GREMLIN Database
TEPA - Translocation-enhancing protein TepA
UniProt: Q99171 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 245 (222)
Sequences: 438 (235)
Seq/√Len: 15.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
176_V187_F5.6491.00
186_K213_Y5.2521.00
135_Y228_K4.0701.00
116_S133_C3.9341.00
77_I86_L3.8161.00
218_H224_Q3.6671.00
186_K189_E3.4970.99
98_E121_G3.1040.99
109_S221_G3.0400.98
208_K212_K2.8880.98
46_L70_V2.8650.98
161_T165_L2.8160.97
88_I133_C2.8050.97
42_N84_E2.6740.96
88_I107_L2.6340.96
228_K232_L2.5900.96
131_V179_H2.4220.94
106_M222_V2.3700.93
228_K231_E2.2530.91
209_D212_K2.1700.89
103_I121_G2.1500.89
165_L204_N2.1280.88
71_I89_I2.0260.85
151_L165_L2.0240.85
98_E103_I1.9780.84
84_E237_R1.9720.84
173_V187_F1.8920.81
181_N217_D1.8850.81
174_K178_S1.8090.78
90_L121_G1.7400.75
49_I151_L1.7100.74
158_V201_I1.6520.71
132_S139_A1.6280.70
166_D188_K1.5900.68
90_L98_E1.5790.67
129_I172_V1.5550.66
122_G142_A1.5530.66
165_L172_V1.5490.66
129_I140_E1.5130.64
146_I189_E1.4700.62
198_T201_I1.4320.60
135_Y218_H1.4230.59
93_V142_A1.4190.59
137_Y216_I1.4050.58
174_K184_E1.4000.58
75_V89_I1.3930.57
218_H228_K1.3900.57
151_L161_T1.3790.57
71_I166_D1.3740.56
111_S134_D1.3670.56
162_F198_T1.3560.55
71_I106_M1.3240.53
88_I158_V1.3200.53
183_T186_K1.3200.53
135_Y156_I1.2950.52
23_M29_L1.2890.51
59_P62_N1.2840.51
155_V164_Y1.2810.51
111_S223_G1.2780.51
114_T133_C1.2660.50
173_V188_K1.2640.50
89_I187_F1.2590.50
40_D82_K1.2590.50
119_L198_T1.2560.50
79_Q86_L1.2550.49
115_V228_K1.2530.49
182_I190_L1.2450.49
98_E119_L1.2430.49
180_S215_L1.2360.48
162_F204_N1.2340.48
51_Q122_G1.2330.48
90_L99_A1.2250.48
20_D235_E1.2220.48
149_V168_M1.2190.47
122_G149_V1.2120.47
26_I30_G1.2070.47
45_C79_Q1.1640.44
143_T221_G1.1590.44
108_A131_V1.1560.44
129_I165_L1.1450.43
73_Q76_A1.1430.43
182_I187_F1.1410.43
145_T198_T1.1330.42
99_A121_G1.1200.42
198_T206_V1.1190.42
28_Q40_D1.1110.41
205_V213_Y1.1080.41
42_N237_R1.0970.40
98_E168_M1.0900.40
98_E201_I1.0740.39
115_V232_L1.0720.39
151_L172_V1.0710.39
151_L164_Y1.0630.39
154_L159_P1.0380.37
45_C75_V1.0300.37
30_G69_H1.0140.36
75_V156_I1.0120.36
31_E131_V1.0100.36
49_I165_L1.0040.35
165_L179_H1.0000.35
158_V196_N0.9950.35
18_A21_S0.9940.35
59_P93_V0.9920.35
31_E184_E0.9900.35
174_K188_K0.9890.35
127_V142_A0.9810.34
83_I97_V0.9810.34
170_E184_E0.9660.33
62_N76_A0.9640.33
97_V152_T0.9590.33
45_C51_Q0.9470.32
93_V127_V0.9470.32
165_L192_F0.9420.32
121_G168_M0.9380.32
155_V168_M0.9330.32
139_A163_E0.9320.32
89_I222_V0.9270.31
110_L149_V0.9200.31
42_N230_N0.9200.31
231_E235_E0.9190.31
135_Y232_L0.9190.31
61_Q73_Q0.9130.31
46_L234_D0.9030.30
107_L133_C0.8990.30
168_M196_N0.8990.30
57_Q196_N0.8970.30
98_E167_K0.8940.30
75_V172_V0.8940.30
165_L199_R0.8910.30
51_Q145_T0.8900.30
108_A179_H0.8880.30
162_F213_Y0.8860.29
33_T36_Q0.8840.29
99_A168_M0.8830.29
44_H77_I0.8830.29
44_H176_V0.8810.29
27_Q227_N0.8760.29
184_E188_K0.8710.29
121_G201_I0.8700.29
51_Q193_S0.8690.29
22_I80_N0.8630.28
119_L151_L0.8580.28
97_V215_L0.8550.28
192_F199_R0.8530.28
117_I194_K0.8500.28
136_S216_I0.8490.28
21_S70_V0.8460.28
60_P93_V0.8450.28
195_G199_R0.8410.27
62_N114_T0.8390.27
49_I104_A0.8390.27
103_I209_D0.8310.27
49_I143_T0.8240.27
83_I187_F0.8220.27
161_T166_D0.8110.26
173_V191_M0.8040.26
59_P122_G0.8040.26
32_T194_K0.8030.26
35_P84_E0.8020.26
158_V167_K0.7960.25
73_Q203_T0.7910.25
227_N231_E0.7810.25
142_A180_S0.7810.25
187_F222_V0.7760.24
154_L190_L0.7730.24
40_D83_I0.7700.24
104_A232_L0.7690.24
189_E193_S0.7690.24
25_K149_V0.7680.24
47_T183_T0.7650.24
114_T119_L0.7590.24
45_C56_V0.7500.23
84_E234_D0.7500.23
77_I116_S0.7490.23
57_Q194_K0.7490.23
129_I151_L0.7480.23
140_E172_V0.7480.23
71_I154_L0.7350.23
129_I205_V0.7350.23
37_L79_Q0.7310.23
51_Q56_V0.7290.23
119_L145_T0.7280.22
198_T204_N0.7230.22
73_Q99_A0.7230.22
58_L163_E0.7220.22
152_T158_V0.7180.22
114_T160_Q0.7170.22
51_Q62_N0.7150.22
168_M206_V0.7110.22
41_T84_E0.7100.22
90_L189_E0.7090.22
201_I209_D0.7090.22
46_L86_L0.7080.22
18_A22_I0.7060.22
26_I46_L0.6990.21
58_L64_T0.6970.21
76_A90_L0.6970.21
181_N236_A0.6920.21
116_S205_V0.6870.21
221_G227_N0.6870.21
198_T209_D0.6800.21
61_Q162_F0.6780.21
80_N97_V0.6780.21
156_I199_R0.6720.20
218_H221_G0.6700.20
174_K183_T0.6640.20
14_E19_K0.6630.20
16_N132_S0.6600.20
71_I74_I0.6590.20
43_I73_Q0.6590.20
49_I152_T0.6580.20
23_M27_Q0.6580.20
75_V199_R0.6570.20
73_Q139_A0.6570.20
141_T215_L0.6560.20
59_P195_G0.6550.20
115_V135_Y0.6530.20
159_P192_F0.6510.20
110_L222_V0.6480.19
164_Y206_V0.6470.19
26_I29_L0.6470.19
24_N28_Q0.6400.19
70_V232_L0.6340.19
166_D204_N0.6330.19
152_T155_V0.6300.19
184_E230_N0.6280.19
35_P81_P0.6280.19
23_M183_T0.6270.19
135_Y146_I0.6260.19
41_T172_V0.6260.19
56_V149_V0.6240.19
136_S139_A0.6230.19
111_S236_A0.6230.19
201_I206_V0.6210.18
107_L182_I0.6200.18
182_I213_Y0.6170.18
139_A201_I0.6170.18
127_V197_L0.6160.18
21_S141_T0.6140.18
121_G167_K0.6130.18
44_H145_T0.6120.18
134_D228_K0.6110.18
129_I199_R0.6080.18
119_L195_G0.6080.18
76_A99_A0.6060.18
162_F237_R0.6010.18
159_P226_I0.6000.18
47_T173_V0.6000.18
71_I75_V0.5990.18
156_I219_A0.5990.18
167_K196_N0.5970.18
58_L76_A0.5960.18
52_I104_A0.5950.18
52_I108_A0.5930.18
45_C131_V0.5930.18
161_T204_N0.5900.17
103_I214_G0.5890.17
19_K22_I0.5880.17
113_P160_Q0.5880.17
58_L122_G0.5860.17
112_K156_I0.5860.17
116_S223_G0.5850.17
44_H75_V0.5830.17
15_K18_A0.5820.17
157_G168_M0.5810.17
107_L140_E0.5780.17
178_S209_D0.5780.17
199_R206_V0.5760.17
183_T235_E0.5760.17
99_A122_G0.5750.17
179_H199_R0.5720.17
161_T176_V0.5690.17
108_A170_E0.5670.17
110_L154_L0.5660.17
184_E226_I0.5640.17
60_P146_I0.5630.17
20_D23_M0.5620.17
197_L222_V0.5600.16
77_I157_G0.5590.16
164_Y182_I0.5570.16
46_L182_I0.5570.16
48_I236_A0.5570.16
144_M156_I0.5560.16
71_I133_C0.5530.16
163_E201_I0.5530.16
41_T230_N0.5520.16
149_V192_F0.5510.16
27_Q212_K0.5490.16
61_Q104_A0.5490.16
21_S237_R0.5480.16
28_Q205_V0.5480.16
64_T76_A0.5450.16
173_V183_T0.5440.16
42_N152_T0.5430.16
43_I141_T0.5430.16
15_K21_S0.5420.16
22_I32_T0.5420.16
51_Q73_Q0.5420.16
51_Q199_R0.5420.16
81_P232_L0.5400.16
59_P145_T0.5390.16
16_N20_D0.5380.16
48_I227_N0.5380.16
170_E173_V0.5360.16
88_I121_G0.5340.16
177_T213_Y0.5340.16
133_C149_V0.5310.16
79_Q84_E0.5310.16
40_D70_V0.5300.16
111_S143_T0.5300.16
166_D226_I0.5280.15
64_T93_V0.5280.15
163_E172_V0.5270.15
83_I191_M0.5270.15
139_A198_T0.5240.15
58_L116_S0.5230.15
88_I98_E0.5190.15
181_N184_E0.5180.15
106_M133_C0.5170.15
78_E110_L0.5170.15
14_E17_D0.5130.15
89_I108_A0.5130.15
177_T186_K0.5120.15
90_L103_I0.5110.15
62_N145_T0.5110.15
61_Q75_V0.5090.15
32_T84_E0.5080.15
219_A236_A0.5050.15
183_T236_A0.5030.15
157_G221_G0.5020.15
190_L221_G0.5020.15
178_S219_A0.5010.15
75_V163_E0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bf0A 3 0.8163 99.8 0.835 Contact Map
4jcqA 5 0.6816 99.7 0.844 Contact Map
2f6iA 5 0.7347 99.7 0.846 Contact Map
3qwdA 5 0.7837 99.7 0.848 Contact Map
2cbyA 3 0.6857 99.7 0.851 Contact Map
3p2lA 4 0.7633 99.7 0.852 Contact Map
4u0gA 4 0.7755 99.7 0.852 Contact Map
1yg6A 4 0.7714 99.7 0.853 Contact Map
4gm2A 3 0.6816 99.7 0.856 Contact Map
1y7oA 5 0.7184 99.6 0.857 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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