GREMLIN Database
YEZE - Uncharacterized HTH-type transcriptional regulator YezE
UniProt: Q7WY76 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 194 (177)
Sequences: 44557 (34946)
Seq/√Len: 2626.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_Q41_R3.9241.00
23_Y32_D3.8681.00
18_E36_H3.5381.00
49_G53_D2.6931.00
20_F28_T2.2321.00
136_Y156_S2.2171.00
34_L44_L2.1921.00
50_T53_D2.1151.00
8_D11_L2.0471.00
10_A61_S2.0251.00
83_A141_R2.0041.00
9_T57_S1.9571.00
136_Y140_L1.9411.00
19_V28_T1.8971.00
22_E36_H1.8811.00
79_S82_E1.8331.00
19_V36_H1.8091.00
11_L15_R1.8001.00
40_A43_S1.7851.00
31_Q35_S1.7801.00
15_R36_H1.7791.00
19_V32_D1.7741.00
140_L144_D1.7571.00
19_V23_Y1.6571.00
140_L155_I1.6411.00
17_I61_S1.6361.00
10_A14_H1.6091.00
16_A20_F1.5921.00
13_L57_S1.5441.00
57_S60_K1.5301.00
30_L41_R1.5221.00
150_G153_T1.5151.00
15_R18_E1.5041.00
140_L143_K1.5011.00
30_L45_Y1.4931.00
60_K123_Y1.4811.00
71_M134_A1.4371.00
32_D35_S1.4331.00
32_D36_H1.4111.00
141_R145_Q1.4021.00
161_Y165_S1.3981.00
14_H61_S1.3871.00
18_E22_E1.3841.00
29_S32_D1.3791.00
61_S65_G1.3701.00
17_I62_Y1.3681.00
9_T47_T1.3651.00
24_G28_T1.3641.00
17_I58_A1.3511.00
132_E160_R1.3331.00
48_Y57_S1.3211.00
56_L60_K1.3011.00
7_F11_L1.2911.00
142_A148_L1.2821.00
16_A54_L1.2731.00
143_K150_G1.2661.00
30_L44_L1.2631.00
28_T33_L1.2601.00
20_F25_Y1.2391.00
143_K153_T1.2381.00
142_A147_E1.2301.00
25_Y55_F1.2261.00
53_D57_S1.2161.00
56_L123_Y1.2131.00
43_S46_D1.2121.00
23_Y27_G1.1921.00
24_G27_G1.1811.00
132_E136_Y1.1581.00
69_A90_E1.1561.00
89_Q183_Q1.1511.00
43_S47_T1.1461.00
149_N153_T1.1411.00
154_D157_A1.1311.00
15_R19_V1.1281.00
82_E86_D1.1241.00
42_Q46_D1.1231.00
40_A46_D1.1171.00
83_A138_G1.1101.00
8_D47_T1.1101.00
52_R56_L1.1011.00
52_R117_D1.0981.00
13_L58_A1.0981.00
79_S147_E1.0911.00
85_R89_Q1.0801.00
39_I43_S1.0761.00
81_K85_R1.0721.00
15_R37_L1.0701.00
44_L54_L1.0681.00
89_Q186_V1.0591.00
7_F10_A1.0571.00
5_K46_D1.0521.00
45_Y50_T1.0511.00
123_Y126_R1.0361.00
86_D89_Q1.0321.00
52_R119_E1.0301.00
80_V145_Q1.0221.00
108_N112_E1.0201.00
13_L48_Y1.0101.00
14_H18_E1.0071.00
60_K64_E1.0061.00
136_Y155_I1.0051.00
41_R45_Y1.0041.00
33_L54_L1.0031.00
67_N130_Q0.9981.00
157_A184_D0.9981.00
129_K133_D0.9961.00
164_Q168_S0.9911.00
53_D56_L0.9801.00
82_E85_R0.9771.00
143_K155_I0.9751.00
94_A98_P0.9701.00
181_R184_D0.9621.00
134_A137_H0.9511.00
137_H141_R0.9441.00
23_Y36_H0.9411.00
61_S64_E0.9411.00
73_R90_E0.9341.00
132_E156_S0.9321.00
71_M75_E0.9311.00
143_K146_G0.9291.00
138_G142_A0.9221.00
17_I21_G0.9161.00
156_S160_R0.9151.00
104_C108_N0.9141.00
137_H140_L0.9141.00
133_D137_H0.9081.00
122_R126_R0.9081.00
57_S61_S0.8981.00
34_L41_R0.8981.00
6_E10_A0.8981.00
116_H119_E0.8981.00
64_E68_A0.8931.00
126_R130_Q0.8881.00
80_V142_A0.8791.00
16_A58_A0.8791.00
69_A72_E0.8711.00
90_E93_N0.8701.00
77_P83_A0.8651.00
178_D181_R0.8641.00
153_T158_L0.8531.00
68_A72_E0.8491.00
8_D39_I0.8421.00
136_Y159_A0.8391.00
41_R46_D0.8361.00
62_Y65_G0.8351.00
141_R144_D0.8241.00
180_D183_Q0.8241.00
86_D90_E0.8241.00
138_G141_R0.8191.00
139_L162_L0.8161.00
26_E112_E0.8101.00
73_R86_D0.8081.00
89_Q93_N0.8031.00
143_K148_L0.7991.00
11_L14_H0.7891.00
19_V22_E0.7881.00
173_A176_T0.7851.00
133_D136_Y0.7761.00
25_Y51_K0.7731.00
5_K8_D0.7721.00
11_L37_L0.7691.00
88_F162_L0.7661.00
67_N71_M0.7641.00
20_F55_F0.7611.00
118_P122_R0.7581.00
13_L61_S0.7511.00
104_C107_I0.7481.00
155_I159_A0.7381.00
23_Y28_T0.7311.00
35_S41_R0.7311.00
139_L143_K0.7281.00
60_K126_R0.7271.00
12_V37_L0.7201.00
139_L155_I0.7121.00
5_K47_T0.7091.00
30_L34_L0.7061.00
14_H17_I0.7061.00
180_D184_D0.7061.00
125_E129_K0.7001.00
37_L40_A0.6991.00
130_Q133_D0.6981.00
12_V44_L0.6981.00
93_N97_D0.6981.00
13_L17_I0.6911.00
123_Y127_Q0.6871.00
121_A125_E0.6861.00
79_S83_A0.6831.00
179_M183_Q0.6801.00
25_Y52_R0.6761.00
164_Q167_L0.6721.00
31_Q45_Y0.6701.00
74_L134_A0.6691.00
150_G154_D0.6651.00
108_N111_I0.6631.00
130_Q134_A0.6601.00
76_A86_D0.6601.00
65_G68_A0.6581.00
77_P86_D0.6571.00
67_N134_A0.6551.00
109_S112_E0.6541.00
72_E90_E0.6511.00
8_D43_S0.6431.00
12_V47_T0.6421.00
5_K9_T0.6351.00
157_A161_Y0.6271.00
112_E116_H0.6271.00
116_H120_L0.6241.00
118_P121_A0.6211.00
22_E32_D0.6201.00
78_G83_A0.6131.00
161_Y164_Q0.6121.00
182_L185_H0.6111.00
81_K147_E0.6101.00
72_E76_A0.6091.00
60_K127_Q0.6081.00
78_G86_D0.6071.00
80_V147_E0.6071.00
68_A71_M0.6031.00
17_I65_G0.6021.00
85_R88_F0.6001.00
8_D40_A0.5981.00
140_L156_S0.5881.00
164_Q172_I0.5821.00
143_K149_N0.5811.00
172_I176_T0.5731.00
63_L127_Q0.5711.00
172_I175_V0.5701.00
6_E9_T0.5691.00
93_N183_Q0.5661.00
91_G95_L0.5651.00
103_A107_I0.5631.00
25_Y28_T0.5611.00
129_K132_E0.5551.00
160_R172_I0.5551.00
157_A160_R0.5531.00
73_R76_A0.5511.00
71_M130_Q0.5481.00
44_L49_G0.5481.00
90_E94_A0.5461.00
122_R125_E0.5451.00
78_G82_E0.5331.00
63_L130_Q0.5331.00
34_L37_L0.5321.00
8_D12_V0.5321.00
83_A142_A0.5301.00
16_A33_L0.5291.00
125_E128_S0.5271.00
105_Y108_N0.5271.00
143_K147_E0.5251.00
134_A138_G0.5251.00
107_I110_A0.5141.00
103_A106_I0.5141.00
26_E115_P0.5131.00
37_L41_R0.5131.00
182_L186_V0.5081.00
34_L39_I0.5081.00
19_V29_S0.5081.00
181_R186_V0.5081.00
168_S171_F0.5071.00
154_D158_L0.5071.00
93_N96_R0.5061.00
42_Q47_T0.5051.00
139_L158_L0.5041.00
92_V183_Q0.5031.00
93_N182_L0.5021.00
31_Q40_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rd3A 2 0.9588 100 0.177 Contact Map
3eupA 2 0.9948 100 0.184 Contact Map
2hyjA 2 0.9845 100 0.185 Contact Map
3qbmA 2 0.9948 100 0.19 Contact Map
2i10A 2 0.9433 100 0.191 Contact Map
3bruA 2 0.9794 100 0.192 Contact Map
4udsA 2 0.9433 100 0.192 Contact Map
3knwA 2 0.933 100 0.195 Contact Map
2g7sA 2 0.9742 100 0.205 Contact Map
4kwaA 2 0.9639 100 0.212 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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