KIPA - BACSU - GREMLIN Contacts

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KIPA - KipI antagonist

UniProt:	Q7WY77	Sequences: MKVLKPGLLTTVQDIGRTGYQKYGVLASGAMDTVSLRIANLLIGNGENEAGLEITMMGPGPSFHFSKQTLIAVTGADFTLRINDEEAPLWKPVLIKENSTVSFGPCKLGSRAYLAAAGGIEVPAVMESKSTYVRGSIGGLHGRALQKEDELNIGEMSALSQTILSRLSSQLGKQGFAAPKWSVSRGRFLPLKKNPVIRVLEGKQFAFFTEESKTRFYEEAFRVTPQSDRMGYRLKGEPLELKAPLEMVSEAVSFGTVQVPPDGNPIILLADRQTTGGYPRIAHIISADLPIVSQIMPGEHVQFEPVSLQEAEALAVEREQHIKELKTRMKMEWLT	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	335 (291)
Sequences:	3113 (2142)
Seq/√Len:	125.6

ECOLI - YBGK
BACSU - KIPA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
83_N	99_S	5.109	1.00
36_L	51_G	5.061	1.00
39_A	115_A	4.185	1.00
198_R	288_D	3.734	1.00
73_V	80_L	3.312	1.00
50_A	129_K	3.288	1.00
10_T	52_L	3.204	1.00
71_I	95_I	3.184	1.00
2_K	66_S	3.069	1.00
2_K	64_H	3.005	1.00
96_K	99_S	2.937	1.00
12_V	120_I	2.721	1.00
68_Q	96_K	2.690	1.00
54_I	114_L	2.532	1.00
35_S	191_L	2.471	1.00
81_R	102_S	2.358	1.00
71_I	93_V	2.316	1.00
64_H	100_T	2.218	1.00
65_F	95_I	2.205	1.00
37_R	47_E	2.156	1.00
3_V	63_F	2.149	1.00
65_F	69_T	2.128	1.00
208_F	259_V	2.097	1.00
124_A	129_K	2.064	1.00
199_V	257_V	2.049	1.00
296_M	299_E	2.038	1.00
4_L	64_H	1.989	1.00
217_Y	305_P	1.976	1.00
307_S	310_E	1.964	1.00
196_V	304_E	1.949	1.00
82_I	95_I	1.931	1.00
31_M	269_L	1.919	1.00
220_A	302_Q	1.913	1.00
67_K	97_E	1.901	1.00
198_R	285_I	1.871	1.00
220_A	300_H	1.869	1.00
2_K	150_E	1.868	1.00
62_S	102_S	1.855	1.00
30_A	36_L	1.833	1.00
6_P	147_K	1.831	1.00
62_S	100_T	1.826	1.00
222_R	300_H	1.807	1.00
204_Q	280_R	1.802	1.00
285_I	306_V	1.795	1.00
116_A	120_I	1.778	1.00
199_V	282_A	1.764	1.00
68_Q	97_E	1.740	1.00
55_T	111_R	1.739	1.00
195_P	295_I	1.721	1.00
78_F	112_A	1.712	1.00
78_F	103_F	1.706	1.00
82_I	87_A	1.677	1.00
257_V	267_I	1.655	1.00
267_I	292_V	1.646	1.00
285_I	288_D	1.644	1.00
77_D	107_K	1.617	1.00
87_A	93_V	1.608	1.00
284_I	288_D	1.607	1.00
79_T	104_G	1.580	1.00
88_P	93_V	1.570	1.00
26_L	132_Y	1.565	1.00
54_I	112_A	1.556	1.00
211_E	240_E	1.552	1.00
65_F	101_V	1.544	1.00
201_E	305_P	1.524	1.00
39_A	43_I	1.501	1.00
143_R	149_D	1.495	1.00
239_L	259_V	1.478	1.00
30_A	51_G	1.461	1.00
9_L	133_V	1.452	1.00
204_Q	250_E	1.446	1.00
15_I	37_R	1.443	1.00
209_T	240_E	1.442	1.00
224_T	235_K	1.441	1.00
212_S	239_L	1.421	1.00
201_E	213_K	1.417	1.00
254_F	272_R	1.405	1.00
39_A	74_T	1.396	1.00
33_T	290_P	1.396	1.00
69_T	153_I	1.364	1.00
43_I	115_A	1.361	1.00
198_R	304_E	1.337	1.00
199_V	217_Y	1.337	1.00
235_K	264_N	1.331	1.00
197_I	292_V	1.320	1.00
63_F	101_V	1.314	1.00
132_Y	135_G	1.312	1.00
134_R	228_D	1.308	1.00
216_F	257_V	1.302	1.00
80_L	103_F	1.300	1.00
21_Q	272_R	1.291	1.00
63_F	114_L	1.286	1.00
197_I	284_I	1.278	1.00
73_V	114_L	1.278	1.00
43_I	72_A	1.258	1.00
201_E	217_Y	1.249	1.00
194_N	220_A	1.249	1.00
210_E	214_T	1.240	1.00
4_L	100_T	1.233	0.99
51_G	115_A	1.231	0.99
194_N	300_H	1.231	0.99
52_L	145_L	1.228	0.99
198_R	314_L	1.226	0.99
139_G	142_G	1.224	0.99
43_I	70_L	1.218	0.99
257_V	282_A	1.213	0.99
284_I	292_V	1.211	0.99
230_M	273_Q	1.203	0.99
1_M	63_F	1.189	0.99
232_Y	269_L	1.181	0.99
74_T	90_W	1.171	0.99
199_V	216_F	1.166	0.99
66_S	150_E	1.160	0.99
54_I	78_F	1.156	0.99
146_Q	149_D	1.147	0.99
216_F	303_F	1.123	0.99
78_F	106_C	1.122	0.99
295_I	299_E	1.122	0.99
222_R	235_K	1.110	0.99
5_K	62_S	1.107	0.99
241_L	246_E	1.092	0.99
214_T	218_E	1.088	0.99
80_L	89_L	1.086	0.99
69_T	95_I	1.078	0.99
295_I	301_V	1.074	0.99
250_E	280_R	1.072	0.99
71_I	101_V	1.071	0.99
256_T	283_H	1.071	0.99
269_L	293_S	1.065	0.98
254_F	289_L	1.061	0.98
4_L	62_S	1.058	0.98
31_M	232_Y	1.029	0.98
38_I	90_W	1.027	0.98
34_V	290_P	1.026	0.98
12_V	50_A	1.022	0.98
25_V	137_I	1.012	0.98
122_V	129_K	1.005	0.98
116_A	153_I	0.997	0.98
103_F	112_A	0.991	0.98
208_F	281_I	0.986	0.98
258_Q	278_Y	0.984	0.97
1_M	65_F	0.984	0.97
42_L	72_A	0.977	0.97
39_A	51_G	0.971	0.97
205_F	213_K	0.967	0.97
312_E	316_V	0.964	0.97
25_V	126_M	0.962	0.97
221_F	266_I	0.960	0.97
219_E	237_E	0.957	0.97
6_P	10_T	0.955	0.97
70_L	94_L	0.950	0.97
80_L	101_V	0.949	0.97
131_T	139_G	0.949	0.97
82_I	99_S	0.946	0.97
80_L	87_A	0.944	0.97
49_E	129_K	0.943	0.97
46_G	49_E	0.942	0.97
287_A	314_L	0.939	0.97
120_I	129_K	0.936	0.97
241_L	245_L	0.934	0.97
121_E	152_N	0.930	0.96
70_L	92_P	0.928	0.96
68_Q	94_L	0.927	0.96
204_Q	256_T	0.908	0.96
201_E	205_F	0.906	0.96
217_Y	282_A	0.899	0.96
90_W	189_L	0.896	0.96
221_F	264_N	0.894	0.96
110_S	296_M	0.890	0.95
71_I	82_I	0.888	0.95
41_L	47_E	0.877	0.95
223_V	295_I	0.876	0.95
223_V	232_Y	0.873	0.95
11_T	144_A	0.872	0.95
253_S	256_T	0.871	0.95
198_R	306_V	0.869	0.95
12_V	129_K	0.869	0.95
120_I	151_L	0.865	0.95
256_T	280_R	0.863	0.95
5_K	147_K	0.859	0.95
42_L	92_P	0.858	0.94
260_P	266_I	0.853	0.94
72_A	115_A	0.853	0.94
45_N	119_G	0.847	0.94
68_Q	99_S	0.844	0.94
215_R	219_E	0.844	0.94
284_I	289_L	0.838	0.94
72_A	92_P	0.838	0.94
212_S	215_R	0.837	0.94
82_I	101_V	0.837	0.94
63_F	95_I	0.833	0.94
77_D	103_F	0.830	0.93
15_I	36_L	0.821	0.93
253_S	283_H	0.821	0.93
7_G	10_T	0.821	0.93
40_N	45_N	0.818	0.93
28_S	132_Y	0.814	0.93
79_T	107_K	0.809	0.93
9_L	144_A	0.807	0.92
188_F	191_L	0.806	0.92
198_R	287_A	0.803	0.92
252_V	268_L	0.792	0.92
12_V	52_L	0.791	0.92
65_F	71_I	0.791	0.92
308_L	312_E	0.790	0.92
251_A	256_T	0.788	0.92
216_F	281_I	0.786	0.91
21_Q	27_A	0.784	0.91
196_V	291_I	0.779	0.91
310_E	313_A	0.778	0.91
76_A	109_G	0.772	0.91
116_A	152_N	0.771	0.91
9_L	55_T	0.768	0.90
216_F	282_A	0.766	0.90
84_D	102_S	0.766	0.90
83_N	86_E	0.762	0.90
252_V	256_T	0.760	0.90
49_E	154_G	0.760	0.90
221_F	236_G	0.760	0.90
26_L	135_G	0.758	0.90
194_N	302_Q	0.757	0.90
87_A	101_V	0.755	0.90
310_E	314_L	0.753	0.90
195_P	291_I	0.752	0.90
81_R	104_G	0.752	0.90
70_L	117_A	0.750	0.89
90_W	191_L	0.749	0.89
306_V	314_L	0.749	0.89
122_V	152_N	0.748	0.89
15_I	48_N	0.747	0.89
196_V	302_Q	0.746	0.89
134_R	230_M	0.745	0.89
77_D	89_L	0.745	0.89
8_L	57_M	0.743	0.89
212_S	240_E	0.741	0.89
54_I	103_F	0.739	0.89
36_L	48_N	0.738	0.89
246_E	279_P	0.738	0.89
5_K	102_S	0.736	0.89
6_P	145_L	0.735	0.88
43_I	92_P	0.734	0.88
12_V	122_V	0.729	0.88
129_K	152_N	0.728	0.88
209_T	212_S	0.727	0.88
241_L	244_P	0.726	0.88
121_E	124_A	0.725	0.88
285_I	314_L	0.725	0.88
207_F	247_M	0.724	0.88
13_Q	130_S	0.722	0.88
58_G	104_G	0.722	0.88
14_D	17_R	0.720	0.87
103_F	114_L	0.719	0.87
120_I	154_G	0.718	0.87
230_M	278_Y	0.718	0.87
122_V	154_G	0.716	0.87
90_W	188_F	0.713	0.87
43_I	117_A	0.712	0.87
33_T	270_A	0.711	0.87
209_T	242_K	0.709	0.87
82_I	93_V	0.706	0.86
211_E	214_T	0.703	0.86
268_L	272_R	0.699	0.86
54_I	57_M	0.696	0.86
79_T	105_P	0.695	0.86
200_L	308_L	0.694	0.85
21_Q	274_T	0.694	0.85
304_E	310_E	0.690	0.85
258_Q	276_G	0.690	0.85
11_T	133_V	0.689	0.85
260_P	264_N	0.688	0.85
31_M	270_A	0.687	0.85
254_F	270_A	0.685	0.85
227_S	297_P	0.685	0.85
65_F	82_I	0.685	0.85
231_G	266_I	0.684	0.85
221_F	303_F	0.683	0.85
88_P	91_K	0.683	0.85
249_S	274_T	0.681	0.84
81_R	86_E	0.681	0.84
227_S	232_Y	0.677	0.84
210_E	213_K	0.675	0.84
73_V	112_A	0.674	0.84
197_I	301_V	0.673	0.84
268_L	273_Q	0.673	0.84
121_E	129_K	0.670	0.83
71_I	116_A	0.669	0.83
138_G	142_G	0.668	0.83
40_N	115_A	0.668	0.83
197_I	288_D	0.667	0.83
234_L	301_V	0.665	0.83
139_G	149_D	0.664	0.83
38_I	41_L	0.661	0.83
267_I	284_I	0.660	0.82
50_A	120_I	0.658	0.82
111_R	293_S	0.656	0.82
230_M	258_Q	0.654	0.82
10_T	54_I	0.648	0.81
207_F	241_L	0.645	0.81
66_S	97_E	0.644	0.81
215_R	240_E	0.643	0.81
89_L	112_A	0.641	0.81
135_G	275_T	0.641	0.81
207_F	245_L	0.636	0.80
204_Q	247_M	0.633	0.80
207_F	243_A	0.629	0.79
312_E	315_A	0.628	0.79
21_Q	254_F	0.628	0.79
54_I	73_V	0.626	0.79
306_V	310_E	0.626	0.79
81_R	84_D	0.625	0.79
39_A	72_A	0.624	0.79
247_M	279_P	0.623	0.79
36_L	115_A	0.618	0.78
95_I	101_V	0.617	0.78
71_I	87_A	0.617	0.78
247_M	250_E	0.616	0.78
205_F	217_Y	0.613	0.78
195_P	299_E	0.611	0.77
15_I	30_A	0.611	0.77
122_V	131_T	0.610	0.77
204_Q	248_V	0.610	0.77
117_A	274_T	0.607	0.77
131_T	142_G	0.606	0.77
35_S	89_L	0.605	0.77
241_L	247_M	0.603	0.76
51_G	120_I	0.603	0.76
108_L	193_K	0.602	0.76
15_I	47_E	0.602	0.76
134_R	280_R	0.600	0.76
33_T	286_S	0.599	0.76
27_A	272_R	0.598	0.76
252_V	273_Q	0.597	0.76
40_N	49_E	0.596	0.76
123_P	129_K	0.592	0.75
77_D	108_L	0.590	0.75
54_I	63_F	0.590	0.75
226_Q	262_D	0.590	0.75
67_K	153_I	0.588	0.75
106_C	112_A	0.585	0.74
64_H	98_N	0.585	0.74
230_M	268_L	0.581	0.74
198_R	284_I	0.581	0.74
270_A	290_P	0.580	0.74
3_V	52_L	0.578	0.73
213_K	305_P	0.575	0.73
120_I	153_I	0.575	0.73
273_Q	280_R	0.575	0.73
121_E	154_G	0.575	0.73
245_L	279_P	0.573	0.73
233_R	266_I	0.572	0.73
84_D	100_T	0.572	0.73
287_A	290_P	0.571	0.73
210_E	310_E	0.571	0.73
193_K	299_E	0.570	0.72
10_T	145_L	0.569	0.72
45_N	118_G	0.569	0.72
77_D	90_W	0.568	0.72
156_M	160_S	0.565	0.72
229_R	271_D	0.565	0.72
211_E	215_R	0.565	0.72
21_Q	275_T	0.563	0.72
73_V	103_F	0.563	0.72
208_F	216_F	0.563	0.72
133_V	228_D	0.563	0.72
35_S	38_I	0.561	0.71
258_Q	273_Q	0.560	0.71
249_S	275_T	0.559	0.71
213_K	217_Y	0.558	0.71
259_V	281_I	0.558	0.71
257_V	265_P	0.557	0.71
85_E	99_S	0.557	0.71
292_V	295_I	0.556	0.71
270_A	289_L	0.555	0.70
253_S	272_R	0.553	0.70
1_M	153_I	0.552	0.70
12_V	140_L	0.551	0.70
212_S	241_L	0.550	0.70
3_V	145_L	0.546	0.69
76_A	104_G	0.545	0.69
257_V	298_G	0.544	0.69
249_S	278_Y	0.543	0.69
285_I	304_E	0.541	0.69
20_Y	126_M	0.541	0.69
5_K	8_L	0.541	0.69
245_L	261_P	0.539	0.68
134_R	248_V	0.539	0.68
33_T	289_L	0.539	0.68
28_S	128_S	0.538	0.68
131_T	143_R	0.538	0.68
208_F	241_L	0.538	0.68
134_R	271_D	0.537	0.68
212_S	259_V	0.537	0.68
8_L	56_M	0.537	0.68
227_S	233_R	0.536	0.68
246_E	261_P	0.536	0.68
79_T	86_E	0.535	0.68
158_A	161_Q	0.533	0.67
92_P	297_P	0.531	0.67
292_V	301_V	0.529	0.67
286_S	315_A	0.528	0.67
76_A	112_A	0.527	0.67
249_S	263_G	0.527	0.67
117_A	160_S	0.525	0.66
74_T	89_L	0.525	0.66
228_D	271_D	0.523	0.66
111_R	267_I	0.522	0.66
52_L	63_F	0.521	0.66
11_T	131_T	0.521	0.66
226_Q	233_R	0.520	0.65
129_K	154_G	0.519	0.65
213_K	242_K	0.519	0.65
306_V	311_A	0.518	0.65
254_F	274_T	0.517	0.65
122_V	142_G	0.515	0.65
208_F	239_L	0.515	0.65
74_T	115_A	0.514	0.65
1_M	150_E	0.514	0.65
132_Y	204_Q	0.512	0.64
25_V	125_V	0.512	0.64
249_S	252_V	0.512	0.64
205_F	256_T	0.508	0.64
203_K	283_H	0.508	0.64
203_K	275_T	0.507	0.64
206_A	216_F	0.507	0.64
193_K	296_M	0.507	0.64
285_I	311_A	0.506	0.63
151_L	154_G	0.506	0.63
288_D	304_E	0.505	0.63
238_P	264_N	0.505	0.63
191_L	195_P	0.505	0.63
5_K	304_E	0.502	0.63
249_S	277_G	0.501	0.63
261_P	279_P	0.501	0.63
18_T	27_A	0.501	0.63
51_G	54_I	0.501	0.63
204_Q	273_Q	0.500	0.62

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3mmlA	2	0.8567	100	0.105	Contact Map
3va7A	1	0.9612	100	0.129	Contact Map
3oepA	1	0.809	100	0.161	Contact Map
2zp2A	1	0.3254	86.6	0.956	Contact Map
3gmgA	2	0.391	58.9	0.965	Contact Map
1f0zA	1	0.1701	54.4	0.966	Contact Map
1x7fA	1	0.7881	53.6	0.966	Contact Map
2cu3A	2	0.1851	29.4	0.971	Contact Map
2phcB	1	0.5731	28.4	0.971	Contact Map
1vykA	1	0.1552	26.2	0.972	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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