TEPA - BACSU - GREMLIN Contacts

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TEPA - Translocation-enhancing protein TepA

UniProt:	Q99171	Sequences: MDHRMENTEEERPEKNDAKDSIMNKIQQLGETTLPQLPQDTNIHCLTIIGQIEGHVQLPPQNKTTKYEHVIPQIVAIEQNPKIEGLLIILNTVGGDVEAGLAIAEMLASLSKPTVSIVLGGGHSIGVPIAVSCDYSYIAETATMTIHPVRLTGLVIGVPQTFEYLDKMQERVVKFVTSHSNITEEKFKELMFSKGNLTRDIGTNVVGKDAVKYGLIDHAGGVGQAINKLNELIDEARKEEGRMIQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	245 (222)
Sequences:	438 (235)
Seq/√Len:	15.8

BACSU - TEPA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
176_V	187_F	5.649	1.00
186_K	213_Y	5.252	1.00
135_Y	228_K	4.070	1.00
116_S	133_C	3.934	1.00
77_I	86_L	3.816	1.00
218_H	224_Q	3.667	1.00
186_K	189_E	3.497	0.99
98_E	121_G	3.104	0.99
109_S	221_G	3.040	0.98
208_K	212_K	2.888	0.98
46_L	70_V	2.865	0.98
161_T	165_L	2.816	0.97
88_I	133_C	2.805	0.97
42_N	84_E	2.674	0.96
88_I	107_L	2.634	0.96
228_K	232_L	2.590	0.96
131_V	179_H	2.422	0.94
106_M	222_V	2.370	0.93
228_K	231_E	2.253	0.91
209_D	212_K	2.170	0.89
103_I	121_G	2.150	0.89
165_L	204_N	2.128	0.88
71_I	89_I	2.026	0.85
151_L	165_L	2.024	0.85
98_E	103_I	1.978	0.84
84_E	237_R	1.972	0.84
173_V	187_F	1.892	0.81
181_N	217_D	1.885	0.81
174_K	178_S	1.809	0.78
90_L	121_G	1.740	0.75
49_I	151_L	1.710	0.74
158_V	201_I	1.652	0.71
132_S	139_A	1.628	0.70
166_D	188_K	1.590	0.68
90_L	98_E	1.579	0.67
129_I	172_V	1.555	0.66
122_G	142_A	1.553	0.66
165_L	172_V	1.549	0.66
129_I	140_E	1.513	0.64
146_I	189_E	1.470	0.62
198_T	201_I	1.432	0.60
135_Y	218_H	1.423	0.59
93_V	142_A	1.419	0.59
137_Y	216_I	1.405	0.58
174_K	184_E	1.400	0.58
75_V	89_I	1.393	0.57
218_H	228_K	1.390	0.57
151_L	161_T	1.379	0.57
71_I	166_D	1.374	0.56
111_S	134_D	1.367	0.56
162_F	198_T	1.356	0.55
71_I	106_M	1.324	0.53
88_I	158_V	1.320	0.53
183_T	186_K	1.320	0.53
135_Y	156_I	1.295	0.52
23_M	29_L	1.289	0.51
59_P	62_N	1.284	0.51
155_V	164_Y	1.281	0.51
111_S	223_G	1.278	0.51
114_T	133_C	1.266	0.50
173_V	188_K	1.264	0.50
89_I	187_F	1.259	0.50
40_D	82_K	1.259	0.50
119_L	198_T	1.256	0.50
79_Q	86_L	1.255	0.49
115_V	228_K	1.253	0.49
182_I	190_L	1.245	0.49
98_E	119_L	1.243	0.49
180_S	215_L	1.236	0.48
162_F	204_N	1.234	0.48
51_Q	122_G	1.233	0.48
90_L	99_A	1.225	0.48
20_D	235_E	1.222	0.48
149_V	168_M	1.219	0.47
122_G	149_V	1.212	0.47
26_I	30_G	1.207	0.47
45_C	79_Q	1.164	0.44
143_T	221_G	1.159	0.44
108_A	131_V	1.156	0.44
129_I	165_L	1.145	0.43
73_Q	76_A	1.143	0.43
182_I	187_F	1.141	0.43
145_T	198_T	1.133	0.42
99_A	121_G	1.120	0.42
198_T	206_V	1.119	0.42
28_Q	40_D	1.111	0.41
205_V	213_Y	1.108	0.41
42_N	237_R	1.097	0.40
98_E	168_M	1.090	0.40
98_E	201_I	1.074	0.39
115_V	232_L	1.072	0.39
151_L	172_V	1.071	0.39
151_L	164_Y	1.063	0.39
154_L	159_P	1.038	0.37
45_C	75_V	1.030	0.37
30_G	69_H	1.014	0.36
75_V	156_I	1.012	0.36
31_E	131_V	1.010	0.36
49_I	165_L	1.004	0.35
165_L	179_H	1.000	0.35
158_V	196_N	0.995	0.35
18_A	21_S	0.994	0.35
59_P	93_V	0.992	0.35
31_E	184_E	0.990	0.35
174_K	188_K	0.989	0.35
127_V	142_A	0.981	0.34
83_I	97_V	0.981	0.34
170_E	184_E	0.966	0.33
62_N	76_A	0.964	0.33
97_V	152_T	0.959	0.33
45_C	51_Q	0.947	0.32
93_V	127_V	0.947	0.32
165_L	192_F	0.942	0.32
121_G	168_M	0.938	0.32
155_V	168_M	0.933	0.32
139_A	163_E	0.932	0.32
89_I	222_V	0.927	0.31
110_L	149_V	0.920	0.31
42_N	230_N	0.920	0.31
231_E	235_E	0.919	0.31
135_Y	232_L	0.919	0.31
61_Q	73_Q	0.913	0.31
46_L	234_D	0.903	0.30
107_L	133_C	0.899	0.30
168_M	196_N	0.899	0.30
57_Q	196_N	0.897	0.30
98_E	167_K	0.894	0.30
75_V	172_V	0.894	0.30
165_L	199_R	0.891	0.30
51_Q	145_T	0.890	0.30
108_A	179_H	0.888	0.30
162_F	213_Y	0.886	0.29
33_T	36_Q	0.884	0.29
99_A	168_M	0.883	0.29
44_H	77_I	0.883	0.29
44_H	176_V	0.881	0.29
27_Q	227_N	0.876	0.29
184_E	188_K	0.871	0.29
121_G	201_I	0.870	0.29
51_Q	193_S	0.869	0.29
22_I	80_N	0.863	0.28
119_L	151_L	0.858	0.28
97_V	215_L	0.855	0.28
192_F	199_R	0.853	0.28
117_I	194_K	0.850	0.28
136_S	216_I	0.849	0.28
21_S	70_V	0.846	0.28
60_P	93_V	0.845	0.28
195_G	199_R	0.841	0.27
62_N	114_T	0.839	0.27
49_I	104_A	0.839	0.27
103_I	209_D	0.831	0.27
49_I	143_T	0.824	0.27
83_I	187_F	0.822	0.27
161_T	166_D	0.811	0.26
173_V	191_M	0.804	0.26
59_P	122_G	0.804	0.26
32_T	194_K	0.803	0.26
35_P	84_E	0.802	0.26
158_V	167_K	0.796	0.25
73_Q	203_T	0.791	0.25
227_N	231_E	0.781	0.25
142_A	180_S	0.781	0.25
187_F	222_V	0.776	0.24
154_L	190_L	0.773	0.24
40_D	83_I	0.770	0.24
104_A	232_L	0.769	0.24
189_E	193_S	0.769	0.24
25_K	149_V	0.768	0.24
47_T	183_T	0.765	0.24
114_T	119_L	0.759	0.24
45_C	56_V	0.750	0.23
84_E	234_D	0.750	0.23
77_I	116_S	0.749	0.23
57_Q	194_K	0.749	0.23
129_I	151_L	0.748	0.23
140_E	172_V	0.748	0.23
71_I	154_L	0.735	0.23
129_I	205_V	0.735	0.23
37_L	79_Q	0.731	0.23
51_Q	56_V	0.729	0.23
119_L	145_T	0.728	0.22
198_T	204_N	0.723	0.22
73_Q	99_A	0.723	0.22
58_L	163_E	0.722	0.22
152_T	158_V	0.718	0.22
114_T	160_Q	0.717	0.22
51_Q	62_N	0.715	0.22
168_M	206_V	0.711	0.22
41_T	84_E	0.710	0.22
90_L	189_E	0.709	0.22
201_I	209_D	0.709	0.22
46_L	86_L	0.708	0.22
18_A	22_I	0.706	0.22
26_I	46_L	0.699	0.21
58_L	64_T	0.697	0.21
76_A	90_L	0.697	0.21
181_N	236_A	0.692	0.21
116_S	205_V	0.687	0.21
221_G	227_N	0.687	0.21
198_T	209_D	0.680	0.21
61_Q	162_F	0.678	0.21
80_N	97_V	0.678	0.21
156_I	199_R	0.672	0.20
218_H	221_G	0.670	0.20
174_K	183_T	0.664	0.20
14_E	19_K	0.663	0.20
16_N	132_S	0.660	0.20
71_I	74_I	0.659	0.20
43_I	73_Q	0.659	0.20
49_I	152_T	0.658	0.20
23_M	27_Q	0.658	0.20
75_V	199_R	0.657	0.20
73_Q	139_A	0.657	0.20
141_T	215_L	0.656	0.20
59_P	195_G	0.655	0.20
115_V	135_Y	0.653	0.20
159_P	192_F	0.651	0.20
110_L	222_V	0.648	0.19
164_Y	206_V	0.647	0.19
26_I	29_L	0.647	0.19
24_N	28_Q	0.640	0.19
70_V	232_L	0.634	0.19
166_D	204_N	0.633	0.19
152_T	155_V	0.630	0.19
184_E	230_N	0.628	0.19
35_P	81_P	0.628	0.19
23_M	183_T	0.627	0.19
135_Y	146_I	0.626	0.19
41_T	172_V	0.626	0.19
56_V	149_V	0.624	0.19
136_S	139_A	0.623	0.19
111_S	236_A	0.623	0.19
201_I	206_V	0.621	0.18
107_L	182_I	0.620	0.18
182_I	213_Y	0.617	0.18
139_A	201_I	0.617	0.18
127_V	197_L	0.616	0.18
21_S	141_T	0.614	0.18
121_G	167_K	0.613	0.18
44_H	145_T	0.612	0.18
134_D	228_K	0.611	0.18
129_I	199_R	0.608	0.18
119_L	195_G	0.608	0.18
76_A	99_A	0.606	0.18
162_F	237_R	0.601	0.18
159_P	226_I	0.600	0.18
47_T	173_V	0.600	0.18
71_I	75_V	0.599	0.18
156_I	219_A	0.599	0.18
167_K	196_N	0.597	0.18
58_L	76_A	0.596	0.18
52_I	104_A	0.595	0.18
52_I	108_A	0.593	0.18
45_C	131_V	0.593	0.18
161_T	204_N	0.590	0.17
103_I	214_G	0.589	0.17
19_K	22_I	0.588	0.17
113_P	160_Q	0.588	0.17
58_L	122_G	0.586	0.17
112_K	156_I	0.586	0.17
116_S	223_G	0.585	0.17
44_H	75_V	0.583	0.17
15_K	18_A	0.582	0.17
157_G	168_M	0.581	0.17
107_L	140_E	0.578	0.17
178_S	209_D	0.578	0.17
199_R	206_V	0.576	0.17
183_T	235_E	0.576	0.17
99_A	122_G	0.575	0.17
179_H	199_R	0.572	0.17
161_T	176_V	0.569	0.17
108_A	170_E	0.567	0.17
110_L	154_L	0.566	0.17
184_E	226_I	0.564	0.17
60_P	146_I	0.563	0.17
20_D	23_M	0.562	0.17
197_L	222_V	0.560	0.16
77_I	157_G	0.559	0.16
164_Y	182_I	0.557	0.16
46_L	182_I	0.557	0.16
48_I	236_A	0.557	0.16
144_M	156_I	0.556	0.16
71_I	133_C	0.553	0.16
163_E	201_I	0.553	0.16
41_T	230_N	0.552	0.16
149_V	192_F	0.551	0.16
27_Q	212_K	0.549	0.16
61_Q	104_A	0.549	0.16
21_S	237_R	0.548	0.16
28_Q	205_V	0.548	0.16
64_T	76_A	0.545	0.16
173_V	183_T	0.544	0.16
42_N	152_T	0.543	0.16
43_I	141_T	0.543	0.16
15_K	21_S	0.542	0.16
22_I	32_T	0.542	0.16
51_Q	73_Q	0.542	0.16
51_Q	199_R	0.542	0.16
81_P	232_L	0.540	0.16
59_P	145_T	0.539	0.16
16_N	20_D	0.538	0.16
48_I	227_N	0.538	0.16
170_E	173_V	0.536	0.16
88_I	121_G	0.534	0.16
177_T	213_Y	0.534	0.16
133_C	149_V	0.531	0.16
79_Q	84_E	0.531	0.16
40_D	70_V	0.530	0.16
111_S	143_T	0.530	0.16
166_D	226_I	0.528	0.15
64_T	93_V	0.528	0.15
163_E	172_V	0.527	0.15
83_I	191_M	0.527	0.15
139_A	198_T	0.524	0.15
58_L	116_S	0.523	0.15
88_I	98_E	0.519	0.15
181_N	184_E	0.518	0.15
106_M	133_C	0.517	0.15
78_E	110_L	0.517	0.15
14_E	17_D	0.513	0.15
89_I	108_A	0.513	0.15
177_T	186_K	0.512	0.15
90_L	103_I	0.511	0.15
62_N	145_T	0.511	0.15
61_Q	75_V	0.509	0.15
32_T	84_E	0.508	0.15
219_A	236_A	0.505	0.15
183_T	236_A	0.503	0.15
157_G	221_G	0.502	0.15
190_L	221_G	0.502	0.15
178_S	219_A	0.501	0.15
75_V	163_E	0.500	0.15

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3bf0A	3	0.8163	99.8	0.835	Contact Map
4jcqA	5	0.6816	99.7	0.844	Contact Map
2f6iA	5	0.7347	99.7	0.846	Contact Map
3qwdA	5	0.7837	99.7	0.848	Contact Map
2cbyA	3	0.6857	99.7	0.851	Contact Map
3p2lA	4	0.7633	99.7	0.852	Contact Map
4u0gA	4	0.7755	99.7	0.852	Contact Map
1yg6A	4	0.7714	99.7	0.853	Contact Map
4gm2A	3	0.6816	99.7	0.856	Contact Map
1y7oA	5	0.7184	99.6	0.857	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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