GREMLIN Database
KIPA - KipI antagonist
UniProt: Q7WY77 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 335 (291)
Sequences: 3113 (2142)
Seq/√Len: 125.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_N99_S5.1091.00
36_L51_G5.0611.00
39_A115_A4.1851.00
198_R288_D3.7341.00
73_V80_L3.3121.00
50_A129_K3.2881.00
10_T52_L3.2041.00
71_I95_I3.1841.00
2_K66_S3.0691.00
2_K64_H3.0051.00
96_K99_S2.9371.00
12_V120_I2.7211.00
68_Q96_K2.6901.00
54_I114_L2.5321.00
35_S191_L2.4711.00
81_R102_S2.3581.00
71_I93_V2.3161.00
64_H100_T2.2181.00
65_F95_I2.2051.00
37_R47_E2.1561.00
3_V63_F2.1491.00
65_F69_T2.1281.00
208_F259_V2.0971.00
124_A129_K2.0641.00
199_V257_V2.0491.00
296_M299_E2.0381.00
4_L64_H1.9891.00
217_Y305_P1.9761.00
307_S310_E1.9641.00
196_V304_E1.9491.00
82_I95_I1.9311.00
31_M269_L1.9191.00
220_A302_Q1.9131.00
67_K97_E1.9011.00
198_R285_I1.8711.00
220_A300_H1.8691.00
2_K150_E1.8681.00
62_S102_S1.8551.00
30_A36_L1.8331.00
6_P147_K1.8311.00
62_S100_T1.8261.00
222_R300_H1.8071.00
204_Q280_R1.8021.00
285_I306_V1.7951.00
116_A120_I1.7781.00
199_V282_A1.7641.00
68_Q97_E1.7401.00
55_T111_R1.7391.00
195_P295_I1.7211.00
78_F112_A1.7121.00
78_F103_F1.7061.00
82_I87_A1.6771.00
257_V267_I1.6551.00
267_I292_V1.6461.00
285_I288_D1.6441.00
77_D107_K1.6171.00
87_A93_V1.6081.00
284_I288_D1.6071.00
79_T104_G1.5801.00
88_P93_V1.5701.00
26_L132_Y1.5651.00
54_I112_A1.5561.00
211_E240_E1.5521.00
65_F101_V1.5441.00
201_E305_P1.5241.00
39_A43_I1.5011.00
143_R149_D1.4951.00
239_L259_V1.4781.00
30_A51_G1.4611.00
9_L133_V1.4521.00
204_Q250_E1.4461.00
15_I37_R1.4431.00
209_T240_E1.4421.00
224_T235_K1.4411.00
212_S239_L1.4211.00
201_E213_K1.4171.00
254_F272_R1.4051.00
39_A74_T1.3961.00
33_T290_P1.3961.00
69_T153_I1.3641.00
43_I115_A1.3611.00
198_R304_E1.3371.00
199_V217_Y1.3371.00
235_K264_N1.3311.00
197_I292_V1.3201.00
63_F101_V1.3141.00
132_Y135_G1.3121.00
134_R228_D1.3081.00
216_F257_V1.3021.00
80_L103_F1.3001.00
21_Q272_R1.2911.00
63_F114_L1.2861.00
197_I284_I1.2781.00
73_V114_L1.2781.00
43_I72_A1.2581.00
201_E217_Y1.2491.00
194_N220_A1.2491.00
210_E214_T1.2401.00
4_L100_T1.2330.99
51_G115_A1.2310.99
194_N300_H1.2310.99
52_L145_L1.2280.99
198_R314_L1.2260.99
139_G142_G1.2240.99
43_I70_L1.2180.99
257_V282_A1.2130.99
284_I292_V1.2110.99
230_M273_Q1.2030.99
1_M63_F1.1890.99
232_Y269_L1.1810.99
74_T90_W1.1710.99
199_V216_F1.1660.99
66_S150_E1.1600.99
54_I78_F1.1560.99
146_Q149_D1.1470.99
216_F303_F1.1230.99
78_F106_C1.1220.99
295_I299_E1.1220.99
222_R235_K1.1100.99
5_K62_S1.1070.99
241_L246_E1.0920.99
214_T218_E1.0880.99
80_L89_L1.0860.99
69_T95_I1.0780.99
295_I301_V1.0740.99
250_E280_R1.0720.99
71_I101_V1.0710.99
256_T283_H1.0710.99
269_L293_S1.0650.98
254_F289_L1.0610.98
4_L62_S1.0580.98
31_M232_Y1.0290.98
38_I90_W1.0270.98
34_V290_P1.0260.98
12_V50_A1.0220.98
25_V137_I1.0120.98
122_V129_K1.0050.98
116_A153_I0.9970.98
103_F112_A0.9910.98
208_F281_I0.9860.98
258_Q278_Y0.9840.97
1_M65_F0.9840.97
42_L72_A0.9770.97
39_A51_G0.9710.97
205_F213_K0.9670.97
312_E316_V0.9640.97
25_V126_M0.9620.97
221_F266_I0.9600.97
219_E237_E0.9570.97
6_P10_T0.9550.97
70_L94_L0.9500.97
80_L101_V0.9490.97
131_T139_G0.9490.97
82_I99_S0.9460.97
80_L87_A0.9440.97
49_E129_K0.9430.97
46_G49_E0.9420.97
287_A314_L0.9390.97
120_I129_K0.9360.97
241_L245_L0.9340.97
121_E152_N0.9300.96
70_L92_P0.9280.96
68_Q94_L0.9270.96
204_Q256_T0.9080.96
201_E205_F0.9060.96
217_Y282_A0.8990.96
90_W189_L0.8960.96
221_F264_N0.8940.96
110_S296_M0.8900.95
71_I82_I0.8880.95
41_L47_E0.8770.95
223_V295_I0.8760.95
223_V232_Y0.8730.95
11_T144_A0.8720.95
253_S256_T0.8710.95
198_R306_V0.8690.95
12_V129_K0.8690.95
120_I151_L0.8650.95
256_T280_R0.8630.95
5_K147_K0.8590.95
42_L92_P0.8580.94
260_P266_I0.8530.94
72_A115_A0.8530.94
45_N119_G0.8470.94
68_Q99_S0.8440.94
215_R219_E0.8440.94
284_I289_L0.8380.94
72_A92_P0.8380.94
212_S215_R0.8370.94
82_I101_V0.8370.94
63_F95_I0.8330.94
77_D103_F0.8300.93
15_I36_L0.8210.93
253_S283_H0.8210.93
7_G10_T0.8210.93
40_N45_N0.8180.93
28_S132_Y0.8140.93
79_T107_K0.8090.93
9_L144_A0.8070.92
188_F191_L0.8060.92
198_R287_A0.8030.92
252_V268_L0.7920.92
12_V52_L0.7910.92
65_F71_I0.7910.92
308_L312_E0.7900.92
251_A256_T0.7880.92
216_F281_I0.7860.91
21_Q27_A0.7840.91
196_V291_I0.7790.91
310_E313_A0.7780.91
76_A109_G0.7720.91
116_A152_N0.7710.91
9_L55_T0.7680.90
216_F282_A0.7660.90
84_D102_S0.7660.90
83_N86_E0.7620.90
252_V256_T0.7600.90
49_E154_G0.7600.90
221_F236_G0.7600.90
26_L135_G0.7580.90
194_N302_Q0.7570.90
87_A101_V0.7550.90
310_E314_L0.7530.90
195_P291_I0.7520.90
81_R104_G0.7520.90
70_L117_A0.7500.89
90_W191_L0.7490.89
306_V314_L0.7490.89
122_V152_N0.7480.89
15_I48_N0.7470.89
196_V302_Q0.7460.89
134_R230_M0.7450.89
77_D89_L0.7450.89
8_L57_M0.7430.89
212_S240_E0.7410.89
54_I103_F0.7390.89
36_L48_N0.7380.89
246_E279_P0.7380.89
5_K102_S0.7360.89
6_P145_L0.7350.88
43_I92_P0.7340.88
12_V122_V0.7290.88
129_K152_N0.7280.88
209_T212_S0.7270.88
241_L244_P0.7260.88
121_E124_A0.7250.88
285_I314_L0.7250.88
207_F247_M0.7240.88
13_Q130_S0.7220.88
58_G104_G0.7220.88
14_D17_R0.7200.87
103_F114_L0.7190.87
120_I154_G0.7180.87
230_M278_Y0.7180.87
122_V154_G0.7160.87
90_W188_F0.7130.87
43_I117_A0.7120.87
33_T270_A0.7110.87
209_T242_K0.7090.87
82_I93_V0.7060.86
211_E214_T0.7030.86
268_L272_R0.6990.86
54_I57_M0.6960.86
79_T105_P0.6950.86
200_L308_L0.6940.85
21_Q274_T0.6940.85
304_E310_E0.6900.85
258_Q276_G0.6900.85
11_T133_V0.6890.85
260_P264_N0.6880.85
31_M270_A0.6870.85
254_F270_A0.6850.85
227_S297_P0.6850.85
65_F82_I0.6850.85
231_G266_I0.6840.85
221_F303_F0.6830.85
88_P91_K0.6830.85
249_S274_T0.6810.84
81_R86_E0.6810.84
227_S232_Y0.6770.84
210_E213_K0.6750.84
73_V112_A0.6740.84
197_I301_V0.6730.84
268_L273_Q0.6730.84
121_E129_K0.6700.83
71_I116_A0.6690.83
138_G142_G0.6680.83
40_N115_A0.6680.83
197_I288_D0.6670.83
234_L301_V0.6650.83
139_G149_D0.6640.83
38_I41_L0.6610.83
267_I284_I0.6600.82
50_A120_I0.6580.82
111_R293_S0.6560.82
230_M258_Q0.6540.82
10_T54_I0.6480.81
207_F241_L0.6450.81
66_S97_E0.6440.81
215_R240_E0.6430.81
89_L112_A0.6410.81
135_G275_T0.6410.81
207_F245_L0.6360.80
204_Q247_M0.6330.80
207_F243_A0.6290.79
312_E315_A0.6280.79
21_Q254_F0.6280.79
54_I73_V0.6260.79
306_V310_E0.6260.79
81_R84_D0.6250.79
39_A72_A0.6240.79
247_M279_P0.6230.79
36_L115_A0.6180.78
95_I101_V0.6170.78
71_I87_A0.6170.78
247_M250_E0.6160.78
205_F217_Y0.6130.78
195_P299_E0.6110.77
15_I30_A0.6110.77
122_V131_T0.6100.77
204_Q248_V0.6100.77
117_A274_T0.6070.77
131_T142_G0.6060.77
35_S89_L0.6050.77
241_L247_M0.6030.76
51_G120_I0.6030.76
108_L193_K0.6020.76
15_I47_E0.6020.76
134_R280_R0.6000.76
33_T286_S0.5990.76
27_A272_R0.5980.76
252_V273_Q0.5970.76
40_N49_E0.5960.76
123_P129_K0.5920.75
77_D108_L0.5900.75
54_I63_F0.5900.75
226_Q262_D0.5900.75
67_K153_I0.5880.75
106_C112_A0.5850.74
64_H98_N0.5850.74
230_M268_L0.5810.74
198_R284_I0.5810.74
270_A290_P0.5800.74
3_V52_L0.5780.73
213_K305_P0.5750.73
120_I153_I0.5750.73
273_Q280_R0.5750.73
121_E154_G0.5750.73
245_L279_P0.5730.73
233_R266_I0.5720.73
84_D100_T0.5720.73
287_A290_P0.5710.73
210_E310_E0.5710.73
193_K299_E0.5700.72
10_T145_L0.5690.72
45_N118_G0.5690.72
77_D90_W0.5680.72
156_M160_S0.5650.72
229_R271_D0.5650.72
211_E215_R0.5650.72
21_Q275_T0.5630.72
73_V103_F0.5630.72
208_F216_F0.5630.72
133_V228_D0.5630.72
35_S38_I0.5610.71
258_Q273_Q0.5600.71
249_S275_T0.5590.71
213_K217_Y0.5580.71
259_V281_I0.5580.71
257_V265_P0.5570.71
85_E99_S0.5570.71
292_V295_I0.5560.71
270_A289_L0.5550.70
253_S272_R0.5530.70
1_M153_I0.5520.70
12_V140_L0.5510.70
212_S241_L0.5500.70
3_V145_L0.5460.69
76_A104_G0.5450.69
257_V298_G0.5440.69
249_S278_Y0.5430.69
285_I304_E0.5410.69
20_Y126_M0.5410.69
5_K8_L0.5410.69
245_L261_P0.5390.68
134_R248_V0.5390.68
33_T289_L0.5390.68
28_S128_S0.5380.68
131_T143_R0.5380.68
208_F241_L0.5380.68
134_R271_D0.5370.68
212_S259_V0.5370.68
8_L56_M0.5370.68
227_S233_R0.5360.68
246_E261_P0.5360.68
79_T86_E0.5350.68
158_A161_Q0.5330.67
92_P297_P0.5310.67
292_V301_V0.5290.67
286_S315_A0.5280.67
76_A112_A0.5270.67
249_S263_G0.5270.67
117_A160_S0.5250.66
74_T89_L0.5250.66
228_D271_D0.5230.66
111_R267_I0.5220.66
52_L63_F0.5210.66
11_T131_T0.5210.66
226_Q233_R0.5200.65
129_K154_G0.5190.65
213_K242_K0.5190.65
306_V311_A0.5180.65
254_F274_T0.5170.65
122_V142_G0.5150.65
208_F239_L0.5150.65
74_T115_A0.5140.65
1_M150_E0.5140.65
132_Y204_Q0.5120.64
25_V125_V0.5120.64
249_S252_V0.5120.64
205_F256_T0.5080.64
203_K283_H0.5080.64
203_K275_T0.5070.64
206_A216_F0.5070.64
193_K296_M0.5070.64
285_I311_A0.5060.63
151_L154_G0.5060.63
288_D304_E0.5050.63
238_P264_N0.5050.63
191_L195_P0.5050.63
5_K304_E0.5020.63
249_S277_G0.5010.63
261_P279_P0.5010.63
18_T27_A0.5010.63
51_G54_I0.5010.63
204_Q273_Q0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mmlA 2 0.8567 100 0.105 Contact Map
3va7A 1 0.9612 100 0.129 Contact Map
3oepA 1 0.809 100 0.161 Contact Map
2zp2A 1 0.3254 86.6 0.956 Contact Map
3gmgA 2 0.391 58.9 0.965 Contact Map
1f0zA 1 0.1701 54.4 0.966 Contact Map
1x7fA 1 0.7881 53.6 0.966 Contact Map
2cu3A 2 0.1851 29.4 0.971 Contact Map
2phcB 1 0.5731 28.4 0.971 Contact Map
1vykA 1 0.1552 26.2 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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