L1.1720.42
566_A607_N1.1690.42
616_S658_T1.1650.42
814_Y1004_P1.1650.42
533_S795_E1.1650.42
593_D596_K1.1640.42
184_E188_R1.1600.42
699_K731_K1.1590.42
922_Q943_T1.1590.42
1090_K1132_N1.1550.41
306_M403_W1.1520.41
470_K993_E1.1520.41
8_K695_T1.1440.41
591_K1006_F1.1430.41
161_I200_D1.1410.41
897_K901_E1.1400.41
933_K938_G1.1360.40
991_T998_I1.1340.40
675_I697_M1.1320.40
727_V752_M1.1260.40
1130_V1142_L1.1190.40
260_I283_V1.1190.40
117_M127_Q1.1180.39
11_V291_I1.1180.39
892_N927_F1.1130.39
750_I779_S1.1100.39
115_L162_I1.1080.39
724_Y755_K1.1060.39
867_D896_E1.1040.39
95_H99_R1.1030.39
990_K994_S1.1020.39
521_A667_T1.0960.38
769_S781_S1.0940.38
644_V670_V1.0940.38
1074_R1077_P1.0930.38
990_K993_E1.0920.38
479_T1033_I1.0870.38
525_A707_H1.0750.37
400_L417_N1.0750.37
162_I202_V1.0740.37
118_F293_V1.0700.37
913_V1126_K1.0680.37
915_L927_F1.0650.37
345_I889_M1.0650.37
422_R1026_L1.0640.37
35_V71_I1.0630.37
246_V407_F1.0610.37
100_C105_I1.0590.36
6_I52_A1.0560.36
246_V447_Y1.0540.36
610_F771_M1.0540.36
186_Y204_V1.0530.36
586_A995_Y1.0530.36
246_V251_S1.0530.36
596_K988_Y1.0520.36
474_Y1001_L1.0520.36
725_E729_A1.0510.36
1101_K1122_S1.0510.36
139_S152_F1.0510.36
593_D610_F1.0510.36
160_I389_I1.0480.36
513_K1014_E1.0470.36
864_R895_T1.0470.36
686_R690_D1.0440.36
382_N387_A1.0440.36
465_K1026_L1.0420.36
638_A669_K1.0380.35
314_Q409_Q1.0380.35
826_H843_Q1.0350.35
503_D507_Q1.0350.35
493_A497_P1.0330.35
536_L794_P1.0320.35
695_T699_K1.0310.35
275_N320_A1.0240.35
160_I1125_I1.0230.35
480_V697_M1.0230.35
758_E774_L1.0220.35
54_L389_I1.0170.34
255_E259_Q1.0170.34
476_G1010_M1.0170.34
855_W1052_P1.0170.34
932_Q941_P1.0170.34
151_Q155_A1.0160.34
528_V535_L1.0120.34
636_Q972_D1.0120.34
974_D985_F1.0120.34
38_K57_E1.0120.34
435_N461_F1.0100.34
146_L183_K1.0090.34
583_F977_A1.0080.34
916_F923_P1.0060.34
208_I220_G1.0050.34
108_I631_K1.0050.34
108_I1126_K1.0050.34
1029_K1047_E1.0050.34
659_L662_D1.0040.34
697_M746_S1.0030.34
149_V160_I1.0020.34
349_V400_L1.0010.33
558_L1001_L1.0010.33
534_V794_P1.0000.33
103_E896_E1.0000.33
1105_L1143_L0.9980.33
220_G772_A0.9970.33
1063_K1097_T0.9940.33
702_E734_I0.9920.33
415_V419_Q0.9900.33
653_W656_G0.9880.33
100_C103_E0.9870.33
240_H1139_G0.9850.33
251_S283_V0.9850.33
1097_T1125_I0.9840.33
315_T330_V0.9830.33
953_V958_I0.9830.33
1060_E1091_V0.9810.32
318_L321_Q0.9790.32
555_S668_G0.9760.32
695_T733_T0.9760.32
125_R935_I0.9760.32
526_N529_K0.9750.32
6_I9_V0.9740.32
891_Q894_L0.9740.32
508_P603_K0.9740.32
297_V616_S0.9720.32
131_A162_I0.9720.32
105_I995_Y0.9720.32
861_M896_E0.9710.32
8_K33_V0.9710.32
9_V415_V0.9680.32
565_T804_L0.9680.32
1057_I1091_V0.9680.32
541_F553_I0.9660.32
448_D1002_D0.9660.32
695_T735_D0.9640.32
508_P563_N0.9640.32
54_L57_E0.9620.32
614_L660_A0.9620.32
897_K900_Y0.9620.32
260_I288_F0.9590.31
1126_K1143_L0.9580.31
873_V924_H0.9580.31
740_L783_F0.9580.31
244_I789_G0.9560.31
246_V250_V0.9550.31
41_S1015_E0.9550.31
390_T1103_D0.9540.31
971_S974_D0.9530.31
632_E976_V0.9510.31
508_P514_Q0.9500.31
585_V661_I0.9500.31
958_I961_E0.9480.31
415_V437_A0.9420.31
790_N793_R0.9410.31
181_E185_A0.9410.31
681_I824_S0.9400.30
466_D469_T0.9400.30
985_F989_V0.9400.30
861_M895_T0.9400.30
832_H1140_D0.9390.30
682_L721_Q0.9380.30
891_Q1002_D0.9360.30
623_T920_I0.9350.30
320_A365_I0.9310.30
1041_T1056_V0.9290.30
306_M374_F0.9280.30
317_I321_Q0.9260.30
676_C872_I0.9260.30
212_K250_V0.9230.30
1005_T1016_I0.9200.30
108_I1089_I0.9200.30
222_K274_I0.9200.30
621_G625_Y0.9190.30
861_M865_V0.9190.30
963_K970_I0.9180.29
108_I345_I0.9170.29
593_D907_D0.9170.29
627_D947_G0.9160.29
1031_I1045_Y0.9160.29
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332_I663_A0.5020.14
1041_T1058_K0.5020.14
206_K250_V0.5010.14
210_N934_L0.5010.14
759_A1019_E0.5010.14
126_E141_G0.5010.14
106_V570_P0.5010.14
146_L824_S0.5010.14
796_M801_V0.5010.14
960_Q1131_K0.5010.14
137_P156_N0.5010.14
166_L201_E0.5010.14
976_V1080_I0.5000.14
115_L295_P0.5000.14
683_D885_M0.5000.14
37_S423_I0.5000.14
968_L971_S0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bg3A 4 0.5889 100 0.634 Contact Map
1rqbA 2 0.4077 100 0.765 Contact Map
3va7A 1 0.8214 100 0.769 Contact Map
3n6rA 1 0.5122 100 0.771 Contact Map
3u9tA 3 0.4834 100 0.775 Contact Map
4rcnA 6 0.4303 100 0.777 Contact Map
2nx9A 2 0.3885 100 0.788 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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