MRPA - BACSU - GREMLIN Contacts

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MRPA - Na(+)/H(+) antiporter subunit A

UniProt:	Q9K2S2	Sequences: MQLLHLAILSPFLFAFIIPFLAKYAKRVHTGWFVLILPVLLFIYFLPMIRMTQSGETLRSVLEWIPSLGINFTVYIDGLGLLFALLITGIGSLVTLYSIFYLSKEKEQLGPFYVYLLMFMGAMLGVVLVDNVMVLYMFWELTSLSSFLLIGYWYKREKSRYGAAKSLLITVSGGLCMLGGFILLYLITDSFSIREMVHQVQLIAGHELFIPAMILILLGAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGIYVIARFSPIFAFSAQWFWIVSLVGLFTMVWGSFHAVKQTDLKSILAFSTVSQLGMIISMLGVSAAALHYGHTEYYTVAAMAAIFHLINHATFKGSLFMAVGIIDHETGTRDIRKLGGLMAIMPITFTISLIGTFSMAGLPPFNGFLSKEMFFTSMLRVTHFDLFNVQTWGVLFPLFAWIGSVFTFIYSMKLLFKTFRGNYQPEQLEKQAHEAPVGMLVPPVILVALAVSLFFFPNILSYSLIEPAMNSIYPTLLDGHEKFHVHISQWHGVTTELLMTAGIVVIGTIGYLSLNKWKGIYKLFPSKLTLNRLYDKLLTMMEKGSYRVTKQYMTGFLRDYLLYIFAGFIILIGGAFAIKGGFSFKTEGMAKIGVYEIILTLVMISATVATVFARSRLTAIIALGVVGYTLALFFVIFRAPDLALTQLVIETISVALFLLCFYHLPKLRLKTKTRTFRMTNFIISLGVGVIVTLLGIASSSQRTKDSIASFFVKHSHDLGGGDNVVNVILVDFRGFDTMFEITVLTIAALGIYSMIKTKVKEEGKSGE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	801 (758)
Sequences:	1615 (1097)
Seq/√Len:	39.8

ECOLI - HYFB
BACSU - MRPA
HALSA - Q9HRL3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
187_I	212_A	6.406	1.00
396_L	538_V	4.652	1.00
260_I	314_I	4.628	1.00
746_V	758_V	4.517	1.00
398_P	523_Q	4.467	1.00
132_V	181_F	4.466	1.00
45_F	84_A	4.405	1.00
409_F	537_I	4.404	1.00
532_L	535_A	4.273	1.00
755_G	761_V	4.237	1.00
188_T	196_M	4.204	1.00
169_I	231_I	3.946	1.00
200_V	204_A	3.889	1.00
748_H	752_L	3.877	1.00
132_V	196_M	3.800	1.00
77_D	262_R	3.719	1.00
739_D	743_S	3.626	1.00
363_E	467_H	3.579	1.00
743_S	747_K	3.565	1.00
210_I	272_Q	3.562	1.00
362_H	467_H	3.497	1.00
301_I	369_I	3.443	1.00
180_G	216_I	3.417	1.00
176_C	218_L	3.394	1.00
317_L	339_A	3.343	1.00
296_T	370_R	3.245	1.00
410_T	414_R	3.215	1.00
12_F	121_G	3.189	1.00
84_A	124_L	3.145	1.00
222_T	229_F	3.093	1.00
180_G	219_G	3.071	1.00
125_G	138_F	3.044	1.00
527_V	532_L	3.000	1.00
14_F	37_L	2.944	1.00
409_F	533_M	2.925	1.00
356_A	386_S	2.919	1.00
41_L	88_T	2.863	1.00
192_S	195_E	2.861	1.00
542_T	546_L	2.848	1.00
750_H	756_D	2.834	1.00
385_I	478_V	2.762	1.00
84_A	128_L	2.752	1.00
70_I	133_M	2.739	1.00
185_Y	191_F	2.662	1.00
210_I	214_I	2.649	1.00
190_S	195_E	2.645	1.00
388_I	484_A	2.610	1.00
621_E	624_A	2.582	1.00
36_I	40_L	2.564	1.00
42_F	89_G	2.538	1.00
607_G	724_I	2.523	1.00
439_V	540_I	2.460	1.00
715_F	718_S	2.455	1.00
719_L	723_V	2.436	1.00
82_L	344_I	2.405	1.00
130_D	194_R	2.404	1.00
209_F	270_S	2.363	1.00
297_D	367_R	2.284	1.00
42_F	88_T	2.279	1.00
753_G	761_V	2.254	1.00
535_A	539_V	2.249	1.00
201_Q	204_A	2.246	1.00
373_G	455_G	2.236	1.00
258_Y	262_R	2.231	1.00
216_I	263_F	2.226	1.00
214_I	276_I	2.226	1.00
65_I	70_I	2.215	0.99
409_F	438_S	2.194	0.99
211_P	214_I	2.183	0.99
203_I	266_I	2.177	0.99
276_I	279_L	2.175	0.99
168_L	572_L	2.170	0.99
532_L	536_G	2.161	0.99
207_E	211_P	2.159	0.99
8_I	74_V	2.135	0.99
387_L	449_L	2.116	0.99
341_F	404_S	2.113	0.99
531_L	535_A	2.086	0.99
386_S	448_L	2.045	0.99
342_H	404_S	2.041	0.99
185_Y	188_T	2.029	0.99
293_V	443_I	2.029	0.99
73_T	192_S	2.016	0.99
637_M	663_T	2.014	0.99
382_T	468_E	2.011	0.99
180_G	263_F	2.007	0.99
18_I	25_A	1.993	0.99
42_F	85_L	1.989	0.99
63_E	71_N	1.985	0.99
39_V	92_S	1.984	0.99
135_L	193_I	1.984	0.99
51_M	56_E	1.978	0.99
221_F	280_V	1.974	0.99
261_A	339_A	1.968	0.99
177_M	181_F	1.959	0.99
596_L	717_I	1.938	0.99
296_T	368_D	1.932	0.99
348_T	400_N	1.932	0.99
261_A	317_L	1.885	0.98
214_I	218_L	1.879	0.98
136_Y	181_F	1.866	0.98
383_F	387_L	1.859	0.98
184_L	203_I	1.859	0.98
227_F	283_F	1.855	0.98
589_G	594_Y	1.839	0.98
21_L	30_T	1.832	0.98
376_M	383_F	1.827	0.98
209_F	267_F	1.820	0.98
132_V	263_F	1.817	0.98
165_K	235_D	1.806	0.98
212_A	216_I	1.793	0.98
529_T	532_L	1.788	0.98
61_V	73_T	1.787	0.98
279_L	283_F	1.786	0.98
390_T	445_S	1.781	0.98
186_L	191_F	1.780	0.98
608_G	612_I	1.779	0.98
285_M	437_G	1.774	0.97
458_Q	461_Q	1.769	0.97
43_I	47_P	1.761	0.97
190_S	193_I	1.759	0.97
410_T	528_T	1.751	0.97
35_L	39_V	1.739	0.97
373_G	458_Q	1.733	0.97
482_A	486_S	1.730	0.97
470_P	473_M	1.716	0.97
11_P	121_G	1.710	0.97
490_F	493_I	1.695	0.97
304_F	307_V	1.690	0.97
286_V	436_I	1.687	0.97
34_V	38_P	1.687	0.97
135_L	181_F	1.663	0.96
345_N	400_N	1.658	0.96
643_A	656_A	1.658	0.96
577_K	581_R	1.648	0.96
600_A	604_I	1.646	0.96
543_I	547_S	1.638	0.96
74_V	128_L	1.629	0.96
726_T	730_I	1.627	0.96
100_F	472_G	1.622	0.96
62_L	72_F	1.606	0.95
349_F	444_Y	1.602	0.95
285_M	312_M	1.584	0.95
18_I	34_V	1.579	0.95
567_L	571_L	1.572	0.95
474_L	477_P	1.567	0.95
184_L	212_A	1.567	0.95
441_T	444_Y	1.567	0.95
319_V	412_M	1.561	0.95
41_L	45_F	1.555	0.95
481_V	484_A	1.554	0.95
277_V	318_G	1.553	0.95
658_G	688_V	1.551	0.94
309_Q	444_Y	1.550	0.94
309_Q	441_T	1.550	0.94
410_T	530_E	1.545	0.94
181_F	193_I	1.541	0.94
640_A	659_V	1.538	0.94
385_I	481_V	1.535	0.94
42_F	46_L	1.527	0.94
130_D	192_S	1.521	0.94
112_F	115_Y	1.519	0.94
528_T	532_L	1.518	0.94
579_S	583_T	1.516	0.94
19_P	22_A	1.510	0.94
37_L	41_L	1.505	0.94
282_L	433_F	1.497	0.93
522_S	525_H	1.493	0.93
49_I	53_Q	1.492	0.93
748_H	751_D	1.485	0.93
431_P	533_M	1.483	0.93
106_K	152_Y	1.481	0.93
503_M	508_P	1.476	0.93
272_Q	276_I	1.470	0.93
429_L	720_G	1.465	0.93
257_I	314_I	1.456	0.92
471_V	475_V	1.439	0.92
603_I	720_G	1.429	0.92
298_L	372_L	1.423	0.91
73_T	131_N	1.419	0.91
400_N	484_A	1.419	0.91
715_F	719_L	1.412	0.91
599_F	721_V	1.407	0.91
38_P	41_L	1.403	0.91
18_I	30_T	1.400	0.91
640_A	688_V	1.400	0.91
22_A	30_T	1.399	0.91
450_F	545_Y	1.397	0.91
432_L	436_I	1.391	0.91
309_Q	342_H	1.380	0.90
662_Y	685_T	1.377	0.90
471_V	478_V	1.371	0.90
10_S	37_L	1.370	0.90
187_I	206_H	1.361	0.90
503_M	516_K	1.360	0.90
352_S	389_G	1.360	0.90
182_I	186_L	1.356	0.89
217_L	277_V	1.352	0.89
400_N	404_S	1.347	0.89
502_A	506_I	1.342	0.89
342_H	345_N	1.342	0.89
755_G	760_N	1.338	0.89
222_T	226_Q	1.328	0.88
108_Q	111_P	1.327	0.88
133_M	181_F	1.325	0.88
90_I	347_A	1.324	0.88
398_P	489_F	1.320	0.88
342_H	349_F	1.315	0.88
53_Q	501_P	1.310	0.88
505_S	508_P	1.308	0.88
35_L	38_P	1.298	0.87
379_M	466_A	1.297	0.87
181_F	219_G	1.296	0.87
313_I	343_L	1.294	0.87
52_T	55_G	1.293	0.87
48_M	58_L	1.292	0.87
391_F	396_L	1.291	0.87
71_N	131_N	1.288	0.87
587_M	594_Y	1.286	0.87
298_L	360_I	1.277	0.86
39_V	43_I	1.276	0.86
635_L	639_S	1.276	0.86
82_L	340_I	1.275	0.86
535_A	635_L	1.272	0.86
495_S	520_H	1.261	0.86
46_L	85_L	1.259	0.85
600_A	717_I	1.259	0.85
274_F	278_S	1.259	0.85
291_H	304_F	1.252	0.85
365_G	396_L	1.252	0.85
297_D	372_L	1.246	0.85
527_V	535_A	1.237	0.84
375_L	379_M	1.237	0.84
30_T	34_V	1.236	0.84
359_I	363_E	1.233	0.84
183_L	212_A	1.233	0.84
70_I	134_V	1.233	0.84
156_R	238_E	1.223	0.84
50_R	54_S	1.222	0.84
271_A	275_W	1.219	0.84
217_L	221_F	1.216	0.83
547_S	550_K	1.216	0.83
596_L	600_A	1.215	0.83
188_T	199_Q	1.211	0.83
145_S	588_T	1.208	0.83
295_Q	300_S	1.203	0.83
341_F	403_L	1.194	0.82
190_S	196_M	1.194	0.82
500_E	504_N	1.192	0.82
204_A	270_S	1.190	0.82
75_Y	194_R	1.188	0.82
44_Y	48_M	1.184	0.82
403_L	521_I	1.184	0.82
340_I	502_A	1.181	0.82
264_S	268_A	1.181	0.82
117_L	121_G	1.180	0.82
5_H	9_L	1.179	0.81
663_T	782_A	1.172	0.81
356_A	448_L	1.171	0.81
442_F	446_M	1.170	0.81
485_V	656_A	1.170	0.81
38_P	44_Y	1.165	0.81
748_H	766_F	1.163	0.81
48_M	51_M	1.161	0.80
390_T	449_L	1.158	0.80
133_M	185_Y	1.156	0.80
345_N	404_S	1.151	0.80
363_E	470_P	1.150	0.80
312_M	349_F	1.149	0.80
7_A	45_F	1.149	0.80
305_S	404_S	1.147	0.80
438_S	441_T	1.144	0.79
212_A	267_F	1.142	0.79
312_M	399_F	1.141	0.79
550_K	553_G	1.134	0.79
583_T	589_G	1.134	0.79
199_Q	202_L	1.133	0.79
195_E	198_H	1.132	0.79
396_L	399_F	1.129	0.79
260_I	267_F	1.128	0.78
77_D	80_G	1.124	0.78
761_V	768_G	1.122	0.78
381_I	384_T	1.121	0.78
761_V	764_V	1.118	0.78
122_A	141_L	1.116	0.78
10_S	14_F	1.114	0.78
84_A	88_T	1.106	0.77
285_M	676_L	1.105	0.77
640_A	660_V	1.101	0.77
337_M	519_V	1.095	0.76
29_H	100_F	1.092	0.76
475_V	479_I	1.091	0.76
38_P	120_M	1.089	0.76
379_M	382_T	1.086	0.76
548_L	552_K	1.083	0.76
474_L	478_V	1.080	0.75
665_A	681_L	1.071	0.75
644_T	653_A	1.069	0.75
374_G	455_G	1.069	0.75
402_F	534_T	1.068	0.75
50_R	53_Q	1.066	0.74
195_E	199_Q	1.066	0.74
60_S	63_E	1.065	0.74
525_H	531_L	1.064	0.74
18_I	26_K	1.063	0.74
22_A	26_K	1.063	0.74
305_S	342_H	1.062	0.74
301_I	360_I	1.061	0.74
115_Y	145_S	1.059	0.74
63_E	66_P	1.056	0.74
351_G	480_L	1.054	0.74
190_S	199_Q	1.053	0.73
581_R	584_K	1.052	0.73
428_V	432_L	1.051	0.73
548_L	551_W	1.050	0.73
348_T	484_A	1.048	0.73
61_V	71_N	1.048	0.73
308_S	444_Y	1.045	0.73
301_I	304_F	1.040	0.73
578_G	582_V	1.038	0.72
391_F	446_M	1.030	0.72
180_G	184_L	1.029	0.72
210_I	600_A	1.029	0.72
83_F	343_L	1.028	0.72
740_S	743_S	1.026	0.72
78_G	502_A	1.026	0.72
15_A	19_P	1.026	0.72
229_F	284_T	1.025	0.71
49_I	81_L	1.024	0.71
181_F	216_I	1.023	0.71
482_A	726_T	1.022	0.71
588_T	593_D	1.020	0.71
707_T	712_M	1.020	0.71
76_I	80_G	1.016	0.71
349_F	754_G	1.013	0.71
184_L	216_I	1.011	0.70
500_E	516_K	1.011	0.70
723_V	726_T	1.010	0.70
112_F	243_V	1.009	0.70
745_F	749_S	1.007	0.70
439_V	544_G	1.006	0.70
403_L	487_L	1.005	0.70
651_L	772_M	1.002	0.70
342_H	444_Y	1.001	0.70
626_I	631_I	0.999	0.69
201_Q	205_G	0.997	0.69
537_I	540_I	0.995	0.69
309_Q	349_F	0.993	0.69
226_Q	769_F	0.991	0.69
131_N	191_F	0.989	0.69
367_R	393_M	0.989	0.69
241_T	361_D	0.987	0.69
63_E	69_G	0.985	0.68
290_F	555_Y	0.984	0.68
341_F	400_N	0.984	0.68
750_H	753_G	0.984	0.68
500_E	519_V	0.983	0.68
278_S	430_F	0.982	0.68
488_F	523_Q	0.977	0.68
493_I	527_V	0.973	0.67
184_L	196_M	0.968	0.67
412_M	431_P	0.968	0.67
339_A	349_F	0.967	0.67
657_L	660_V	0.966	0.67
148_L	217_L	0.966	0.67
159_S	685_T	0.964	0.67
426_W	432_L	0.963	0.67
547_S	631_I	0.961	0.66
435_W	536_G	0.958	0.66
745_F	762_I	0.957	0.66
744_F	748_H	0.957	0.66
643_A	652_T	0.956	0.66
12_F	504_N	0.955	0.66
347_A	440_F	0.952	0.66
257_I	301_I	0.951	0.66
109_L	159_S	0.946	0.65
124_L	364_T	0.945	0.65
48_M	76_I	0.945	0.65
349_F	445_S	0.942	0.65
213_M	276_I	0.941	0.65
359_I	385_I	0.939	0.65
651_L	655_I	0.939	0.65
235_D	565_N	0.939	0.65
336_A	340_I	0.937	0.64
377_A	457_Y	0.937	0.64
381_I	478_V	0.936	0.64
21_L	26_K	0.935	0.64
766_F	769_F	0.935	0.64
88_T	124_L	0.932	0.64
543_I	546_L	0.931	0.64
716_I	720_G	0.931	0.64
30_T	33_F	0.931	0.64
14_F	18_I	0.928	0.64
745_F	758_V	0.925	0.63
308_S	778_L	0.925	0.63
109_L	152_Y	0.922	0.63
52_T	490_F	0.921	0.63
570_K	574_M	0.921	0.63
432_L	543_I	0.920	0.63
450_F	454_R	0.919	0.63
388_I	485_V	0.918	0.63
165_K	231_I	0.917	0.63
387_L	390_T	0.915	0.63
17_I	122_A	0.915	0.63
753_G	763_L	0.914	0.63
619_K	624_A	0.912	0.62
231_I	238_E	0.912	0.62
536_G	540_I	0.906	0.62
603_I	607_G	0.906	0.62
220_A	317_L	0.904	0.62
280_V	283_F	0.904	0.62
269_F	272_Q	0.903	0.62
494_L	527_V	0.901	0.61
624_A	627_G	0.898	0.61
472_G	475_V	0.897	0.61
581_R	585_Q	0.894	0.61
131_N	192_S	0.894	0.61
261_A	343_L	0.891	0.61
641_T	660_V	0.889	0.60
442_F	538_V	0.888	0.60
745_F	755_G	0.887	0.60
264_S	336_A	0.887	0.60
286_V	437_G	0.887	0.60
557_L	716_I	0.885	0.60
231_I	672_R	0.883	0.60
540_I	638_I	0.882	0.60
600_A	635_L	0.881	0.60
540_I	544_G	0.881	0.60
359_I	469_A	0.877	0.59
547_S	551_W	0.877	0.59
723_V	727_L	0.876	0.59
251_T	351_G	0.874	0.59
384_T	387_L	0.873	0.59
207_E	717_I	0.872	0.59
310_L	405_K	0.872	0.59
12_F	18_I	0.868	0.58
305_S	441_T	0.868	0.58
8_I	633_L	0.867	0.58
65_I	68_L	0.866	0.58
442_F	541_G	0.865	0.58
220_A	392_S	0.864	0.58
153_W	156_R	0.864	0.58
349_F	393_M	0.863	0.58
340_I	344_I	0.861	0.58
500_E	503_M	0.859	0.58
489_F	523_Q	0.858	0.58
579_S	582_V	0.857	0.58
15_A	121_G	0.856	0.57
438_S	537_I	0.856	0.57
389_G	481_V	0.855	0.57
126_V	255_A	0.853	0.57
45_F	76_I	0.853	0.57
361_D	367_R	0.851	0.57
710_F	713_T	0.848	0.57
444_Y	447_K	0.847	0.57
721_V	732_S	0.845	0.56
196_M	731_A	0.845	0.56
388_I	481_V	0.844	0.56
143_S	249_S	0.843	0.56
37_L	40_L	0.842	0.56
363_E	469_A	0.841	0.56
226_Q	766_F	0.841	0.56
349_F	441_T	0.841	0.56
611_A	751_D	0.837	0.56
526_G	531_L	0.835	0.56
381_I	474_L	0.831	0.55
275_W	279_L	0.830	0.55
681_L	776_T	0.830	0.55
124_L	128_L	0.829	0.55
295_Q	399_F	0.828	0.55
268_A	336_A	0.827	0.55
160_R	302_L	0.825	0.55
257_I	785_I	0.824	0.55
40_L	43_I	0.824	0.55
151_G	761_V	0.824	0.55
287_W	291_H	0.823	0.54
436_I	476_P	0.822	0.54
84_A	202_L	0.821	0.54
584_K	604_I	0.821	0.54
535_A	538_V	0.821	0.54
147_F	682_V	0.820	0.54
121_G	692_L	0.820	0.54
394_A	445_S	0.817	0.54
18_I	22_A	0.816	0.54
79_L	257_I	0.816	0.54
301_I	561_K	0.816	0.54
45_F	128_L	0.815	0.54
509_T	516_K	0.815	0.54
309_Q	678_L	0.815	0.54
340_I	509_T	0.814	0.54
79_L	262_R	0.814	0.54
389_G	485_V	0.812	0.53
87_I	221_F	0.807	0.53
182_I	191_F	0.806	0.53
749_S	787_S	0.805	0.53
548_L	555_Y	0.804	0.53
518_H	718_S	0.803	0.53
144_L	263_F	0.803	0.53
709_T	712_M	0.803	0.53
349_F	789_I	0.801	0.52
133_M	191_F	0.801	0.52
712_M	715_F	0.798	0.52
297_D	366_T	0.798	0.52
305_S	444_Y	0.795	0.52
628_V	632_I	0.794	0.52
143_S	674_P	0.794	0.52
32_W	96_L	0.793	0.52
144_L	217_L	0.792	0.52
298_L	367_R	0.792	0.52
660_V	696_Y	0.791	0.52
758_V	768_G	0.791	0.52
322_A	504_N	0.791	0.52
750_H	761_V	0.789	0.51
284_T	405_K	0.788	0.51
181_F	191_F	0.786	0.51
435_W	533_M	0.785	0.51
360_I	452_T	0.785	0.51
55_G	483_L	0.785	0.51
632_I	642_V	0.784	0.51
729_G	733_S	0.783	0.51
639_S	657_L	0.782	0.51
498_L	501_P	0.781	0.51
103_S	153_W	0.781	0.51
123_M	142_T	0.778	0.50
129_V	147_F	0.777	0.50
159_S	602_F	0.775	0.50
263_F	290_F	0.775	0.50
175_L	179_G	0.774	0.50
447_K	451_K	0.773	0.50
755_G	763_L	0.771	0.50
551_W	555_Y	0.771	0.50
376_M	456_N	0.771	0.50
702_R	705_T	0.771	0.50
635_L	772_M	0.770	0.50
139_W	259_V	0.770	0.50
43_I	46_L	0.769	0.50
221_F	226_Q	0.769	0.50
321_A	335_A	0.768	0.49
692_L	785_I	0.767	0.49
276_I	280_V	0.766	0.49
94_V	352_S	0.766	0.49
763_L	772_M	0.765	0.49
442_F	537_I	0.764	0.49
703_L	707_T	0.763	0.49
313_I	692_L	0.761	0.49
15_A	384_T	0.760	0.49
637_M	659_V	0.760	0.49
45_F	583_T	0.759	0.49
65_I	755_G	0.758	0.48
462_L	466_A	0.757	0.48
211_P	272_Q	0.757	0.48
191_F	316_M	0.756	0.48
757_N	760_N	0.756	0.48
595_L	599_F	0.754	0.48
227_F	266_I	0.754	0.48
264_S	320_S	0.754	0.48
488_F	494_L	0.753	0.48
716_I	727_L	0.751	0.48
373_G	456_N	0.749	0.48
308_S	349_F	0.749	0.48
641_T	644_T	0.749	0.48
71_N	198_H	0.746	0.47
730_I	746_V	0.745	0.47
143_S	741_I	0.745	0.47
450_F	455_G	0.745	0.47
82_L	89_G	0.745	0.47
180_G	212_A	0.744	0.47
651_L	664_L	0.743	0.47
17_I	371_K	0.742	0.47
537_I	778_L	0.741	0.47
436_I	493_I	0.740	0.47
25_A	29_H	0.739	0.47
260_I	317_L	0.739	0.47
15_A	658_G	0.738	0.47
341_F	345_N	0.738	0.47
711_R	714_N	0.737	0.47
203_I	390_T	0.737	0.47
393_M	437_G	0.737	0.47
356_A	481_V	0.736	0.46
41_L	44_Y	0.733	0.46
169_I	531_L	0.733	0.46
352_S	356_A	0.732	0.46
415_V	427_G	0.732	0.46
558_F	708_R	0.730	0.46
25_A	30_T	0.729	0.46
7_A	390_T	0.729	0.46
171_V	568_Y	0.728	0.46
443_I	544_G	0.728	0.46
395_G	524_W	0.728	0.46
132_V	185_Y	0.727	0.46
302_L	668_F	0.727	0.46
768_G	782_A	0.726	0.46
272_Q	275_W	0.724	0.45
133_M	731_A	0.723	0.45
165_K	672_R	0.723	0.45
88_T	92_S	0.723	0.45
255_A	320_S	0.718	0.45
75_Y	181_F	0.716	0.45
145_S	690_L	0.715	0.45
308_S	342_H	0.714	0.44
444_Y	754_G	0.713	0.44
197_V	266_I	0.713	0.44
404_S	686_I	0.713	0.44
634_T	637_M	0.713	0.44
342_H	754_G	0.713	0.44
94_V	647_A	0.712	0.44
92_S	428_V	0.712	0.44
715_F	745_F	0.712	0.44
381_I	471_V	0.711	0.44
555_Y	559_P	0.711	0.44
177_M	219_G	0.710	0.44
246_Y	780_I	0.709	0.44
94_V	653_A	0.709	0.44
183_L	494_L	0.709	0.44
112_F	150_I	0.709	0.44
96_L	470_P	0.708	0.44
627_G	630_E	0.708	0.44
348_T	392_S	0.707	0.44
106_K	110_G	0.706	0.44
89_G	93_L	0.706	0.44
80_G	745_F	0.706	0.44
73_T	486_S	0.706	0.44
183_L	751_D	0.705	0.44
95_T	117_L	0.699	0.43
654_I	695_F	0.699	0.43
161_Y	569_D	0.699	0.43
304_F	648_R	0.699	0.43
761_V	775_I	0.697	0.43
7_A	94_V	0.696	0.43
568_Y	685_T	0.695	0.43
154_Y	658_G	0.695	0.43
204_A	485_V	0.694	0.43
645_V	648_R	0.694	0.43
258_Y	442_F	0.693	0.43
637_M	664_L	0.693	0.43
153_W	162_G	0.691	0.42
197_V	200_V	0.691	0.42
9_L	464_K	0.690	0.42
290_F	293_V	0.690	0.42
441_T	654_I	0.689	0.42
89_G	483_L	0.689	0.42
641_T	645_V	0.688	0.42
726_T	733_S	0.687	0.42
90_I	177_M	0.686	0.42
336_A	364_T	0.686	0.42
383_F	449_L	0.685	0.42
432_L	553_G	0.685	0.42
487_L	494_L	0.684	0.42
451_K	548_L	0.683	0.42
203_I	718_S	0.682	0.42
619_K	622_G	0.682	0.42
377_A	384_T	0.680	0.41
734_S	779_T	0.680	0.41
45_F	166_S	0.679	0.41
239_A	247_L	0.678	0.41
304_F	564_L	0.678	0.41
160_R	386_S	0.678	0.41
351_G	476_P	0.678	0.41
86_L	347_A	0.677	0.41
196_M	274_F	0.677	0.41
369_I	753_G	0.677	0.41
269_F	274_F	0.677	0.41
572_L	579_S	0.677	0.41
113_Y	305_S	0.677	0.41
291_H	295_Q	0.676	0.41
199_Q	203_I	0.676	0.41
411_S	527_V	0.675	0.41
606_I	616_F	0.674	0.41
599_F	717_I	0.672	0.41
732_S	736_R	0.672	0.41
542_T	556_K	0.671	0.41
308_S	691_F	0.670	0.41
379_M	490_F	0.670	0.41
590_F	593_D	0.670	0.41
623_M	626_I	0.669	0.40
219_G	568_Y	0.669	0.40
165_K	768_G	0.668	0.40
623_M	768_G	0.668	0.40
660_V	785_I	0.668	0.40
644_T	660_V	0.667	0.40
294_K	476_P	0.667	0.40
5_H	720_G	0.667	0.40
193_I	196_M	0.667	0.40
524_W	531_L	0.666	0.40
626_I	630_E	0.666	0.40
196_M	266_I	0.665	0.40
301_I	595_L	0.665	0.40
619_K	637_M	0.664	0.40
523_Q	526_G	0.664	0.40
83_F	177_M	0.663	0.40
142_T	252_M	0.663	0.40
664_L	775_I	0.663	0.40
193_I	747_K	0.663	0.40
753_G	760_N	0.663	0.40
776_T	783_L	0.663	0.40
141_L	145_S	0.662	0.40
524_W	528_T	0.661	0.40
349_F	530_E	0.661	0.40
166_S	171_V	0.660	0.40
364_T	688_V	0.660	0.40
148_L	284_T	0.660	0.40
369_I	451_K	0.660	0.40
19_P	26_K	0.659	0.40
172_S	257_I	0.659	0.40
700_K	711_R	0.658	0.40
409_F	435_W	0.656	0.39
642_V	646_F	0.655	0.39
95_T	116_L	0.655	0.39
56_E	482_A	0.654	0.39
126_V	157_E	0.654	0.39
360_I	749_S	0.654	0.39
312_M	444_Y	0.653	0.39
688_V	787_S	0.652	0.39
74_V	82_L	0.650	0.39
36_I	135_L	0.650	0.39
188_T	202_L	0.649	0.39
439_V	536_G	0.649	0.39
627_G	638_I	0.649	0.39
613_K	658_G	0.649	0.39
309_Q	312_M	0.649	0.39
740_S	789_I	0.648	0.39
292_A	349_F	0.647	0.39
634_T	641_T	0.647	0.39
693_L	753_G	0.646	0.38
34_V	345_N	0.646	0.38
392_S	632_I	0.646	0.38
308_S	338_A	0.646	0.38
362_H	525_H	0.645	0.38
288_G	465_Q	0.644	0.38
712_M	716_I	0.644	0.38
373_G	636_V	0.643	0.38
345_N	407_M	0.642	0.38
18_I	33_F	0.642	0.38
572_L	711_R	0.641	0.38
400_N	487_L	0.641	0.38
25_A	33_F	0.641	0.38
574_M	579_S	0.641	0.38
177_M	790_K	0.641	0.38
732_S	735_Q	0.640	0.38
68_L	753_G	0.638	0.38
344_I	549_N	0.637	0.38
382_T	453_F	0.637	0.38
141_L	640_A	0.637	0.38
772_M	776_T	0.636	0.38
8_I	730_I	0.636	0.38
556_K	768_G	0.636	0.38
386_S	390_T	0.636	0.38
74_V	588_T	0.635	0.38
121_G	148_L	0.633	0.37
282_L	540_I	0.633	0.37
608_G	717_I	0.632	0.37
172_S	503_M	0.632	0.37
87_I	127_V	0.632	0.37
161_Y	565_N	0.632	0.37
656_A	696_Y	0.632	0.37
782_A	786_Y	0.632	0.37
503_M	599_F	0.631	0.37
151_G	160_R	0.631	0.37
92_S	96_L	0.631	0.37
430_F	538_V	0.630	0.37
27_R	30_T	0.630	0.37
626_I	641_T	0.630	0.37
16_F	195_E	0.630	0.37
131_N	190_S	0.630	0.37
175_L	773_F	0.630	0.37
112_F	152_Y	0.629	0.37
652_T	772_M	0.629	0.37
128_L	455_G	0.629	0.37
308_S	447_K	0.629	0.37
89_G	151_G	0.628	0.37
367_R	372_L	0.628	0.37
156_R	349_F	0.627	0.37
683_I	754_G	0.627	0.37
469_A	475_V	0.627	0.37
172_S	175_L	0.626	0.37
725_V	746_V	0.626	0.37
14_F	23_K	0.626	0.37
632_I	643_A	0.626	0.37
717_I	751_D	0.626	0.37
305_S	409_F	0.625	0.37
361_D	650_R	0.625	0.37
554_I	567_L	0.625	0.37
21_L	25_A	0.624	0.37
14_F	30_T	0.624	0.37
491_P	690_L	0.624	0.37
76_I	230_Y	0.624	0.37
153_W	348_T	0.623	0.36
409_F	434_A	0.621	0.36
369_I	552_K	0.620	0.36
619_K	625_K	0.619	0.36
13_L	43_I	0.619	0.36
294_K	304_F	0.619	0.36
479_I	716_I	0.618	0.36
23_K	391_F	0.618	0.36
148_L	370_R	0.617	0.36
132_V	184_L	0.616	0.36
399_F	481_V	0.616	0.36
408_F	438_S	0.615	0.36
412_M	434_A	0.615	0.36
144_L	787_S	0.614	0.36
384_T	639_S	0.614	0.36
344_I	503_M	0.614	0.36
129_V	134_V	0.613	0.36
187_I	208_L	0.613	0.36
502_A	507_Y	0.613	0.36
347_A	785_I	0.612	0.36
437_G	789_I	0.611	0.35
652_T	687_S	0.611	0.35
457_Y	540_I	0.610	0.35
7_A	10_S	0.610	0.35
316_M	408_F	0.610	0.35
375_L	467_H	0.610	0.35
51_M	508_P	0.610	0.35
96_L	476_P	0.609	0.35
50_R	66_P	0.609	0.35
162_G	408_F	0.609	0.35
19_P	34_V	0.608	0.35
49_I	52_T	0.608	0.35
518_H	642_V	0.607	0.35
713_T	717_I	0.607	0.35
766_F	783_L	0.607	0.35
409_F	474_L	0.607	0.35
9_L	479_I	0.607	0.35
65_I	479_I	0.607	0.35
159_S	392_S	0.606	0.35
535_A	632_I	0.605	0.35
36_I	122_A	0.605	0.35
35_L	92_S	0.604	0.35
63_E	571_L	0.604	0.35
349_F	447_K	0.604	0.35
83_F	342_H	0.602	0.35
208_L	211_P	0.602	0.35
444_Y	678_L	0.600	0.35
201_Q	561_K	0.600	0.35
722_G	726_T	0.600	0.35
148_L	219_G	0.600	0.35
124_L	145_S	0.598	0.34
686_I	690_L	0.598	0.34
190_S	761_V	0.598	0.34
612_I	715_F	0.597	0.34
282_L	315_S	0.597	0.34
72_F	307_V	0.597	0.34
82_L	565_N	0.597	0.34
369_I	450_F	0.596	0.34
183_L	211_P	0.596	0.34
9_L	12_F	0.596	0.34
148_L	298_L	0.596	0.34
288_G	538_V	0.596	0.34
747_K	752_L	0.595	0.34
432_L	435_W	0.595	0.34
96_L	100_F	0.595	0.34
550_K	723_V	0.594	0.34
571_L	575_M	0.593	0.34
761_V	769_F	0.593	0.34
20_F	214_I	0.593	0.34
371_K	742_A	0.593	0.34
457_Y	460_E	0.592	0.34
633_L	789_I	0.592	0.34
595_L	641_T	0.591	0.34
268_A	788_M	0.591	0.34
176_C	215_L	0.591	0.34
714_N	753_G	0.591	0.34
452_T	455_G	0.590	0.34
466_A	481_V	0.590	0.34
438_S	726_T	0.589	0.34
177_M	575_M	0.589	0.34
43_I	340_I	0.589	0.34
376_M	387_L	0.588	0.34
588_T	594_Y	0.587	0.33
263_F	283_F	0.587	0.33
108_Q	355_M	0.587	0.33
539_V	716_I	0.586	0.33
263_F	322_A	0.586	0.33
649_S	702_R	0.585	0.33
689_A	729_G	0.585	0.33
657_L	668_F	0.584	0.33
768_G	775_I	0.584	0.33
43_I	719_L	0.583	0.33
497_S	779_T	0.583	0.33
183_L	545_Y	0.582	0.33
388_I	540_I	0.582	0.33
687_S	782_A	0.581	0.33
345_N	484_A	0.581	0.33
449_L	452_T	0.581	0.33
560_S	718_S	0.580	0.33
660_V	691_F	0.580	0.33
761_V	782_A	0.580	0.33
369_I	377_A	0.580	0.33
74_V	134_V	0.579	0.33
118_M	145_S	0.579	0.33
96_L	473_M	0.579	0.33
437_G	590_F	0.579	0.33
19_P	23_K	0.578	0.33
175_L	764_V	0.578	0.33
276_I	561_K	0.577	0.33
371_K	743_S	0.577	0.33
308_S	441_T	0.577	0.33
543_I	723_V	0.577	0.33
707_T	710_F	0.577	0.33
483_L	528_T	0.576	0.33
272_Q	509_T	0.576	0.33
25_A	51_M	0.575	0.33
341_F	487_L	0.574	0.32
586_Y	603_I	0.574	0.32
308_S	678_L	0.574	0.32
86_L	89_G	0.573	0.32
317_L	336_A	0.573	0.32
315_S	434_A	0.573	0.32
471_V	477_P	0.573	0.32
138_F	230_Y	0.572	0.32
760_N	763_L	0.572	0.32
252_M	765_D	0.572	0.32
8_I	12_F	0.572	0.32
320_S	598_I	0.571	0.32
178_L	181_F	0.571	0.32
589_G	685_T	0.571	0.32
342_H	430_F	0.571	0.32
200_V	266_I	0.571	0.32
7_A	25_A	0.570	0.32
46_L	55_G	0.570	0.32
45_F	88_T	0.570	0.32
450_F	456_N	0.570	0.32
285_M	468_E	0.570	0.32
20_F	631_I	0.570	0.32
320_S	640_A	0.570	0.32
40_L	635_L	0.570	0.32
710_F	715_F	0.569	0.32
590_F	781_A	0.567	0.32
436_I	540_I	0.567	0.32
495_S	500_E	0.567	0.32
180_G	403_L	0.566	0.32
59_R	63_E	0.566	0.32
360_I	547_S	0.566	0.32
730_I	782_A	0.565	0.32
36_I	459_P	0.565	0.32
90_I	104_K	0.565	0.32
56_E	716_I	0.565	0.32
112_F	650_R	0.564	0.32
689_A	695_F	0.564	0.32
488_F	497_S	0.563	0.32
383_F	454_R	0.563	0.32
276_I	470_P	0.563	0.32
686_I	706_K	0.563	0.32
390_T	611_A	0.563	0.32
57_T	475_V	0.563	0.32
158_K	238_E	0.563	0.32
172_S	176_C	0.563	0.32
407_M	519_V	0.562	0.31
126_V	682_V	0.562	0.31
8_I	11_P	0.561	0.31
16_F	201_Q	0.560	0.31
166_S	788_M	0.560	0.31
315_S	430_F	0.560	0.31
46_L	276_I	0.560	0.31
527_V	540_I	0.560	0.31
553_G	556_K	0.559	0.31
110_G	530_E	0.559	0.31
363_E	468_E	0.559	0.31
20_F	646_F	0.559	0.31
681_L	763_L	0.558	0.31
179_G	755_G	0.557	0.31
162_G	300_S	0.557	0.31
612_I	719_L	0.557	0.31
657_L	764_V	0.557	0.31
18_I	23_K	0.556	0.31
530_E	534_T	0.556	0.31
117_L	671_F	0.556	0.31
147_F	562_L	0.556	0.31
520_H	534_T	0.553	0.31
33_F	543_I	0.552	0.31
446_M	450_F	0.552	0.31
696_Y	784_G	0.552	0.31
484_A	686_I	0.551	0.31
640_A	647_A	0.550	0.31
408_F	434_A	0.550	0.31
39_V	558_F	0.549	0.30
20_F	24_Y	0.549	0.30
96_L	475_V	0.549	0.30
273_W	722_G	0.549	0.30
290_F	548_L	0.548	0.30
482_A	638_I	0.548	0.30
528_T	534_T	0.548	0.30
83_F	744_F	0.547	0.30
204_A	207_E	0.547	0.30
151_G	587_M	0.547	0.30
68_L	594_Y	0.547	0.30
109_L	113_Y	0.547	0.30
340_I	758_V	0.546	0.30
729_G	732_S	0.545	0.30
413_L	479_I	0.545	0.30
490_F	724_I	0.545	0.30
174_G	405_K	0.545	0.30
679_T	760_N	0.544	0.30
52_T	58_L	0.544	0.30
572_L	576_E	0.544	0.30
706_K	773_F	0.544	0.30
600_A	607_G	0.543	0.30
209_F	213_M	0.543	0.30
205_G	635_L	0.543	0.30
140_E	405_K	0.543	0.30
277_V	503_M	0.542	0.30
114_V	539_V	0.541	0.30
534_T	537_I	0.541	0.30
355_M	594_Y	0.541	0.30
494_L	498_L	0.540	0.30
647_A	652_T	0.540	0.30
52_T	81_L	0.540	0.30
150_I	785_I	0.540	0.30
364_T	425_T	0.539	0.30
151_G	371_K	0.538	0.30
633_L	638_I	0.538	0.30
62_L	746_V	0.538	0.30
33_F	489_F	0.538	0.30
99_I	109_L	0.537	0.30
660_V	664_L	0.537	0.30
186_L	189_D	0.537	0.30
721_V	725_V	0.536	0.29
71_N	639_S	0.536	0.29
539_V	543_I	0.536	0.29
637_M	687_S	0.536	0.29
50_R	343_L	0.536	0.29
129_V	561_K	0.535	0.29
604_I	607_G	0.535	0.29
44_Y	47_P	0.535	0.29
321_A	683_I	0.535	0.29
636_V	663_T	0.535	0.29
498_L	749_S	0.533	0.29
309_Q	672_R	0.533	0.29
252_M	302_L	0.533	0.29
760_N	764_V	0.533	0.29
410_T	468_E	0.532	0.29
43_I	712_M	0.532	0.29
153_W	342_H	0.531	0.29
689_A	749_S	0.531	0.29
744_F	766_F	0.530	0.29
363_E	464_K	0.530	0.29
488_F	761_V	0.530	0.29
574_M	577_K	0.530	0.29
618_F	637_M	0.530	0.29
13_L	286_V	0.529	0.29
124_L	669_V	0.529	0.29
114_V	676_L	0.529	0.29
451_K	545_Y	0.529	0.29
167_L	610_F	0.529	0.29
266_I	339_A	0.528	0.29
341_F	521_I	0.528	0.29
83_F	249_S	0.528	0.29
13_L	436_I	0.527	0.29
546_L	550_K	0.527	0.29
579_S	584_K	0.527	0.29
226_Q	251_T	0.526	0.29
624_A	628_V	0.526	0.29
686_I	739_D	0.526	0.29
52_T	56_E	0.525	0.29
360_I	549_N	0.525	0.29
571_L	574_M	0.524	0.29
105_E	728_L	0.524	0.29
733_S	747_K	0.524	0.29
475_V	483_L	0.524	0.29
499_I	693_L	0.524	0.29
238_E	361_D	0.524	0.29
769_F	790_K	0.523	0.28
322_A	508_P	0.523	0.28
356_A	477_P	0.523	0.28
295_Q	788_M	0.523	0.28
355_M	506_I	0.523	0.28
5_H	25_A	0.523	0.28
453_F	653_A	0.523	0.28
13_L	17_I	0.523	0.28
539_V	772_M	0.523	0.28
143_S	357_V	0.522	0.28
753_G	756_D	0.522	0.28
52_T	59_R	0.522	0.28
378_I	458_Q	0.521	0.28
709_T	713_T	0.520	0.28
21_L	33_F	0.520	0.28
661_G	684_E	0.520	0.28
690_L	763_L	0.519	0.28
100_F	359_I	0.519	0.28
352_S	482_A	0.519	0.28
457_Y	636_V	0.519	0.28
753_G	766_F	0.518	0.28
746_V	749_S	0.518	0.28
630_E	634_T	0.517	0.28
480_L	755_G	0.517	0.28
96_L	396_L	0.516	0.28
11_P	15_A	0.516	0.28
435_W	439_V	0.516	0.28
436_I	440_F	0.516	0.28
74_V	198_H	0.516	0.28
59_R	194_R	0.516	0.28
502_A	505_S	0.515	0.28
603_I	721_V	0.515	0.28
128_L	782_A	0.515	0.28
67_S	137_M	0.514	0.28
172_S	596_L	0.513	0.28
343_L	753_G	0.513	0.28
493_I	497_S	0.513	0.28
79_L	664_L	0.513	0.28
297_D	361_D	0.513	0.28
305_S	408_F	0.512	0.28
81_L	85_L	0.512	0.28
649_S	701_L	0.511	0.28
195_E	556_K	0.511	0.28
355_M	697_H	0.511	0.28
391_F	730_I	0.511	0.28
429_L	432_L	0.511	0.28
39_V	542_T	0.510	0.28
411_S	486_S	0.510	0.28
570_K	577_K	0.510	0.28
142_T	302_L	0.510	0.28
204_A	643_A	0.508	0.27
80_G	409_F	0.508	0.27
255_A	259_V	0.508	0.27
76_I	84_A	0.508	0.27
337_M	499_I	0.507	0.27
100_F	473_M	0.507	0.27
123_M	224_S	0.507	0.27
626_I	633_L	0.507	0.27
159_S	438_S	0.507	0.27
745_F	766_F	0.506	0.27
57_T	80_G	0.506	0.27
312_M	408_F	0.506	0.27
334_V	360_I	0.505	0.27
87_I	460_E	0.505	0.27
264_S	399_F	0.505	0.27
276_I	388_I	0.504	0.27
662_Y	681_L	0.504	0.27
143_S	768_G	0.504	0.27
696_Y	781_A	0.504	0.27
165_K	404_S	0.503	0.27
87_I	760_N	0.502	0.27
451_K	628_V	0.502	0.27
159_S	399_F	0.502	0.27
116_L	297_D	0.501	0.27
535_A	631_I	0.500	0.27
93_L	351_G	0.500	0.27

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3rkoL	1	0.7116	100	0.568	Contact Map
4he8L	1	0.7104	100	0.58	Contact Map
3rkoM	1	0.6017	100	0.633	Contact Map
4he8M	1	0.573	100	0.655	Contact Map
3rkoN	1	0.5693	100	0.666	Contact Map
4he8N	1	0.5318	100	0.698	Contact Map
4he8J	1	0.1948	98.3	0.964	Contact Map
3rkoJ	1	0.1873	97.1	0.972	Contact Map
4he8K	1	0.1161	38.3	0.987	Contact Map
3rkoK	1	0.1211	33.3	0.987	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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