GREMLIN Database
YWTF - Putative transcriptional regulator YwtF
UniProt: Q7WY78 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 322 (288)
Sequences: 6277 (4725)
Seq/√Len: 278.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
178_K206_T5.6651.00
116_I132_F3.9101.00
178_K204_T3.7541.00
208_D211_E3.6581.00
158_Y265_N3.4221.00
100_V113_M3.2221.00
216_V234_V3.0161.00
222_D229_Q2.9911.00
180_T204_T2.9151.00
184_D201_Q2.8341.00
75_S103_T2.7641.00
184_D202_K2.7001.00
37_A41_V2.5931.00
101_L156_V2.5851.00
102_V113_M2.5241.00
79_L144_T2.3821.00
99_N132_F2.3751.00
34_S38_Y2.2981.00
206_T241_K2.2691.00
201_Q205_H2.1261.00
305_N308_K2.1121.00
123_N129_Y2.0811.00
101_L154_I2.0711.00
79_L99_N2.0681.00
215_Y230_R2.0671.00
116_I148_V2.0621.00
105_N108_E2.0351.00
130_D134_H2.0201.00
207_L211_E2.0151.00
120_A304_L1.9901.00
192_K199_V1.9841.00
267_S270_D1.9071.00
77_L148_V1.9071.00
168_E210_E1.8851.00
181_V205_H1.8601.00
167_F216_V1.8301.00
99_N144_T1.8161.00
172_N209_G1.8081.00
173_E257_T1.7611.00
78_L102_V1.7501.00
174_L238_I1.7411.00
38_Y42_K1.6901.00
167_F213_L1.6831.00
177_V234_V1.6601.00
139_G143_L1.6151.00
184_D199_V1.6001.00
73_S106_R1.5991.00
149_E155_P1.5891.00
123_N150_E1.5721.00
33_G37_A1.5551.00
74_F104_F1.5471.00
121_Y129_Y1.5371.00
124_I135_A1.5351.00
96_S144_T1.5161.00
20_V24_L1.5071.00
17_W20_V1.4871.00
195_K220_K1.4831.00
218_T221_A1.4821.00
132_F148_V1.4771.00
309_L313_K1.4671.00
143_L147_T1.4441.00
35_V39_A1.4321.00
124_I130_D1.4191.00
145_V265_N1.4161.00
23_G27_F1.4021.00
145_V149_E1.3871.00
130_D138_Y1.3861.00
135_A139_G1.3841.00
121_Y301_Y1.3761.00
179_V207_L1.3601.00
222_D226_L1.3601.00
182_K233_E1.3551.00
169_D261_N1.3441.00
310_Q314_K1.3431.00
114_L316_L1.3421.00
308_K311_E1.3391.00
215_Y233_E1.3381.00
73_S103_T1.3221.00
180_T205_H1.3171.00
18_V21_V1.3081.00
125_P143_L1.3001.00
22_A26_A1.2981.00
135_A144_T1.2891.00
112_K285_E1.2781.00
27_F31_A1.2721.00
291_G302_F1.2701.00
311_E315_E1.2551.00
33_G36_G1.2451.00
113_M286_S1.2351.00
181_V201_Q1.2321.00
177_V212_A1.2271.00
225_L302_F1.2191.00
200_L214_A1.2181.00
276_P279_T1.2131.00
171_V234_V1.2111.00
185_K200_L1.2041.00
131_K301_Y1.2031.00
121_Y131_K1.1961.00
169_D260_Q1.1861.00
174_L242_S1.1791.00
16_K20_V1.1781.00
181_V200_L1.1781.00
19_K23_G1.1751.00
272_I276_P1.1691.00
122_V147_T1.1641.00
17_W21_V1.1621.00
177_V237_A1.1561.00
96_S99_N1.1561.00
31_A35_V1.1471.00
228_G232_M1.1421.00
306_Q310_Q1.1351.00
179_V234_V1.1291.00
196_G214_A1.1271.00
124_I147_T1.1251.00
304_L309_L1.1221.00
176_G209_G1.1201.00
226_L229_Q1.1191.00
79_L141_V1.1161.00
151_M309_L1.1021.00
179_V215_Y1.0961.00
272_I275_F1.0931.00
73_S105_N1.0921.00
296_P299_V1.0881.00
16_K19_K1.0871.00
15_K19_K1.0841.00
211_E214_A1.0811.00
121_Y299_V1.0811.00
74_F158_Y1.0801.00
164_F213_L1.0691.00
122_V132_F1.0691.00
110_T285_E1.0551.00
83_A163_N1.0481.00
185_K218_T1.0441.00
101_L152_L1.0431.00
237_A241_K1.0411.00
134_H137_A1.0401.00
32_A36_G1.0401.00
124_I143_L1.0401.00
237_A240_D1.0401.00
96_S135_A1.0321.00
76_V104_F1.0181.00
103_T114_L1.0051.00
134_H138_Y1.0041.00
168_E213_L1.0041.00
141_V159_V0.9981.00
241_K244_S0.9971.00
95_R134_H0.9961.00
294_Y303_K0.9961.00
96_S161_E0.9951.00
127_H143_L0.9951.00
119_D131_K0.9911.00
15_K18_V0.9871.00
158_Y270_D0.9751.00
200_L207_L0.9671.00
270_D273_G0.9661.00
200_L205_H0.9641.00
234_V238_I0.9621.00
75_S157_D0.9601.00
181_V184_D0.9581.00
252_D256_D0.9571.00
125_P147_T0.9551.00
145_V159_V0.9531.00
232_M236_S0.9461.00
157_D265_N0.9461.00
101_L116_I0.9341.00
95_R138_Y0.9331.00
36_G40_F0.9321.00
181_V207_L0.9311.00
118_R219_R0.9311.00
42_K256_D0.9301.00
179_V237_A0.9261.00
233_E237_A0.9231.00
295_E298_G0.9221.00
180_T202_K0.9221.00
82_D95_R0.9201.00
296_P301_Y0.9161.00
232_M286_S0.9151.00
223_S226_L0.9011.00
143_L146_K0.8931.00
298_G301_Y0.8931.00
228_G288_Q0.8891.00
225_L291_G0.8881.00
213_L217_R0.8871.00
112_K287_I0.8861.00
116_I120_A0.8841.00
178_K241_K0.8841.00
182_K215_Y0.8831.00
84_R164_F0.8811.00
172_N208_D0.8781.00
250_A253_D0.8761.00
74_F106_R0.8731.00
136_H161_E0.8691.00
39_A42_K0.8691.00
131_K299_V0.8661.00
131_K300_Y0.8641.00
126_G143_L0.8611.00
125_P146_K0.8601.00
40_F44_N0.8521.00
147_T151_M0.8501.00
35_V38_Y0.8491.00
72_D107_K0.8471.00
210_E214_A0.8461.00
221_A226_L0.8421.00
39_A43_L0.8421.00
127_H138_Y0.8381.00
244_S247_S0.8351.00
116_I152_L0.8351.00
20_V23_G0.8301.00
100_V235_L0.8271.00
249_P253_D0.8271.00
41_V45_N0.8271.00
229_Q232_M0.8190.99
266_L271_A0.8180.99
225_L228_G0.8170.99
46_A259_G0.8140.99
198_V214_A0.8130.99
76_V102_V0.8100.99
115_S228_G0.8090.99
253_D257_T0.8080.99
43_L47_S0.8070.99
42_K46_A0.8010.99
47_S51_H0.7950.99
24_L28_L0.7930.99
162_S166_A0.7890.99
131_K134_H0.7890.99
125_P150_E0.7850.99
151_M304_L0.7850.99
193_D196_G0.7830.99
180_T233_E0.7830.99
124_I127_H0.7820.99
183_S202_K0.7790.99
36_G39_A0.7770.99
60_S63_R0.7770.99
145_V156_V0.7760.99
171_V208_D0.7760.99
245_L248_I0.7740.99
95_R130_D0.7720.99
158_Y267_S0.7720.99
26_A30_I0.7700.99
93_Q137_A0.7640.99
239_I243_K0.7620.99
122_V151_M0.7600.99
198_V211_E0.7590.99
81_I161_E0.7580.99
266_L270_D0.7580.99
130_D299_V0.7560.99
72_D106_R0.7530.99
105_N110_T0.7400.99
296_P303_K0.7390.99
14_L19_K0.7370.99
233_E236_S0.7320.99
115_S232_M0.7320.99
83_A161_E0.7310.99
292_Y305_N0.7280.99
303_K306_Q0.7270.99
293_D300_Y0.7230.99
100_V228_G0.7220.99
176_G206_T0.7200.99
81_I84_R0.7200.99
277_F281_L0.7180.99
293_D302_F0.7170.99
200_L211_E0.7100.99
307_Q311_E0.7080.98
275_F279_T0.7050.98
173_E253_D0.7050.98
100_V115_S0.7040.98
78_L160_V0.7010.98
130_D298_G0.6980.98
142_D146_K0.6970.98
132_F147_T0.6960.98
230_R233_E0.6940.98
194_T199_V0.6940.98
163_N261_N0.6930.98
46_A50_A0.6930.98
130_D135_A0.6920.98
49_E53_S0.6920.98
170_V174_L0.6860.98
124_I138_Y0.6860.98
44_N47_S0.6840.98
268_L271_A0.6820.98
310_Q313_K0.6800.98
14_L18_V0.6800.98
184_D205_H0.6800.98
168_E172_N0.6790.98
171_V174_L0.6780.98
79_L96_S0.6780.98
38_Y41_V0.6770.98
232_M288_Q0.6760.98
198_V205_H0.6750.98
77_L99_N0.6740.98
229_Q233_E0.6710.98
22_A29_V0.6700.98
193_D197_K0.6700.98
165_T169_D0.6690.98
97_D219_R0.6660.98
235_L239_I0.6660.98
95_R137_A0.6630.98
30_I33_G0.6590.98
111_A281_L0.6540.97
170_V254_I0.6530.97
255_V259_G0.6510.97
221_A230_R0.6510.97
179_V233_E0.6490.97
78_L162_S0.6480.97
43_L46_A0.6470.97
148_V151_M0.6460.97
181_V233_E0.6430.97
212_A234_V0.6420.97
19_K22_A0.6420.97
149_E154_I0.6400.97
61_V64_I0.6400.97
120_A131_K0.6390.97
119_D219_R0.6350.97
225_L288_Q0.6340.97
136_H141_V0.6310.97
307_Q310_Q0.6300.97
76_V158_Y0.6270.97
246_S250_A0.6270.97
76_V266_L0.6260.97
44_N48_K0.6240.97
120_A289_L0.6230.97
105_N109_K0.6210.97
141_V161_E0.6200.97
117_P288_Q0.6200.97
30_I34_S0.6200.97
181_V185_K0.6180.96
278_I281_L0.6180.96
153_D313_K0.6170.96
97_D118_R0.6140.96
218_T222_D0.6130.96
236_S240_D0.6120.96
290_T308_K0.6120.96
75_S101_L0.6120.96
77_L101_L0.6120.96
92_D95_R0.6110.96
256_D259_G0.6110.96
269_K273_G0.6100.96
28_L31_A0.6050.96
44_N49_E0.6040.96
135_A147_T0.6040.96
18_V29_V0.5990.96
121_Y296_P0.5980.96
224_D228_G0.5970.96
149_E157_D0.5970.96
104_F274_L0.5960.96
277_F282_K0.5940.96
287_I315_E0.5930.96
169_D173_E0.5920.95
169_D172_N0.5910.95
173_E254_I0.5880.95
149_E156_V0.5880.95
21_V25_M0.5860.95
294_Y297_A0.5850.95
25_M28_L0.5840.95
273_G276_P0.5830.95
289_L304_L0.5790.95
185_K221_A0.5780.95
161_E263_K0.5770.95
215_Y234_V0.5760.95
257_T261_N0.5740.95
108_E111_A0.5720.95
166_A261_N0.5710.95
77_L144_T0.5700.94
78_L166_A0.5700.94
34_S37_A0.5700.94
195_K214_A0.5690.94
295_E299_V0.5690.94
120_A302_F0.5670.94
243_K246_S0.5640.94
150_E153_D0.5630.94
144_T151_M0.5630.94
23_G26_A0.5630.94
311_E314_K0.5620.94
213_L216_V0.5610.94
97_D227_R0.5610.94
72_D157_D0.5590.94
14_L17_W0.5580.94
224_D231_Q0.5570.94
83_A94_A0.5550.94
73_S108_E0.5550.94
118_R227_R0.5540.94
178_K205_H0.5540.94
177_V241_K0.5510.93
76_V160_V0.5490.93
185_K199_V0.5490.93
48_K51_H0.5490.93
46_A51_H0.5480.93
166_A170_V0.5450.93
21_V24_L0.5450.93
170_V173_E0.5440.93
62_K65_K0.5440.93
193_D200_L0.5430.93
43_L49_E0.5430.93
253_D256_D0.5420.93
29_V32_A0.5410.93
26_A33_G0.5400.93
292_Y303_K0.5400.93
39_A47_S0.5390.93
110_T283_S0.5370.93
41_V44_N0.5370.93
23_G30_I0.5360.93
99_N116_I0.5340.92
159_V265_N0.5310.92
245_L250_A0.5280.92
109_K280_S0.5260.92
104_F111_A0.5260.92
172_N176_G0.5250.92
309_L312_V0.5250.92
182_K229_Q0.5240.92
245_L249_P0.5240.92
185_K214_A0.5230.92
26_A29_V0.5220.92
249_P252_D0.5220.92
18_V22_A0.5200.91
95_R133_T0.5190.91
148_V152_L0.5190.91
42_K45_N0.5170.91
140_G143_L0.5140.91
98_A115_S0.5140.91
121_Y294_Y0.5120.91
85_E91_V0.5120.91
102_V111_A0.5120.91
68_D72_D0.5110.91
181_V204_T0.5090.90
226_L230_R0.5070.90
228_G286_S0.5060.90
114_L287_I0.5060.90
181_V202_K0.5050.90
133_T136_H0.5030.90
193_D199_V0.5030.90
182_K202_K0.5010.90
218_T226_L0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3owqA 1 0.7267 100 0.144 Contact Map
3pe5A 1 0.7888 100 0.158 Contact Map
4de9A 1 0.7422 100 0.19 Contact Map
3nxhA 1 0.6584 100 0.192 Contact Map
3okzA 1 0.8106 100 0.199 Contact Map
3qfiA 1 0.7236 100 0.212 Contact Map
2xxpA 1 0.9565 100 0.258 Contact Map
4obmA 1 0.7733 97.5 0.901 Contact Map
2m8rA 1 0.1273 64.9 0.95 Contact Map
2kogA 1 0.1242 50 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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