GREMLIN Database
EXUR - Probable HTH-type transcriptional repressor ExuR
UniProt: Q9JMQ1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 333 (319)
Sequences: 36647 (26582)
Seq/√Len: 1488.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
160_K199_S3.3381.00
175_H238_T3.1251.00
10_L42_Q3.1061.00
261_R264_D3.0121.00
194_K198_L2.5951.00
166_A269_I2.5901.00
116_G302_L2.5821.00
175_H267_S2.4311.00
273_D288_K2.4251.00
153_T305_L2.3821.00
164_Q203_Q2.2881.00
30_E34_K2.2501.00
38_E42_Q2.2211.00
224_F257_A2.2081.00
228_E258_K2.1481.00
34_K38_E2.1461.00
88_A91_E2.1261.00
168_E200_A2.0611.00
164_Q199_S2.0601.00
164_Q200_A2.0421.00
171_I204_H2.0381.00
161_E165_E2.0351.00
228_E254_A2.0241.00
297_L300_Q2.0231.00
88_A300_Q1.9831.00
21_A36_I1.9751.00
89_I299_A1.9411.00
160_K195_E1.8971.00
33_K37_L1.8901.00
162_G271_F1.8761.00
22_L40_A1.8741.00
5_K15_H1.8671.00
84_G295_S1.8491.00
173_S328_V1.8331.00
168_E172_Q1.8281.00
163_S167_V1.8261.00
170_F239_A1.8241.00
88_A296_V1.8231.00
255_I266_I1.7801.00
288_K321_E1.7741.00
223_G250_G1.7701.00
232_A258_K1.7661.00
163_S241_F1.7611.00
304_S309_P1.7571.00
10_L39_L1.7551.00
167_V197_Y1.7391.00
297_L316_I1.7251.00
11_A39_L1.7151.00
87_Q292_E1.7121.00
168_E204_H1.7031.00
164_Q168_E1.6861.00
224_F254_A1.6861.00
260_L265_D1.6471.00
290_P293_K1.6441.00
179_A237_P1.6391.00
177_D209_K1.6221.00
227_M251_A1.6191.00
63_G114_Y1.6191.00
180_I243_S1.6111.00
84_G292_E1.6071.00
165_E320_T1.6021.00
242_C251_A1.5911.00
283_R326_D1.5821.00
254_A258_K1.5771.00
261_R265_D1.5741.00
143_L298_G1.5661.00
169_Y173_S1.5501.00
37_L41_E1.5411.00
256_F281_T1.5391.00
161_E164_Q1.5271.00
177_D236_P1.5171.00
169_Y172_Q1.5151.00
171_I200_A1.4971.00
195_E199_S1.4901.00
254_A257_A1.4771.00
214_V229_R1.4641.00
293_K297_L1.4561.00
169_Y324_V1.4471.00
158_N161_E1.4421.00
7_I39_L1.4241.00
21_A40_A1.4221.00
37_L40_A1.4171.00
198_L202_I1.4161.00
60_H115_D1.3991.00
192_Q195_E1.3891.00
303_L307_S1.3871.00
273_D325_R1.3851.00
200_A203_Q1.3811.00
293_K296_V1.3701.00
162_G320_T1.3621.00
88_A299_A1.3601.00
10_L43_L1.3381.00
255_I260_L1.3321.00
224_F253_N1.3271.00
177_D238_T1.3141.00
224_F228_E1.3141.00
167_V171_I1.3081.00
228_E257_A1.3011.00
30_E33_K1.2971.00
5_K9_K1.2881.00
179_A230_L1.2871.00
227_M240_V1.2841.00
209_K212_Y1.2811.00
167_V200_A1.2781.00
167_V196_G1.2681.00
35_K39_L1.2611.00
217_Q222_S1.2511.00
39_L42_Q1.2501.00
6_D9_K1.2471.00
169_Y328_V1.2451.00
228_E232_A1.2421.00
60_H93_Y1.2421.00
227_M255_I1.2371.00
29_K32_T1.2361.00
20_R25_S1.2331.00
160_K164_Q1.2321.00
163_S196_G1.2291.00
165_E168_E1.2271.00
62_I89_I1.2171.00
131_Y135_E1.2171.00
252_M268_V1.2081.00
118_I298_G1.2041.00
98_R105_N1.1991.00
196_G200_A1.1941.00
175_H239_A1.1911.00
7_I11_A1.1911.00
168_E203_Q1.1871.00
39_L43_L1.1871.00
300_Q304_S1.1831.00
176_Q238_T1.1791.00
85_V299_A1.1761.00
89_I95_L1.1711.00
229_R233_L1.1631.00
7_I43_L1.1591.00
197_Y201_L1.1591.00
32_T35_K1.1581.00
4_I15_H1.1531.00
160_K192_Q1.1501.00
292_E296_V1.1421.00
98_R109_V1.1371.00
107_D132_H1.1251.00
200_A204_H1.1251.00
21_A28_I1.1181.00
63_G109_V1.1161.00
64_L85_V1.1151.00
269_I285_S1.1141.00
301_K316_I1.1031.00
226_A229_R1.0961.00
34_K37_L1.0911.00
180_I194_K1.0911.00
85_V118_I1.0891.00
267_S328_V1.0881.00
234_P237_P1.0861.00
181_I251_A1.0821.00
178_I201_L1.0781.00
297_L301_K1.0781.00
61_T96_Y1.0781.00
221_E225_Q1.0761.00
166_A241_F1.0761.00
38_E41_E1.0731.00
295_S299_A1.0631.00
160_K196_G1.0621.00
199_S203_Q1.0621.00
219_D222_S1.0571.00
250_G254_A1.0551.00
240_V251_A1.0551.00
24_N33_K1.0481.00
86_N90_S1.0441.00
4_I18_V1.0411.00
64_L95_L1.0401.00
61_T94_N1.0351.00
173_S324_V1.0331.00
50_N53_S1.0311.00
195_E198_L1.0231.00
48_N54_L1.0211.00
185_E215_K1.0121.00
93_Y303_L1.0081.00
288_K323_M1.0041.00
103_L107_D1.0031.00
172_Q204_H0.9981.00
214_V226_A0.9981.00
177_D235_N0.9971.00
245_D286_T0.9941.00
171_I206_I0.9911.00
191_Q195_E0.9861.00
201_L206_I0.9841.00
161_E319_N0.9831.00
197_Y241_F0.9831.00
242_C248_A0.9801.00
276_F279_Y0.9791.00
173_S267_S0.9791.00
242_C247_M0.9761.00
225_Q229_R0.9731.00
153_T301_K0.9731.00
256_F283_R0.9721.00
222_S225_Q0.9711.00
40_A43_L0.9701.00
296_V300_Q0.9681.00
223_G227_M0.9671.00
297_L318_E0.9621.00
302_L306_I0.9611.00
245_D270_G0.9461.00
178_I239_A0.9451.00
11_A18_V0.9391.00
83_K87_Q0.9381.00
220_M253_N0.9351.00
290_P321_E0.9341.00
154_N315_K0.9311.00
188_K192_Q0.9281.00
252_M262_V0.9261.00
208_I211_E0.9231.00
166_A287_V0.9181.00
176_Q206_I0.9141.00
227_M231_L0.9131.00
48_N51_A0.9111.00
321_E324_V0.9061.00
118_I302_L0.9041.00
24_N37_L0.8991.00
82_I86_N0.8981.00
91_E296_V0.8961.00
167_V201_L0.8941.00
252_M280_I0.8931.00
198_L208_I0.8911.00
47_P52_K0.8851.00
127_N131_Y0.8701.00
186_G191_Q0.8671.00
87_Q296_V0.8671.00
158_N317_L0.8651.00
171_I176_Q0.8631.00
225_Q228_E0.8561.00
21_A37_L0.8551.00
157_S290_P0.8541.00
260_L266_I0.8521.00
240_V266_I0.8501.00
85_V295_S0.8461.00
155_I301_K0.8431.00
153_T314_E0.8391.00
161_E320_T0.8381.00
290_P318_E0.8381.00
77_F291_V0.8351.00
231_L254_A0.8331.00
273_D323_M0.8321.00
62_I118_I0.8321.00
116_G306_I0.8281.00
276_F280_I0.8281.00
301_K304_S0.8281.00
183_G218_Y0.8251.00
156_L317_L0.8241.00
64_L82_I0.8221.00
157_S320_T0.8191.00
156_L315_K0.8171.00
177_D212_Y0.8151.00
81_T143_L0.8131.00
179_A240_V0.8121.00
324_V328_V0.8101.00
13_V36_I0.8041.00
159_D193_R0.8031.00
299_A303_L0.7991.00
199_S202_I0.7971.00
49_V52_K0.7961.00
61_T112_M0.7951.00
194_K213_S0.7951.00
255_I268_V0.7931.00
245_D273_D0.7901.00
222_S226_A0.7871.00
51_A54_L0.7861.00
110_T136_K0.7861.00
169_Y322_F0.7831.00
31_H34_K0.7821.00
157_S289_R0.7821.00
170_F269_I0.7811.00
227_M254_A0.7741.00
236_P260_L0.7741.00
80_D292_E0.7721.00
182_E194_K0.7711.00
16_T20_R0.7701.00
87_Q91_E0.7701.00
192_Q196_G0.7661.00
231_L258_K0.7641.00
59_S115_D0.7631.00
85_V95_L0.7631.00
132_H135_E0.7611.00
84_G296_V0.7601.00
58_K115_D0.7601.00
181_I242_C0.7591.00
158_N319_N0.7581.00
83_K86_N0.7581.00
201_L208_I0.7571.00
146_D315_K0.7561.00
104_K107_D0.7521.00
253_N256_F0.7511.00
216_G247_M0.7511.00
31_H35_K0.7511.00
84_G88_A0.7481.00
285_S328_V0.7461.00
227_M230_L0.7451.00
17_T20_R0.7451.00
20_R27_Y0.7441.00
180_I241_F0.7421.00
126_D129_F0.7331.00
82_I97_V0.7311.00
270_G286_T0.7291.00
134_R152_I0.7281.00
212_Y233_L0.7261.00
20_R26_P0.7251.00
248_A270_G0.7171.00
165_E287_V0.7141.00
249_I280_I0.7071.00
46_T111_P0.7051.00
67_T78_F0.7031.00
86_N99_G0.6991.00
86_N95_L0.6941.00
21_A33_K0.6931.00
273_D277_S0.6911.00
164_Q196_G0.6901.00
107_D111_P0.6901.00
255_I262_V0.6891.00
63_G117_I0.6881.00
131_Y134_R0.6881.00
253_N283_R0.6861.00
169_Y285_S0.6851.00
216_G222_S0.6821.00
229_R232_A0.6811.00
62_I299_A0.6811.00
96_Y114_Y0.6801.00
142_V147_I0.6761.00
34_K41_E0.6741.00
116_G141_V0.6741.00
241_F269_I0.6731.00
272_D289_R0.6721.00
245_D248_A0.6721.00
214_V230_L0.6701.00
140_L152_I0.6701.00
304_S308_E0.6691.00
133_I140_L0.6681.00
277_S280_I0.6671.00
253_N257_A0.6661.00
58_K307_S0.6651.00
214_V233_L0.6621.00
116_G298_G0.6601.00
134_R140_L0.6601.00
190_S218_Y0.6581.00
118_I143_L0.6531.00
141_V302_L0.6521.00
165_E169_Y0.6511.00
129_F132_H0.6501.00
206_I210_H0.6491.00
194_K215_K0.6461.00
96_Y112_M0.6451.00
110_T138_I0.6451.00
13_V32_T0.6421.00
233_L237_P0.6391.00
178_I238_T0.6391.00
171_I201_L0.6381.00
65_F105_N0.6381.00
170_F241_F0.6371.00
180_I197_Y0.6361.00
252_M256_F0.6311.00
238_T267_S0.6311.00
5_K55_A0.6301.00
80_D291_V0.6261.00
233_L236_P0.6261.00
218_Y243_S0.6261.00
18_V40_A0.6261.00
142_V152_I0.6231.00
223_G226_A0.6221.00
198_L213_S0.6201.00
141_V305_L0.6201.00
144_N159_D0.6201.00
134_R151_T0.6191.00
283_R325_R0.6181.00
117_I138_I0.6141.00
27_Y32_T0.6141.00
244_N247_M0.6091.00
35_K38_E0.6071.00
103_L129_F0.6071.00
183_G190_S0.6061.00
41_E44_N0.6051.00
106_Y117_I0.6031.00
84_G291_V0.5981.00
83_K292_E0.5981.00
227_M250_G0.5971.00
141_V155_I0.5961.00
159_D192_Q0.5961.00
182_E215_K0.5951.00
62_I306_I0.5941.00
144_N189_S0.5921.00
7_I18_V0.5911.00
107_D110_T0.5891.00
46_T107_D0.5891.00
220_M250_G0.5881.00
93_Y306_I0.5861.00
104_K108_S0.5851.00
18_V21_A0.5851.00
164_Q167_V0.5841.00
20_R28_I0.5791.00
77_F81_T0.5791.00
253_N281_T0.5771.00
244_N272_D0.5761.00
249_I274_I0.5761.00
142_V154_N0.5751.00
89_I303_L0.5741.00
81_T291_V0.5731.00
46_T50_N0.5721.00
301_K305_L0.5671.00
62_I116_G0.5671.00
255_I258_K0.5661.00
198_L210_H0.5661.00
308_E311_T0.5651.00
197_Y208_I0.5621.00
110_T113_R0.5601.00
141_V298_G0.5591.00
285_S322_F0.5591.00
280_I283_R0.5581.00
146_D154_N0.5581.00
218_Y247_M0.5571.00
241_F271_F0.5571.00
93_Y115_D0.5541.00
179_A212_Y0.5541.00
253_N278_Q0.5531.00
221_E224_F0.5531.00
178_I197_Y0.5531.00
59_S94_N0.5531.00
242_C270_G0.5521.00
105_N108_S0.5501.00
52_K56_M0.5491.00
287_V320_T0.5491.00
190_S243_S0.5461.00
108_S111_P0.5451.00
166_A239_A0.5441.00
141_V301_K0.5441.00
128_S131_Y0.5441.00
256_F261_R0.5411.00
182_E213_S0.5411.00
109_V114_Y0.5401.00
62_I93_Y0.5401.00
224_F250_G0.5401.00
278_Q283_R0.5381.00
206_I209_K0.5371.00
305_L308_E0.5371.00
83_K101_D0.5361.00
85_V89_I0.5361.00
169_Y269_I0.5341.00
294_I318_E0.5331.00
25_S28_I0.5311.00
89_I93_Y0.5301.00
304_S314_E0.5301.00
226_A230_L0.5291.00
177_D237_P0.5271.00
269_I328_V0.5271.00
18_V36_I0.5261.00
13_V18_V0.5261.00
98_R108_S0.5251.00
125_I129_F0.5241.00
245_D274_I0.5241.00
297_L304_S0.5241.00
251_A255_I0.5231.00
61_T115_D0.5211.00
28_I33_K0.5211.00
88_A303_L0.5211.00
271_F289_R0.5211.00
292_E295_S0.5201.00
155_I297_L0.5181.00
78_F120_M0.5181.00
128_S132_H0.5171.00
132_H136_K0.5161.00
16_T25_S0.5141.00
6_D10_L0.5141.00
260_L263_P0.5131.00
262_V265_D0.5121.00
53_S56_M0.5111.00
80_D275_G0.5101.00
317_L320_T0.5041.00
76_S246_D0.5041.00
224_F227_M0.5021.00
157_S162_G0.5021.00
181_I226_A0.5021.00
237_P240_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dbiA 2 0.8138 100 0.087 Contact Map
2hsgA 1 0.964 100 0.092 Contact Map
2o20A 2 0.8078 100 0.098 Contact Map
1qpzA 2 0.982 100 0.101 Contact Map
4o5aA 2 0.7898 100 0.105 Contact Map
3bilA 2 0.7508 100 0.106 Contact Map
3ctpA 2 0.7778 100 0.107 Contact Map
3e3mA 2 0.7868 100 0.11 Contact Map
3h5tA 2 0.9339 100 0.113 Contact Map
3kjxA 2 0.976 100 0.113 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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