GREMLIN Database
PPAX - Pyrophosphatase PpaX
UniProt: Q9JMQ2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 216 (201)
Sequences: 30439 (23734)
Seq/√Len: 1674.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_T160_E4.2151.00
149_L153_Q2.8011.00
120_K125_G2.7761.00
139_N143_D2.6991.00
165_G170_D2.6441.00
174_G181_T2.5881.00
95_D127_F2.4631.00
8_T156_S2.4271.00
112_R116_N2.4151.00
6_V180_K2.3401.00
91_Y95_D2.3031.00
105_G130_T2.2731.00
149_L152_K2.2351.00
103_T129_E2.2311.00
112_R136_D2.1281.00
108_T115_V2.1251.00
151_L161_A2.1101.00
175_K200_D2.1001.00
11_F104_L2.0741.00
107_V146_P2.0581.00
204_E208_D2.0211.00
34_H71_M2.0051.00
139_N145_E1.9481.00
130_T153_Q1.9381.00
171_V181_T1.9381.00
172_L176_N1.8281.00
41_K44_D1.8131.00
157_E160_E1.7891.00
98_K129_E1.7631.00
180_K200_D1.7221.00
30_H75_Y1.7151.00
9_I102_F1.7141.00
151_L179_T1.7111.00
98_K127_F1.6521.00
10_L163_M1.6511.00
162_I182_A1.6351.00
104_L128_F1.6291.00
163_M174_G1.6031.00
96_A100_A1.6001.00
10_L150_A1.5501.00
90_V206_M1.5491.00
151_L158_P1.5151.00
156_S161_A1.5081.00
185_A204_E1.5071.00
8_T154_L1.4821.00
10_L107_V1.4751.00
116_N125_G1.4651.00
105_G154_L1.4141.00
6_V162_I1.4051.00
9_I97_L1.4031.00
168_Y172_L1.3561.00
9_I164_V1.3471.00
87_Y186_W1.3441.00
93_T206_M1.3431.00
182_A203_L1.3351.00
34_H75_Y1.3091.00
96_A99_K1.3041.00
185_A202_M1.2831.00
35_Y71_M1.2831.00
144_P148_L1.2651.00
205_K208_D1.2541.00
75_Y78_D1.2461.00
13_L106_I1.2421.00
13_L115_V1.2341.00
89_T92_E1.2331.00
191_P195_A1.2311.00
55_D58_S1.2281.00
71_M74_A1.2241.00
30_H34_H1.2091.00
13_L18_I1.2081.00
132_V153_Q1.2041.00
116_N120_K1.1991.00
30_H79_M1.1991.00
17_L90_V1.1901.00
16_T164_V1.1891.00
182_A201_F1.1821.00
115_V133_T1.1601.00
71_M75_Y1.1471.00
10_L161_A1.1411.00
132_V150_A1.1391.00
70_A74_A1.1241.00
92_E207_S1.1151.00
75_Y79_M1.1131.00
147_V163_M1.1071.00
8_T161_A1.1061.00
67_D71_M1.0951.00
161_A179_T1.0841.00
8_T103_T1.0821.00
42_R46_L1.0731.00
95_D99_K1.0711.00
148_L152_K1.0611.00
147_V173_A1.0511.00
31_T35_Y1.0511.00
98_K104_L1.0421.00
26_A79_M1.0361.00
86_E124_I1.0341.00
54_F58_S1.0271.00
26_A30_H1.0231.00
175_K181_T1.0211.00
14_D20_T1.0141.00
106_I128_F1.0111.00
94_L128_F1.0031.00
13_L110_K1.0001.00
147_V179_T0.9991.00
30_H33_E0.9981.00
145_E149_L0.9951.00
112_R133_T0.9921.00
107_V150_A0.9871.00
173_A177_A0.9841.00
92_E95_D0.9831.00
150_A154_L0.9781.00
171_V199_P0.9711.00
130_T154_L0.9691.00
74_A78_D0.9671.00
115_V118_G0.9651.00
29_L33_E0.9641.00
8_T105_G0.9611.00
163_M179_T0.9601.00
10_L179_T0.9541.00
123_G126_E0.9501.00
191_P204_E0.9461.00
117_M121_L0.9351.00
55_D59_S0.9351.00
91_Y127_F0.9351.00
108_T133_T0.9251.00
147_V165_G0.9191.00
148_L177_A0.9121.00
145_E148_L0.9081.00
117_M120_K0.9041.00
14_D108_T0.9021.00
89_T205_K0.8981.00
169_H172_L0.8971.00
180_K201_F0.8961.00
14_D110_K0.8921.00
95_D126_E0.8821.00
10_L154_L0.8761.00
137_V149_L0.8701.00
183_G194_L0.8691.00
32_L37_P0.8691.00
112_R135_D0.8681.00
26_A83_L0.8661.00
40_Y44_D0.8601.00
203_L209_L0.8541.00
94_L127_F0.8491.00
138_T145_E0.8491.00
43_E47_A0.8491.00
26_A29_L0.8471.00
158_P179_T0.8451.00
97_L102_F0.8421.00
86_E91_Y0.8411.00
57_F61_D0.8341.00
148_L158_P0.8311.00
104_L127_F0.8311.00
105_G150_A0.8311.00
66_E70_A0.8291.00
164_V182_A0.8281.00
6_V102_F0.8261.00
9_I162_I0.8191.00
162_I180_K0.8161.00
132_V149_L0.8151.00
51_P59_S0.8121.00
13_L118_G0.8101.00
175_K198_E0.8061.00
87_Y90_V0.7921.00
192_E195_A0.7911.00
110_K115_V0.7871.00
181_T200_D0.7831.00
87_Y184_V0.7831.00
58_S65_C0.7821.00
97_L104_L0.7791.00
14_D166_D0.7731.00
79_M82_S0.7701.00
7_T102_F0.7671.00
69_I73_R0.7591.00
89_T207_S0.7561.00
91_Y123_G0.7551.00
18_I122_T0.7541.00
25_I29_L0.7491.00
18_I118_G0.7451.00
72_Y76_N0.7411.00
183_G202_M0.7401.00
43_E46_L0.7361.00
182_A209_L0.7331.00
156_S160_E0.7291.00
6_V160_E0.7281.00
133_T136_D0.7271.00
147_V170_D0.7271.00
91_Y126_E0.7271.00
186_W206_M0.7271.00
27_S31_T0.7191.00
203_L206_M0.7151.00
29_L42_R0.7151.00
7_T103_T0.7121.00
146_P150_A0.7121.00
164_V209_L0.7061.00
163_M170_D0.7031.00
16_T170_D0.7001.00
109_T140_A0.6951.00
136_D153_Q0.6901.00
92_E96_A0.6901.00
14_D118_G0.6881.00
144_P176_N0.6841.00
54_F66_E0.6811.00
184_V206_M0.6811.00
109_T142_P0.6791.00
119_L125_G0.6731.00
10_L105_G0.6731.00
44_D47_A0.6721.00
24_I28_F0.6711.00
70_A73_R0.6701.00
19_N85_T0.6681.00
171_V183_G0.6681.00
46_L49_I0.6581.00
104_L129_E0.6571.00
107_V163_M0.6571.00
172_L175_K0.6561.00
7_T156_S0.6541.00
73_R77_H0.6541.00
22_E85_T0.6491.00
158_P161_A0.6471.00
132_V146_P0.6461.00
68_M72_Y0.6461.00
90_V94_L0.6421.00
116_N131_V0.6371.00
23_L84_V0.6341.00
98_K126_E0.6341.00
24_I72_Y0.6311.00
68_M71_M0.6301.00
15_G21_N0.6281.00
86_E122_T0.6271.00
115_V131_V0.6251.00
18_I84_V0.6221.00
89_T93_T0.6221.00
130_T150_A0.6201.00
98_K101_G0.6151.00
35_Y67_D0.6151.00
151_L156_S0.6121.00
93_T164_V0.6111.00
44_D49_I0.6101.00
65_C69_I0.6091.00
27_S75_Y0.6071.00
146_P173_A0.6061.00
49_I52_S0.6041.00
151_L177_A0.5981.00
11_F93_T0.5971.00
33_E38_S0.5971.00
16_T184_V0.5941.00
56_T60_M0.5941.00
67_D70_A0.5941.00
40_Y45_V0.5931.00
65_C68_M0.5911.00
137_V146_P0.5891.00
89_T186_W0.5891.00
109_T169_H0.5881.00
134_L146_P0.5881.00
103_T156_S0.5871.00
24_I110_K0.5861.00
95_D98_K0.5851.00
19_N87_Y0.5841.00
163_M173_A0.5831.00
10_L147_V0.5801.00
107_V132_V0.5801.00
119_L124_I0.5781.00
19_N22_E0.5781.00
120_K126_E0.5721.00
128_F131_V0.5711.00
20_T110_K0.5671.00
22_E26_A0.5671.00
148_L151_L0.5631.00
81_D117_M0.5601.00
151_L157_E0.5571.00
93_T97_L0.5551.00
115_V119_L0.5531.00
88_E207_S0.5521.00
77_H117_M0.5521.00
44_D48_F0.5501.00
28_F32_L0.5491.00
113_D117_M0.5491.00
183_G199_P0.5441.00
51_P55_D0.5431.00
110_K165_G0.5391.00
56_T59_S0.5391.00
93_T203_L0.5321.00
110_K114_T0.5281.00
52_S55_D0.5251.00
25_I45_V0.5241.00
109_T134_L0.5211.00
20_T24_I0.5201.00
168_Y183_G0.5191.00
25_I42_R0.5181.00
90_V93_T0.5181.00
93_T96_A0.5171.00
45_V49_I0.5131.00
113_D116_N0.5121.00
17_L94_L0.5091.00
9_I104_L0.5091.00
74_A77_H0.5071.00
79_M83_L0.5031.00
147_V174_G0.5021.00
6_V9_I0.5021.00
72_Y75_Y0.5011.00
109_T167_N0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1swvA 2 0.9769 100 0.261 Contact Map
3d6jA 1 0.9537 100 0.267 Contact Map
4uw9A 1 0.9074 100 0.267 Contact Map
3sd7A 1 0.9769 100 0.267 Contact Map
3s6jA 2 0.9722 100 0.268 Contact Map
3iruA 4 0.9954 100 0.268 Contact Map
4eekA 2 0.9861 100 0.271 Contact Map
2hszA 1 0.9861 100 0.271 Contact Map
1te2A 2 0.9769 100 0.273 Contact Map
2hdoA 1 0.9491 100 0.275 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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