GREMLIN Database
MRPA - Na(+)/H(+) antiporter subunit A
UniProt: Q9K2S2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 801 (758)
Sequences: 1615 (1097)
Seq/√Len: 39.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
187_I212_A6.4061.00
396_L538_V4.6521.00
260_I314_I4.6281.00
746_V758_V4.5171.00
398_P523_Q4.4671.00
132_V181_F4.4661.00
45_F84_A4.4051.00
409_F537_I4.4041.00
532_L535_A4.2731.00
755_G761_V4.2371.00
188_T196_M4.2041.00
169_I231_I3.9461.00
200_V204_A3.8891.00
748_H752_L3.8771.00
132_V196_M3.8001.00
77_D262_R3.7191.00
739_D743_S3.6261.00
363_E467_H3.5791.00
743_S747_K3.5651.00
210_I272_Q3.5621.00
362_H467_H3.4971.00
301_I369_I3.4431.00
180_G216_I3.4171.00
176_C218_L3.3941.00
317_L339_A3.3431.00
296_T370_R3.2451.00
410_T414_R3.2151.00
12_F121_G3.1891.00
84_A124_L3.1451.00
222_T229_F3.0931.00
180_G219_G3.0711.00
125_G138_F3.0441.00
527_V532_L3.0001.00
14_F37_L2.9441.00
409_F533_M2.9251.00
356_A386_S2.9191.00
41_L88_T2.8631.00
192_S195_E2.8611.00
542_T546_L2.8481.00
750_H756_D2.8341.00
385_I478_V2.7621.00
84_A128_L2.7521.00
70_I133_M2.7391.00
185_Y191_F2.6621.00
210_I214_I2.6491.00
190_S195_E2.6451.00
388_I484_A2.6101.00
621_E624_A2.5821.00
36_I40_L2.5641.00
42_F89_G2.5381.00
607_G724_I2.5231.00
439_V540_I2.4601.00
715_F718_S2.4551.00
719_L723_V2.4361.00
82_L344_I2.4051.00
130_D194_R2.4041.00
209_F270_S2.3631.00
297_D367_R2.2841.00
42_F88_T2.2791.00
753_G761_V2.2541.00
535_A539_V2.2491.00
201_Q204_A2.2461.00
373_G455_G2.2361.00
258_Y262_R2.2311.00
216_I263_F2.2261.00
214_I276_I2.2261.00
65_I70_I2.2150.99
409_F438_S2.1940.99
211_P214_I2.1830.99
203_I266_I2.1770.99
276_I279_L2.1750.99
168_L572_L2.1700.99
532_L536_G2.1610.99
207_E211_P2.1590.99
8_I74_V2.1350.99
387_L449_L2.1160.99
341_F404_S2.1130.99
531_L535_A2.0860.99
386_S448_L2.0450.99
342_H404_S2.0410.99
185_Y188_T2.0290.99
293_V443_I2.0290.99
73_T192_S2.0160.99
637_M663_T2.0140.99
382_T468_E2.0110.99
180_G263_F2.0070.99
18_I25_A1.9930.99
42_F85_L1.9890.99
63_E71_N1.9850.99
39_V92_S1.9840.99
135_L193_I1.9840.99
51_M56_E1.9780.99
221_F280_V1.9740.99
261_A339_A1.9680.99
177_M181_F1.9590.99
596_L717_I1.9380.99
296_T368_D1.9320.99
348_T400_N1.9320.99
261_A317_L1.8850.98
214_I218_L1.8790.98
136_Y181_F1.8660.98
383_F387_L1.8590.98
184_L203_I1.8590.98
227_F283_F1.8550.98
589_G594_Y1.8390.98
21_L30_T1.8320.98
376_M383_F1.8270.98
209_F267_F1.8200.98
132_V263_F1.8170.98
165_K235_D1.8060.98
212_A216_I1.7930.98
529_T532_L1.7880.98
61_V73_T1.7870.98
279_L283_F1.7860.98
390_T445_S1.7810.98
186_L191_F1.7800.98
608_G612_I1.7790.98
285_M437_G1.7740.97
458_Q461_Q1.7690.97
43_I47_P1.7610.97
190_S193_I1.7590.97
410_T528_T1.7510.97
35_L39_V1.7390.97
373_G458_Q1.7330.97
482_A486_S1.7300.97
470_P473_M1.7160.97
11_P121_G1.7100.97
490_F493_I1.6950.97
304_F307_V1.6900.97
286_V436_I1.6870.97
34_V38_P1.6870.97
135_L181_F1.6630.96
345_N400_N1.6580.96
643_A656_A1.6580.96
577_K581_R1.6480.96
600_A604_I1.6460.96
543_I547_S1.6380.96
74_V128_L1.6290.96
726_T730_I1.6270.96
100_F472_G1.6220.96
62_L72_F1.6060.95
349_F444_Y1.6020.95
285_M312_M1.5840.95
18_I34_V1.5790.95
567_L571_L1.5720.95
474_L477_P1.5670.95
184_L212_A1.5670.95
441_T444_Y1.5670.95
319_V412_M1.5610.95
41_L45_F1.5550.95
481_V484_A1.5540.95
277_V318_G1.5530.95
658_G688_V1.5510.94
309_Q444_Y1.5500.94
309_Q441_T1.5500.94
410_T530_E1.5450.94
181_F193_I1.5410.94
640_A659_V1.5380.94
385_I481_V1.5350.94
42_F46_L1.5270.94
130_D192_S1.5210.94
112_F115_Y1.5190.94
528_T532_L1.5180.94
579_S583_T1.5160.94
19_P22_A1.5100.94
37_L41_L1.5050.94
282_L433_F1.4970.93
522_S525_H1.4930.93
49_I53_Q1.4920.93
748_H751_D1.4850.93
431_P533_M1.4830.93
106_K152_Y1.4810.93
503_M508_P1.4760.93
272_Q276_I1.4700.93
429_L720_G1.4650.93
257_I314_I1.4560.92
471_V475_V1.4390.92
603_I720_G1.4290.92
298_L372_L1.4230.91
73_T131_N1.4190.91
400_N484_A1.4190.91
715_F719_L1.4120.91
599_F721_V1.4070.91
38_P41_L1.4030.91
18_I30_T1.4000.91
640_A688_V1.4000.91
22_A30_T1.3990.91
450_F545_Y1.3970.91
432_L436_I1.3910.91
309_Q342_H1.3800.90
662_Y685_T1.3770.90
471_V478_V1.3710.90
10_S37_L1.3700.90
187_I206_H1.3610.90
503_M516_K1.3600.90
352_S389_G1.3600.90
182_I186_L1.3560.89
217_L277_V1.3520.89
400_N404_S1.3470.89
502_A506_I1.3420.89
342_H345_N1.3420.89
755_G760_N1.3380.89
222_T226_Q1.3280.88
108_Q111_P1.3270.88
133_M181_F1.3250.88
90_I347_A1.3240.88
398_P489_F1.3200.88
342_H349_F1.3150.88
53_Q501_P1.3100.88
505_S508_P1.3080.88
35_L38_P1.2980.87
379_M466_A1.2970.87
181_F219_G1.2960.87
313_I343_L1.2940.87
52_T55_G1.2930.87
48_M58_L1.2920.87
391_F396_L1.2910.87
71_N131_N1.2880.87
587_M594_Y1.2860.87
298_L360_I1.2770.86
39_V43_I1.2760.86
635_L639_S1.2760.86
82_L340_I1.2750.86
535_A635_L1.2720.86
495_S520_H1.2610.86
46_L85_L1.2590.85
600_A717_I1.2590.85
274_F278_S1.2590.85
291_H304_F1.2520.85
365_G396_L1.2520.85
297_D372_L1.2460.85
527_V535_A1.2370.84
375_L379_M1.2370.84
30_T34_V1.2360.84
359_I363_E1.2330.84
183_L212_A1.2330.84
70_I134_V1.2330.84
156_R238_E1.2230.84
50_R54_S1.2220.84
271_A275_W1.2190.84
217_L221_F1.2160.83
547_S550_K1.2160.83
596_L600_A1.2150.83
188_T199_Q1.2110.83
145_S588_T1.2080.83
295_Q300_S1.2030.83
341_F403_L1.1940.82
190_S196_M1.1940.82
500_E504_N1.1920.82
204_A270_S1.1900.82
75_Y194_R1.1880.82
44_Y48_M1.1840.82
403_L521_I1.1840.82
340_I502_A1.1810.82
264_S268_A1.1810.82
117_L121_G1.1800.82
5_H9_L1.1790.81
663_T782_A1.1720.81
356_A448_L1.1710.81
442_F446_M1.1700.81
485_V656_A1.1700.81
38_P44_Y1.1650.81
748_H766_F1.1630.81
48_M51_M1.1610.80
390_T449_L1.1580.80
133_M185_Y1.1560.80
345_N404_S1.1510.80
363_E470_P1.1500.80
312_M349_F1.1490.80
7_A45_F1.1490.80
305_S404_S1.1470.80
438_S441_T1.1440.79
212_A267_F1.1420.79
312_M399_F1.1410.79
550_K553_G1.1340.79
583_T589_G1.1340.79
199_Q202_L1.1330.79
195_E198_H1.1320.79
396_L399_F1.1290.79
260_I267_F1.1280.78
77_D80_G1.1240.78
761_V768_G1.1220.78
381_I384_T1.1210.78
761_V764_V1.1180.78
122_A141_L1.1160.78
10_S14_F1.1140.78
84_A88_T1.1060.77
285_M676_L1.1050.77
640_A660_V1.1010.77
337_M519_V1.0950.76
29_H100_F1.0920.76
475_V479_I1.0910.76
38_P120_M1.0890.76
379_M382_T1.0860.76
548_L552_K1.0830.76
474_L478_V1.0800.75
665_A681_L1.0710.75
644_T653_A1.0690.75
374_G455_G1.0690.75
402_F534_T1.0680.75
50_R53_Q1.0660.74
195_E199_Q1.0660.74
60_S63_E1.0650.74
525_H531_L1.0640.74
18_I26_K1.0630.74
22_A26_K1.0630.74
305_S342_H1.0620.74
301_I360_I1.0610.74
115_Y145_S1.0590.74
63_E66_P1.0560.74
351_G480_L1.0540.74
190_S199_Q1.0530.73
581_R584_K1.0520.73
428_V432_L1.0510.73
548_L551_W1.0500.73
348_T484_A1.0480.73
61_V71_N1.0480.73
308_S444_Y1.0450.73
301_I304_F1.0400.73
578_G582_V1.0380.72
391_F446_M1.0300.72
180_G184_L1.0290.72
210_I600_A1.0290.72
83_F343_L1.0280.72
740_S743_S1.0260.72
78_G502_A1.0260.72
15_A19_P1.0260.72
229_F284_T1.0250.71
49_I81_L1.0240.71
181_F216_I1.0230.71
482_A726_T1.0220.71
588_T593_D1.0200.71
707_T712_M1.0200.71
76_I80_G1.0160.71
349_F754_G1.0130.71
184_L216_I1.0110.70
500_E516_K1.0110.70
723_V726_T1.0100.70
112_F243_V1.0090.70
745_F749_S1.0070.70
439_V544_G1.0060.70
403_L487_L1.0050.70
651_L772_M1.0020.70
342_H444_Y1.0010.70
626_I631_I0.9990.69
201_Q205_G0.9970.69
537_I540_I0.9950.69
309_Q349_F0.9930.69
226_Q769_F0.9910.69
131_N191_F0.9890.69
367_R393_M0.9890.69
241_T361_D0.9870.69
63_E69_G0.9850.68
290_F555_Y0.9840.68
341_F400_N0.9840.68
750_H753_G0.9840.68
500_E519_V0.9830.68
278_S430_F0.9820.68
488_F523_Q0.9770.68
493_I527_V0.9730.67
184_L196_M0.9680.67
412_M431_P0.9680.67
339_A349_F0.9670.67
657_L660_V0.9660.67
148_L217_L0.9660.67
159_S685_T0.9640.67
426_W432_L0.9630.67
547_S631_I0.9610.66
435_W536_G0.9580.66
745_F762_I0.9570.66
744_F748_H0.9570.66
643_A652_T0.9560.66
12_F504_N0.9550.66
347_A440_F0.9520.66
257_I301_I0.9510.66
109_L159_S0.9460.65
124_L364_T0.9450.65
48_M76_I0.9450.65
349_F445_S0.9420.65
213_M276_I0.9410.65
359_I385_I0.9390.65
651_L655_I0.9390.65
235_D565_N0.9390.65
336_A340_I0.9370.64
377_A457_Y0.9370.64
381_I478_V0.9360.64
21_L26_K0.9350.64
766_F769_F0.9350.64
88_T124_L0.9320.64
543_I546_L0.9310.64
716_I720_G0.9310.64
30_T33_F0.9310.64
14_F18_I0.9280.64
745_F758_V0.9250.63
308_S778_L0.9250.63
109_L152_Y0.9220.63
52_T490_F0.9210.63
570_K574_M0.9210.63
432_L543_I0.9200.63
450_F454_R0.9190.63
388_I485_V0.9180.63
165_K231_I0.9170.63
387_L390_T0.9150.63
17_I122_A0.9150.63
753_G763_L0.9140.63
619_K624_A0.9120.62
231_I238_E0.9120.62
536_G540_I0.9060.62
603_I607_G0.9060.62
220_A317_L0.9040.62
280_V283_F0.9040.62
269_F272_Q0.9030.62
494_L527_V0.9010.61
624_A627_G0.8980.61
472_G475_V0.8970.61
581_R585_Q0.8940.61
131_N192_S0.8940.61
261_A343_L0.8910.61
641_T660_V0.8890.60
442_F538_V0.8880.60
745_F755_G0.8870.60
264_S336_A0.8870.60
286_V437_G0.8870.60
557_L716_I0.8850.60
231_I672_R0.8830.60
540_I638_I0.8820.60
600_A635_L0.8810.60
540_I544_G0.8810.60
359_I469_A0.8770.59
547_S551_W0.8770.59
723_V727_L0.8760.59
251_T351_G0.8740.59
384_T387_L0.8730.59
207_E717_I0.8720.59
310_L405_K0.8720.59
12_F18_I0.8680.58
305_S441_T0.8680.58
8_I633_L0.8670.58
65_I68_L0.8660.58
442_F541_G0.8650.58
220_A392_S0.8640.58
153_W156_R0.8640.58
349_F393_M0.8630.58
340_I344_I0.8610.58
500_E503_M0.8590.58
489_F523_Q0.8580.58
579_S582_V0.8570.58
15_A121_G0.8560.57
438_S537_I0.8560.57
389_G481_V0.8550.57
126_V255_A0.8530.57
45_F76_I0.8530.57
361_D367_R0.8510.57
710_F713_T0.8480.57
444_Y447_K0.8470.57
721_V732_S0.8450.56
196_M731_A0.8450.56
388_I481_V0.8440.56
143_S249_S0.8430.56
37_L40_L0.8420.56
363_E469_A0.8410.56
226_Q766_F0.8410.56
349_F441_T0.8410.56
611_A751_D0.8370.56
526_G531_L0.8350.56
381_I474_L0.8310.55
275_W279_L0.8300.55
681_L776_T0.8300.55
124_L128_L0.8290.55
295_Q399_F0.8280.55
268_A336_A0.8270.55
160_R302_L0.8250.55
257_I785_I0.8240.55
40_L43_I0.8240.55
151_G761_V0.8240.55
287_W291_H0.8230.54
436_I476_P0.8220.54
84_A202_L0.8210.54
584_K604_I0.8210.54
535_A538_V0.8210.54
147_F682_V0.8200.54
121_G692_L0.8200.54
394_A445_S0.8170.54
18_I22_A0.8160.54
79_L257_I0.8160.54
301_I561_K0.8160.54
45_F128_L0.8150.54
509_T516_K0.8150.54
309_Q678_L0.8150.54
340_I509_T0.8140.54
79_L262_R0.8140.54
389_G485_V0.8120.53
87_I221_F0.8070.53
182_I191_F0.8060.53
749_S787_S0.8050.53
548_L555_Y0.8040.53
518_H718_S0.8030.53
144_L263_F0.8030.53
709_T712_M0.8030.53
349_F789_I0.8010.52
133_M191_F0.8010.52
712_M715_F0.7980.52
297_D366_T0.7980.52
305_S444_Y0.7950.52
628_V632_I0.7940.52
143_S674_P0.7940.52
32_W96_L0.7930.52
144_L217_L0.7920.52
298_L367_R0.7920.52
660_V696_Y0.7910.52
758_V768_G0.7910.52
322_A504_N0.7910.52
750_H761_V0.7890.51
284_T405_K0.7880.51
181_F191_F0.7860.51
435_W533_M0.7850.51
360_I452_T0.7850.51
55_G483_L0.7850.51
632_I642_V0.7840.51
729_G733_S0.7830.51
639_S657_L0.7820.51
498_L501_P0.7810.51
103_S153_W0.7810.51
123_M142_T0.7780.50
129_V147_F0.7770.50
159_S602_F0.7750.50
263_F290_F0.7750.50
175_L179_G0.7740.50
447_K451_K0.7730.50
755_G763_L0.7710.50
551_W555_Y0.7710.50
376_M456_N0.7710.50
702_R705_T0.7710.50
635_L772_M0.7700.50
139_W259_V0.7700.50
43_I46_L0.7690.50
221_F226_Q0.7690.50
321_A335_A0.7680.49
692_L785_I0.7670.49
276_I280_V0.7660.49
94_V352_S0.7660.49
763_L772_M0.7650.49
442_F537_I0.7640.49
703_L707_T0.7630.49
313_I692_L0.7610.49
15_A384_T0.7600.49
637_M659_V0.7600.49
45_F583_T0.7590.49
65_I755_G0.7580.48
462_L466_A0.7570.48
211_P272_Q0.7570.48
191_F316_M0.7560.48
757_N760_N0.7560.48
595_L599_F0.7540.48
227_F266_I0.7540.48
264_S320_S0.7540.48
488_F494_L0.7530.48
716_I727_L0.7510.48
373_G456_N0.7490.48
308_S349_F0.7490.48
641_T644_T0.7490.48
71_N198_H0.7460.47
730_I746_V0.7450.47
143_S741_I0.7450.47
450_F455_G0.7450.47
82_L89_G0.7450.47
180_G212_A0.7440.47
651_L664_L0.7430.47
17_I371_K0.7420.47
537_I778_L0.7410.47
436_I493_I0.7400.47
25_A29_H0.7390.47
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151_G160_R0.6310.37
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162_G300_S0.5570.31
612_I719_L0.5570.31
657_L764_V0.5570.31
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530_E534_T0.5560.31
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33_F543_I0.5520.31
446_M450_F0.5520.31
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340_I758_V0.5460.30
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413_L479_I0.5450.30
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679_T760_N0.5440.30
52_T58_L0.5440.30
572_L576_E0.5440.30
706_K773_F0.5440.30
600_A607_G0.5430.30
209_F213_M0.5430.30
205_G635_L0.5430.30
140_E405_K0.5430.30
277_V503_M0.5420.30
114_V539_V0.5410.30
534_T537_I0.5410.30
355_M594_Y0.5410.30
494_L498_L0.5400.30
647_A652_T0.5400.30
52_T81_L0.5400.30
150_I785_I0.5400.30
364_T425_T0.5390.30
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660_V664_L0.5370.30
186_L189_D0.5370.30
721_V725_V0.5360.29
71_N639_S0.5360.29
539_V543_I0.5360.29
637_M687_S0.5360.29
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129_V561_K0.5350.29
604_I607_G0.5350.29
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451_K545_Y0.5290.29
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266_I339_A0.5280.29
341_F521_I0.5280.29
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546_L550_K0.5270.29
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226_Q251_T0.5260.29
624_A628_V0.5260.29
686_I739_D0.5260.29
52_T56_E0.5250.29
360_I549_N0.5250.29
571_L574_M0.5240.29
105_E728_L0.5240.29
733_S747_K0.5240.29
475_V483_L0.5240.29
499_I693_L0.5240.29
238_E361_D0.5240.29
769_F790_K0.5230.28
322_A508_P0.5230.28
356_A477_P0.5230.28
295_Q788_M0.5230.28
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5_H25_A0.5230.28
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13_L17_I0.5230.28
539_V772_M0.5230.28
143_S357_V0.5220.28
753_G756_D0.5220.28
52_T59_R0.5220.28
378_I458_Q0.5210.28
709_T713_T0.5200.28
21_L33_F0.5200.28
661_G684_E0.5200.28
690_L763_L0.5190.28
100_F359_I0.5190.28
352_S482_A0.5190.28
457_Y636_V0.5190.28
753_G766_F0.5180.28
746_V749_S0.5180.28
630_E634_T0.5170.28
480_L755_G0.5170.28
96_L396_L0.5160.28
11_P15_A0.5160.28
435_W439_V0.5160.28
436_I440_F0.5160.28
74_V198_H0.5160.28
59_R194_R0.5160.28
502_A505_S0.5150.28
603_I721_V0.5150.28
128_L782_A0.5150.28
67_S137_M0.5140.28
172_S596_L0.5130.28
343_L753_G0.5130.28
493_I497_S0.5130.28
79_L664_L0.5130.28
297_D361_D0.5130.28
305_S408_F0.5120.28
81_L85_L0.5120.28
649_S701_L0.5110.28
195_E556_K0.5110.28
355_M697_H0.5110.28
391_F730_I0.5110.28
429_L432_L0.5110.28
39_V542_T0.5100.28
411_S486_S0.5100.28
570_K577_K0.5100.28
142_T302_L0.5100.28
204_A643_A0.5080.27
80_G409_F0.5080.27
255_A259_V0.5080.27
76_I84_A0.5080.27
337_M499_I0.5070.27
100_F473_M0.5070.27
123_M224_S0.5070.27
626_I633_L0.5070.27
159_S438_S0.5070.27
745_F766_F0.5060.27
57_T80_G0.5060.27
312_M408_F0.5060.27
334_V360_I0.5050.27
87_I460_E0.5050.27
264_S399_F0.5050.27
276_I388_I0.5040.27
662_Y681_L0.5040.27
143_S768_G0.5040.27
696_Y781_A0.5040.27
165_K404_S0.5030.27
87_I760_N0.5020.27
451_K628_V0.5020.27
159_S399_F0.5020.27
116_L297_D0.5010.27
535_A631_I0.5000.27
93_L351_G0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rkoL 1 0.7116 100 0.568 Contact Map
4he8L 1 0.7104 100 0.58 Contact Map
3rkoM 1 0.6017 100 0.633 Contact Map
4he8M 1 0.573 100 0.655 Contact Map
3rkoN 1 0.5693 100 0.666 Contact Map
4he8N 1 0.5318 100 0.698 Contact Map
4he8J 1 0.1948 98.3 0.964 Contact Map
3rkoJ 1 0.1873 97.1 0.972 Contact Map
4he8K 1 0.1161 38.3 0.987 Contact Map
3rkoK 1 0.1211 33.3 0.987 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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