GREMLIN Database
YIZA - Uncharacterized protein YizA
UniProt: Q7WY73 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 159 (152)
Sequences: 131 (104)
Seq/√Len: 8.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_F79_S4.2580.98
115_D119_H3.5980.96
112_Y150_G2.6070.80
86_I90_L2.5120.78
13_D83_R2.3510.73
62_I82_F2.3240.72
98_K115_D2.3080.71
51_S61_D2.2000.67
93_H119_H2.1590.66
10_Q151_R2.1260.65
54_R85_E2.1250.65
98_K119_H2.1130.64
79_S114_R2.0750.63
64_V82_F2.0490.62
3_K148_F2.0330.61
93_H115_D2.0140.60
23_T29_K1.9540.58
50_Y64_V1.9370.57
56_I102_V1.9010.56
54_R61_D1.8640.54
56_I117_I1.8350.53
14_Q54_R1.7700.50
17_T20_H1.7670.50
116_E152_T1.7270.48
54_R78_L1.6470.45
79_S112_Y1.6430.45
94_S97_I1.6410.45
50_Y79_S1.6340.44
23_T32_L1.6240.44
22_L129_I1.6120.43
5_F8_N1.5800.42
101_L111_L1.4890.38
63_A82_F1.3900.35
21_Q141_L1.3760.34
48_V147_S1.3720.34
139_L144_V1.3680.34
129_I148_F1.3510.33
56_I97_I1.3470.33
79_S118_L1.3410.33
61_D145_S1.3030.31
43_F69_Y1.2960.31
55_A72_L1.2910.31
74_K129_I1.2710.30
136_A150_G1.2700.30
41_T57_Q1.2690.30
66_F74_K1.2540.30
72_L132_L1.2540.30
3_K6_E1.2530.30
116_E123_A1.2490.29
14_Q151_R1.2290.29
28_L75_V1.2280.29
66_F141_L1.2220.29
65_Q69_Y1.2170.28
50_Y86_I1.2050.28
37_N99_D1.1810.27
40_Y117_I1.1810.27
72_L75_V1.1770.27
114_R145_S1.1650.27
69_Y74_K1.1590.26
27_L39_L1.1520.26
45_I73_N1.1480.26
2_M117_I1.1450.26
18_W143_P1.1280.25
67_A121_I1.1220.25
78_L82_F1.1150.25
51_S59_K1.1140.25
4_F151_R1.1090.25
43_F66_F1.1040.25
65_Q139_L1.0850.24
10_Q129_I1.0840.24
48_V51_S1.0740.24
116_E147_S1.0720.24
1_M8_N1.0690.24
87_I91_Q1.0690.24
134_V148_F1.0660.24
6_E87_I1.0540.23
104_V150_G1.0430.23
59_K85_E1.0410.23
102_V114_R1.0180.22
16_F114_R1.0180.22
119_H140_K1.0090.22
17_T77_S1.0050.22
53_I146_A0.9920.21
50_Y114_R0.9850.21
94_S141_L0.9830.21
61_D82_F0.9740.21
45_I125_E0.9700.21
39_L58_G0.9700.21
118_L153_L0.9670.21
32_L99_D0.9430.20
147_S152_T0.9430.20
104_V118_L0.9420.20
73_N77_S0.9350.20
77_S89_V0.9260.20
23_T70_Q0.9250.20
123_A146_A0.9140.19
65_Q96_Q0.9080.19
1_M5_F0.9070.19
100_E134_V0.9070.19
122_I136_A0.9060.19
19_C48_V0.8890.19
90_L134_V0.8870.19
115_D152_T0.8750.18
76_K86_I0.8680.18
7_Y11_V0.8610.18
93_H140_K0.8440.17
102_V118_L0.8380.17
68_D142_S0.8350.17
98_K109_G0.8340.17
98_K152_T0.8300.17
114_R117_I0.8250.17
4_F113_T0.8180.17
137_R143_P0.8150.17
95_D111_L0.8110.17
113_T122_I0.8060.17
51_S123_A0.8050.17
13_D151_R0.8000.16
116_E153_L0.7990.16
115_D123_A0.7950.16
4_F85_E0.7880.16
93_H98_K0.7870.16
6_E144_V0.7860.16
40_Y87_I0.7860.16
56_I106_W0.7820.16
4_F64_V0.7810.16
117_I153_L0.7810.16
106_W112_Y0.7800.16
6_E83_R0.7760.16
10_Q79_S0.7750.16
51_S85_E0.7740.16
17_T30_N0.7720.16
2_M103_S0.7700.16
61_D148_F0.7670.16
11_V84_T0.7610.16
75_V86_I0.7590.16
21_Q104_V0.7570.15
77_S81_T0.7560.15
123_A126_I0.7560.15
46_I82_F0.7550.15
90_L118_L0.7520.15
66_F150_G0.7510.15
6_E84_T0.7470.15
56_I114_R0.7470.15
25_E71_T0.7440.15
14_Q125_E0.7430.15
145_S150_G0.7430.15
2_M104_V0.7420.15
89_V93_H0.7150.15
10_Q13_D0.7120.14
73_N121_I0.7120.14
14_Q71_T0.7120.14
76_K80_N0.6850.14
100_E114_R0.6820.14
102_V150_G0.6790.14
46_I73_N0.6790.14
54_R88_D0.6790.14
109_G140_K0.6790.14
85_E151_R0.6730.14
70_Q74_K0.6710.14
2_M6_E0.6660.14
5_F9_W0.6640.14
102_V108_T0.6630.14
127_H133_S0.6560.13
71_T153_L0.6500.13
75_V153_L0.6440.13
23_T106_W0.6440.13
95_D142_S0.6400.13
82_F146_A0.6400.13
63_A108_T0.6390.13
23_T151_R0.6380.13
99_D103_S0.6380.13
41_T48_V0.6380.13
86_I119_H0.6350.13
46_I64_V0.6320.13
88_D103_S0.6260.13
28_L66_F0.6230.13
2_M136_A0.6200.13
120_H133_S0.6190.13
120_H127_H0.6190.13
11_V129_I0.6160.13
47_D51_S0.6110.13
16_F112_Y0.6110.13
56_I148_F0.6090.12
60_E86_I0.5910.12
21_Q144_V0.5890.12
43_F97_I0.5840.12
21_Q106_W0.5840.12
4_F96_Q0.5800.12
107_E112_Y0.5770.12
54_R64_V0.5770.12
94_S139_L0.5720.12
32_L100_E0.5720.12
22_L74_K0.5700.12
90_L98_K0.5670.12
32_L94_S0.5650.12
121_I152_T0.5630.12
123_A152_T0.5620.12
29_K46_I0.5610.12
96_Q144_V0.5600.12
28_L117_I0.5590.12
64_V114_R0.5580.12
68_D139_L0.5580.12
76_K100_E0.5560.12
88_D148_F0.5550.12
30_N139_L0.5530.11
48_V85_E0.5520.11
104_V107_E0.5520.11
37_N86_I0.5500.11
82_F137_R0.5500.11
39_L75_V0.5460.11
13_D43_F0.5400.11
71_T90_L0.5400.11
111_L139_L0.5350.11
136_A152_T0.5340.11
6_E57_Q0.5340.11
36_E75_V0.5320.11
60_E84_T0.5310.11
80_N101_L0.5310.11
106_W121_I0.5270.11
18_W129_I0.5250.11
106_W134_V0.5240.11
55_A136_A0.5190.11
6_E73_N0.5160.11
55_A87_I0.5130.11
93_H152_T0.5090.11
66_F94_S0.5080.11
65_Q76_K0.5070.11
25_E65_Q0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qe9A 2 1 100 0.687 Contact Map
3gorA 2 0.9371 99.8 0.775 Contact Map
2qnlA 2 0.8553 99.7 0.781 Contact Map
3dkaA 2 0.9371 99.7 0.784 Contact Map
2hkvA 2 0.8994 99.7 0.787 Contact Map
2f22A 2 0.8868 99.7 0.79 Contact Map
2p1aA 2 0.8868 99.7 0.792 Contact Map
2ou6A 2 0.8491 99.7 0.792 Contact Map
3cexA 2 0.8805 99.7 0.793 Contact Map
3di5A 1 0.9057 99.6 0.802 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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